• Disease
  • Gastric
  • Gastric Emptying
  • William Lee Hasler

    Prominent publications by William Lee Hasler

    KOL Index score: 14848

    BACKGROUND: Patients with scleroderma may have abnormal motility of the small intestine, with pseudoobstruction and bacterial overgrowth. Standard stimulatory agents are often ineffective in such patients. Because the somatostatin analogue octreotide evokes intestinal motor activity in normal subjects, we hypothesized that it might increase motility in patients with scleroderma.

    METHODS: We studied the effects of octreotide on intestinal motility and plasma motilin concentrations in five ...

    Also Ranks for: Intestinal Motility |  bacterial overgrowth |  scleroderma patients |  normal subjects |  effects octreotide
    KOL Index score: 12884

    In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. A multilumen GI ...

    Also Ranks for: Gastrointestinal Tract |  vivo dissolution |  fasted conditions |  ibuprofen stomach |  physiological administration
    KOL Index score: 12200

    BACKGROUND & AIMS: Colonic transit time (CTT) traditionally is assessed with radiopaque markers (ROMs), which requires radiation and is hindered by lack of standardization and compliance. We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM.

    METHODS: Seventy-eight constipated (Rome II) and 87 healthy subjects ingested a 260-kcal meal, a ROM ...

    Also Ranks for: Radiopaque Markers |  gut transit |  ctt wgtt |  constipated subjects |  wireless motility capsule
    KOL Index score: 11531

    BACKGROUND & AIMS: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry.

    METHODS: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG.

    RESULTS: The mean age of 243 patients with ...

    Also Ranks for: Gastric Emptying |  gastroparesis severity |  symptom onset |  national institute |  abdominal pain
    KOL Index score: 11511

    BACKGROUND & AIMS: It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis.

    METHODS: We performed a prospective study of 167 subjects with ...

    Also Ranks for: Suspected Gastroparesis |  ges wmc |  gastric emptying |  motility capsule |  diabetes mellitus
    KOL Index score: 11289

    BACKGROUND & AIMS: There are few effective treatments for nausea and other symptoms in patients with gastroparesis and related syndromes. We performed a randomized trial of the ability of the neurokinin-1 receptor antagonist aprepitant to reduce symptoms in patients with chronic nausea and vomiting caused by gastroparesis or gastroparesis-like syndrome.

    METHODS: We conducted a 4-week multicenter, double-masked trial of 126 patients with at least moderate symptoms of chronic nausea and ...

    Also Ranks for: Patients Gastroparesis |  nausea vomiting |  symptom severity |  chronic disease |  method female
    KOL Index score: 10943

    BACKGROUND & AIMS: Gastroparesis can be diabetic or idiopathic, yet little is known about differences in their presentation. We compared clinical characteristics, symptoms, and gastric emptying in patients with type 1 or type 2 diabetic (DG) or idiopathic (IG) gastroparesis.

    METHODS: We analyzed data from 416 patients with gastroparesis who were enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Registry; 254 had IG (most were female and ...

    Also Ranks for: Idiopathic Gastroparesis |  patients symptoms |  clinical characteristics |  vomiting dg |  type 1
    KOL Index score: 10742

    Relationships of regional colonic motility to transit in health, constipation, and constipation-predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to 1) characterize regional differences in colon pressure, 2) relate motor differences in constipation to colon transit, and 3) quantify the role of IBS in altered contractility with constipation. Colon pH and pressure were measured by wireless capsules in 53 healthy and 36 constipated subjects. Numbers of ...

    Also Ranks for: Colon Transit |  wireless capsule |  numbers contractions |  functional constipation |  bowel syndrome
    KOL Index score: 10741

    BACKGROUND: Nausea and vomiting are classic symptoms of gastroparesis. It remains unclear if characteristics of nausea and vomiting are similar in different etiologies of gastroparesis. The aims of this article were as follows: to describe characteristics of nausea and vomiting in patients with gastroparesis and to determine if there are differences in nausea and vomiting in diabetic (DG) and idiopathic gastroparesis (IG).

    METHODS: Gastroparetic patients enrolling in the NIDDK ...

    Also Ranks for: Nausea Vomiting |  diabetic gastroparesis |  quality life |  gastric emptying |  pagi sym
    KOL Index score: 10640

    BACKGROUND: Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET).

    AIMS: To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics.

    METHODS: Eighty-seven healthy subjects and 61 ...

    Also Ranks for: Gastric Emptying |  nondigestible capsule |  gastroparetic subjects |  gastrointestinal transit |  sensitivity specificity
    KOL Index score: 10524

    Impaired fundic accommodation (FA) limits fundic relaxation and the ability to act as a reservoir for food. Assessing intragastric meal distribution (IMD) during gastric emptying scintigraphy (GES) allows for a simple measure of FA. The 3 goals of this study were to evaluate trained readers' (nuclear medicine and radiology physicians) visual assessments of FA from solid-meal GES; develop software to quantify GES IMD; and correlate symptoms of gastroparesis with IMD and gastric emptying. ...

    Also Ranks for: Gastric Emptying |  fundic accommodation |  symptoms gastroparesis |  meal distribution |  ges imd
    KOL Index score: 10394

    BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing.

    METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and ...

    Also Ranks for: Gastric Emptying |  early satiety |  postprandial fullness |  patients gastroparesis |  quality life
    KOL Index score: 10317

    BACKGROUND: The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner.

    AIM: To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC.

    METHODS: Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, ...

    Also Ranks for: Gastrointestinal Transit |  wireless motility capsule |  study country |  gastric emptying |  small bowel
    KOL Index score: 10118

    BackgroundThe prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.AimsThe aims of this study were (1) to define prevalence of generalized dysmotility using wireless motility capsules (WMC), (2) to relate to symptoms in suspected regional delay, (3) to compare results of WMC testing to conventional transit studies to quantify new diagnoses, and (4) to assess the impact of results of ...

    Also Ranks for: Intestinal Dysmotility |  slow transit constipation |  wmc testing |  suspected gastroparesis |  motility capsule
    KOL Index score: 10057

    In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time, from 37 healthy subjects after oral administration of an 800 mg immediate-release tablet of ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted and fed states (simulated by ingestion of a liquid meal). Simultaneously, ...

    Also Ranks for: Buffer Capacity |  vivo dissolution |  ionizable drugs |  human gastrointestinal |  oral administration


    William Lee Hasler: Influence Statistics

    Sample of concepts for which William Lee Hasler is among the top experts in the world.
    Concept World rank
    discomfort antiemetic benefits #1
    traditional thoughts pathophysiology #1
    medication treatment complications #1
    device measures transit #1
    slow wave gradients #1
    gastroparesis exhibit #1
    reduce nausea #1
    ingestion solid portion #1
    agents delayed vomiting #1
    transit contractility #1
    prevalent condition symptoms #1
    gastrointestinal phenomena #1
    large 338 41 #1
    wmc testing patients #1
    cns rome #1
    gastroparesis ghrelin humans #1
    emptying testing #1
    neuromodulators theoretical utility #1
    cannabis cyclic vomiting #1
    gastroparetics controls #1
    therapies diverse mechanisms #1
    pyloric activity dynamic #1
    directed laboratory #1
    gastroparesis antiemetics #1
    hypoglycemia effective relief #1
    gastroparesis opiates #1
    cunv antiemetic drugs #1
    perception rectal #1
    scrutinizing state #1
    wmc gastric #1
    dysrhythmic activity #1
    medical pathogenesis #1
    distensibility increased variations #1
    cardiac arrhythmogenic effects #1
    autonomic basis #1
    behavioral treatments nausea #1
    gpoem gastroparesis #1
    topic gastroparesis #1
    medications gastric evacuation #1
    agonist tegaserod #1
    delineation pressure abnormalities #1
    scintigraphic retention #1
    upper gut propulsion #1
    william hasler #1
    impact physiology #1
    guide treatments gastroparesis #1
    advances pyloric injection #1
    motor nerves cns #1
    agents autonomic nervous #1
    gastroparesis pathogenesis #1

    Key People For Gastric Emptying

    Top KOLs in the world
    Michael C HOROWITZ,
    gastric emptying energy intake blood glucose
    Camilleri Camilleri
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    Richard W McCallum
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    Alan R Zinsmeister
    irritable bowel syndrome olmsted county colonic transit
    Karen Louise Jones
    gastric emptying blood pressure type 2 diabetes
    Robert S Fisher
    gastric emptying colonic transit botulinum toxin

    William Lee Hasler:Expert Impact

    Concepts for whichWilliam Lee Haslerhas direct influence:Gastric emptying,  Idiopathic gastroparesis,  Suspected gastroparesis,  Healthy humans,  Patients gastroparesis,  Rectal distention,  Gastric retention,  Diabetic complications.

    William Lee Hasler:KOL impact

    Concepts related to the work of other authors for whichfor which William Lee Hasler has influence:Functional dyspepsia,  Gastric emptying,  Irritable bowel syndrome,  Diabetic gastroparesis,  Gastrointestinal tract,  Abdominal pain,  Diabetes mellitus.



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    Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA | Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA | University of Michigan Health System, Ann Arbor,