 | William Lee HaslerDivision of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA | Division of Gastroenterology and Hepatology, Michigan Medicine, ... |
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William Lee Hasler:Expert Impact
Concepts for whichWilliam Lee Haslerhas direct influence:Gastric emptying,Idiopathic gastroparesis,Suspected gastroparesis,Healthy humans,Patients gastroparesis,Rectal distention,Gastric retention,Diabetic complications.
William Lee Hasler:KOL impact
Concepts related to the work of other authors for whichfor which William Lee Hasler has influence:Functional dyspepsia,Gastric emptying,Irritable bowel syndrome,Diabetic gastroparesis,Gastrointestinal tract,Abdominal pain,Diabetes mellitus.
KOL Resume for William Lee Hasler
| Year | |
|---|---|
| 2022 | Division of Gastroenterology and Hepatology, University of Michigan Health System, Ann Arbor, Michigan, USA |
| 2021 | Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA University of Michigan Health System, Ann Arbor, MI; |
| 2020 | Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan. American Gastroenterological Association. |
| 2019 | Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, USA University of Michigan Health System, Ann Arbor, Michigan |
| 2018 | Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 1500 E. Medical Center Dr., SPC 5362, 48109, Ann Arbor, MI, USA University of Michigan, Ann Arbor, MI, United States |
| 2017 | University of Michigan Division of Gastroenterology Ann Arbor MI USA |
| 2016 | Department of Internal Medicine, College of Medicine, University of Michigan, Ann Arbor, Michigan, 48109, United States |
| 2015 | University of Michigan Health System, Ann Arbor, MI, USA |
| 2014 | University of Michigan Health System, Division of Gastroenterology , 3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109 , USA +1 734 936 4780 ; +1 734 936 7392 ; |
| 2013 | University of Michigan, Ann Arbor |
| 2012 | Department of Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan |
| 2011 | Gastroenterology Section, Department of Medicine, University of Michigan, Ann Arbor, Michigan |
| 2010 | Department of Gastroenterology, University of Michigan, Ann Arbor, MI, USA |
| 2009 | Department of Medicine, University of Michigan, Ann Arbor, Michigan |
| 2008 | 1Gastroenterology, University of Mississippi Medical Center, Jackson, Mississippi; 2Gastroenterology, Mayo Clinic School of Medicine, Rochester, Minnesota; 3Nuclear Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts; 4Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan; 5Gastroenterology, University of Southern California, Los Angeles, California; 6Nuclear Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania; 7Gastroenterology, University of Kansas Medical Center, Kansas City, Kansas; 8Central Indiana Gastroenterology Group and Saint Vincent Hospital, Indianapolis, Indiana; 9Nuclear Medicine, University of Texas Medical Branch; Galveston, Texas; 10Gastroenterology, Temple University School of Medicine, Philadelphia, Pennsylvania; 11Advanced Radiology, P.C. and Spectrum Health, Grand Rapids, Michigan; 12Gastroenterology, California Pacific Medical Center, San Francisco, California; and 13Nuclear Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan, USA. |
| 2007 | Gastroenterology, University of Michigan Medical Center, Ann Arbor, Michigan; |
| 2006 | Dr. Hasler serves as Associate Professor of Internal Medicine in the Division of Gastroenterology at the University of Michigan Medical Center, Ann Arbor, MI. W. L. Hasler: Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, Ann Arbor, Michigan 48109. Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan |
| 2005 | Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. |
| 2004 | University of Michigan Medical Center, Ann Arbor, USA |
| 2003 | Division of Gastroenterology, University of Michigan School of Medicine, and McMaster University, Hamilton, Canada Centre Hospitalier University de Nantes, Nantes, France University Hospital Gasthuisberg, Leuven, Belgium Westfalische Wilhelms-Univeritat, Munster, Germany |
| 2002 | Division of Gastroenterology, Department of Medicine, University of Michigan Medical Center, 3912 Taubman Center, Box 0362, Ann Arbor, MI 48109, USA University of Michigan, Ann Arbor, Michigan 48109 |
| 2001 | Divisions of Gastroenterology, Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA Division of Gastroenterology, Department of Internal Medicine, and |
| 2000 | Division of Gastroenterology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA |
| 1999 | Divisions of Gastroenterology, University of California, San Francisco, San Francisco, Calif., University of Michigan Medical Center, Ann Arbor, Mich., USA Department of Internal Medicine, Division of Gastroenterology, and |
| 1998 | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA |
| 1997 | Department of Internal Medicine, University of Michigan MedicalCenter, Ann Arbor 48109, USA. |
| 1996 | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA |
| 1995 | Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA |
| 1994 | Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor. |
| Concept | World rank |
|---|---|
| gastrointestinal motility wmc | #1 |
| agents delayed vomiting | #1 |
| retention stomach | #1 |
| amitriptyline perception | #1 |
| pyloric activity gastroparesis | #1 |
| context cyclic vomiting | #1 |
| gastroparesis opiates | #1 |
| geography lessons | #1 |
| meals caloric | #1 |
| gastroparesis pathogenesis | #1 |
| pyloric botulinum toxin | #1 |
| manometry time | #1 |
| considerable advances gastroparesis | #1 |
| decade video capsule | #1 |
| emptying testing | #1 |
| background wireless | #1 |
| antral compliance | #1 |
| thickness gastric tissue | #1 |
| medical pathogenesis | #1 |
| distensibility 02 | #1 |
| unmasks triggers symptoms | #1 |
| 50 endoflip inflation | #1 |
| neuromodulators theoretical utility | #1 |
| medication treatment complications | #1 |
| theoretical utility benefits | #1 |
| vomiting result | #1 |
| altered gas transit | #1 |
| food endoscopy | #1 |
| meal agents | #1 |
| symptoms normal emptying | #1 |
| gastric evacuation agents | #1 |
| extraintestinal regions | #1 |
| agents autonomic nervous | #1 |
| condition systemic disorders | #1 |
| gastroduodenal serotonin | #1 |
| geography lessons state | #1 |
| wmc testing patients | #1 |
| vomiting include | #1 |
| reflex colonic | #1 |
| coupling propagation | #1 |
| emesis autonomic basis | #1 |
| electrogastrographic parameters | #1 |
| standard motility tests | #1 |
| udo bonnet | #1 |
| gut transit wmc | #1 |
| dynamic endoflip | #1 |
| gastroparesis new findings | #1 |
| pylorus dominant frequencies | #1 |
| illness antiemetic drugs | #1 |
| endoflip balloon inflation | #1 |
Prominent publications by William Lee Hasler
BACKGROUND: Patients with scleroderma may have abnormal motility of the small intestine, with pseudoobstruction and bacterial overgrowth. Standard stimulatory agents are often ineffective in such patients. Because the somatostatin analogue octreotide evokes intestinal motor activity in normal subjects, we hypothesized that it might increase motility in patients with scleroderma.
METHODS: We studied the effects of octreotide on intestinal motility and plasma motilin concentrations in five ...
| Known for Intestinal Motility | Bacterial Overgrowth | Scleroderma Patients | Normal Subjects | Effects Octreotide |
In vivo drug dissolution in the gastrointestinal (GI) tract is largely unmeasured. The purpose of this clinical study was to evaluate the in vivo drug dissolution and systemic absorption of the BCS class IIa drug ibuprofen under fed and fasted conditions by direct sampling of stomach and small intestinal luminal content. Expanding current knowledge of drug dissolution in vivo will help to establish physiologically relevant in vitro models predictive of drug dissolution. A multilumen GI ...
| Known for Gastrointestinal Tract | Vivo Dissolution | Fasted Conditions | Ibuprofen Stomach | Physiological Administration |
Investigation of Colonic and Whole-Gut Transit With Wireless Motility Capsule and Radiopaque Markers in Constipation
[ PUBLICATION ]
BACKGROUND & AIMS: Colonic transit time (CTT) traditionally is assessed with radiopaque markers (ROMs), which requires radiation and is hindered by lack of standardization and compliance. We assessed regional and CTT with the SmartPill (SmartPill Corporation, Buffalo, NY), a new wireless pH and pressure recording capsule, in constipated and healthy subjects and compared this with ROM.
METHODS: Seventy-eight constipated (Rome II) and 87 healthy subjects ingested a 260-kcal meal, a ROM ...
| Known for Radiopaque Markers | Gut Transit | Ctt Wgtt | Constipated Subjects | Wireless Motility Capsule |
BACKGROUND & AIMS: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry.
METHODS: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG.
RESULTS: The mean age of 243 patients with ...
| Known for Gastric Emptying | Gastroparesis Severity | Symptom Onset | National Institute | Abdominal Pain |
Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis
[ PUBLICATION ]
BACKGROUND & AIMS: It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis.
METHODS: We performed a prospective study of 167 subjects with ...
| Known for Suspected Gastroparesis | Ges Wmc | Gastric Emptying | Motility Capsule | Diabetes Mellitus |
Aprepitant Has Mixed Effects on Nausea and Reduces Other Symptoms in Patients With Gastroparesis and Related Disorders
[ PUBLICATION ]
BACKGROUND & AIMS: There are few effective treatments for nausea and other symptoms in patients with gastroparesis and related syndromes. We performed a randomized trial of the ability of the neurokinin-1 receptor antagonist aprepitant to reduce symptoms in patients with chronic nausea and vomiting caused by gastroparesis or gastroparesis-like syndrome.
METHODS: We conducted a 4-week multicenter, double-masked trial of 126 patients with at least moderate symptoms of chronic nausea and ...
| Known for Patients Gastroparesis | Nausea Vomiting | Symptom Severity | Chronic Disease | Method Female |
BACKGROUND & AIMS: Gastroparesis can be diabetic or idiopathic, yet little is known about differences in their presentation. We compared clinical characteristics, symptoms, and gastric emptying in patients with type 1 or type 2 diabetic (DG) or idiopathic (IG) gastroparesis.
METHODS: We analyzed data from 416 patients with gastroparesis who were enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Registry; 254 had IG (most were female and ...
| Known for Idiopathic Gastroparesis | Patients Symptoms | Clinical Characteristics | Vomiting Dg | Type 1 |
Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS
[ PUBLICATION ]
Relationships of regional colonic motility to transit in health, constipation, and constipation-predominant irritable bowel syndrome (C-IBS) are poorly characterized. This study aimed to 1) characterize regional differences in colon pressure, 2) relate motor differences in constipation to colon transit, and 3) quantify the role of IBS in altered contractility with constipation. Colon pH and pressure were measured by wireless capsules in 53 healthy and 36 constipated subjects. Numbers of ...
| Known for Colon Transit | Wireless Capsule | Numbers Contractions | Functional Constipation | Bowel Syndrome |
Nausea and vomiting in gastroparesis: similarities and differences in idiopathic and diabetic gastroparesis
[ PUBLICATION ]
BACKGROUND: Nausea and vomiting are classic symptoms of gastroparesis. It remains unclear if characteristics of nausea and vomiting are similar in different etiologies of gastroparesis. The aims of this article were as follows: to describe characteristics of nausea and vomiting in patients with gastroparesis and to determine if there are differences in nausea and vomiting in diabetic (DG) and idiopathic gastroparesis (IG).
METHODS: Gastroparetic patients enrolling in the NIDDK ...
| Known for Nausea Vomiting | Diabetic Gastroparesis | Quality Life | Gastric Emptying | Pagi Sym |
Comparison of gastric emptying of a nondigestible capsule to a radio‐labelled meal in healthy and gastroparetic subjects
[ PUBLICATION ]
BACKGROUND: Gastric emptying scintigraphy (GES) using a radio-labelled meal is used to measure gastric emptying. A nondigestible capsule, SmartPill, records luminal pH, temperature, and pressure during gastrointestinal transit providing a measure of gastric emptying time (GET).
AIMS: To compare gastric emptying time and GES by assessing their correlation, and to compare GET and GES for discriminating healthy subjects from gastroparetics.
METHODS: Eighty-seven healthy subjects and 61 ...
| Known for Gastric Emptying | Nondigestible Capsule | Gastroparetic Subjects | Gastrointestinal Transit | Sensitivity Specificity |
Impaired fundic accommodation (FA) limits fundic relaxation and the ability to act as a reservoir for food. Assessing intragastric meal distribution (IMD) during gastric emptying scintigraphy (GES) allows for a simple measure of FA. The 3 goals of this study were to evaluate trained readers' (nuclear medicine and radiology physicians) visual assessments of FA from solid-meal GES; develop software to quantify GES IMD; and correlate symptoms of gastroparesis with IMD and gastric emptying. ...
| Known for Gastric Emptying | Fundic Accommodation | Symptoms Gastroparesis | Meal Distribution | Ges Imd |
BACKGROUND: Early satiety (ES) and postprandial fullness (PPF) are often present in gastroparesis, but the importance of these symptoms in gastroparesis has not been well-described. The aims were: (i) Characterize ES and PPF in patients with gastroparesis. (ii) Assess relationships of ES and PPF with etiology of gastroparesis, quality of life, body weight, gastric emptying, and water load testing.
METHODS: Gastroparetic patients filled out questionnaires assessing symptoms (PAGI-SYM) and ...
| Known for Gastric Emptying | Early Satiety | Postprandial Fullness | Patients Gastroparesis | Quality Life |
BACKGROUND: The wireless motility capsule (WMC) offers the ability to investigate luminal gastrointestinal (GI) physiology in a minimally invasive manner.
AIM: To investigate the effect of testing protocol, gender, age and study country on regional GI transit times and associated pH values using the WMC.
METHODS: Regional GI transit times and pH values were determined in 215 healthy volunteers from USA and Sweden studied using the WMC over a 6.5-year period. The effects of test protocol, ...
| Known for Gastrointestinal Transit | Wireless Motility Capsule | Study Country | Gastric Emptying | Small Bowel |
BackgroundThe prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown.AimsThe aims of this study were (1) to define prevalence of generalized dysmotility using wireless motility capsules (WMC), (2) to relate to symptoms in suspected regional delay, (3) to compare results of WMC testing to conventional transit studies to quantify new diagnoses, and (4) to assess the impact of results of ...
| Known for Intestinal Dysmotility | Slow Transit Constipation | Wmc Testing | Suspected Gastroparesis | Motility Capsule |
In this study, we determined the pH and buffer capacity of human gastrointestinal (GI) fluids (aspirated from the stomach, duodenum, proximal jejunum, and mid/distal jejunum) as a function of time, from 37 healthy subjects after oral administration of an 800 mg immediate-release tablet of ibuprofen (reference listed drug; RLD) under typical prescribed bioequivalence (BE) study protocol conditions in both fasted and fed states (simulated by ingestion of a liquid meal). Simultaneously, ...
| Known for Buffer Capacity | Vivo Dissolution | Ionizable Drugs | Human Gastrointestinal | Oral Administration |
