SPECT Imaging of the Stomach: Comparison With Barostat, and Effects of Sex, Age, Body Mass Index, and Fundoplication

Authors: Camilleri CamilleriDuane D BurtonGeorge M ThomfordeErnest P BourasSilvia Delgado‐ArosHeather J ChialEmma Janet Castillo
Year: 2002
Times cited: 181

Key People For Gastric Volumes

Top KOLs in the world
Camilleri *********
irritable bowel syndrome colonic transit gastric emptying
Duane * ******
colonic transit gastric volume irritable bowel syndrome
Jan * ****
functional dyspepsia irritable bowel syndrome chronic constipation
Melvin *******
functional dyspepsia gastric emptying gerd patients
Alan * ***********
irritable bowel syndrome olmsted county colonic transit
Michael * *********
gastric emptying energy intake blood glucose

SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication


BACKGROUND: Impaired gastric accommodation may lead to dyspeptic symptoms. A non-invasive method using single photon emission computed tomography (SPECT) has been developed to measure gastric volumes.

AIMS AND METHODS: Our aims were: to assess the accuracy of SPECT with three dimensional image analysis to measure balloon volumes in vitro; to compare gastric barostat balloon volumes measured post-meal and post-distension with total gastric volumes measured simultaneously with SPECT; to present normal gastric volume data for healthy adults; and to compare SPECT data in health with symptomatic post-fundoplication patients.

RESULTS: In vitro balloon volumes measured by SPECT were highly accurate (R(2)=0.99). When measured simultaneously by gastric barostat and SPECT, postprandial/fasting volume ratios (2.2 (0.12) (mean (SEM)) v 2.3 (0.15), respectively; p=0.6) and post-distension volume ratios (1.4 (0.1) v1.3 (0.1); p=0.2) were highly comparable. In females, postprandial gastric volumes (675 (14) v 744 (20) ml for males; p=0.004) and changes in gastric volumes (464 (14) ml v 521 (20) ml for males; p=0.01) measured by SPECT were significantly lower than in males. No effects of age or body mass index were noted. The postprandial/fasting gastric volume ratio by SPECT was lower in post-fundoplication patients (2.7 (0.2)) than in healthy controls (3.4 (0.1); p=0.003).

CONCLUSIONS: SPECT provides a non-invasive estimate of the effect of a meal on total gastric volume that is comparable to changes in balloon volume observed with the gastric barostat. The SPECT technique is promising for investigation of gastric volumes in health and disease and the effects of pharmacological agents.

to see all concepts, it's free!