Tom R DeMeester
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA | University of Southern California, Los Angeles, CA, USA | Department of Surgery, Keck School ...
KOL Resume for Tom R DeMeester
Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
University of Southern California, Los Angeles, CA, USA
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA. Electronic address:
Keck School of Medicine, University of Southern California, Los Angeles, CA 91108, United States
Department of Surgery Keck School of Medicine University of Southern California Los Angeles, California.
Department of Surgery, Keck Medical Center of University of Southern California, 892 Huntington Garden Drive, San Marino, 91108, Los Angeles, CA, USA
Professor of Surgery, Emeritus, Keck School of Medicine, University of Southern California, San Marino, CA
Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California
Keck School of Medicine, University of Southern California Department of Surgery Los Angeles California USA
Department of Foregut Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA
Esophageal Diagnostic Working Group, Digestive Disease Week 2011, Chicago, Illinois, USA
Departments of Surgery
1510 San Pablo Street, Suite 514, 90033, Los Angeles, CA, USA
Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, Calif
Departments of Surgery and
Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, CA
Department of Surgery, Keck School of Medicine, University of Southern California, 1510 San Pablo Street Suite 514, 90033, Los Angeles, CA, USA
Chief, Division of Thoracic and Foregut Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
University of Toronto Faculty of Medicine, Senior Surgeon, Division of Thoracic Surgery, The Toronto General Hospital, Toronto, Ontario, Canada
Professor of Surgery, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio
Daniel and Karen Lee Chair in Thoracic Surgery, Head, Section of General Thoracic Surgery, Cleveland Clinic
Departments of Surgical Pathology and Foregut Surgery, Keck School of Medicine and University of Southern California, Los Angeles, CA
USC – Thoracic and Foregut Surgery, Los Angeles, California and Rochester School of Medicine – Surgery, Rochester, New York, USA
Division of Thoracic Foregut Surgery, Department of Surgery, Keck School of Medicine, University of Southern California (Drs Banki, Mason, Oh, Hagen, S. R. DeMeester, Lipham, Yacoub, and T. R. DeMeester) and Response Genetics Inc (Drs Tanaka and P. V. Danenberg and Ms K. D. Danenberg), Los Angeles.
Departments of Surgery,
KECK School of Medicine, University of Southern California, Los Angeles, California, USA
Departments of Surgery and Cardiothoracic Surgery, Keck School of Medicine, The University of Southern California, Los Angeles, California
Departments of Surgery University of Southern California School of Medicine, Los Angeles, USA
USC, Los Angeles, CA; Response Genetics, Inc., Los Angeles, CA
From the Department of Surgery, University of Southern California, Los Angeles, California.
Tom R DeMeester: Influence Statistics
|etiology intestinal metaplasia||#1|
|outcome respiratory symptoms||#1|
|69 abnormal test||#1|
|multilayered epithelium biopsies||#1|
|early gerd patients||#1|
|01 mm fundoplication||#1|
|t1b extended lymphadenectomy||#1|
|distal esophagus expression||#1|
|gastroesophageal junction prevalence||#1|
|cim endoscopic biopsies||#1|
|intramucosal cancer esophagectomy||#1|
|normal eating pattern||#1|
|barrett esophagus cardia||#1|
|nerd barrett esophagus||#1|
|female fundoplication hernia||#1|
|reflux episodes procedure||#1|
|disease bronchogenic carcinoma||#1|
|patients supine reflux||#1|
|esophageal intestinaltype mucosa||#1|
|patients incompetent cardia||#1|
|50 normal volunteers||#1|
|cdx2 pitx1 messenger||#1|
|hiatal hernia manometry||#1|
|diverticula surgical myotomy||#1|
|paraesophageal hernia decade||#1|
|cardiac mucosa cim||#1|
|pharyngoesophageal swallowing disorders||#1|
|challenges intragastric pressure||#1|
|squamous epithelium reflux||#1|
|patients reflux symptoms||#1|
|gastric duodenal juices||#1|
|myotomy isolated hypertensive||#1|
Open the FULL List in Excel
Prominent publications by Tom R DeMeester
Vascular endothelial growth factor and basic fibroblast growth factor expression in esophageal adenocarcinoma and Barrett esophagus
[ PUBLICATION ]
OBJECTIVE: This study was undertaken to investigate the role of the angiogenic factors vascular endothelial growth factor and basic fibroblast growth factor in the development and progression of Barrett esophagus and adenocarcinomas of the esophagus and gastroesophageal junction.
METHODS: Vascular endothelial growth factor and basic fibroblast growth factor messenger RNA expression levels, relative to the control gene encoding beta-actin, were measured by using a quantitative reverse ...
|Known for Growth Factor | Barrett Esophagus | Vascular Endothelial | Esophageal Adenocarcinoma | Basic Fibroblast|
Cytokeratin and DAS-1 immunostaining reveal similarities among cardiac mucosa, CIM, and Barrett's esophagus
[ PUBLICATION ]
OBJECTIVE: The normal histology at the gastroesophageal junction, and in particular the nature of cardiac mucosa, remains in dispute. Likewise, the relationship of intestinal metaplasia at the gastroesophageal junction (CIM) to Barrett's and intestinal metaplasia of the stomach (GIM) is unclear. The aim of this study was to assess the immunostaining characteristics of cardiac mucosa and CIM and compare their staining pattern with that of other foregut mucosal types. We hypothesized that ...
|Known for Cardiac Mucosa | Cim Barrett | Gastroesophageal Junction | Humans Metaplasia | Staining Pattern|
OBJECTIVE: The aim of this study was to determine whether antireflux surgery is more effective in producing loss of intestinal metaplasia located only at the gastroesophageal junction than it has been in patients with intestinal metaplasia extending up into the distal esophagus.
SUMMARY BACKGROUND DATA: Biopsies of a normal appearing gastroesophageal junction will demonstrate cardiac mucosa containing goblet cells--the hallmark of intestinal metaplasia--in 10% to 15% of patients who are ...
|Known for Intestinal Metaplasia | Patients Cim | Esophagus Cardia | Antireflux Procedure | Columnar Epithelium|
Is intestinal metaplasia a necessary precursor lesion for adenocarcinomas of the distal esophagus, gastroesophageal junction and gastric cardia?
[ PUBLICATION ]
Adenocarcinoma of the distal esophagus and gastroesophageal junction are believed to arise in Barrett's esophagus with intestinal metaplasia. Whether adenocarcinoma can arise in columnar lined esophagus without intestinal metaplasia is in doubt. Whether adenocarcinoma of the gastric cardia arises in intestinal metaplasia of the gastric cardia is also in doubt. We aim to evaluate the relationship of size and stage of adenocarcinoma of the distal esophagus, gastroesophageal junction and ...
|Known for Intestinal Metaplasia | Gastric Cardia | Distal Esophagus | Gastroesophageal Junction | Precursor Lesion|
The Prevalence of Lymph Node Metastases in Patients With T1 Esophageal Adenocarcinoma
[ PUBLICATION ]
Knowledge of the risk of lymph node metastases is critical to planning therapy for T1 esophageal adenocarcinoma. This study retrospectively reviews 75 T1a and 51 T1b tumors and correlates lymph node metastases with depth of tumor invasion, tumor size, presence of lymphovascular invasion, and tumor grade.
OBJECTIVES: Increasingly, patients with superficial esophageal adenocarcinoma are being treated endoscopically or with limited surgical resection techniques. Since no lymph nodes are ...
|Known for Lymph Node Metastases | Tumor Size | Poor Differentiation | Submucosal Invasion | Patients Esophageal Adenocarcinoma|
Telomerase reverse transcriptase expression is increased early in the Barrett's metaplasia, dysplasia, adenocarcinoma sequence
[ PUBLICATION ]
Barrett's esophagus is a multistage polyclonal disease that is associated with the development of adenocarcinoma of the esophagus and esophagogastric junction. Telomerase activation is associated with cellular immortality and carcinogenesis, and increased expression of the telomerase reverse transcriptase catalytic subunit (hTERT) has been used for the early detection of malignant diseases. To identify biomarkers associated with each stage of the Barrett's process, relative mRNA ...
|Known for Telomerase Reverse | Patients Cancer | Barrett Esophagus | Neoplastic Humans | Intestinal Metaplasia|
Inflammation and Specialized Intestinal Metaplasia of Cardiac Mucosa Is a Manifestation of Gastroesophageal Reflux Disease
[ PUBLICATION ]
OBJECTIVE: The purpose of the study was to test the hypothesis that cardiac mucosa, carditis, and specialized intestinal metaplasia at an endoscopically normal-appearing cardia are manifestations of gastroesophageal reflux disease.
SUMMARY BACKGROUND DATA: In the absence of esophageal mucosal injury, the diagnosis of gastroesophageal reflux disease currently rests on 24-hour pH monitoring. Histologic examination of the esophagus is not useful. The recent identification of specialized ...
|Known for Reflux Disease | Cardiac Mucosa | Intestinal Metaplasia | Patients Carditis | Gastroesophageal Junction|
Clinical characteristics, biologic behavior, and survival after esophagectomy are similar for adenocarcinoma of the gastroesophageal junction and the distal esophagus
[ PUBLICATION ]
OBJECTIVE: The Siewert classification system differentiates between adenocarcinoma of the gastroesophageal junction and that of the distal esophagus. The purpose of this study was to evaluate whether there were differences in the location and prevalence of lymph node metastases, type of recurrence, and survival with these tumors that warrant distinguishing between them in clinical practice.
METHODS: Records of all patients who underwent resection for adenocarcinoma of the distal ...
|Known for Gastroesophageal Junction | Distal Esophagus | Patients Adenocarcinoma | Survival Esophagectomy | Lymph Node Metastases|
OBJECTIVE: To investigate the prevalence of Barrett's esophagus in patients with adenocarcinomas located at the gastroesophageal junction.
DESIGN: A case series of patients who underwent esophagogastrectomy for adenocarcinoma was retrospectively reviewed. Tumors were grouped by location as esophageal, cardiac, and subcardiac, and the prevalence of specialized intestinal metaplasia in the histological specimens was determined.
SETTING: A university department of surgery that specializes ...
|Known for Cardiac Adenocarcinomas | Patients Adenocarcinoma | Barretts Metaplasia | Barrett Esophagus | Cardia Prevalence|
OBJECTIVE: To assess the long-term outcome of antireflux surgery in patients with Barrett's esophagus.
SUMMARY BACKGROUND DATA: The prevalence of Barrett's esophagus is increasing, and its treatment is problematic. Antireflux surgery has the potential to stop reflux and induce a quiescent mucosa. Its long-term outcome, however, has recently been challenged with reports of poor control of reflux and the inability to prevent progression to cancer.
METHODS: The outcome of antireflux surgery ...
|Known for Antireflux Surgery | Patients Barrett Esophagus | Reflux Symptoms | Intestinal Metaplasia | 5 Years|
Short-segment Barrett's Esophagus: a prevalent complication of gastroesophageal reflux disease with malignant potential
[ PUBLICATION ]
The significance of finding specialized intestinal epithelium localized to the region of the gastroesophageal junction is unclear. We tested the hypothesis that short segments of specialized intestinal epithelium are a consequence of gastroesophageal reflux disease and are premalignant. Two hundred forty-one patients with reflux symptoms underwent gastroscopy with rigorous biopsy. Barrett's esophagus was diagnosed when specialized intestinal epithelium was present on biopsy. Patients ...
|Known for Gastroesophageal Reflux Disease | Segment Barrett | Esophagus Patients | Specialized Intestinal | Reflux Symptoms|
Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
[ PUBLICATION ]
BACKGROUND: The CDX2 (caudal-related homeobox gene 2) and PITX1 (pituitary homeobox 1) genes have essential roles in human development. Forced expression of Cdx2 alone in the murine stomach results in gastric intestinal metaplasia (IM). This study was undertaken to investigate the expression pattern of these critical morphogenesis genes in the Barrett's multistage carcinogenesis model.
METHODS: CDX2 and PITX1 messenger RNA (mRNA) expression levels, relative to the control gene ...
|Known for Gene Expression | Barretts Esophagus | Pitx1 Homeobox | Esophageal Neoplasms | Cdx2 Mrna|
OBJECTIVE: To compare the frequency and spectrum of p53 gene mutations in adenocarcinomas of the esophagus and cardia and to compare clinical and pathologic features in patients with p53 mutant and nonmutant cancers.
SUMMARY BACKGROUND DATA: The p53 gene is commonly mutated in human cancers, and a p53 mutation is reported to be present in more than 50% of esophageal adenocarcinomas. Although many studies have investigated the frequency of p53 protein overexpression in adenocarcinomas of ...
|Known for P53 Mutations | Esophagus Cardia | Clinical Significance | Esophagogastric Junction | Female Genes|
Hiatal Hernia, Lower Esophageal Sphincter Incompetence, and Effectiveness of Nissen Fundoplication in the Spectrum of Gastroesophageal Reflux Disease
[ PUBLICATION ]
Background and AimsGastroesophageal reflux disease (GERD) is a spectrum of disease that includes nonerosive reflux disease (NERD), erosive reflux disease (ERD), and Barrett’s esophagus (BE). Treatment outcomes for patients with different stages have differed in many studies. In particular, acid suppressant medication therapy is reported to be less effective for treating patients with NERD and Barrett’s esophagus. The aims of this study were to investigate (1) the role of mechanical ...
|Known for Hiatal Hernia | Nissen Fundoplication | Reflux Disease | Lower Esophageal | Nerd Patients|
Key People For Gastroesophageal Reflux
Tom R DeMeester:Expert Impact
Concepts for whichTom R DeMeesterhas direct influence:Gastroesophageal reflux, Gastroesophageal reflux disease, Intestinal metaplasia, Esophageal adenocarcinoma, Nissen fundoplication, Reflux disease, Antireflux surgery, Barretts esophagus.
Tom R DeMeester:KOL impact
Concepts related to the work of other authors for whichfor which Tom R DeMeester has influence:Gastroesophageal reflux, Esophageal cancer, Eosinophilic esophagitis, Barrett esophagus, Nissen fundoplication, Hiatal hernia, Intestinal metaplasia.
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