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  • Gene Expression
  • Jonathan Pevsner

    Prominent publications by Jonathan Pevsner

    KOL Index score: 15483

    The mechanism(s) underlying lead neurotoxicity are not fully elucidated. cDNA expression microarray analysis identified lead-sensitive genes in immortalized human fetal astrocytes (SV-FHA). Of the represented genes expressed, vascular endothelial growth factor (VEGF) was one of the most sensitive. Lead induced VEGF mRNA 3-fold and VEGF protein approximately 2-fold with maximum mRNA induction following incubation with 10 micrometer lead acetate for 24 h. Phorbol 12-myristate 13-acetate ...

    Also Ranks for: Growth Factor |  vascular endothelial |  protein kinase |  vegf mrna |  signaling pathway
    KOL Index score: 13343

    The Munc-18-syntaxin 1A complex has been postulated to act as a negative control on the regulated exocytotic process because its formation blocks the interaction of syntaxin with vesicle SNARE proteins. However, the formation of this complex is simultaneously essential for the final stages of secretion as evidenced by the necessity of Munc-18's homologues in Saccharomyces cerevisiae (Sec1p), Drosophila (ROP), and Caenorhabditis elegans (Unc-18) for proper secretion in these organisms. As ...

    Also Ranks for: Syntaxin 1a |  kinase 5 |  proteins munc18 |  cyclin dependent |  saccharomyces cerevisiae
    KOL Index score: 13113

    Endocytosis in alveolar macrophages can be reversibly inhibited, permitting the isolation of endocytic vesicles at defined stages of maturation. Using an in vitro fusion assay, we determined that each isolated endosome population was capable of homotypic fusion. All vesicle populations were also capable of heterotypic fusion in a temporally specific manner; early endosomes, isolated 4 min after internalization, could fuse with endosomes isolated 8 min after internalization but not with ...

    Also Ranks for: Syntaxin 7 |  late endosome |  lysosome fusion |  snare proteins |  sensitive factor
    KOL Index score: 12216

    The possibility that single-cell organisms undergo programmed cell death has been questioned in part because they lack several key components of the mammalian cell death machinery. However, yeast encode a homolog of human Drp1, a mitochondrial fission protein that was shown previously to promote mammalian cell death and the excessive mitochondrial fragmentation characteristic of apoptotic mammalian cells. In support of a primordial origin of programmed cell death involving mitochondria, ...

    Also Ranks for: Cell Death |  mitochondrial fission |  human drp1 |  saccharomyces cerevisiae |  yeast homolog
    KOL Index score: 11884

    BACKGROUND: Studies examining the brains of individuals with autism have identified anatomic and pathologic changes in regions such as the cerebellum and hippocampus. Little, if anything, is known, however, about the molecules that are involved in the pathogenesis of this disorder.

    OBJECTIVE: To identify genes with abnormal expression levels in the cerebella of subjects with autism.

    METHOD: Brain samples from a total of 10 individuals with autism and 23 matched controls were collected, ...

    Also Ranks for: Ampa Receptors |  genes autism |  glutamate abnormalities |  amino acid |  microarray analysis
    KOL Index score: 11698

    BACKGROUND: The Sturge-Weber syndrome is a sporadic congenital neurocutaneous disorder characterized by a port-wine stain affecting the skin in the distribution of the ophthalmic branch of the trigeminal nerve, abnormal capillary venous vessels in the leptomeninges of the brain and choroid, glaucoma, seizures, stroke, and intellectual disability. It has been hypothesized that somatic mosaic mutations disrupting vascular development cause both the Sturge-Weber syndrome and port-wine ...

    Also Ranks for: Weber Syndrome |  somatic mutation |  wine stain |  gtp binding |  alpha subunits
    KOL Index score: 11059

    Kaposi's sarcoma (KS)-associated herpesvirus (KSHV; also called human herpesvirus 8) is believed to be the etiologic agent of Kaposi's sarcoma, multicentric Castleman's disease, and AIDS-associated primary effusion lymphoma. KSHV infection of human dermal microvascular endothelial cells (DMVEC) in culture results in the conversion of cobblestone-shaped cells to spindle-shaped cells, a characteristic morphological feature of cells in KS lesions. All spindle-shaped cells in KSHV-infected ...

    Also Ranks for: Gene Expression |  endothelial cell |  altered patterns |  viral herpesvirus |  dermal microvascular
    KOL Index score: 10933

    Rett syndrome (RTT) is an X-linked neurodevelopmental disorder linked to heterozygous de novo mutations in the MECP2 gene. MECP2 encodes methyl-CpG-binding protein 2 (MeCP2), which represses gene transcription by binding to 5-methylcytosine residues in symmetrically positioned CpG dinucleotides. Direct MeCP2 targets underlying RTT pathogenesis remain largely unknown. Here, we report that FXYD1, which encodes a transmembrane modulator of Na(+), K(+) -ATPase activity, is elevated in ...

    Also Ranks for: Mecp2 Target Gene |  rett syndrome |  null mice |  fxyd1 rtt |  cpg binding
    KOL Index score: 10804

    The cystic fibrosis gene encodes a cyclic AMP-gated chloride channel (CFTR) that mediates electrolyte transport across the luminal surfaces of a variety of epithelial cells1,2,3,4. The molecular mechanisms that modulate CFTR activity in epithelial tissues are poorly understood. Here we show that CFTR is regulated by an epithelially expressed syntaxin (syntaxin 1A), a membrane protein that also modulates neurosecretion5,6,7 and calcium-channel gating8,9,10,11 in brain. Syntaxin 1A ...

    Also Ranks for: Cftr Chloride Channels |  munc18 isoforms |  proteins syntaxin |  epithelial cells |  xenopus oocytes
    KOL Index score: 10151

    Sturge-Weber syndrome (SWS) is a neurocutaneous disorder that presents with a facial port-wine stain and a leptomeningeal angioma. Fibronectin expression regulates angiogenesis and vasculogenesis and participates in brain tissue responses to ischemia and seizures. We therefore hypothesized that abnormal gene expression of fibronectin and other extracellular matrix genes would be found in SWS brain tissue and SWS port-wine skin fibroblasts. Fibronectin gene and protein expression from ...

    Also Ranks for: Fibronectin Expression |  weber syndrome |  port wine |  brain tissue |  derived fibroblasts
    KOL Index score: 9680

    De novo mutation is highly implicated in autism spectrum disorder (ASD). However, the contribution of post-zygotic mutation to ASD is poorly characterized. We performed both exome sequencing of paired samples and analysis of de novo variants from whole-exome sequencing of 2,388 families. While we find little evidence for tissue-specific mosaic mutation, multi-tissue post-zygotic mutation (i.e. mosaicism) is frequent, with detectable mosaic variation comprising 5.4% of all de novo ...

    Also Ranks for: Mosaic Variants |  autism spectrum disorder |  asd contribution |  novo mutations |  exome sequencing
    KOL Index score: 9586

    The movement of hydrolases and other proteins to lysosomes is accomplished by vesicle trafficking. Specific vesicles are targeted from the trans-Golgi network via a prelysosomal compartment to lysosomes. The specificity of vesicle transport is thought to occur through the interaction of vesicle proteins with receptors on a particular target membrane. The syntaxins are a family of transmembrane proteins that have been implicated as vesicle receptors involved in vesicle docking and fusion. ...

    Also Ranks for: Vesicle Trafficking |  human syntaxin |  transport proteins |  plasma membrane |  golgi complex
    KOL Index score: 9474

    We have identified n-Sec1, a rat brain homolog of the yeast Sec1p protein that participates in the constitutive secretory pathway between the Golgi apparatus and the plasma membrane. The rat brain cDNA is predicted to encode a 68-kDa protein with 65% amino acid identity to Drosophila rop, 59% identity to Caenorhabditis elegans unc-18, and 27% identity to Saccharomyces cerevisiae Sec1p. By RNA blot analysis, n-Sec1 mRNA expression is neural-specific. An anti-peptide antiserum directed ...

    Also Ranks for: Binding Protein |  northern blotting |  sequence homology |  synaptic vesicle docking |  specific syntaxin
    KOL Index score: 8927

    Synaptic vesicles are proposed to dock at the presynaptic plasma membrane through the interaction of two integral membrane proteins of synaptic vesicles, VAMP and synaptotagmin, and two plasma membrane proteins, syntaxin and SNAP-25. We have characterized the binding properties of these proteins and observed SNAP-25 potentiation of VAMP 2 binding to syntaxins 1a and 4 but not syntaxins 2 or 3. n-sec1, a neuron-specific syntaxin-binding protein, bound syntaxin with nanomolar affinity, ...

    Also Ranks for: Synaptic Vesicle |  syntaxin snap25 |  docking complex |  protein binding |  nerve tissue
    KOL Index score: 8819

    Sec1p, Vps33p, Vps45p and Sly1p constitute a family of proteins implicated in vesicle trafficking at distinct stages of the yeast secretory pathway. Several mammalian homologues of Sec1p have been described, including n-sec1 which has been implicated in the regulation of synaptic vesicle docking at the nerve terminal. We have characterized cDNA clones encoding three additional mammalian homologues belonging to this family: r-vps33a and r-vps33b from rat, which are 30 and 26% identical to ...

    Also Ranks for: Vesicle Trafficking |  molecular dna |  proteins sequence |  amino acid |  vacuolar protein


    Jonathan Pevsner: Influence Statistics

    Sample of concepts for which Jonathan Pevsner is among the top experts in the world.
    Concept World rank
    webaccessible interface #1
    mutant gαq #1
    additional mammalian #1
    ncam brain samples #1
    patient t310 #1
    seizures glaucoma #1
    unexpected relationships #1
    186 ceph individuals #1
    abnormalities ampa #1
    sensitivity mosaic events #1
    copyimbalanced genes #1
    sws surgical #1
    autistic serum #1
    mosaicism variety #1
    entire chromosomes disease #1
    diagnosis sws #1
    chromosomal genomic microarrays #1
    cdk5 syntaxin 1a #1
    population data descent #1
    ucsc viewable tracks #1
    chromosomewide basis #1
    wine fibroblasts #1
    astonishingly sharp break #1
    stain reverse #1
    phase iii populations #1
    hemizygous deletions patients #1
    additional software users #1
    genes subsequent inclusion #1
    lysosomes vesicle trafficking #1
    sws normal skin #1
    munc18 cdk5 #1
    ncam autistic #1
    samples lcls #1
    snomad webimplementation #1
    pedisnp haplotypes #1
    unigene swissprot #1
    referencing array #1
    areas autistic brain #1

    Key People For Gene Expression

    Top KOLs in the world
    Eric S Lander
    human genome gene expression complex traits
    Thomas D Schmittgen
    pancreatic cancer gene expression cell lines
    Kenneth J Livak
    consultancy funding chronic lymphocytic leukemia single cell
    David Botstein
    gene expression saccharomyces cerevisiae salmonella typhimurium
    Patrick O Brown
    gene expression viral dna saccharomyces cerevisiae
    Gordon K Smyth
    gene expression gut microbiome insulin resistance

    Jonathan Pevsner:Expert Impact

    Concepts for whichJonathan Pevsnerhas direct influence:Gene expression,  Weber syndrome,  Vesicle trafficking,  Somatic mutation,  Syntaxin 7,  Rett syndrome,  Microarray data,  Chromosomal abnormalities.

    Jonathan Pevsner:KOL impact

    Concepts related to the work of other authors for whichfor which Jonathan Pevsner has influence:Gene expression,  Rett syndrome,  Dna methylation,  Cell death,  Snare proteins,  Syntaxin 1a,  Binding protein.



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    Department of Neurology, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD (A.L.N., J.T., J.P.). | Department of Psychiatry and Behavioral Sciences, John Hopkins University School of Medicine, Baltimore, MD 21205,