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  • Gene Expression
  • Todd R Golub

    Prominent publications by Todd R Golub

    KOL Index score: 17713

    The TEL/PDGF beta R fusion protein is the product of the t(5;12) translocation in patients with chronic myelomonocytic leukemia. The TEL/PDGF beta R is an unusual fusion of a putative transcription factor, TEL, to a receptor tyrosine kinase. The translocation fuses the amino terminus of TEL, containing the helix-loop-helix (HLH) domain, to the transmembrane and cytoplasmic domain of the PDGF beta R. We hypothesized that TEL/PDGF beta R self-association, mediated by the HLH domain of TEL, ...

    Also Ranks for: Growth Factor |  transforming protein |  myelomonocytic leukemia |  tel pdgf beta |  signaling pathways
    KOL Index score: 16412

    BACKGROUND: The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogenetic event in these patients, and that enzymatic inhibition of JAK2V617F may be of therapeutic benefit in this context. However, a significant proportion of patients with ET or MF are ...

    Also Ranks for: Activating Mutation |  patients mf |  extramedullary hematopoiesis |  myeloid metaplasia |  thrombopoietin receptor mpl
    KOL Index score: 16354

    Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has been validated by the success of RAF and MEK inhibitors in clinical trials. However, clinical responses to targeted anticancer therapeutics are frequently confounded by de novo ...

    Also Ranks for: Raf Inhibition |  kinase pathway |  therapeutic strategies |  drives resistance |  tumor clinical trials
    KOL Index score: 16015

    All-trans-retinoic acid (RA) treatment induces remissions in acute promyelocytic leukemia (APL) cases expressing the t(15;17) product, promyelocytic leukemia (PML)/RA receptor alpha (RARalpha). Microarray analyses previously revealed induction of UBE1L (ubiquitin-activating enzyme E1-like) after RA treatment of NB4 APL cells. We report here that this occurs within 3 h in RA-sensitive but not RA-resistant APL cells, implicating UBE1L as a direct retinoid target. A 1.3-kb fragment of the ...

    Also Ranks for: Promyelocytic Leukemia |  retinoid target |  pml raralpha |  apl cells |  oncogene proteins
    KOL Index score: 15632

    TEL is a member of the Ets family of transcription factors which are frequently rearranged in human leukemia. The mechanism of TEL-mediated transformation, however, is unknown. We report the cloning and characterization of a chromosomal translocation associated with acute myeloid leukemia which fuses TEL to the ABL tyrosine kinase. The TEL-ABL fusion confers growth factor-independent growth to the marine hematopoietic cell line Ba/F3 and transforms Rat-1 fibroblasts and primary murine ...

    Also Ranks for: Abl Tyrosine Kinase |  protein tel |  messenger rna |  human leukemia |  cytoskeletal localization
    KOL Index score: 15631

    Tumor necrosis factor-alpha (TNF-alpha) is a contributing cause of the insulin resistance seen in obesity and obesity-linked type 2 diabetes, but the mechanism(s) by which TNF-alpha induces insulin resistance is not understood. By using 3T3-L1 adipocytes and oligonucleotide microarrays, we identified 142 known genes reproducibly upregulated by at least threefold after 4 h and/or 24 h of TNF-alpha treatment, and 78 known genes downregulated by at least twofold after 24 h of TNF-alpha ...

    Also Ranks for: Necrosis Factor |  l1 adipocytes |  tnf alpha |  adipocyte gene |  insulin receptor
    KOL Index score: 15177

    The recurrent (12;21)(p13;q22) translocation fuses the two genes TEL and AML1 that have previously been cloned from translocation breakpoints in myeloid leukemias. Using mainly reverse transcriptase-polymerase chain reaction (RT-PCR), the TEL-AML1 chimeric transcript has been observed in 22–27% of pediatric patients with acute lymphoblastic leukemia (ALL), in particular in the early B-lineage ALL subtype, making it the most common genetic lesion in these patients. The vast majority of ...

    Also Ranks for: Cell Lines |  aml1 fusion |  human pair |  genetic translocation |  pediatric patients
    KOL Index score: 14489

    ICSBP (IRF-8) is a transcription factor of the IRF family expressed only in the immune system. It is induced in macrophages by gamma interferon (IFN-gamma) and contributes to macrophage functions. By interacting with Ets family protein PU.1, ICSBP binds to the IRF/Ets composite element and stimulates transcription. ICSBP binds to another DNA element, the IFN-stimulated response element (ISRE), a common target of the IRF family. Limited knowledge as to how ICSBP and other IRF proteins ...

    Also Ranks for: Icsbp Tel |  ifn gamma |  binding protein |  histone deacetylase |  element isre
    KOL Index score: 14064

    Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we developed a co-culture system to systematically assay the ability of 23 stromal cell types to influence the innate resistance of 45 cancer cell lines to 35 anticancer drugs. We found that stroma-mediated resistance is common, ...

    Also Ranks for: Innate Resistance |  brafmutant melanoma |  tumor microenvironment |  stromal cell |  targeted agents
    KOL Index score: 13880

    Chromosomal rearrangements involving band 12p13 are found in a wide variety of human leukemias but are particularly common in childhood acute lymphoblastic leukemia. The genes involved in these rearrangements, however, have not been identified. We now report the cloning of a t(12;21) translocation breakpoint involving 12p13 and 21q22 in two cases of childhood pre-B acute lymphoblastic leukemia, in which t(12;21) rearrangements were not initially apparent. The consequence of the ...

    Also Ranks for: Aml1 Gene |  lymphoblastic leukemia |  pair cloning |  fusion transcription factor |  binding proteins
    KOL Index score: 13824

    We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Overexpression of CRKL in immortalized human airway epithelial cells promoted anchorage-independent growth and tumorigenicity. Oncogenic CRKL activates the SOS1-RAS-RAF-ERK and SRC-C3G-RAP1 ...

    Also Ranks for: Cell Lung |  growth factor |  inhibitor resistance |  crkl amplifications |  proteins signal
    KOL Index score: 13250

    The TEL/AML1 fusion associated with t(12;21)(p13;q22) is the most common gene rearrangement in childhood leukemia, occurring in approximately 25% of pediatric acute lymphoblastic leukemia (ALL), and is associated with a favorable prognosis. For example, a cohort of pediatric patients with ALL retrospectively analyzed for the TEL/AML1 fusion treated on Dana-Farber Cancer Institute (DFCI) ALL Consortium protocols between 1980 to 1991 demonstrated a 100% relapse-free survival in ...

    Also Ranks for: Aml1 Fusion |  acute lymphoblastic |  pediatric patients |  leukemia tel |  favorable prognosis
    KOL Index score: 13200

    BACKGROUND: It is a challenge to identify patients who, after undergoing potentially curative treatment for hepatocellular carcinoma, are at greatest risk for recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissue.

    METHODS: We aimed to ...

    Also Ranks for: Hepatocellular Carcinoma |  gene expression |  fixed tissues |  survival liver tissue |  analysis paraffin


    Todd R Golub: Influence Statistics

    Sample of concepts for which Todd R Golub is among the top experts in the world.
    Concept World rank
    relative barcode abundance #1
    compacted layered canvases #1
    mesenchymal neural cells #1
    rapamycin rapamycin deprivation #1
    perils opportunities #1
    driverspecific routes #1
    raf cot expression #1
    mef2a genes #1
    shrnavirus #1
    crkl human #1
    fusion protein gmp #1
    proceedings mpe #1
    inhibitors pdgfr #1
    target mrna transcripts #1
    multiple myeloma identifies #1
    proliferation dexamethasone #1
    locus maestro #1
    genomic stability pdxs #1
    demeter analytical framework #1
    gdf15 supplementation #1
    fkbp51 androgen #1
    mpakt mice #1
    genomic evolution pdxs #1
    multiple mrna targets #1
    effectively1 #1
    bcl2 promoter mitf #1
    depth mutation testing #1
    melanocyte lineage melanoma #1
    tss motif #1
    lesional gene #1
    cas9 activates #1
    instance disease #1
    intratumor gammaproteobacteria #1
    cdk12cyclin #1
    pts derived pdxs #1
    crispr gproteincoupled receptors #1
    celastrol gedunin #1
    braf genomic status #1
    fewer reads locus #1
    erythroid differentiation rps19 #1
    expression profiling p53 #1
    common downstream target #1
    increased proliferation dlbcl #1
    essential thrombocythemia metaplasia #1
    genetic dependency #1
    lymphomas initial attempts #1
    instability extent #1
    increased expression dsamkl #1
    additional patient cohort #1
    ets‐related factor tel #1

    Key People For Gene Expression

    Top KOLs in the world
    Eric S Lander
    human genome gene expression complex traits
    Thomas D Schmittgen
    pancreatic cancer gene expression cell lines
    Kenneth J Livak
    consultancy funding chronic lymphocytic leukemia single cell
    David Botstein
    gene expression saccharomyces cerevisiae salmonella typhimurium
    Patrick O Brown
    gene expression viral dna saccharomyces cerevisiae
    Gordon K Smyth
    gene expression gut microbiome insulin resistance

    Todd R Golub:Expert Impact

    Concepts for whichTodd R Golubhas direct influence:Gene expression,  Cancer cells,  Prostate cancer,  Tel gene,  Cell lines,  Multiple myeloma,  Breast cancer,  Genomic evolution.

    Todd R Golub:KOL impact

    Concepts related to the work of other authors for whichfor which Todd R Golub has influence:Gene expression,  Prostate cancer,  Hepatocellular carcinoma,  Stem cells,  Cell lines,  Transcription factors,  Multiple myeloma.



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    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA, USA. | Harvard Medical School, Boston, MA, USA. | Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA. | Departments of Pediatric and Medic