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    • Todd Lencz
    • Todd Lencz

      Todd Lencz

      Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA | Departments of Psychiatry and Molecular Medicine, Zucker School of Medicine at ...



      KOL Resume for Todd Lencz


      Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA

      Hofstra Northwell School of Medicine


      Institute for Behavioral Science, The Feinstein Institutes for Medical Research, Manhasset, NY, 11030

      Division of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA

      FIMR/Zucker Hillside Hospital/Hofstra School of Medicine


      The Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, NY, USA

      FIMR/Zucker Hillside Hospital/Hofstra North Shore-LIJ

      Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, NY

      Departments of Psychiatry and Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, New York 11550

      Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York


      Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research

      Hofstra University, Hempstead, New York

      Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK


      Departments of Psychiatry and Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, NY, USA

      Psychiatry Research, Zucker Hillside Hospital, Northwell Health System, Glen Oaks, NY.

      Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, Manhasset, NY

      Zucker Hillside Hospital, Feinstein Institute for Medical Research



      Todd Lencz: Influence Statistics

      Sample of concepts for which Todd Lencz is among the top experts in the world.
      Concept World rank
      baseline predicts #1
      2 advisability #1
      reduced prefrontal area #1
      psychopathy prefrontal volume #1
      distribution ibd sharing #1
      prefrontal structural deficit #1
      admixture ashkenazi #1
      adolescence limited lateonset #1
      schizophrenia additional diagnosis #1
      deceitful individuals #1
      oppositeside #1
      pathological liars #1
      prodrome anti #1
      literature warrant consideration #1
      affective disorders subgroup #1
      preliminary questions schizophrenia #1
      ashkenazi genomic segment #1
      153 reduction #1
      discussions multidisciplinary experts #1
      cognitive genomics #1
      time admixture events #1
      ocd occipital cortex #1
      83 community volunteers #1
      impaired adolescent development #1
      1 exit strategy #1
      deficits memory strategy #1
      electrodermal hypo #1
      2digit #1
      media academic coverage #1
      individuals hypersharing individuals #1
      personality callosal #1
      worse attentional performance #1
      antisocial tendencies controls #1
      virusimmunerelated gene #1
      cognitiveperceptual deficits individuals #1
      task 2digit #1
      13 successful psychopaths #1
      ashkenazi admixture #1
      ocd gray matter #1
      hippocampal structural asymmetry #1
      ca3 patients #1
      cohortaveraged sharing #1
      3642 reduction #1
      single gwas cohorts #1
      pes media #1
      controls unsuccessful psychopaths #1
      ispg psychiatric genetics #1
      existing psychopathy psychological #1
      223 reduction #1


      Prominent publications by Todd Lencz

      KOL-Index: 14721

      OBJECTIVE: The aim of this study was to examine predictors of diagnostic and symptomatic outcome in adolescents with either psychotic disorder not otherwise specified (PsyNOS) or brief psychotic disorder (BrPsy) followed in a schizophrenia prodromal program.

      METHODS: As part of a naturalistic study of adolescents considered at clinical high risk for schizophrenia, 26 youths (mean age, 15.9 +/- 2.6 years, 65.4% male) with psychosis not fulfilling criteria for schizophrenia/schizoaffective ...

      Known for Bipolar Disorder | Risk Schizophrenia | Male Predictive | Schizotypal Personality | Studies Psychotic
      KOL-Index: 14631

      Importance: Schizophrenia is associated with widespread cognitive impairments. Although cognitive deficits are one of the factors most strongly associated with functional outcome in schizophrenia, current treatment strategies largely fail to ameliorate these impairments. To develop more efficient treatment strategies in patients with schizophrenia, a better understanding of the pathogenesis of these cognitive deficits is needed. Accumulating evidence indicates that genetic risk of ...

      Known for Genetic Loci | Cognitive Function | Schizophrenia Risk | Genome Wide | Quantitative Trait
      KOL-Index: 13964

      DISC1 influences susceptibility to psychiatric disease and related phenotypes. Intact functions of DISC1 and its binding partners, NDEL1 and NDE1, are critical to neurodevelopmental processes aberrant in schizophrenia (SZ). Despite evidence of an NDEL1-DISC1 protein interaction, there have been no investigations of the NDEL1 gene or the relationship between NDEL1 and DISC1 in SZ. We genotyped six NDEL1 single-nucleotide polymorphisms (SNPs) in 275 Caucasian SZ patients and 200 controls ...

      Known for Ndel1 Disc1 | Risk Schizophrenia | Psychiatric Disease | Binding Partners | Single Nucleotide
      KOL-Index: 13847

      IMPORTANCE: Previous evidence has implicated corticostriatal abnormalities in the pathophysiology of psychosis. Although the striatum is the primary target of all efficacious antipsychotics, the relationship between its functional connectivity and symptomatic reduction remains unknown.

      OBJECTIVE: To explore the longitudinal effect of treatment with second-generation antipsychotics on functional connectivity of the striatum during the resting state in patients experiencing a first episode ...

      Known for Functional Connectivity | Antipsychotic Treatment | Episode Schizophrenia | Striatal Regions | Patients Baseline
      KOL-Index: 12414

      It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of genetic overlap between risk for SCZ and cognitive phenotypes has been suggested by the presence of cognitive deficits in first-degree relatives of patients with SCZ; however, until recently, molecular genetic approaches to test this overlap have been lacking. Within the last few ...

      Known for Genetic Overlap | Cognitive Genomics | Risk Scz | Polygenic Component | Illness Onset
      KOL-Index: 11525

      OBJECTIVE: To investigate abnormalities in the structural integrity of brain white matter as suggested by diffusion tensor imaging in adolescents with early-onset schizophrenia (onset of psychosis by age 18).

      METHOD: Twenty-six patients with schizophrenia and 34 age- and gender-matched healthy volunteers received diffusion tensor imaging and structural magnetic resonance imaging examinations. Fractional anisotropy maps were compared between groups in the white matter using a voxelwise ...

      Known for Diffusion Tensor Imaging | Onset Schizophrenia | White Matter | Fractional Anisotropy | Healthy Volunteers Patients
      KOL-Index: 11267

      A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10−7), and stronger evidence when the phenotype was broadened to include bipolar disorder (P=9.96 × 10−9). In this study we provide additional evidence for association through meta-analysis of a larger data set (schizophrenia/schizoaffective disorder N=18 945, schizophrenia plus bipolar disorder N=21 274 and ...

      Known for Bipolar Disorder | Association Rs1344706 | Znf804a Locus | Genome Wide | Fine Mapping
      KOL-Index: 11046

      OBJECTIVE: Although several magnetic resonance imaging (MRI) studies have been conducted in adults with obsessive-compulsive disorder (OCD), few studies have used voxel-based morphometry to examine brain structure, especially in psychotropic drug-naive pediatric patients.

      METHOD: MRI examinations of 37 psychotropic drug-naive pediatric OCD patients and 26 age- and sex-matched healthy volunteers were acquired on a 1.5 T MRI system, normalized to a customized template, and segmented with ...

      Known for Gray Matter | Based Morphometry | Ocd Patients | Compulsive Disorder | Brain Regions
      KOL-Index: 10941

      CONTEXT: Cognitive impairment in schizophrenia is frequent, involves multiple domains, and is enduring. Numerous recent clinical trials have suggested that second-generation antipsychotic medications significantly enhance cognition in schizophrenia. However, none of these studies included healthy controls undergoing repeated testing to assess the possibility that improvements might reflect simple practice effects.

      OBJECTIVE: To report the results on cognition of a randomized comparison ...

      Known for Episode Schizophrenia | Cognitive Improvement | Healthy Control | Generation Antipsychotic | Practice Effects
      KOL-Index: 10738

      OBJECTIVE: The authors investigated volumetric alterations of the anterior hippocampal formation in patients experiencing a first episode of schizophrenia relative to healthy comparison subjects.

      METHOD: From contiguous 1.5-mm coronal magnetic resonance images, the hippocampal formation was divided into posterior and anterior segments, and the anterior hippocampal formation was separated from the amygdala. Volumes of the posterior and anterior hippocampal formation and amygdala were ...

      Known for Episode Schizophrenia | Hippocampal Formation | Naive Patients | Amygdala Volumes | Psychotic Disorders
      KOL-Index: 10552

      CONTEXT: Second-generation antipsychotics (SGAs) are increasingly used in the treatment of many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with substantial weight gain, with no means to predict which patients are at greatest risk.

      OBJECTIVE: To identify single-nucleotide polymorphisms associated with antipsychotic drug–induced weight gain.

      DESIGN: Pharmacogenetic association study.

      SETTING: The discovery cohort was from a US general psychiatric ...

      Known for Antipsychotic Drug | Weight Gain | Melanocortin 4 | Common Variants | 12 Weeks
      KOL-Index: 10433

      The objective of this study was to investigate the clinical and neuropsychological correlates of white matter abnormalities in patients with schizophrenia studied early in the course of illness. A total of 33 (21 male/12 female) patients with recent onset schizophrenia and 30 (18 male/12 female) healthy volunteers completed structural and diffusion tensor imaging exams. Patients also received clinical and neuropsychological assessments. Fractional anisotropy (FA) maps were compared ...

      Known for White Matter Abnormalities | Onset Schizophrenia | Healthy Volunteers Patients | Greater Severity | Uncinate Fasciculus
      KOL-Index: 10407

      BACKGROUND: Neurocognitive impairments have been documented in adolescents with early-onset schizophrenia (EOS; onset by age 18) and are important treatment targets. Information concerning the severity, pattern, and clinical correlates of these deficits in EOS remains limited.

      METHODS: Tests assessing motor skills, attention, memory, visuospatial abilities and executive functioning were administered to 54 clinically stabilized adolescents with EOS and 52 age- and sex-matched healthy ...

      Known for Onset Schizophrenia | Neurocognitive Profile | Adolescents Eos | Executive Functioning | Compared Controls
      KOL-Index: 10143

      We conducted data-mining analyses using the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) and molecular genetics of schizophrenia genome-wide association study supported by the genetic association information network (MGS-GAIN) schizophrenia data sets and performed bioinformatic prioritization for all the markers with P-values ⩽0.05 in both data sets. In this process, we found that in the CMYA5 gene, there were two non-synonymous markers, rs3828611 and rs10043986, ...

      Known for Risk Gene | Cmya5 Schizophrenia | Data Mining | Single Nucleotide | Genome Wide
      KOL-Index: 10108

      Although frontal lobe structural and functional abnormalities have been identified in schizophrenia, their relationship remains elusive. Because the frontal lobes are both structurally and functionally heterogeneous, it is possible that some measures of frontal lobe structure may not have accurately identified relevant frontal lobe subregions. The authors hypothesized that the volumes of two dorsal, 'archicortical' subregions (i.e. superior frontal gyrus and anterior cingulate gyrus), ...

      Known for Executive Dysfunction | Anterior Cingulate | Episode Schizophrenia | Cinguli Humans | Frontal Gyrus

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      Todd Lencz:Expert Impact

      Concepts for whichTodd Lenczhas direct influence:General cognitive function,  Episode schizophrenia,  Bipolar disorder,  Weight gain,  General cognitive ability,  Schizophrenia prodrome,  Cognitive flexibility,  Schizoaffective disorder.

      Todd Lencz:KOL impact

      Concepts related to the work of other authors for whichfor which Todd Lencz has influence:Bipolar disorder,  Negative symptoms,  Schizophrenia patients,  Gene expression,  White matter,  Educational attainment,  Magnetic resonance.



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      Division of Psychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA | Departments of Psychiatry and Molecular Medicine, Zucker School of Medicine at Hofstra/Northwell; Hempstead, NY, USA | Department of Psychiatry, Zucker School of Medicine

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