• Disease
  • Hellp
  • Hellp Syndrome
  • Karin J Blakemore

    Prominent publications by Karin J Blakemore

    KOL Index score: 10274

    BACKGROUND: The study of the immunogenetics of the human platelet antigens is important to the improvement of diagnosis and genetic counseling and to the development of screening programs for women at risk of having babies with neonatal alloimmune thrombocytopenia. Description of the immunogenetics of the human platelet antigens in some racial groups has been incomplete.

    STUDY DESIGN AND METHODS: A reverse dot blot technique employing polymerase chain reaction-amplified genomic DNA was ...

    Also Ranks for: Gene Frequencies |  human platelet antigens |  african americans |  polymerase chain |  continental ancestry
    KOL Index score: 10075

    The role of HLA antibodies in neonatal alloimmune thrombocytopenia is controversial. We prospectively studied the sera of obstetric patients at delivery for HLA antibodies and correlated their presence with umbilical cord blood platelet counts. We studied 493 births at The Johns Hopkins Hospital comprising of 357 African American, 115 Caucasian, and 21 babies of other racial groups. One hundred and thirty nine mothers had HLA antibodies. Of these HLA alloimmunized mothers, only ten ...

    Also Ranks for: Hla Antibodies |  neonatal thrombocytopenia |  blood platelet |  maternal fetal |  antigens humans
    KOL Index score: 10032

    BACKGROUND: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a severe variant of hypertensive disorders of pregnancy affecting approximately 1% of all pregnancies, and has significant maternal and fetal morbidity. Previously, we showed that upregulation of the alternative pathway of complement (APC) plays a role in HELLP syndrome. We hypothesize that HELLP syndrome follows a 2-hit disease model similar to atypical hemolytic uremic syndrome (aHUS), requiring both ...

    Also Ranks for: Hellp Syndrome |  alternative pathway |  complement apc |  pregnant women |  functional assay
    KOL Index score: 9633

    HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of pre-eclampsia whose pathogenesis remains unclear. Recent evidence and clinical similarities suggest a link to atypical hemolytic uremic syndrome, a disease of excessive activation of the alternative complement pathway effectively treated with a complement inhibitor, eculizumab. Therefore, we used a functional complement assay, the modified Ham test, to analyze sera of women with classic or ...

    Also Ranks for: Hellp Syndrome |  complement activation |  hemolytic uremic |  modified test |  low platelets
    KOL Index score: 8641

    The effect of epidural anesthesia on neonatal acid-base status, before, during, and after labor, was determined by review of funic blood-gas values from 142 women with normal term pregnancies and normal fetal heart rate patterns. Funic acid-base parameters were compared by type of anesthesia when stratified by mode of delivery (vaginal, cesarean section in the active phase of labor, or elective cesarean section). Use of epidural analgesia for vaginal delivery was associated with ...

    Also Ranks for: Epidural Anesthesia |  elective cesarean |  base values |  obstetric pregnancy |  fetal blood
    KOL Index score: 8516

    OBJECTIVE: To compare the accuracy of predicted birth weight by the gestation-adjusted projection method using ultrasonographic measurements obtained just before and at term.

    METHODS: The study group comprised patients with singleton pregnancies who underwent sonograms between 34.0 and 36.9 weeks' gestation (period 1) and at 37 weeks and beyond (period 2). The mean error in birth weight prediction, absolute birth weight error, and signed and absolute percent errors were compared with ...

    Also Ranks for: Birth Weight |  absolute error |  newborn predictive |  pregnancy pregnancy trimester |  37 weeks
    KOL Index score: 8461

    OBJECTIVE: Our purpose was (1) to establish the accuracy of a deoxyribonucleic acid amplification method in determination of RhD status in adult blood samples, including weak D variants (previously referred to as Du) and a D mosaic, and (2) to apply the method to determine fetal RhD status in alloimmunized pregnancies.

    STUDY DESIGN: Twenty-five adult blood samples, including five weak D variants and one D mosaic, were analyzed with a polymerase chain reaction to determine RhD type. The ...

    Also Ranks for: Polymerase Chain Reaction |  fetal rhd status |  rhd type |  amniotic fluid |  samples amniocentesis
    KOL Index score: 7851

    OBJECTIVE: Perinatal infection increases the risk of neonatal neurologic injury. Our objective is to determine whether histologically confirmed chorioamnionitis and funisitis is associated with fetal metabolic acidosis.

    STUDY DESIGN: This is a retrospective cohort study of all infants 34 weeks or less born at a single tertiary hospital admitted to the neonatal intensive care unit (NICU) between April 1999 and September 2002. Maternal and neonatal records and placental pathology reports ...

    Also Ranks for: Gestational Age |  chorioamnionitis funisitis |  newborn infant |  intrauterine infection |  base excess
    KOL Index score: 7831

    OBJECTIVE: Our hypothesis was that the degree of antenatally diagnosed cerebral ventriculomegaly is related to aneuploidy, perinatal mortality and long-term neurological morbidity.

    METHODS: Ninety-one cases of ventriculomegaly identified from 1 June 1994 to 1 July 1999 were examined for prenatal, intrapartum and neonatal complications. Pediatric follow-up was reviewed for infants with ventriculomegaly from birth up to as long as 4 years. Minor neurological morbidity was defined as a ...

    Also Ranks for: Cases Ventriculomegaly |  15 mm |  cerebral palsy |  neurological morbidity |  ventricular diameter
    KOL Index score: 7205

    Two cases of mosaic trisomy 7 confined to the cultured cells and not found in direct preparation were detected from 200 consecutive first-trimester chorionic villus samples (CVS) analysed. The mosaicism was similar in the two cases, but the pregnancy outcome was different. In both cases, the direct metaphases from the CVS were 46,XY. Culture metaphases were mos46,XY/47,XY, +7; the trisomy 7 was seen in 34 per cent of cells from case 1 and 53 per cent from case 2. A sonogram at 15 1/2 ...

    Also Ranks for: Trisomy 7 |  chorionic villus |  human pair |  direct preparation |  pregnancy outcome
    KOL Index score: 6818

    We describe a potential screening method for the second trimester detection of the fetus with Down syndrome by the use of standard sonographic biometry. Retrospective assessment of the biparietal diameter, femur length, and biparietal diameter/femur length ratio in 55 fetuses with Down syndrome and 544 control fetuses was performed at two medical centers. Adequate numbers of cases and controls were available to permit statistically significant comparisons between the groups at 15 to 23 ...

    Also Ranks for: Biparietal Diameter |  gestational age |  fetuses syndrome |  normal population |  screening method


    Karin J Blakemore: Influence Statistics

    Sample of concepts for which Karin J Blakemore is among the top experts in the world.
    Concept World rank
    preterm delivery clinic #1
    cent normal karyotypes #1
    service university hospitals #1
    timely manner prenatal #1
    donor gestational #1
    90 subsequent pregnancies #1
    mother infant patients #1
    placenta afp #1
    quinacrine polymorphisms #1
    sexual discordance #1
    dilated fetal stomach #1
    10 fetuses pregnancies #1
    subsequent pregnancies case #1
    nonviable female #1
    rhd type method #1
    skeletal dysplasia march #1
    molecular testing strategies #1
    hygroma normal #1
    gravida gestation #1
    cell dosage parameters #1
    recurrence risk 90 #1
    pregnancies incompatibility #1
    method rhd variants #1
    sex turner #1
    uts infants #1
    weak variants mosaic #1
    hscs engraftment levels #1
    weak variants #1
    blood cells conclusions #1
    thrombocytopenia hemorrhagic complications #1
    weak variants method #1
    utero human #1
    patients mco #1
    cared mco #1
    city managed #1
    questions fmait #1
    hemorrhagic complications diagnosis #1
    dysplasias molecular #1
    status polymerase #1
    delivery cared #1
    normal 46xy cell #1
    etiology fetal #1

    Key People For Hellp Syndrome

    Top KOLs in the world
    Baha M Sibaı̈
    severe preeclampsia gestational age cesarean delivery
    James Nello Martin
    hellp syndrome amniotic fluid severe preeclampsia
    Steven A Friedman
    severe preeclampsia hellp syndrome magnesium sulfate
    Louis Weinstein
    hemolytic disease hellp syndrome silver sulfadiazine
    Brian M Mercer
    preterm birth cesarean delivery premature rupture
    Pamela G Blake
    hellp syndrome plasma exchange severe preeclampsia

    Karin J Blakemore:Expert Impact

    Concepts for whichKarin J Blakemorehas direct influence:Hellp syndrome,  Birth weight,  Gestational age,  Preterm delivery,  Prenatal diagnosis,  Fetal blood,  Preterm labor,  Intracranial hemorrhage.

    Karin J Blakemore:KOL impact

    Concepts related to the work of other authors for whichfor which Karin J Blakemore has influence:Prenatal diagnosis,  Cystic hygroma,  Situ hybridization,  Gestational age,  Fetal surgery,  Human pair,  Domestic violence.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Division of Maternal Fetal Medicine, The Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. | Department of Gynecology and Obstetrics, Division of Maternal Fetal Medicine, Johns Hopkins Schoo