• Disease
  • Severe
  • Severe Sepsis
  • Yalçın Seyhun

    Prominent publications by Yalçın Seyhun

    KOL Index score: 7764

    IntroductionIn this prospective, randomized controlled study, we aimed to evaluate the effect of IgM-enriched immunoglobulin treatment on progression of organ failure and septic shock in patients with severe sepsis.Materials and methodsForty-two patients with severe sepsis were enrolled in the study. Patients in the study group (n = 21) received an intravenous immunoglobulin preparation (Pentaglobin®) in addition to standard therapy. Pentaglobin® therapy was commenced on the day of ...

    Also Ranks for: Severe Sepsis |  organ failure |  enriched immunoglobulin |  patients control |  septic shock
    KOL Index score: 5423

    After allogeneic hematopoietic stem cell transplantation, risk factors for cytomegalovirus (CMV) reactivation include pretransplantation donor and recipient CMV serologic status and posttransplantation development of acute graft-vs-host disease (aGvHD). Human leukocyte antigen (HLA) allele type is an additional factor in CMV infection. The present study included 108 patients who received an allogeneic stem cell graft from an HLA-identical sibling between 1993 and 2004. All recipients and ...

    Also Ranks for: Cmv Infection |  stem cell |  hla antigens |  allogeneic hematopoietic |  human leukocyte antigen
    KOL Index score: 5405

    The aims of this study were to determine the levels of procalcitonin (PCT) and C-reactive protein (CRP) in Helicobacter pylori-positive (HP+) patients diagnosed with duodenal and gastric ulcer and to evaluate the correlation of PCT and CRP levels with other invasive and non-invasive diagnostic methods for determination of H. pylori eradication in post-treatment follow-up. Thirty-five HP+ patients with dyspepsia were included in this study. Serum samples (5 ml) were collected at admission ...

    Also Ranks for: Helicobacter Pylori |  reactive protein |  crp levels |  dyspepsia female |  biomarkers biopsy
    KOL Index score: 4446

    BACKGROUND: This study was designed to determine whether human leukocyte antigen (HLA) and major histocompatibility complex class I chain-related A (MICA) antibody (Ab) production during the first 6 months posttransplantation correlated with long-term graft survival and rejection rate. The study group included 147 first transplantations from either living related (LRDs) or deceased donors (DDs) who were divided into two subgroups: rejection (RG, n = 28) and nonrejection (NRG, n = 119). ...

    Also Ranks for: Kidney Transplantation |  hla class |  major histocompatibility |  human leukocyte |  graft rejection
    KOL Index score: 4040

    INTRODUCTION: Certain cytokine gene polymorphisms (CGPs) have been shown to be associated with renal transplant rejection or graft outcomes. We sought to evaluate the relationship between gene polymorphisms in patients with acute rejection episodes (rejection group, RG, n = 19) versus those with stable graft function (nonrejection group, NRG, n = 71) in comparison with healthy control subjects (HCG, n = 150). The follow-up time period was 18 months. In the present study, 22 single ...

    Also Ranks for: Gene Polymorphisms |  graft rejection |  renal transplant |  interleukin2 il2 |  chain reaction
    KOL Index score: 3960

    BACKGROUND: Certain cytokine gene polymorphisms (CGPs) have been shown to be associated with renal transplant rejection episodes or graft outcomes. We sought to evaluate the relationships between gene polymorphisms and acute rejection episodes (RG, n = 19) versus stable graft function (NRG, n = 71) in transplant recipients compared with healthy control subjects (HCG, n = 150). The follow-up time period was 18 months. Using polymerase chain reaction sequence-specific primers with the ...

    Also Ranks for: Gene Polymorphisms |  graft rejection |  renal transplant |  single nucleotide |  case control
    KOL Index score: 3903

    Cytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They are characterized by large interindividual variability in their pharmacokinetics; therefore, monitoring their blood concentrations is important to predict their optimal ...

    Also Ranks for: Renal Transplant |  growth factor |  immunosuppressive agents |  genetic association |  csa tacrolimus
    KOL Index score: 3875

    The number of patients with end stage renal disease (ESRD) is increasing faster than the number of renal transplantations performed per year worldwide. Of the primary diseases leading to ESRD, diabetic nephropathy is the leading cause. The purpose of the present study is to investigate the association of HLA with the primary diseases leading to ESRD in Turkish patients. A total of 3230 individuals comprising 587 ESRD patients and 2643 healthy controls were enrolled into the study. Class ...

    Also Ranks for: Stage Renal Disease |  diabetic nephropathy |  esrd patients |  hla antigens |  kidney transplantation
    KOL Index score: 3687

    Exposure to human leukocyte antigens (HLA) via blood transfusions, pregnancies, and previous transplantations can result in anti-HLA antibody production. The presence of anti-HLA antibodies in recipient sera before transplantation is an important risk factor. To demonstrate the anti-HLA antibody status of Turkish end-stage renal disease (ESRD) patients, 674 patients (mean age, 40.35 +/- 13.15 years; female/male, 328/346) were enrolled into the study. Anti-HLA antibody screening and ...

    Also Ranks for: Hla Antigens |  kidney transplantation |  antibodies frequent |  renal dialysis |  failure chronic
    KOL Index score: 2271

    Gingival hyperplasia, a well-known side effect of ciclosporin A (CS-A), is much more prominent when CS-A is used in combination with calcium channel blockers, especially dihydropyridines. On the other hand, it is interesting to note that this complication is not observed in all patients using this drug combination. This study was conducted in order to investigate the relationship (if any) between major histocompatibility complex antigens and gingival hyperplasia. Seventy-six renal ...

    Also Ranks for: Renal Transplant Recipients |  gingival hyperplasia |  calcium channel |  cyclosporine female |  transplantation male
    KOL Index score: 758

    OBJECTIVE: The objective of this study is to confirm whether there is relation between the human leucocyte antigen (HLA) locus and restenosis after percutaneous coronary intervention (PCI) holds in our patient population and whether it can be useful as a prognostic factor.

    METHODS: We examined the HLA phenotypes in 46 consecutive patients (39 men, 7 women, mean age of 57 ± 9 years) who had successful stent implantation in the coronary artery. Selective coronary arteriography was ...

    Also Ranks for: Coronary Artery |  stent implantation |  pcr ssp
    KOL Index score: 392
    Also Ranks for: Autoimmune Hepatitis |  hla drb1


    Yalçın Seyhun: Influence Statistics

    Sample of concepts for which Yalçın Seyhun is among the top experts in the world.
    Concept World rank
    gg il2 #6
    primers cytokine #6
    ratio blood concentration #6
    330 il6 #6
    cytokines blood concentrations #6
    immunosuppressive drugs production #7
    calcineurin inhibitors cytokines #8
    blood concentration dose #9
    pranegative #10
    standard sepsis therapy #10
    prapositive #10
    330 gg #10
    blood concentrations cnis #12
    pentaglobin therapy #13
    study cytokine polymorphisms #13
    turkish renal #20
    concentrations cnis #21
    cnis renal #27
    beta transplant #27
    neonatal sepsis diagnosis #31
    patients genotype gg #38
    β codon #39
    hyperplasia hla #43
    10 il2 #51
    il2 330 #54
    immunosuppressive dosage #57
    month csa #60
    effects igm #62
    polymorphisms graft #72
    cnis patients #76
    month ratio #84
    difference pct #88

    Key People For Severe Sepsis

    Top KOLs in the world
    JeanLouis MD JeanLouis
    septic shock severe sepsis critically patients
    Derek C Angus
    severe sepsis united states septic shock
    Mitchell M Levy
    severe sepsis septic shock fluid responsiveness
    John C MD Marshall
    septic shock critical illness severe sepsis
    Steven Michael Opal
    severe sepsis septic shock antithrombin iii
    Konrad MD Reinhart
    severe sepsis septic shock hydroxyethyl starch

    Yalçın Seyhun:Expert Impact

    Concepts for whichYalçın Seyhunhas direct influence:Severe sepsis,  Neonatal sepsis,  Graft rejection,  Calcineurin inhibitors,  Pct crp,  Crp pct,  Renal transplant,  Stage renal disease.

    Yalçın Seyhun:KOL impact

    Concepts related to the work of other authors for whichfor which Yalçın Seyhun has influence:Neonatal sepsis,  Septic shock,  Acute rejection,  Renal transplantation,  Intravenous immunoglobulin,  Reactive protein,  Adjunctive therapy.



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    Istanbul University Department of Medical Biology Istanbul Faculty of Medicine Istanbul Turkey | Department of Medical Biology, Istanbul University, Istanbul, Turkey | Department of Medical Biology and Genetics, Istanbul Bilim University, Istanbul, T