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    • Gluten Sensitivity
    • Myopathy Associated With...
    • Myopathy associated with gluten sensitivity: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Gluten sensitivity,Glutenfree diet,Skeletal muscle,Sensitivity patients,Free diet,Gluten free,Muscle skeletal,Myositis patients.

      Key People For Gluten Sensitivity

      Top KOLs in the world
      #1
      Marios Hadjivassiliou
      coeliac disease gluten sensitivity cerebellar ataxia
      #2
      David Surendran Sanders
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      #3
      Peter H R Green
      celiac disease villous atrophy united states
      #4
      Umberto Volta
      celiac disease coeliac patients gluten sensitivity
      #5
      Alessio Fasano
      celiac disease intestinal permeability zonula occludens toxin
      #6
      Markku J Mäki
      celiac disease dermatitis herpetiformis glutenfree diet

      Myopathy associated with gluten sensitivity

      Abstract

      Ataxia and peripheral neuropathy are the most common neurological manifestations of gluten sensitivity. Myopathy is a less common and poorly characterized additional neurological manifestation of gluten sensitivity. We present our experience with 13 patients who presented with symptoms and signs suggestive of a myopathy and in whom investigation led to the diagnosis of gluten sensitivity. Three of these patients had a neuropathy with or without ataxia in addition to the myopathy. The mean age at onset of the myopathic symptoms was 54 years. Ten patients had neurophysiological evidence of myopathy. Inflammatory myopathy was the most common finding on neuropathological examination. One patient had basophilic rimmed vacuoles suggestive of inclusion-body myositis. Six patients received immunosuppressive treatment in addition to starting on a gluten-free diet; five improved and one remained unchanged. Among seven patients not on immunosuppressive treatment, four showed clinical improvement of the myopathy with a gluten-free diet. The improvement was also associated with reduction or normalization of serum creatine kinase level. The myopathy progressed in one patient who refused the gluten-free diet. Myopathy may be another manifestation of gluten sensitivity and is likely to have an immune-mediated pathogenesis. A gluten-free diet may be a useful therapeutic intervention.

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