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  • Anwar Ahmed Hoosen

    Prominent publications by Anwar Ahmed Hoosen

    KOL Index score: 13079

    BACKGROUND: The GenoType® MTBDRsl assay is a new rapid assay for the detection of resistance to second-line anti-tuberculosis drugs.

    OBJECTIVE: To evaluate the MTBDRsl assay on 342 multidrug-resistant tuberculosis isolates for resistance to ofloxacin (OFX), kanamycin (KM), capreomycin (CPM) and ethambutol (EMB), to compare the results to the agar proportion method, and to test discrepant results using DNA sequencing.

    RESULT: The sensitivity and specificity of the MTBDRsl assay were ...

    Also Ranks for: Mtbdrsl Assay |  susceptibility testing |  sensitivity specificity |  tuberculosis drugs |  detection resistance
    KOL Index score: 12673

    OBJECTIVE: To study the microbial aetiology of genital ulcer disease (GUD) in women.

    DESIGN: Microbial and clinical assessment of genital ulcers in women.

    SETTING: City Health sexually transmitted diseases clinic, King Edward VIII Hospital, Durban, South Africa.

    PARTICIPANTS: 100 Zulu women with genital ulceration who had not received antibiotics in the previous two weeks.

    RESULTS: Syphilis was diagnosed in 40%, genital herpes in 18%, donovanosis (granuloma inguinale) in 16%, chancroid ...

    Also Ranks for: South Africa |  genital ulcer disease |  gud women |  secondary syphilis |  prevalence sarcoptes durban
    KOL Index score: 12410

    BACKGROUND: Little is known regarding the human papillomaviruses (HPV) genotypes prevalent in women in South Africa, a country with a high incidence of cervical cancer.

    OBJECTIVE: To determine the prevalence and HPV genotypes in women with squamous abnormalities and normal cervixes participating in a community-based microbicide study.

    STUDY DESIGN: A total of 159 cervical specimens, including 56 specimens from women with abnormal cytology (cases) and 103 randomly selected specimens from ...

    Also Ranks for: South Africa |  hpv genotypes |  intraepithelial lesions |  women normal cytology |  cervical cancer
    KOL Index score: 11300

    Despite South Africa being one of the high-burden multidrug-resistant tuberculosis (MDR-TB) countries, information regarding the population structure of drug-resistant Mycobacterium tuberculosis strains is limited from many regions of South Africa. This study investigated the population structure and transmission patterns of drug-resistant M. tuberculosis isolates in a high-burden setting of South Africa as well as the possible association of genotypes with drug resistance and ...

    Also Ranks for: South Africa |  tuberculosis isolates |  resistant mycobacterium |  transmission patterns |  proportion method
    KOL Index score: 11283

    River water sources and diarrhoeic stools of residents in the Venda Region, Limpopo Province of South Africa were analysed for the prevalence of Escherichia coli ( E. coli ) and the presence of virulence genes among the isolates. A control group of 100 nondiarrhoeic stool samples was included. Escherichia coli was isolated and identified by standard cultural and biochemical methods. Pathogenicity of environmental and human isolates was determined by amplification of genes associated with ...

    Also Ranks for: Escherichia Coli |  river sources |  south africa |  virulence markers |  water isolates
    KOL Index score: 11151

    BACKGROUND: Diagnosis of tuberculous (TB) pleuritis is difficult and better diagnostic tools are needed. New blood based interferon-gamma (IFN-gamma) tests are promising, but sensitivity could be low in HIV positive patients. The IFN-gamma tests have not yet been validated for use in pleural fluid, a compartment with higher level of immune activation than in blood.

    METHODS: The QuantiFERON TB-Gold (QFT-TB) test was analysed in blood and pleural fluid from 34 patients presenting with ...

    Also Ranks for: Pleural Fluid |  immune responses |  patients hiv |  ifn gamma |  tuberculous pleuritis
    KOL Index score: 10788

    Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recommended for HIV patients concurrently receiving protease inhibitors because of reduced induction of CYP3A4. This study sought to determine the proportion of RFB susceptible isolates among RIF-resistant strains in a high HIV prevalence setting in South ...

    Also Ranks for: South Africa |  mycobacterium tuberculosis |  rpob mutations |  rif rfb |  isolates resistant
    KOL Index score: 10214

    BACKGROUND: The presence of multi-drug resistant Acinetobacter baumannii raises a big therapeutic challenge in our hospital. Tigecycline, a new glycylcycline with expanded broad spectrum of activity against multi-drug resistant organisms was recently licensed in South Africa.

    AIM: The aim of this study was to evaluate the in vitro activity of tigecycline against carbapenem resistant A. baumannii complex.

    METHODS: Consecutive clinical isolates of carbapenem resistant A. baumannii complex ...

    Also Ranks for: South Africa |  acinetobacter baumannii |  vitro activity |  clinical isolates |  drug resistant
    KOL Index score: 9506

    A growing body of evidence indicates that human immunodeficiency virus (HIV)-positive individuals are more likely to be infected with hepatitis B virus (HBV) than HIV-negative individuals, possibly as a result of shared risk factors. There is also evidence that HIV-positive individuals who are subsequently infected with HBV are more likely to become HBV chronic carriers, have a high HBV replication rate, and remain hepatitis Be antigen positive for a much longer period. In addition, it ...

    Also Ranks for: Hepatitis Virus Hbv |  hiv infection |  human immunodeficiency virus |  liver disease |  subsaharan africa
    KOL Index score: 9341

    OBJECTIVE: To investigate the accuracy of clinical diagnosis in genital ulcer disease (GUD); to devise management strategies for improving the control of GUD and thereby limit the spread of HIV-1 infection.

    DESIGN: Clinical and microbiological assessment of GUD in men and women. The index of suspicion, diagnostic accuracy, diagnostic efficiency and positive and negative predictive values of a clinical diagnosis were investigated.

    SETTING: City Health Sexually Transmitted Diseases Clinic, ...

    Also Ranks for: South Africa |  genital ulcer disease |  mixed infections |  lymphogranuloma venereum lgv |  granuloma inguinale
    KOL Index score: 9192

    OBJECTIVE: To assess the role of bacterial vaginosis (BV) on pregnancy complications in a developing community where mixed cervico-vaginal infections are common.

    SETTING: The antenatal clinic at King Edward VIII Hospital (KEH), Durban, South Africa, which is a large urban tertiary hospital serving mainly a Black underprivileged population of KwaZulu/Natal.

    METHODS: Asymptomatic pregnant women < or = 30 weeks gestation were recruited at their first antenatal visit. Clinical data including ...

    Also Ranks for: Bacterial Vaginosis |  women bv |  pregnancy outcome |  antenatal clinic |  south africa
    KOL Index score: 9108

    BACKGROUND: Adenosine Deaminase Activity (ADA) is a commonly used marker for the diagnosis of tuberculous pleural effusion. There has been concern about its usefulness in immunocompromised patients, especially HIV positive patients with very low CD4 counts. The objective of this study was to evaluate the sensitivity of ADA in pleural fluid in patients with low CD4 counts.

    MATERIALS AND METHODS: This was a retrospective case control study. Medical files of patients with tuberculous ...

    Also Ranks for: Tuberculous Pleuritis |  cd4 counts |  adenosine deaminase |  pleural fluid |  patients hiv
    KOL Index score: 8928

    OBJECTIVE--To determine the association of sexually transmitted pathogens in women with cervical intra-epithelial neoplasia (CIN). SETTING--An urban tertiary referral hospital serving a large indigent developing community. PARTICIPANTS--48 women attending a colposcopy clinic and 49 women attending a family planning clinic. METHODS--Vaginal, endocervical, rectal swab specimens and sera were collected for the detection of sexually transmitted pathogens. Cervical cytology was performed on ...

    Also Ranks for: Developing Community |  sexually transmitted |  bacterial vaginosis |  women cervical |  middle aged neisseria
    KOL Index score: 8710

    Neonatal candidaemia is a common, deadly and costly hospital-associated disease. To determine the genetic diversity of Candida parapsilosis causing fungaemia in South African neonatal intensive care units (NICUs). From February 2009 through to August 2010, cases of candidaemia were reported through laboratory-based surveillance. C. parapsilosis isolates from neonatal cases were submitted for identification by internal transcribed spacer (ITS) region sequencing, antifungal susceptibility ...

    Also Ranks for: South Africa |  candida parapsilosis |  newborn intensive units |  isolates fluconazole |  neonatal unit
    KOL Index score: 8701

    The aim of this study was to identify and characterize 97 methicillin-resistant Staphylococcus aureus (MRSA) isolates. Two conventional multiplex PCR assays, a real-time PCR assay and two PCR-based genotyping techniques including the spa- and hypervariable region (HVR)-typing methods were used to identify and characterize 97 MRSA strains isolated between April 2006 to September 2007 from the Steve Biko Academic Hospital. All MRSA isolates were positive for 16S rRNA gene, 99% were ...

    Also Ranks for: Mrsa Isolates |  pvl gene |  spa typing |  bacterial proteins |  sccmec types


    Anwar Ahmed Hoosen: Influence Statistics

    Sample of concepts for which Anwar Ahmed Hoosen is among the top experts in the world.
    Concept World rank
    genitalium vaginalis #1
    dtp reduction #1
    topic clinical effectiveness #1
    female hiv haemophilus #1
    ulcers endocervix #1
    epidemic donovanosis #1
    muellerhinton base #1
    south africa syphilis #1
    gram negative diplococci #1
    hib dtp #1
    women endocervix #1
    sexual intercourse gud #1
    donovanosis guidance #1
    rapidiff technique #1
    cerebrospinal fuid resistance #1
    south african setting #1
    zulu women durban #1
    100 zulu #1
    chocolate horse blood #1
    individual constituent vaccines #1
    gud zulu women #1
    secreted antigen lam #1
    sexual behaviour zulu #1
    calymmatobacterium #1
    nongavi funded countries #1
    tvv 819 #1
    positive culture antigens #1
    endourethral specimens patients #1
    inguinale donovanosis #1
    endourethral specimens #1
    sexual behaviour women #1
    conditions granuloma inguinale #1
    serving indigent #1
    genital herpes 18 #1
    participants100 #1
    durban secondary #1
    ducreyi media #1
    gud intercourse #1
    isolates urethritis #1
    penicillin 0 6 #1
    producing neisseria strains #1
    chancroid donovanosis #1

    Key People For South Africa

    Top KOLs in the world
    Rachel K Jewkes
    south africa intimate partner violence stepping stones
    Debbie Bradshaw
    south africa cape town cervical cancer
    Landon B Myer
    south africa cape town antiretroviral therapy
    Linda‐Gail Bekker
    south africa cape town young women
    Carl J Lombard
    south africa cape town sperm morphology
    R Alan Wood
    south africa antiretroviral therapy cape town

    Anwar Ahmed Hoosen:Expert Impact

    Concepts for whichAnwar Ahmed Hoosenhas direct influence:South africa,  Granuloma inguinale,  South african,  Genital ulcer disease,  Sexually transmitted pathogens,  Mycobacterium tuberculosis,  Calymmatobacterium granulomatis,  Neisseria gonorrhoeae.

    Anwar Ahmed Hoosen:KOL impact

    Concepts related to the work of other authors for whichfor which Anwar Ahmed Hoosen has influence:South africa,  Mycobacterium tuberculosis,  Bacterial vaginosis,  Hiv infection,  Cervical cancer,  Neisseria gonorrhoeae,  Trichomonas vaginalis.



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    Department of Medical Microbiology, Faculty of Health Sciences, University of Pretoria, South Africa | Pathcare - Vermaak & Partners Pathologists and Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa | Department of M