• Disease
  • Growth
  • Growth Cones
  • Corey S Goodman

    Prominent publications by Corey S Goodman

    KOL Index score: 14452

    Semaphorins and their receptors, plexins, are widely expressed in embryonic and adult tissues. In general, their functions are poorly characterized, but in neurons they provide essential attractive and repulsive cues that are necessary for axon guidance [1-3]. The Rho family GTPases Rho, Rac, and Cdc42 control signal transduction pathways that link plasma membrane receptors to the actin cytoskeleton and thus regulate many actin-driven processes, including cell migration and axon guidance ...

    Also Ranks for: Actin Cytoskeleton |  active rac |  axon guidance |  binding proteins |  rho activation
    KOL Index score: 13244

    Retrograde signaling plays an important role in synaptic homeostasis, growth, and plasticity. A retrograde signal at the neuromuscular junction (NMJ) of Drosophila controls the homeostasis of neurotransmitter release. Here, we show that this retrograde signal is regulated by the postsynaptic activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Reducing CaMKII activity in muscles enhances the signal and increases neurotransmitter release, while constitutive activation of ...

    Also Ranks for: Synaptic Transmission |  neuromuscular junction |  retrograde control |  neurotransmitter release |  nmj drosophila
    KOL Index score: 12403

    Highwire (Hiw), a putative RING finger E3 ubiquitin ligase, negatively regulates synaptic growth at the neuromuscular junction (NMJ) in Drosophila. hiw mutants have dramatically larger synaptic size and increased numbers of synaptic boutons. Here we show that Hiw binds to the Smad protein Medea (Med). Med is part of a presynaptic bone morphogenetic protein (BMP) signaling cascade consisting of three receptor subunits, Wit, Tkv, and Sax, in addition to the Smad transcription factor Mad. ...

    Also Ranks for: Bmp Signaling |  synaptic growth |  hiw mutants |  proteins cell |  neuromuscular junction
    KOL Index score: 11955

    The growth cone of the G neuron selectively fasciculates upon specific axon bundles in a stereotypic sequence as it navigates through the developing central nervous system of the grasshopper embryo. It turns and extends anteriorly in the contralateral neuropil of the second thoracic ganglion at a specific choice point where it fasciculates with the A/P axon bundle which contains the axons of the A1, A2, P1, and P2 neurons. We previously hypothesized (Raper, J. A., M. J. Bastiani, and C. ...

    Also Ranks for: Growth Cone |  grasshopper embryo |  fascicle filopodia |  selective affinity |  choice point
    KOL Index score: 11942

    Previous studies showed that Roundabout (Robo) in Drosophila is a repulsive axon guidance receptor that binds to Slit, a repellent secreted by midline glia. In robo mutants, growth cones cross and recross the midline, while, in slit mutants, growth cones enter the midline but fail to leave it. This difference suggests that Slit must have more than one receptor controlling midline guidance. In the absence of Robo, some other Slit receptor ensures that growth cones do not stay at the ...

    Also Ranks for: Robo Receptors |  midline guidance |  growth cones |  distinct roles |  insect proteins
    KOL Index score: 11908

    In the companion paper (Bastiani, M. J., J. A. Raper, and C. S. Goodman (1984) J. Neurosci. 4: 2311-2328), we show that as the G growth cone reaches its choice point and turns anteriorly on the A/P fascicle, its filopodia demonstrate selective affinity for the A/P fascicle as compared to the other approximately 25 longitudinal axon fascicles, and within the A/P fascicle itself, G's filopodia selectively contact the P axons as compared to the A axons. These results support the hypothesis ...

    Also Ranks for: Growth Cone |  grasshopper embryos |  fascicle filopodia |  choice point |  selective affinity
    KOL Index score: 11897

    1. We have examined the mature electrical properties of five identified neurones in embryos of the grasshopper Schistocerca nitens. The five cells arise from two different precursor cells: the median neuroblast, whose first three progency are called DUM 3,4,5; DUM 4,5; and DUM 5; and mid-line precursor 3, which divides once to produce the H cell and the H cell sibling.2. Electrical coupling was investigated by dual intracellular penetrations. Action potentials were elicited by ...

    Also Ranks for: Electrical Properties |  identified neurones |  action potentials |  cells day |  grasshopper embryos
    KOL Index score: 11831

    We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate synapse growth of the Drosophila neuromuscular junction (NMJ). gbb mutants have a reduced NMJ synapse size, decreased neurotransmitter release, and aberrant presynaptic ultrastructure. These defects are similar to those we observe in mutants of BMP receptors and Smad transcription factors. However, whereas these BMP receptors and signaling components are required in the presynaptic motoneuron, Gbb ...

    Also Ranks for: Retrograde Signal |  drosophila neuromuscular |  bmp receptors |  developmental genes |  synapse growth
    KOL Index score: 11607

    1. We have examined the development of the electrical properties of five identified neurones in grasshopper embryos between days 10 and 13 of embryogenesis (hatching occurs on day 20). DUM 3,4,5; DUM 4,5; DUM 5; the H cell; and the H cell sibling are the progeny of two different precursor cells. Electrical coupling and electrical excitability were assayed by intracellular recordings. 2. Midway through embryogenesis, on day 10, the five cells are highly electrically coupled to each other ...

    Also Ranks for: Electrical Properties |  identified neurones |  cells day |  action potential |  normal saline
    KOL Index score: 11606

    Previous studies suggested that Roundabout (Robo) is a repulsive guidance receptor on growth cones that binds to an unknown midline ligand. Here we present genetic evidence that Slit is the midline Robo ligand; a companion paper presents biochemical evidence that Slit binds Robo. Slit is a large extracellular matrix protein expressed by midline glia. In slit mutants, growth cones enter the midline but never leave it; they abnormally continue to express high levels of Robo while at the ...

    Also Ranks for: Slit Midline |  robo receptor |  growth cones |  molecular dna |  drosophila proteins
    KOL Index score: 11392

    Frazzled (Fra) is the DCC-like Netrin receptor in Drosophila that mediates attraction; Roundabout (Robo) is a Slit receptor that mediates repulsion. Both ligands are expressed at the midline; both receptors have related structures and are often expressed by the same neurons. To determine if attraction versus repulsion is a modular function encoded in the cytoplasmic domain of these receptors, we created chimeras carrying the ectodomain of one receptor and the cytoplasmic domain of the ...

    Also Ranks for: Cytoplasmic Domain |  netrin receptors |  slit receptor |  drosophila proteins |  attraction repulsion
    KOL Index score: 11371

    The ventral midline of the nervous system is an important choice point at which growing axons decide whether to cross and project contralaterally or remain on the same side of the brain. In Drosophila, the decision to cross or avoid the CNS midline is controlled, at least in part, by the Roundabout (Robo) receptor on the axons and its ligand, Slit, an inhibitory extracellular matrix molecule secreted by the midline glia. Vertebrate homologs of these molecules have been cloned and have ...

    Also Ranks for: Optic Chiasm |  axon guidance |  retinal ganglion |  ventral midline |  mice mice
    KOL Index score: 11186

    Numerous reports have described variability in the morphology of identified neurons; none, however, has previously reported variability in the pattern of synaptic connection. In this report we describe variability in the synaptic connections of an identified interneuron in two species of locust (Locusta migratoria and Schistocerca gregaria) and show that this variability is associated with a large variation in the structure of the interneuron.

    The morphology of the descending ...

    Also Ranks for: Identified Interneuron |  synaptic connections |  dcmd feti |  flight motoneurons |  ganglia grasshoppers
    KOL Index score: 11181

    Two tandem Netrin genes in Drosophila are expressed at the midline of the developing CNS and in different subsets of neurons, muscles, and epidermal patches. In embryos carrying a small deficiency that deletes both genes, CNS axon commissures are partially missing or thinner. This phenotype is rescued by expressing either Netrin gene at the midline. Pan-neural expression of either gene causes disruption of commissural and longitudinal tracts, indicating that the pattern of Netrin ...

    Also Ranks for: Motor Axons |  netrin genes |  genetic analysis |  drosophila midline |  expression gene


    Corey S Goodman: Influence Statistics

    Sample of concepts for which Corey S Goodman is among the top experts in the world.
    Concept World rank
    insect embryos mechanisms #1
    tissue agedependent manner #1
    grasshopper embryo proposal #1
    model plexb #1
    active zones bars #1
    periodic bridges supramp #1
    neuronal development insects #1
    wrapper amino acid #1
    excitability electrical #1
    stimulation quantal content #1
    mesodermal neuronal cells #1
    glial cells position #1
    divergent choice #1
    action potentials embryos #1
    medial axons #1
    variability identified neurons #1
    apparent selective adhesion #1
    notion surfaces #1
    dpak member #1
    neuronal recognition #1
    function pathways #1
    robo ligand #1
    eti apodeme wall #1
    temperature current threshold #1
    pattern grasshopper #1
    pathways synapse formation #1
    genetic analysis fasciclin #1
    snd motor axons #1
    grasshopper neurogenesis #1
    sibling rp1 #1
    ectopic gcm expression #1
    lower level fasciclin #1
    landmesser growth cones #1
    identified neurons variability #1
    complementary functions data #1
    interneuron l5 #1
    segmentally repeated stripes #1
    distinct boutons #1
    bars synaptic vesicles #1
    insect neurogenesis #1
    classes mutant phenotypes #1
    kinesincam #1
    ubiquitination pathway neurons #1
    tea excitable response #1
    body wall apodeme #1
    antihrp glycoproteins fasciclin #1
    glial cells glial #1
    cd8fas #1
    biological tenascin cns #1
    roundabout receptor rac #1

    Key People For Growth Cones

    Top KOLs in the world
    Paul C Letourneau
    growth cones schwann cells cell adhesion
    Corey S Goodman
    growth cones grasshopper embryo genetic analysis
    Mu‐ming Poo
    growth cone neuromuscular synapses transmitter secretion
    Marc Tessier‐Lavigne
    floor plate axon guidance spinal cord
    Stanley B Kater
    growth cones intracellular calcium identified neurons
    Christine E Holt
    growth cones local translation axon guidance

    Corey S Goodman:Expert Impact

    Concepts for whichCorey S Goodmanhas direct influence:Growth cones,  Grasshopper embryo,  Growth cone,  Fasciclin iii,  Grasshopper embryos,  Genetic analysis,  Growth cone guidance,  Embryonic development.

    Corey S Goodman:KOL impact

    Concepts related to the work of other authors for whichfor which Corey S Goodman has influence:Gene expression,  Axon guidance,  Growth cones,  Cell adhesion,  Drosophila melanogaster,  Spinal cord,  Central nervous.



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    Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA | Department of Molecular and Cell Biology, University of California, Berkeley, California, USA | Department of Molecular and Cell Biology, 279 Life Sciences Addi