• Disease
  • Stasis
  • Stasis Dermatitis
  • Piotr Nockowski

    Prominent publications by Piotr Nockowski

    KOL Index score: 10658

    Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw*06 allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence of particular KIR genes. We hypothesized that either activatory KIR2DS1 or inhibitory KIR2DL1 gene frequencies might be different in ...

    Also Ranks for: Psoriasis Vulgaris |  natural killer |  immunologic receptors |  kir2dl1 kir2ds1 |  kir genes
    KOL Index score: 6858

    Stasis dermatitis is a common disorder, which is a consequence of impaired venous drainage of the legs. It is characterized histologically by proliferation of small blood vessels in the papillary dermis. This neovascularization may lead occasionally to the formation of discrete papules due to inflammatory processes. In order to evaluate the role of matrix metalloproteinases (MMPs) in the acute phase of chronic venous insufficiency, we examined the production of MMP-1, -2, -13 and tissue ...

    Also Ranks for: Stasis Dermatitis |  matrix metalloproteinases |  tissue inhibitor |  venous insufficiency |  chain reaction
    KOL Index score: 6339

    Recently we described an association between psoriasis and KIR2DS1, a gene for a stimulatory natural killer cell receptor, in a Polish population. The association was independently reported among Japanese and confirmed in a U.S. population. Prompted by these findings, we reanalyzed data by a multivariate approach in search of possible effects of KIR genes other than KIR2DS1 (non-KIR2DS1). The methodology was based on a stratified analysis and multiple logistic regression. We found that ...

    Also Ranks for: Kir Gene |  psoriasis receptors |  association hla |  predisposition disease |  antigens humans
    KOL Index score: 5887

    Interleukin (IL)-7 is a multifunctional cytokine which is involved in the regulation of keratinocyte-T lymphocyte interactions; the latter is an important factor in the pathogenesis of psoriasis. In vitro, IL-7 is able to induce release of cytokines, including IL-6; IL-6 expression is known to be enhanced in psoriatic patients. Serum levels of IL-7 and IL-6 were measured by ELISA in 40 psoriatic patients and compared with cytokine levels in 18 healthy individuals. Serum levels of IL-7 ...

    Also Ranks for: Psoriatic Patients |  serum levels |  pathogenesis psoriasis |  interleukin7 male |  inflammatory agents
    KOL Index score: 4682

    Psoriasis vulgaris is a multifactorial disease with an autoimmune component, and T lymphocytes seem to be involved in its aetiology. CTLA-4 molecule is an important down-regulator of T-lymphocyte activation, and several polymorphisms of the CTLA-4 gene were found to be associated with some autoimmune diseases. We examined whether single nucleotide polymorphisms (SNPs) in the CTLA-4 gene, CT60A>G and +49A>G, are associated with psoriasis vulgaris. Alleles of these two SNPs were determined ...

    Also Ranks for: Psoriasis Vulgaris |  single nucleotide |  ctla4 gene |  autoimmune diseases |  polymorphisms snps
    KOL Index score: 4398

    CTLA-4 molecule is an important inhibitor of T-lymphocyte activation. Several single nucleotide polymorphisms (SNPs) in the CTLA-4 gene were found, and their associations with many human diseases were described. So far, however, such studies have not been performed in psoriasis vulgaris in Caucasoids. Therefore, we examined the distribution of three CTLA-4 SNPs: -1147C/T, -318C/T and +49 A/G in 116 patients with psoriasis vulgaris and 123 healthy blood donors using the polymerase chain ...

    Also Ranks for: Psoriasis Vulgaris |  gene polymorphisms |  antigens differentiation ctla4 |  alleles genotypes |  single nucleotide
    KOL Index score: 4377

    BACKGROUND: Psoriasis is a chronic autoimmune hyperproliferative skin disease of varying severity affecting approximately 2-3% of the general population in the USA and Europe. Although the pathogenesis of psoriasis has not been fully elucidated, an immunologic-genetic relationship is likely. Cutaneous and systemic overexpression of various proinflammatory cytokines (TNF, interleukins, interferon-gamma) has been demonstrated in psoriatic patients.

    METHODS: We reviewed the current database ...

    Also Ranks for: Pathogenesis Psoriasis |  psoriatic patients |  animals cytokines |  interferon gamma |  necrosis factor
    KOL Index score: 4361

    E-selectin is an adhesion molecule expressed on vascular endothelial cells in several inflammatory skin diseases, including psoriasis. It is responsible for the adherence between microvascular endothelium and neutrophils, monocytes, eosinophils and subsets of T cells. Soluble E-selectin (sE-selectin) serum levels were measured by ELISA in 32 psoriatic patients before treatment and compared with both post-treatment sE-selectin levels in 16 patients and sE-selectin values in 10 healthy ...

    Also Ranks for: Serum Levels |  psoriatic patients |  treatment psoriasis |  soluble e‐selectin |  pasi scores
    KOL Index score: 3701

    INTRODUCTION: The standard treatment for lichen sclerosus (LS) is symptomatic and is primarily based on the chronic use of corticosteroids, sometimes resulting in unsatisfactory effects. Therefore, other non-pharmacological methods are being sought, which are less aggravating for the patient. LS can be treated topically by using photodynamic therapy (PDT) based on 5-aminolevulinic acid (5-ALA). Unfortunately, therapy with the red light is often connected with severe local pain during the ...

    Also Ranks for: Photodynamic Therapy |  vulvar lichen |  pdt treatment |  5aminolevulinic acid |  photosensitizing agents
    KOL Index score: 3565

    Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations. It has not yet been studied in Polish patients at DNA level, but only by serology that is inadequate for HLA-C. Therefore, we examined the distribution of HLA-C alleles by means of low resolution PCR-SSP in 102 Polish psoriatics and 123 healthy controls. We have found significantly higher representation of HLA-Cw*06 (odds ratio, 18.73; P(cor)<0.001) and significantly lower representation of ...

    Also Ranks for: Strong Association |  psoriasis hla |  123 healthy controls |  cw6 allele |  antigens humans


    Piotr Nockowski: Influence Statistics

    Sample of concepts for which Piotr Nockowski is among the top experts in the world.
    Concept World rank
    structure selected cytokines #2
    14 human population #2
    genetic factors structure #2
    receptors genes location #2
    genes location cytokine #2
    ifngamma work #2
    selected cytokines pathogenesis #2
    green light pdt #3
    increased interleukin‐7 #3
    severe pain sessions #3
    interleukin‐7 levels #3
    540nm±15 #3
    increased interleukin‐7 levels #3
    preliminary green #3
    lichen sclerosus chronic #3
    psoriatic patients lack #3
    chronic characterised #3
    il19 il23 #3
    cw06 adolescent #4
    hlac human populations #4
    hlacw06 odds ratio #4
    serology hlac #4
    association hlacw06 #4
    strong association psoriasis #4
    il18 il19 #4
    psoriasis kir2ds1 #4
    nonkir2ds1 genes #4
    02 pcor #4
    polish hlac #4
    odds ratio pcor0038 #4
    kir2ds1positive individuals #4
    light characterised #4
    102 polish psoriatics #4
    hlacw06 psoriasis #4
    effects kir2ds1 #4
    effects kir genes #4
    pcor0001 hlacw07 #4
    dna level serology #4
    cw06 odds #4
    02 pcor decrease #4
    hlacw genotypes #4
    psoriasis polish #5
    pcor0001 #5
    il12 il11 #5
    kir2ds1 susceptibility #6
    kir2dl1 activatory receptor #6
    fourteen gene combinations #6
    selected cytokines receptors #6
    kir2d inhibitory #6
    cw6 molecule #6

    Key People For Stasis Dermatitis

    Top KOLs in the world
    Erwin Schöpf
    atopic dermatitis langerhans cells human keratinocytes
    Johannes Norgauer
    dendritic cells xeroderma pigmentosum actin polymerization
    Yared Herouy
    xeroderma pigmentosum dendritic cells venous leg ulcers
    John J Bergan
    venous insufficiency varicose veins saphenous vein
    Robert Scott Kirsner
    wound healing skin cancer venous leg ulcers
    Luigi Pascarella
    venous hypertension sclerosant foam surgery clerkship

    Piotr Nockowski:Expert Impact

    Concepts for whichPiotr Nockowskihas direct influence:Stasis dermatitis,  Photodynamic therapy,  Psoriasis vulgaris,  Green light,  Psoriatic patients,  Serum concentrations,  Venous ulceration,  Serum levels.

    Piotr Nockowski:KOL impact

    Concepts related to the work of other authors for whichfor which Piotr Nockowski has influence:Psoriasis vulgaris,  Psoriatic patients,  Serum levels,  Nk cells,  Photodynamic therapy,  Kir genes,  Killer cell.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland, | Department of Dermatology, Wroclaw Medical University, Chalubinskiego 4, 50-367 Wroclaw, Poland | Department and Clinic of Dermatology, Venereology