• Disease
  • Azelaic
  • Azelaic Acid
  • Mauro Picardo

    Prominent publications by Mauro Picardo

    KOL Index score: 14298

    Fibroblast growth factor 10 is a novel member of the fibroblast growth factor family, which is involved in morphogenesis and epithelial proliferation. It is highly homologous to the keratinocyte growth factor (or fibroblast growth factor 7), a key mediator of keratinocyte growth and differentiation. Both fibroblast growth factor 10 and keratinocyte growth factor bind with high affinity to the tyrosine kinase keratinocyte growth factor receptor. Here we analyzed the effect of fibroblast ...

    Also Ranks for: Growth Factor |  type 2 receptors |  human keratinocytes |  10 fibroblast |  cell differentiation
    KOL Index score: 12228

    BACKGROUND: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases.

    METHODS: To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 patients with generalized vitiligo who were of European-derived white (CEU) ancestry and compared ...

    Also Ranks for: Generalized Vitiligo |  susceptibility loci |  autoimmune diseases |  patchy depigmentation |  melanocyte loss
    KOL Index score: 11801

    PURPOSE: The aim of this study is to evaluate the neuroprotective effect of antioxidant supplementation with vitamin E in patients treated with cisplatin chemotherapy.

    METHODS: Between April 1999 and October 2000, forty-seven patients were randomly assigned to either group one, which received vitamin E supplementation during cisplatin chemotherapy, or to group two, which received cisplatin chemotherapy alone. Alpha-tocopherol (vitamin E; 300 mg/d) was administered orally before cisplatin ...

    Also Ranks for: Cisplatin Chemotherapy |  vitamin patients |  severity neurotoxicity |  preclinical studies |  antioxidant supplementation
    KOL Index score: 11492

    In order to evaluate the free radical defense systems of melanocytes and their possible correlation with melanoma, we have studied in cultured normal human melanocytes (20), normal melanocytes from melanoma patients (15), and melanoma cells (40) the fatty acid pattern of membrane phospholipids as a target of peroxidative damage and the superoxide dismutase and catalase activities, vitamin E, and ubiquinone levels as intracellular antioxidants. Cells were cultured in the same medium and ...

    Also Ranks for: Melanoma Cells |  normal melanocytes |  fatty acids |  antioxidant pool |  unsaturated humans
    KOL Index score: 10922

    Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR). KGF induces keratinocyte motility and cytoskeletal rearrangement, whereas a direct role of FGF10 on keratinocyte migration is not clearly established. Here we analyzed the motogenic activity of FGF10 and KGF on human keratinocytes. Migration assays and immunofluorescence of actin cytoskeleton ...

    Also Ranks for: Growth Factor |  kgf fgf10 |  cell migration |  actin cytoskeleton |  human keratinocytes
    KOL Index score: 10860

    The transfer of melanin from melanocytes to keratinocytes is a crucial process underlying maintenance of skin pigmentation and photoprotection against UV damage. Here, we present evidence supporting coupled exocytosis of the melanin core, or melanocore, by melanocytes and subsequent endocytosis by keratinocytes as a predominant mechanism of melanin transfer. Electron microscopy analysis of human skin samples revealed three lines of evidence supporting this: (1) the presence of ...

    Also Ranks for: Melanin Transfer |  melanocytes keratinocytes |  electron microscopy |  predominant mechanism |  skin pigmentation
    KOL Index score: 10653

    Melanogenesis and melanosome transfer from the melanocytes to the neighboring keratinocytes are induced by ultraviolet radiation and modulated by autocrine and paracrine factors. Keratinocyte growth factor (KGF/fibroblast growth factor (FGF)7) is a paracrine mediator of human keratinocyte growth and differentiation. We evaluated the influence of KGF on melanosome transfer in co-cultures of keratinocytes and melanocytes. Immunofluorescence analysis using anti-tyrosinase and anti-human ...

    Also Ranks for: Melanosome Transfer |  keratinocyte growth factor |  kgf receptor |  increased expression |  ultraviolet radiation
    KOL Index score: 10617

    The MET proto-oncogene encodes for the hepatocyte growth factor (HGF) receptor, a plasma membrane tyrosine kinase that is involved in melanocyte growth and melanoma development. In mouse melanoma cells, Met expression is increased by alphaMSH via the activation of the cAMP pathway. However, the mechanism by which cAMP regulates MET and the biological consequences of this increase were not known. In the present report, we show that alphaMSH regulates MET expression in both human ...

    Also Ranks for: Melanoma Cells |  hepatocyte growth factor |  mitf expression |  human melanocytes |  hgf receptor
    KOL Index score: 10355

    Acne is the most common inflammatory skin disease in which IL-1 plays a central role. Although alpha-melanocyte-stimulating hormone has immunomodulatory effects, its usefulness as an anti-inflammatory agent in acne is hampered owing to its lipid- and pigment-inducing effects via activation of melanocortin receptors (MC-Rs). We used the immortalized human sebocyte line SZ95 as an in vitro model to investigate the anti-inflammatory potential of KdPT, a tripeptide derivative of the ...

    Also Ranks for: Tripeptide Derivative |  stimulating hormone |  kdpt il1ri |  signal transduction |  melanocortin receptors
    KOL Index score: 10216

    BACKGROUND: Human papillomavirus (HPV) plays a role in the development of benign and malign neoplasms in both sexes. The Italian recommendations for HPV vaccines consider only females. The BEST II study (Bayesian modelling to assess the Effectiveness of a vaccination Strategy to prevent HPV-related diseases) evaluates 1) the cost-effectiveness of immunization strategies targeting universal vaccination compared with cervical cancer screening and female-only vaccination and 2) the economic ...

    Also Ranks for: Papillomavirus Vaccination |  dynamic bayesian |  cervical cancer screening |  hpv vaccines |  effectiveness analysis
    KOL Index score: 10207

    Glycogen synthase kinase 3beta (GSK3beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and the insulin response. GSK3beta also plays a key role in the Wnt/beta-catenin pathway. The master regulator of the pigmentation microphthalmia-associated transcription factor (MITF) is a target for the Wnt pathway, however, to date, the regulatory role of GSK3beta in the control of melanogenesis has not been elucidated. In this study, we ...

    Also Ranks for: Melanoma Cell |  synthase kinase |  gsk3β inhibition |  melanin synthesis |  human melanocytes
    KOL Index score: 10149

    BACKGROUND: Lipid synthesis and storage are accomplished by lipid droplets (LDs). The perilipin family of LD-associated proteins, comprising 5 members (PLIN1-PLIN5), has been well characterized in adipocytes but not in sebocytes, epithelial cells in which LD formation is a key feature of the cellular differentiation.

    METHODS: Perilipin expression in the sebaceous gland cell line SZ95 and in human sebaceous glands was studied by qRT-PCR, Western blots, and immunohistochemistry. Lipid ...

    Also Ranks for: Lipid Accumulation |  sebocyte differentiation |  sebaceous gland |  plin2 plin3 |  linoleic acid
    KOL Index score: 9701

    BackgroundCombination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We previously reported in lung cancer that CSCs maintenance is due to altered lipid metabolism and dependent upon Stearoyl-CoA-desaturase (SCD1)-mediated upregulation of YAP and TAZ. On this ground, ...

    Also Ranks for: Cancer Stem Cells |  coa desaturase |  mek inhibition |  melanoma patients |  kinase inhibitors
    KOL Index score: 9678

    Ultraviolet irradiation of mammalian cells induces several events that include activation of growth factor receptors and triggering of signal transduction pathway. Most of the UV responses are mediated by the production of reactive oxygen species (ROS) and can be blocked by antioxidants. In this study, we analysed the effect of UVB irradiation at physiologic doses and that of the pro-oxidant agent cumene hydroperoxide (CUH) on the activation of the receptor for keratinocyte growth factor ...

    Also Ranks for: Growth Factor |  kgfr activation |  type 2 receptors |  ultraviolet irradiation |  receptor fibroblast


    Mauro Picardo: Influence Statistics

    Sample of concepts for which Mauro Picardo is among the top experts in the world.
    Concept World rank
    p38 mapk melanogenesis #1
    hydroquinones hydroxybenzoates #1
    palladium hypersensitivity #1
    tests sulfates #1
    fibroblastderived growth factors #1
    biomarkers ndds #1
    female hormone stimulation #1
    proliferation pparγ #1
    mitochondria malignant melanocytes #1
    hypermelanoses clinical practice #1
    ndds biomarkers discovery #1
    pici nmr #1
    pparγ azelaic acid #1
    melanosome uptake keratinocytes #1
    unprecedented frame #1
    03 nickel chloride #1
    sulfates divalent metals #1
    hydroquinones hydroxybenzoates hyperpigmentation #1
    methanol extract shoots #1
    ifngamma nickel stimulation #1
    mc1r stimulation catalase #1
    niso4‐positive patients #1
    data lipid mediators #1
    humanistic burden vitiligo #1
    ligands subjects #1
    biomechanical prostheses #1
    compounds concomitant reactions #1
    apyapa #1
    cultures normal melanocytes #1
    vitiqol qol #1
    generation lipoperoxides #1
    acute photoexposure #1
    12nitroalcohols abundant components #1
    energetic mitochondrial #1
    aspergillus parasiticus role #1
    sulfate 01 #1
    toxicity scavenger enzymes #1
    01 aq #1
    action cover #1
    pbmc vitro stimulation #1
    non‐melanocytic skin cells #1
    pparγ upmodulation #1
    palladium ions skin #1
    positive reactions ethgcl #1
    capillary electrophoresis gsh #1
    betaoxidation ingested diacids #1
    disease humans melasma #1
    transfer melanin #1
    mitochondrial oxidoreductases #1

    Key People For Azelaic Acid

    Top KOLs in the world
    Marcella NAZZARO‐PORRO
    azelaic acid melanoma cells lentigo maligna
    Mauro Picardo
    azelaic acid growth factor contact dermatitis
    Siro Passi
    azelaic acid aflatoxin production melanoma cells
    William James Cunliffe
    acne vulgaris benzoyl peroxide sebum excretion rate
    Keith T Holland
    propionibacterium acnes staphylococcus epidermidis azelaic acid
    azelaic acid electron microscopy langerhans cells

    Mauro Picardo:Expert Impact

    Concepts for whichMauro Picardohas direct influence:Azelaic acid,  Polyunsaturated fatty acids,  Growth factor,  Melanoma cells,  Contact dermatitis,  Fatty acids,  Normal melanocytes,  Generalized vitiligo.

    Mauro Picardo:KOL impact

    Concepts related to the work of other authors for whichfor which Mauro Picardo has influence:Oxidative stress,  Acne vulgaris,  Melanoma cells,  Vitiligo patients,  Azelaic acid,  Human skin,  Atopic dermatitis.



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    San Gallicano Dermatological Institute IRCCS, Rome, Italy | Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute, IRCCS, Rome, Italy | Laboratory of Cutaneous Physiopathology a