• Disease
  • Precocious
  • Precocious Puberty
  • Gordon B Cutler,

    Prominent publications by Gordon B CUTLER,

    KOL Index score: 16295

    To determine whether petrosal sinus sampling is useful to distinguish patients with mild or intermittent Cushing's disease from normal subjects and individuals with pseudo-Cushing states, we performed bilateral inferior petrosal sinus sampling for ACTH before and after the administration of CRH in 7 eucortisolemic volunteers, 8 hypercortisolemic patients with pseudo-Cushing states, and 40 patients with ACTH-dependent Cushing's disease whose urinary free cortisol excretion was within the ...

    Also Ranks for: Petrosal Sinus |  cushings disease |  cushing states |  releasing hormone |  normal physiology
    KOL Index score: 15725

    Objective. —The biochemical and phenotypic presentation of mild hypercortisolism in Cushing's syndrome is often indistinguishable from that seen in pseudo-Cushing's states such as depression. Both dexamethasone suppression and corticotropin-releasing hormone (CRH) stimulation tests have been used individually to distinguish these conditions, but neither approach has achieved a diagnostic accuracy greater than 85%. Therefore, we sought to develop a combined dexamethasone-CRH test that ...

    Also Ranks for: Cushings Syndrome |  dose dexamethasone |  crh test |  100 specificity |  releasing hormone
    KOL Index score: 15373

    CONTEXT: Growth impairment in short stature homeobox-containing gene (SHOX) deficiency and Turner syndrome share a similar etiology. Because of the established effect of GH treatment on height in patients with Turner syndrome, we hypothesized that GH therapy would also stimulate growth in patients with SHOX deficiency.

    OBJECTIVE: Our objectives were to evaluate long-term efficacy of GH treatment in short patients with SHOX deficiency and to compare the effect on final (adult) height (FH) ...

    Also Ranks for: Turner Syndrome |  shox deficiency |  gh treatment |  patients short |  stature homeobox
    KOL Index score: 14870

    BACKGROUND: Short stature and ovarian failure are characteristic features of Turner's syndrome. Although recombinant human growth hormone is commonly used to treat the short stature associated with this syndrome, a randomized, placebo-controlled trial is needed to document whether such treatment increases adult height. Furthermore, it is not known whether childhood estrogen replacement combined with growth hormone therapy provides additional benefit. We examined the independent and ...

    Also Ranks for: Growth Hormone |  adult height |  dose estrogen |  turners syndrome |  ethinyl estradiol
    KOL Index score: 14728

    BACKGROUND: Measurement of adrenocorticotropin levels in plasma from the inferior petrosal sinuses of patients with Cushing's syndrome can distinguish adrenocorticotropin-secreting pituitary tumors (Cushing's disease) from other causes of the syndrome, principally ectopic adrenocorticotropin secretion from an occult tumor. However, it is unknown whether such measurement consistently identifies patients with Cushing's disease and whether testing with corticotropin-releasing hormone (CRH) ...

    Also Ranks for: Patients Cushings Disease |  releasing hormone |  differential diagnosis |  petrosal sinus sampling |  crh administration
    KOL Index score: 14703

    Although the GnRH agonist analogs have become an established treatment for precocious puberty, there have been few long term studies of reproductive function and general health after discontinuation of therapy. To this end, we compared peak LH and FSH after 100 microg sc GnRH, estradiol, mean ovarian volume (MOV), age of onset and frequency of menses, body mass (BMI), and incidence of neurological and psychiatric problems in 2 groups of girls: those with precocious puberty due to ...

    Also Ranks for: Hypothalamic Hamartoma |  precocious puberty |  reproductive axis |  releasing hormone |  discontinuation treatment
    KOL Index score: 14266

    Transsphenoidal resection of adrenocorticotrophic hormone (ACTH)-producing pituitary adenomas has the potential of curing most patients with Cushing's disease. However, transsphenoidal exploration of the pituitary is not always curative, and patients who have remission of hypercortisolism following surgery occasionally develop a recurrence. Whether repeat pituitary surgery should be performed for recurrent or persistent Cushing's disease has not been evaluated previously. To determine ...

    Also Ranks for: Transsphenoidal Surgery |  patients remission |  selective adenomectomy |  cushings disease |  risk hypopituitarism
    KOL Index score: 13800

    BACKGROUND AND METHODS: Cushing's syndrome is rare in children and adolescents. We analyzed the clinical presentation, diagnostic evaluation, and treatment of 59 patients with Cushing's syndrome between the ages of 4 and 20 years who were admitted to the National Institutes of Health during the period from 1982 to 1992. The cause of hypercortisolism was identified by low- and high-dose dexamethasone suppression tests, the ovine corticotropin-releasing hormone (CRH) stimulation test, ...

    Also Ranks for: Cushings Syndrome |  children adolescents |  patients cushing |  diagnostic evaluation |  diagnosis therapy
    KOL Index score: 13604

    Between 1979 and 1983, 129 children (95 girls) with precocious puberty were referred to the National Institutes of Health and received treatment for at least 6 months with the long-acting LHRH analogue D-Trp6-Pro9-NEt-LHRH. The majority (107 of 129) of the children had central precocious puberty mediated by activation of the hypothalamic-pituitary-gonadal axis in association with hypothalamic hamartomas (24 of 107) or other central nervous system lesions (21 of 107), or idiopathic ...

    Also Ranks for: Precocious Puberty |  releasing hormone |  growth rate |  hypothalamic hamartomas |  united states


    Gordon B CUTLER,: Influence Statistics

    Sample of concepts for which Gordon B CUTLER, is among the top experts in the world.
    Concept World rank
    specificity cushing #1
    western countries patient #1
    oxandrolone 4 years #1
    patient hypercortisolism #1
    assay estrogen levels #1
    gonadotropin therapy glucocorticoids #1
    girls childhood low #1
    deslorelin 4 #1
    hypothesis carbenoxolone #1
    biological puberty #1
    estrogen level girls #1
    deslorelin dose #1
    skeletal maturation conditions #1
    agonist8–12 #1
    reduced hydrocortisone dose #1
    antiandrogen aromatase inhibitor #1
    patients escalating ee2 #1
    psychological adaptation children #1
    micrograms kgday #1
    treatment fadrozole #1
    69 ± age #1
    hormone estrogen #1
    axis discontinuation #1
    puberty mccune #1
    study human chromosomes #1
    inhaled gh injection #1
    abnormal developmental tempo #1
    puberty spironolactone #1
    gnrha boys #1
    arithmetic ld #1
    inhibitor testolactone #1
    mphd developed #1
    injection childhood #1
    inhaled growth #1
    higher incidence oligomenorrhea #1
    spironolactone months #1
    pamoate adolescent #1
    hlhr gene children #1
    inhibitor gnrha #1
    isolated thelarche #1
    adolescents timed puberty #1
    greater height children #1
    wrat3 reading groups #1
    wrat3 frequency #1
    peak fsh #1
    precocious puberty girls #1
    children precocious puberty #1
    liter normal children #1
    girls precocious puberty #1
    ee2 childhood #1

    Key People For Precocious Puberty

    Top KOLs in the world
    Gordon B CUTLER,
    precocious puberty turner syndrome growth hormone
    Ora Hirsch Pescovitz
    precocious puberty growth hormone fibrous dysplasia
    precocious puberty releasing hormone cushing syndrome
    Jean‐Claude Carel
    growth hormone turner syndrome precocious puberty
    Anders Juul
    growth factor semen quality serum levels
    Kevin M Barnes
    precocious puberty growth plate adult height

    Gordon B CUTLER :Expert Impact

    Concepts for whichGordon B CUTLER has direct influence:Precocious puberty,  Turner syndrome,  Growth hormone,  Adult height,  Cushing syndrome,  Releasing hormone,  Congenital adrenal hyperplasia,  Luteinizing hormone.

    Gordon B CUTLER :KOL impact

    Concepts related to the work of other authors for whichfor which Gordon B CUTLER has influence:Growth hormone,  Turner syndrome,  Precocious puberty,  Short stature,  Adult height,  Congenital adrenal hyperplasia,  Anorexia nervosa.



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    Gordon Cutler Consultancy LLC, Deltaville, Virginia, USA. | Eunice Kennedy Shriver National Institutes of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA. | Gordon Cutler Consultancy LLC, Deltaville, Virginia, USA | Gordon Cutler C