Prominent publications by John A H Wass

KOL Index score: 16654

OBJECTIVES: Recent animal studies have suggested that insulin-like growth factor binding protein (IGFBP)-1 may regulate the insulin-like actions of the circulating IGFs. In man, IGFBP-1 levels change rapidly with nutritional status and are inversely related to changes in insulin. In-vitro studies have shown that both insulin and glucose independently regulate IGFBP-1 secretion in an inverse manner. A rapid rise of serum IGFBP-1 levels following insulin-induced hypoglycaemia suggested ...

Known for Binding Protein |  Igfbp1 Insulin |  Growth Factor |  180 Minutes |  Nutritional Status
KOL Index score: 16492

OBJECTIVE: An undetectable postoperative serum cortisol has been regarded as a definition of cure in Cushing's disease. However, we noted disease recurrence amongst patients with Cushing's disease despite undetectable postoperative cortisol levels, and this led us to audit our data. We have also previously assessed surgical outcome for acromegaly and microprolactinoma for a single surgeon. The aims of this study were two-fold: (i) to investigate the treatment and surgical outcome of ...

Known for Postoperative Cortisol |  Cushings Disease |  Patients Cushing |  Surgical Outcome |  Remission Rate
KOL Index score: 15760

OBJECTIVE: Germline mutations in the MEN1 gene predispose to the multiple endocrine neoplasia (MEN1) syndrome; however, approximately 10-20% of patients with MEN1 do not have a detectable MEN1 mutation. A rat strain with multiple endocrine tumours, a phenotypic overlap of both MEN1 and MEN2, has been reported to have a homozygous germline p27 (CDKN1B) mutation. Recently, two MEN1 mutation-negative MEN1 syndrome patients have been identified to harbour a germline CDKN1B mutation. The ...

Known for Multiple Endocrine |  Kinase Inhibitor |  Mutations Cdkn1b |  Aryl Hydrocarbon |  Patients Men1
KOL Index score: 15087

BACKGROUND: Treatment of acromegaly with octreotide increases the proportion of deoxycholic acid in, and the cholesterol saturation of, bile and induces the formation of gallstones. Prolongation of intestinal transit has been proposed as the mechanism for the increase in the proportion of deoxycholic acid in bile.

AIMS: To study the effects of octreotide on intestinal transit in acromegalic patients during octreotide treatment, and to examine the relation between intestinal transit and ...

Known for Deoxycholic Acid |  Intestinal Transit |  Large Bowel |  Acromegalic Patients |  Octreotide Treatment
KOL Index score: 15030

Using a moderate-sized cohort selected with extreme BMD (n = 344; absolute value BMD, 1.5-4.0), significant association of several members of the Wnt signaling pathway with bone densitometry measures was shown. This confirms that extreme truncate selection is a powerful design for quantitative trait association studies of bone phenotypes.

INTRODUCTION: Although the high heritability of BMD variation has long been established, few genes have been conclusively shown to affect the variation ...

Known for Wnt Pathway |  Low Bmd |  Extreme Truncate |  Single Nucleotide |  Cohort Selected
KOL Index score: 14977

OBJECTIVE: Insulin-like growth factor binding protein (IGFBP)-1 levels increase overnight, being inversely related to changes in insulin. With prolonged fasting IGFBP-1 levels increase further. In animal studies high IGFBP-1 levels increase plasma glucose levels possibly by regulating the insulin-like actions of 'bio-available' plasma IGF. Following prolonged fasting, there is an increase in insulin requirement. A proportion of this reversible insulin resistance may be due to inhibitory ...

Known for Binding Protein |  Igfbp1 Levels |  Growth Factor |  Insulin Resistance |  Overnight Fasting
KOL Index score: 14240

Conventional surgery and radiotherapy for acromegaly have limitations. There are few data on the use of the somatostatin analog octreotide (Oct) as primary medical therapy. An open prospective study of 27 patients with newly diagnosed acromegaly was conducted in nine endocrine centers in the United Kingdom. Twenty patients had macroadenomas, and 7 had microadenomas. For the first 24 wk (phase 1), patients received sc Oct in an initial dose of 100 microg, 3 times daily, increased to 200 ...

Known for Growth Hormone |  Primary Medical Therapy |  Tumor Size |  Intramuscular Injections |  Serum Gh
KOL Index score: 14110

Genetic studies based on cohorts with rare and extreme bone phenotypes have shown that the LRP5 gene is an important genetic modulator of BMD. Using family-based and case-control approaches, this study examines the role of the LRP5 gene in determining normal population variation of BMD and describes significant association and suggestive linkage between LRP5 gene polymorphisms and BMD in >900 individuals with a broad range of BMD.

INTRODUCTION: Osteoporosis is a common, highly heritable ...

Known for Lrp5 Polymorphisms |  Normal Variation |  Femoral Neck |  Lumbar Spine |  Total Hip
KOL Index score: 13539

OBJECTIVE: The diagnosis of Cushing's syndrome remains a major challenge in clinical endocrinology. Various screening tests are commonly used to support a biochemical diagnosis in the context of clinical suspicion. The aim of this study was to compare the sensitivity in the diagnosis of Cushing's syndrome of a single in-patient sleeping midnight cortisol to a standard 48-hour in-patient low-dose dexamethasone suppression test (LDDST) during the same admission.

DESIGN: A retrospective ...

Known for Midnight Cortisol |  Cushings Syndrome |  50 Nmol |  100 Sensitivity |  Diagnosis Cushing
KOL Index score: 13517

BACKGROUND: Macroadenomas causing acromegaly are cured surgically in only around 50% of patients. Primary medical treatment with somatostatin analogues has been suggested to be a means of treating patients with a potentially poor surgical outcome. Previous retrospective studies have also suggested that surgical debulking of pituitary tumours causing acromegaly improves control by somatostatin analogues. No prospective study using lanreotide has been carried out thus far to assess whether ...

Known for Surgical Debulking |  Acromegaly Patients |  Pituitary Macroadenomas |  Somatostatin Analogues |  Surgery Gh
KOL Index score: 13515

BACKGROUND: The long-acting depot somatostatin analogues [octreotide LAR (LAR) and lanreotide (LAN)] are among the most effective available medical therapies for acromegaly. However, published data on a biochemical test suitable for predicting the responsiveness to these depot agents are lacking.

AIM: To investigate the value of an acute octreotide suppression test (OST) in predicting the responses to treatment with long-acting somatostatin analogues in patients with active ...

Known for Active Acromegaly |  Gh Levels |  Somatostatin Analogues |  Acute Octreotide |  Suppression Test
KOL Index score: 13270

Synthetic CRF-41 has been given to 43 patients with hypothalamic, pituitary or adrenal diseases and contrasted with the responses in 20 normal subjects. In the normal subjects the mean increment in serum cortisol (+/- SE) was 276 +/- 38 nmol/l; the increments showed a significant negative correlation with the basal serum cortisol levels (r = -0.56; P less than 0.02). The mean peak serum cortisol was 662 +/- 34 nmol/l and the mean peak corticosterone was 28.6 +/- 3.8 nmol/l. There was a ...

Known for Normal Subjects |  Serum Cortisol |  Corticotrophin Releasing Factor |  Response Crf41 |  Patients Pituitary Disease
KOL Index score: 13268

Osteoporosis is a common disease with a strong genetic component, characterized by reduced bone mass and an increased risk of fracture. Bone mineral density (BMD) is a highly heritable trait and a key determinant of osteoporotic fracture risk, but the genes responsible are incompletely defined. Here, we identified quantitative trait loci (QTL) for regulation of BMD by a genome wide scan involving 3691 individuals from 715 families, who were selected because of reduced BMD values at the ...

Known for Bone Mineral Density |  Qtl Bmd |  50 Years |  Linkage Analysis |  Genome Wide
KOL Index score: 13170

Obesity may be characterized by abnormal sex steroid secretion and reduced sex hormone binding globulin (SHBG) which in turn is related to fat distribution and insulin secretion. Recent in-vitro and in-vivo evidence suggests that insulin is the common mechanism regulating the secretion of SHBG and insulin-like growth factor small binding protein (IGFBP-1). IGFBP-1 appears not only to be a carrier for insulin growth factors (IGFs) but also to play an active role in growth processes, ...

Known for Growth Factor |  Igfbp1 Shbg |  Sex Hormone |  Binding Globulin |  Extreme Obesity


John A H Wass: Influence Statistics

Sample of concepts for which John A H Wass is among the top experts in the world.
Concept World rank
glucose meal log #1
active acromegaly gh #1
musculoskeletal problems acromegaly #1
55 sms #1
diagnosis nfpas #1
lanreotide treatment surgery #1
aged cholelithiasis humans #1
investigation protocol #1
nutrients duodenum #1
pmc n8 #1
ogtt gh 17 #1
disease status ghdc #1
oxford female follow #1
hours propranolol #1
polycystic multicystic ovaries #1
presence gastritis #1
2 aims2 life #1
patients gh level #1
neurosurgeons radiotherapists #1
igfbp1 normal human #1
subjects nfas #1
sms growth hormone #1
tumour recurrence nfa #1
ppv lan #1
acm surgery #1
aghd cai #1
transcriptional regulation npr2 #1
therapy recurrence #1
fall igfbp1 levels #1
macronfa mortality data #1
release oct #1
departments subjects #1
patients macronfa #1
gastrin plasma somatostatin #1
chapter 9 somatostatin #1
pitcs adrcs #1
gh 07 #1
acromegalic cases #1
gastrin3 #1
predicting gh #1
turners syndrome females #1
ogtt positive predictive #1
nadir gh 07 #1
undetectable cortisol #1
ghr mutation #1
gh 07 ogtt #1
microprolactinomas prolactin levels #1
baseline pitcs #1
plasma somatostatin subjects #1
codon ghr #1

Key People For Growth Hormone

Top KOLs in the world
Michael O Thorner
growth hormone gh secretion prolactin release
Ron G Rosenfeld
growth factor binding protein turner syndrome
Raymond L Hintz
growth factor insulin receptors binding proteins
Jens Sandahl Sandahl Christiansen
growth hormone body composition turner syndrome
BengtÅke NÅ Bengtsson†
growth hormone body composition gh replacement
David Robert Clemmons
growth factor binding protein smooth muscle

John A H Wass:Expert Impact

Concepts for whichJohn A H Wasshas direct influence:Growth hormone,  Pituitary adenomas,  Polycystic ovary syndrome,  Growth factor,  Plasma somatostatin,  Pituitary tumours,  Major stress,  Normal subjects.

John A H Wass:KOL impact

Concepts related to the work of other authors for whichfor which John A H Wass has influence:Pituitary adenomas,  Growth hormone,  Polycystic ovary syndrome,  Patients acromegaly,  Insulin resistance,  Transsphenoidal surgery,  Binding protein.



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Endocrinology Department, Oxford University, Churchill Hospital, Oxford, United Kingdom | J Wass, Endocrinology, Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, United Kingdom of Great Britain and Northern Ireland | University of Oxf

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