• Disease
  • Hairless
  • Hairless Mice
  • Peter Alshede Philipsen

    Prominent publications by Peter Alshede Philipsen

    KOL Index score: 16494

    OBJECTIVES: To examine during what behaviors people apply sunscreen and to assess the relationship to UV exposure monitored by personal dosimetry and diaries.

    DESIGN: Open prospective observational study.

    SETTING: University hospital.

    PARTICIPANTS: A convenience sample of 340 Danish volunteers: children, adolescents, indoor workers, sun worshippers, golfers, and gardeners (age range, 4-68 years). Intervention Subjects recorded sunscreen use and sun-exposure behavior in diaries and ...

    Also Ranks for: Uv Exposure |  sunscreen risk behavior |  sunburn p001 |  sun worshippers |  age children
    KOL Index score: 13691

    OBJECTIVE: To assess individual time-related (time-stamped) UV radiation (UVR) dose pattern and sun exposure behavior.

    DESIGN: Open prospective observational study.

    SETTING: University hospital. Study Subjects Two hundred eighty-five Danish volunteers with apparently healthy skin: children, adolescents, indoor workers, sun worshippers, golfers, and gardeners (age range, 4-68 years). Measurements We developed a personal electronic UVR dosimeter in a wristwatch (SunSaver) and measured ...

    Also Ranks for: Sun Behavior |  radiation exposure |  uvr dose |  children adolescents |  stamped personal
    KOL Index score: 12114

    OBJECTIVE: To assess when sunburn occurs and who experiences sunburn by personal UV dosimetry and diaries.

    DESIGN: Open prospective observational study.

    SETTING: University hospital.

    PARTICIPANTS: A convenience sample of 340 Danish volunteers: children, adolescents, indoor workers, sun worshippers, golfers, and gardeners (age range, 4-68 years).

    MAIN OUTCOME MEASURES: Subjects recorded sunburn and sun-exposure behavior in diaries and carried personal, electronic, wristwatch UV radiation ...

    Also Ranks for: Risk Behavior |  uv radiation exposure |  indoor workers |  children adolescents |  sun worshippers
    KOL Index score: 12023

    UVB radiation increases serum vitamin D level expressed as 25-hydroxyvitamin-D(3) (25(OH)D), but the influence of skin pigmentation, baseline 25(OH)D level, and total cholesterol has not been well characterized. To determine the importance of skin pigmentation, baseline 25(OH)D level, and total cholesterol on 25(OH)D production after UVB exposure, 182 persons were screened for 25(OH)D level. A total of 50 participants with a wide range in baseline 25(OH)D levels were selected to define ...

    Also Ranks for: Skin Pigmentation |  total cholesterol |  uvb exposure |  25ohd level |  baseline vitamin
    KOL Index score: 11928

    Melanoma is the most aggressive skin cancer. The specificity and sensitivity of clinical diagnosis varies from around 40% to 80%. Here, we investigated whether the chemical changes in the melanoma tissue detected by Raman spectroscopy and neural networks can be used for diagnostic purposes. Near-infrared Fourier transform Raman spectra were obtained from samples of melanoma (n=22) and other skin tumors that can be clinically confused with melanoma: pigmented nevi (n=41), basal cell ...

    Also Ranks for: Melanoma Diagnosis |  neural networks |  raman spectroscopy |  sensitivity specificity |  normal skin
    KOL Index score: 11537

    BACKGROUND: Photodynamic therapy (PDT) is an attractive therapy for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolaevulinate (MAL)-PDT is approved for the treatment of thin or nonhyperkeratotic AKs on the face and scalp. However, thick AK lesions are often treated as well when present in the field-cancerized treatment area.

    OBJECTIVES: In a randomized multicentre study to evaluate efficacy ...

    Also Ranks for: Actinic Keratoses |  daylightmediated pdt |  photodynamic therapy |  treatment daylight |  grade iii
    KOL Index score: 11219

    Numerous studies have demonstrated the utility of topical tacrolimus ointment in atopic dermatitis. However, there is a concern that local immunosuppression by calcineurin inhibitors may enhance dermal photocarcinogenesis and carcinogenesis. Therefore, we investigated the influence of topical tacrolimus ointment on squamous cell carcinoma formation in hairless female C3.Cg/TifBomTac immunocompetent mice exposed to solar simulated radiation (SSR). In a first experiment, mice (n = 200) had ...

    Also Ranks for: Hairless Mice |  topical tacrolimus |  simulated solar radiation |  4 sed |  skin tumor
    KOL Index score: 10940

    BACKGROUND: Photodynamic therapy (PDT) is a highly effective treatment for actinic keratoses (AK); however, it is time consuming and often painful for the patient. Daylight-PDT would make the treatment independent of the clinic and less painful due to the continuous activation of small amounts of porphyrins during its formation.

    OBJECTIVES: The objective of this randomized controlled study was to compare response rates and adverse effects after methyl aminolevulinate (MAL)-PDT using ...

    Also Ranks for: Continuous Activation |  actinic keratoses |  photodynamic therapy |  scalp dermatoses |  daylight pdt
    KOL Index score: 10673

    Pimecrolimus and tacrolimus are topical calcineurin inhibitors developed specifically for the treatment of atopic eczema. Experience with long-term use of topical calcineurin inhibitors is limited and the risk of rare but serious adverse events remains a concern. We have previously demonstrated the absence of carcinogenic effect of tacrolimus alone and in combination with simulated solar radiation (SSR) on hairless mice. The aim of this study is to determine whether pimecrolimus ...

    Also Ranks for: Hairless Mice |  topical pimecrolimus |  simulated solar radiation |  skin neoplasms |  accelerate photocarcinogenesis
    KOL Index score: 10225

    BACKGROUND: Topical photodynamic therapy (PDT) for actinic keratoses (AK) is hampered by pain during illumination and inferior efficacy in organ-transplant recipients (OTR).

    OBJECTIVES: We assessed ablative fractional laser (AFL)-assisted daylight photodynamic therapy (PDT) (AFL-dPDT) compared with daylight PDT (dPDT), conventional PDT (cPDT) and AFL alone (AFL) in field treatment of AK in OTR.

    METHODS: In each patient, four areas in the same region were randomized to one treatment with ...

    Also Ranks for: Actinic Keratosis |  ablative fractional laser |  transplant recipients |  dpdt cpdt |  daylight pdt
    KOL Index score: 10164

    BACKGROUND: Actinic keratoses (AKs) are common dysplastic skin lesions that may differentiate into invasive squamous cell carcinomas. Although a superior cosmetic outcome of photodynamic therapy (PDT) is advantageous compared with equally effective treatments such as cryotherapy and curettage, the inconvenience of clinic attendance and discomfort during therapy are significant drawbacks. Daylight-mediated PDT could potentially reduce these and may serve as an alternative to conventional ...

    Also Ranks for: Daylight Exposure |  methyl aminolaevulinate |  actinic keratoses |  photodynamic therapy |  randomized multicentre study
    KOL Index score: 9783

    BACKGROUND: Pain during photodynamic therapy (PDT) is a considerable problem that needs to be studied to improve this otherwise attractive treatment of skin diseases.

    OBJECTIVES: To compare pain during PDT using two different fluence rates, and also to evaluate the association between pain and protoporphyrin IX (PpIX) fluorescence, lesion type, lesion preparation and lesion localization.

    METHODS: Twenty-six patients with actinic keratoses (AKs) in different localizations and 34 patients ...

    Also Ranks for: Fluence Rate |  photodynamic therapy |  pain pdt |  ppix fluorescence |  treatment area
    KOL Index score: 9701

    INTRODUCTION: Acne is an inflammatory disease of the pilosebaceous unit, which can be investigated in vivo using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT).

    OBJECTIVES: By means of RCM and OCT to identify morphological characteristics of acne that may be associated with clinical acne severity.

    METHODS: Patients with mild to moderate facial acne (n = 14, Investigators Global Assessment scale, IGA 1-3), and healthy participants (n = 7, IGA 0) were included ...

    Also Ranks for: Optical Coherence |  confocal microscopy |  vivo reflectance |  rcm oct |  acne vulgaris
    KOL Index score: 9557

    BACKGROUND: Personal annual ultraviolet (UV) radiation data based on daily records are needed to develop protective strategies.

    OBJECTIVES: To compare UV radiation exposure patterns in the winter half-year (October-March) and the summer half-year (April-September) for Danish indoor workers.

    METHODS: Nineteen indoor workers (age range 17-56 years) wore personal UV dosimeters, measuring time-stamped UV doses continuously during a year. The corresponding sun exposure behaviour was recorded ...

    Also Ranks for: Radiation Exposure |  winter summer |  sed denmark |  uv dose |  age range
    KOL Index score: 9187

    BACKGROUND AND AIM: The incidence of squamous cell carcinomas (SCC) is increasing, and effective chemopreventative strategies are needed. We hypothesized that repeated treatments with ingenol mebutate (IngMeb) would postpone development of SCC in hairless mice, and that application of a corticosteroid would reduce IngMeb-induced local skin responses (LSRs) without affecting tumor postponement.

    METHODS: Hairless mice (n=150; 6 groups á 25 mice) were irradiated with solar simulated ...

    Also Ranks for: Hairless Mice |  ingenol mebutate |  repeated treatments |  lsr ingmeb |  squamous cell


    Peter Alshede Philipsen: Influence Statistics

    Sample of concepts for which Peter Alshede Philipsen is among the top experts in the world.
    Concept World rank
    skin type groups #1
    september 25ohd #2
    micromorphology transfollicular #2
    ppix fluorescence increase #2
    spent application #2
    backgroundsun exposure #2
    keratosis tests #2
    sunscreen 8 #2
    sunburn risk factors #2
    sed rural #2
    8 55 #2
    28 sun worshippers #2
    25ohd solar #2
    rcm median #2
    ssrirradiated experiment #2
    inorganic sunscreen #2
    danes irish #2
    8 volunteers comparison #2
    8 activities #2
    sed 0·0001 #2
    sunscreen diagnosed #2
    derivatives photocarcinogenesis #2
    “ handful #2
    dose 0·0001 #2
    behavior diaries #2
    pigmentation solar #2
    25ohd dark #2
    noon sunburn #2
    14 uvb #2
    pretreated afxl #2
    cmm garden #2
    peroxide hairless #2
    clothes shade #2
    beachgoers duration #2
    decreased hyperkeratinization #2
    uvr dosimeters #2
    gardeners age range #2
    vitamin supplements recommendations #2
    constitutive skin type #2
    betamethasone bf200 #2
    occupation sunburn #2
    summer uvr reactivity #2
    epp vitamin supplements #2
    sunscreen minute bsa #2
    replace curettage #2
    lifetime uv #2

    Key People For Hairless Mice

    Top KOLs in the world
    Gary J Fisher
    human skin retinoic acid growth factor
    John J Voorhees
    human skin retinoic acid ultraviolet irradiation
    Hasan Mukhtar
    green tea prostate cancer human skin
    Sewon Sewon
    human skin retinoic acid ultraviolet irradiation
    Frank R de Gruijl
    hairless mice skin cancer uv radiation
    James A Varani
    organ culture tumor cells human skin

    Peter Alshede Philipsen:Expert Impact

    Concepts for whichPeter Alshede Philipsenhas direct influence:Hairless mice,  Skin pigmentation,  Uvr exposure,  Photodynamic therapy,  Skin cancer,  Solar lentigines,  Uvb exposure,  Sun exposure.

    Peter Alshede Philipsen:KOL impact

    Concepts related to the work of other authors for whichfor which Peter Alshede Philipsen has influence:Photodynamic therapy,  Skin cancer,  Sun exposure,  Actinic keratosis,  Raman spectroscopy,  Ultraviolet radiation,  Vitamin deficiency.



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    Department of Dermatology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark | Department of Dermatology D92, Bispebjerg Hospital, University of Copenhagen, Nielsine Nielsens Vej 17, 2400, Copenhagen NV, Denmark | Department of Dermatolo