Direct Impact

Concepts for which Bruce F Pennington has direct influence:

reading disability
executive function
genetic influences
individual differences
developmental dyslexia
speech sound disorder
phoneme awareness

External impact

Concepts related to the work of other authors for which Bruce F Pennington has influence:

developmental dyslexia
word reading
functional connectivity
automatized naming
angular gyrus
cognitive predictor
working memory

Prominent publications by Bruce. F. Pennington

KOL-Index: 123 Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the ...
Known for
-Rna 924 Host Gene | Genome-Wide Scan | Deficits | Largest
KOL-Index: 75 Abstract The use of spoken and written language is a capacity that is unique to humans. Individual differences in reading- and language-related skills are influenced by genetic variation, with twin-based heritability estimates of 30-80%, depending on the trait. The relevant genetic architecture is complex, heterogeneous, and multifactorial, and yet to be investigated with well-powered ...
Known for
Gwas | Spoken Written Language | Nonword | Reading
KOL-Index: 69 ABSTRACT Reading disability is a complex neurodevelopmental disorder that is characterized by difficulties in reading despite educational opportunity and normal intelligence. Performance on rapid automatized naming (RAN) and rapid alternating stimulus (RAS) tests gives a reliable predictor of reading outcome. These tasks involve the integration of different neural and ...
Known for
Letters Ras | Hispanic African American Youth | Word | Contribute Reading
KOL-Index: 64 BACKGROUND: Reading and language skills have overlapping genetic bases, most of which are still unknown. Part of the missing heritability may be caused by copy number variants (CNVs). METHODS: In a dataset of children recruited for a history of reading disability (RD, also known as dyslexia) or attention deficit hyperactivity disorder (ADHD) and their siblings, we investigated the effects of ...
Known for
Cnvs Reading | Cnv Effects
KOL-Index: 32 BACKGROUND: Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms. OBJECTIVE: To identify shared genetic factors ...
Known for
1331 Hispanic American African-American | Inferior Parietal Lobule | Chromatin Contact Maps | Cortical Regions
KOL-Index: 32 Four genes have recently been proposed as candidates for dyslexia: dyslexia susceptibility 1 candidate 1 (DYX1C1), roundabout Drosophila homolog 1 (ROBO1), doublecortin domain-containing protein 2 (DCDC2) and KIAA0319. Each gene is implicated in global brain-development processes such as neural migration and axonal guidance, with the exception of DYX1C1, the function of which is still ...
Known for
Genetic Screening | Doublecortin Domain-Containing Protein | 1 Candidate | Gene-Gene Gene-Environment Interactions
KOL-Index: 29 Developmental dyslexia (DD) is a learning disorder affecting the ability to read, with a heritability of 40-60%. A notable part of this heritability remains unexplained, and large genetic studies are warranted to identify new susceptibility genes and clarify the genetic bases of dyslexia. We carried out a genome-wide association study (GWAS) on 2274 dyslexia cases and 6272 controls, testing ...
Known for
Associations Dyslexia | Large-Scale Gwas | Cross-Disorder | Snp-Based Heritability
KOL-Index: 27 This chapter explores the utility of neuropsychological conceptualizations of developmental psychopathology. The field of neuropsychology is concerned with understanding brain-behavior relations. The application of a neuropsychological approach to understanding disorders of development, especially developmental psychopathology, is a relatively recent phenomenon. The chapter reviews the ...
Known for
Disorders Developmental | Model Chapter | Neuropsychological Conceptualizations | Brain-Behavior Relations
KOL-Index: 27 Reading and language abilities are heritable traits that are likely to share some genetic influences with each other. To identify pleiotropic genetic variants affecting these traits, we first performed a genome-wide association scan (GWAS) meta-analysis using three richly characterized datasets comprising individuals with histories of reading or language problems, and their siblings. GWAS ...
Known for
Gwas Meta-Analysis | Flnc | Reading- Language-Related Abilities | Histories
KOL-Index: 26 BACKGROUND: Six independent studies have identified linkage to chromosome 18 for developmental dyslexia or general reading ability. Until now, no candidate genes have been identified to explain this linkage. Here, we set out to identify the gene(s) conferring susceptibility by a two stage strategy of linkage and association analysis. METHODOLOGY/PRINCIPAL FINDINGS: Linkage analysis: 264 UK ...
Known for
Dyslexia Genotyped | 187 Uk Families | Subsequent Replication Attempts | Snps Genes

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