Malcolm R. Sears

Malcolm R. Sears

Professor, Department Of Medicine, Mcmaster University, Hamilton, Ontario, Canada

Direct Impact

Concepts for which Malcolm R Sears has direct influence:

lung function
gut microbiota
childhood asthma
reliever therapy
south asian
young adults
birth weight

External impact

Concepts related to the work of other authors for which Malcolm R Sears has influence:

recurrent wheezing
gut microbiota
lung function
childhood asthma
preschool children
breast milk
inhaled corticosteroids

Prominent publications by Malcolm R. Sears

KOL-Index: 75 BackgroundAsthma management may involve a step up in treatment when symptoms are not well controlled. We examined whether budesonide/formoterol maintenance and reliever therapy (MRT) is as effective as higher, fixed-dose budesonide plus as-needed terbutaline in patients requiring step-up from Step 2 treatment (low-dose inhaled corticosteroids), stratified by baseline reliever use.MethodsA ...
Known for
Reliever Baseline | Backgroundasthma Management | Symptomatic Asthma | 1239
KOL-Index: 69 BACKGROUND: The lung clearance index (LCI) is a measure of pulmonary function. Variable feasibility (50->80%) in preschool children has been reported. There are limited studies exploring its relationship to respiratory symptoms and how it predicts persistent wheeze. We aimed to assess the association with respiratory symptoms in preschool-aged children with LCI and determine its utility in ...
Known for
Childrens Respiratory Symptoms | 232 | 3rc Ncs | Age Recurrent
KOL-Index: 66 The Canadian Healthy Infant Longitudinal Development birth cohort was designed to elucidate interactions between environment and genetics underlying development of asthma and allergy. Over 3600 pregnant mothers were recruited from the general population in four provinces with diverse environments. The child is followed to age 5 years, with prospective characterization of diverse exposures ...
Known for
Months Biological | Exposures Canadian | Child Birth | Activity Behavior
KOL-Index: 63 BACKGROUND: The assessment of asthma control is pivotal to the evaluation of treatment response in individuals and in clinical trials. Previously, asthma control, severity, and exacerbations were defined and assessed in many different ways. PURPOSE: The Task Force was established to provide recommendations about standardization of outcomes relating to asthma control, severity, and ...
Known for
Relevant Asthma | Weaknesses | Force Recommendations | Severity Exacerbations
KOL-Index: 60 Background: The rising prevalence of atopic diseases implies a strong influence of environmental determinants. Epidemiological studies have identified several early life exposures that appear to influence the risk of developing atopic sensitization, but the combined influence of these exposures is unknown. We sought to estimate the proportion of atopy that could be attributed to common ...
Known for
Aeroallergens | Environmental Determinants | Identified Protective | Early Exposures
KOL-Index: 56 Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but the association between them is unclear. We assessed associations between blood eosinophils and lung function decline in a population-based cohort of young adults.We used linear mixed models to analyse associations between blood eosinophils and spirometry at 21, 26, 32 and 38 years adjusting for sex, ...
Known for
Analyse Associations | Airway Remodelling | Enhanced Decline | Counts Spirometry
KOL-Index: 49 BACKGROUND AND AIMS: Increasing evidence supports the role of early-life gut microbiota in developing atopic diseases, but ecological changes to gut microbiota during infancy in relation to food sensitization remain unclear. We aimed to characterize and associate these changes with the development of food sensitization in children. METHODS: In this observational study, using 16S rRNA ...
Known for
Early-Life Gut Microbiota | Infancy Sensitization | Post-Hoc | Bacteroides Abundance
KOL-Index: 48 Common colds often trigger asthma exacerbations. The present study compared cold-related severe exacerbations during budesonide/formoterol maintenance and reliever therapy, and different regimens of maintenance inhaled corticosteroids (ICS), with or without long-acting β(2)-agonists (LABA), and with as-needed short-acting β(2)-agonists (SABA) or LABA. Reported colds and severe exacerbations ...
Known for
Oral Corticosteroid | Maintenance Reliever | Saba Severe | Comparators
KOL-Index: 46 The biodiversity hypothesis that contact with natural environments (e.g. native vegetation) and biodiversity, through the influence of environmental microbes, may be beneficial for human commensal microbiota has been insufficiently tested. We aimed to study the association between living near natural environments in the urban context, and gut microbiota diversity and composition in young ...
Known for
Fed Infants | Environments Urban | Beta-Diversity | Verrucomicrobiales Colonization
KOL-Index: 46 In-utero nutrition is an under-studied aspect of cognitive development. Fruit has been an important dietary constituent for early hominins and humans. Among 808 eligible CHILD-Edmonton sub-cohort subjects, 688 (85%) had 1-year cognitive outcome data. We found that each maternal daily serving of fruit (sum of fruit plus 100% fruit juice) consumed during pregnancy was associated with a 2.38 ...
Known for
Reduced Ca2-Calmodulin-Dependent Adenylyl Cyclase | Under-Studied Aspect | 808 Eligible Child-Edmonton Sub-Cohort | In-Utero Nutrition

Professor, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

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