Prominent publications by Masashi Akiyama

KOL Index score: 15991

BACKGROUND: Mutations in the gene encoding filaggrin (FLG) were identified to underlie ichthyosis vulgaris (IV) and also shown to predispose to atopic eczema. Until now, no FLG mutations have been described in the Taiwanese population.

OBJECTIVES: To elucidate filaggrin mutations in the Taiwanese population and further to clarify the population genetics of filaggrin gene mutations in the Asian populations.

METHODS: In the present study, 12 individuals from four unrelated Taiwanese IV ...

Known for Flg Mutations |  Asian Populations |  Ichthyosis Vulgaris |  Population Genetics |  Disease Genotype Humans
KOL Index score: 14940

Serotonergic projections from the midbrain raphe nuclei to the suprachiasmatic nuclei (SCN) are known to regulate the photic entrainment of circadian clocks. However, it is not known which 5-hydroxytryptamine (5-HT) receptor subtypes are involved in the circadian regulation. In order to verify the role of 5-HT1A receptors, we examined the effects of 5-¿3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]-propoxy¿-1,3-b enzodioxole HCl (MKC-242), a selective 5-HT1A receptor agonist, on photic ...

Known for Photic Entrainment |  Ht1a Receptor |  Potentiating Action |  Circadian Activity |  Selective 5
KOL Index score: 14484

Terminally differentiated stratified squamous epithelium forms a lining of the plasma membrane called the cornified cell envelope, a thick layer of several covalently cross-linked precursor proteins including involucrin, small proline-rich proteins, and loricrin. Their cross-linking isodipeptide bonds are formed by epidermal transglutaminases 1-3. Material from lamellar granules is attached on the extracellular surface of corneocytes during the keratinization process. The formation of ...

Known for Periderm Cells |  Cornified Cell Envelope |  Epidermal Development |  Involucrin Loricrin |  Regression Process
KOL Index score: 14179

Circadian rhythms in mammals are regulated by a light-entrainable circadian pacemaker in the hypothalamic suprachiasmatic nucleus and food-entrainable oscillators located elsewhere in the brain and body. The dorsomedial hypothalamic nucleus (DMH) has been proposed to be the site of oscillators driving food-anticipatory circadian rhythms, but this is controversial. To further evaluate this hypothesis, we measured clock gene, temperature and activity rhythms in intact and DMH-ablated mice. ...

Known for Circadian Rhythms |  Clock Gene |  Hypothalamic Nucleus |  Temperature Activity |  Brain Regions
KOL Index score: 14042

It is known that Ca(2+)-dependent phosphorylation of cAMP response element binding protein (CREB) and the rapid induction of mPer1 and mPer2, mouse period genes in the suprachiasmatic nucleus (SCN) are associated with light-induced phase shifting. The CREB/CRE transcriptional pathway has been shown to be activated by calcium/calmodulin dependent kinase II (CaMKII) and mitogen-activated protein kinase (MAPK); however, there is a lack of evidence concerning whether the activation of CaMKII ...

Known for Protein Kinase |  Suprachiasmatic Nucleus |  Gene Expression |  Induced Phase |  Camkii Scn
KOL Index score: 13666

OBJECTIVE: The purpose of this study was to evaluate the feasibility of the middle cerebral artery peak systolic velocity for the detection of fetal anemia in pregnancies that are complicated by parvovirus B19 infection.

STUDY DESIGN: Doppler measurements of the middle cerebral artery peak systolic velocity were performed weekly in 32 fetuses at risk for anemia because of maternal parvovirus infection documented by the presence of serum immunoglobulin M antibody. The values of the middle ...

Known for Parvovirus Infection |  Doppler Ultrasonography |  Fetal Anemia |  Noninvasive Diagnosis |  Middle Cerebral
KOL Index score: 13649

Filaggrin is a key protein involved in skin barrier function. Mutations in the gene encoding filaggrin (FLG) have been identified as the cause of ichthyosis vulgaris and have been shown to be major predisposing factors for atopic eczema (AE), initially in European populations. Subsequently, FLG mutations were identified in Japanese, Chinese, Taiwanese and Korean populations. It was demonstrated that FLG mutations are closely associated with AE in the Japanese population. Notably, the ...

Known for Flg Mutations |  Ichthyosis Vulgaris |  Atopic Eczema |  Intermediate Filament |  Japanese Population
KOL Index score: 13622

BACKGROUND: Mutations in the gene encoding filaggrin (FLG) have been shown to predispose to atopic eczema (AE).

OBJECTIVES: Further to establish population genetics of FLG mutations in the Japanese population and to elucidate effects of FLG mutations to filaggrin biosynthesis in skin of patients with AE.

METHODS: We searched for FLG mutations in 19 newly recruited Japanese patients with AE. We then screened 137 Japanese patients with AE and 134 Japanese control individuals for a novel ...

Known for Japanese Patients |  Atopic Eczema |  Flg Mutations |  Nonsense Mutation |  Population Genetics
KOL Index score: 13609

Triazolam reportedly causes phase advances in hamster wheel-running rhythm after injection during subjective daytime. However, it is unclear whether benzodiazepine affects the PER: gene expression accompanying a behavioural phase shift. Brotizolam (0.5 - 10 mg kg(-1)) induced large phase advances in hamster rhythm when injected during mid-subjective daytime (circadian time 6 or 9), but not at circadian time 0, 3 or 15. Brotizolam (5 mg kg(-1)) significantly reduced the expression of ...

Known for Suprachiasmatic Nucleus |  Inhibitory Action |  Circadian Time |  Per1 Per2 |  5 Kg1
KOL Index score: 13607

Daily restricted feeding (RF) can produce food-entrainable oscillations in both intact and suprachiasmatic nucleus (SCN)-lesioned animals. Thus, there are two circadian rhythms, one of which is SCN-dependent and the other SCN-independent. Recently, it has been established that several mouse clock genes, such as mPer1, mPer2 and mPer3 are expressed in the SCN and other brain tissues. Although the role of mPer genes expressed in the SCN has recently been evaluated in the SCN-dependent ...

Known for Cerebral Cortex |  Mper2 Mrna |  Suprachiasmatic Nucleus |  Expression Scn |  Circadian Proteins
KOL Index score: 13341

Plasminogen activator inhibitor-1 (PAI-1) is a key factor of fibrinolytic activity. The activity and mRNA abundance show a daily rhythm. To elucidate the mechanism of daily Pai-1 gene expression, the expression of Pai-1 and several clock genes was examined in the heart of homozygous Clock mutant (Clock/Clock) mice. Damping of the daily oscillation of Pai-1 gene expression in Clock/Clock mice was accompanied with damped or attenuated oscillations of mPer1, mPer2, mBmal1, and mNpas2 mRNA. ...

Known for Clock Genes |  Restricted Feeding |  Daily Expression |  Mutant Mice |  Pai1 Mrna
KOL Index score: 13185

In mammals, the environmental light/dark cycle strongly synchronizes the circadian clock within the suprachiasmatic nuclei (SCN) to 24 hr. It is well known that not only photic but also nonphotic stimuli can entrain the SCN clock. Actually, many studies have shown that a daytime injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT), a serotonin 1A/7 receptor agonist, as a nonphotic stimulus induces phase advances in hamster behavioral circadian rhythms in vivo, as well as the ...

Known for Mrna Levels |  Suprachiasmatic Nuclei |  Photic Entrainment |  Receptor Agonists |  Hamster Per1
KOL Index score: 13183

While the suprachiasmatic nucleus (SCN) coordinates the majority of daily rhythms, some circadian patterns of expression are controlled from outside of the SCN. These include responses to daily methamphetamine (MAP) injection, or daily restricted feeding. The mechanisms underlying these SCN-independent circadian rhythms are unknown. A circadian oscillation in the expression of mPer1 and/or mPer2, mouse period, in the SCN is considered necessary to generate an SCN-dependent circadian ...

Known for Gene Expression |  Circadian Rhythm |  Suprachiasmatic Nucleus |  Map Injection |  Striatum Daily
KOL Index score: 12774

Because the rapid induction of Period (Per) genes is associated with the photic entrainment of the biological clock, we examined whether N-methyl-D-aspartate (NMDA) receptors were involved in the photic induction of Per genes in the hamster suprachiasmatic nucleus (SCN). In situ hybridization observation revealed that light during the early subjective night [circadian time (CT) 13.5] or the late subjective night (CT20) caused an induction of Per1 and Per2 but not Per3 mRNA in the SCN. ...

Known for Photic Entrainment |  Period Genes |  Phase Shifts |  Aspartate Receptor |  Mrna Scn
KOL Index score: 12285

BACKGROUND: Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD).

OBJECTIVE: To study the role of FLG mutations in IV/AD in Japan.

METHODS: The known filaggrin mutations were studied by genotyping and new mutations identified by DNA sequencing.

RESULTS: The European-specific mutations R501X ...

Known for Filaggrin Gene |  Japanese Patients |  Atopic Dermatitis |  Unique Mutations |  Ichthyosis Vulgaris


Masashi Akiyama: Influence Statistics

Sample of concepts for which Masashi Akiyama is among the top experts in the world.
Concept World rank
disorders lamellar ichthyosis #1
c3orf52 mutations #1
association topical minoxidil #1
monocyte apheresis mutation #1
20 cases gpp #1
circadian expression mper2 #1
7day conditions #1
dorfmanchanarin syndrome #1
c736t c742c #1
nuchal edema visualization #1
tlr4 ditra #1
lha faa #1
abca12 lipoxygenase genes #1
acylceramides eos #1
elisa pnp serum #1
bulge pdgf chain #1
pv majority #1
liph pathogenic #1
ichthyosis pathogenesis #1
components functional lipid #1
sedatives per1 #1
ichthyosis #1
intermediate filaments electron #1
chronic perturbation #1
apparent homozygosity patient #1
pacap mper1 expression #1
infant death patients #1
arg10x #1
high‐performance skin samples #1
epidermolytic #1
patient epidermis #1
direct sequencing gdna #1
harlequin ichthyosis ichthyosis #1
alpha1receptor activation #1
il36rn patients #1
ichthyosis syndromes #1
ditra il36rn #1
mutations confining nonsense #1
genes molecules ichthyosis #1
cpu mapinduced increase #1
woolly hair #1
adar1 mutations #1
inflammatory keratinization #1
mper1 mrna level #1
daily map injection #1
posttranslational psoriasis #1
papulosquamous skin pigmentation #1
exon deletion mutation #1
antimda5ab levels #1
confining nonsense allele #1

Key People For Harlequin Ichthyosis

Top KOLs in the world
Philip H Fleckman
harlequin ichthyosis chronic wounds granular layer
Masashi Akiyama
harlequin ichthyosis ichthyosiform erythroderma atopic dermatitis
Beverly A Dale
harlequin ichthyosis stratum corneum epithelial cells
Hiroshi Shimizu
bullous pemphigoid epidermolysis bullosa prenatal diagnosis
Virginia P Sybert
turner syndrome prenatal diagnosis epidermolysis bullosa
Edel A O’Toole
type vii collagen pachyonychia congenita harlequin ichthyosis

Masashi Akiyama:Expert Impact

Concepts for whichMasashi Akiyamahas direct influence:Harlequin ichthyosis,  Atopic dermatitis,  Ichthyosiform erythroderma,  Suprachiasmatic nucleus,  Lymphatic flow,  Amniotic fluid,  Lamellar ichthyosis,  Congenital ichthyosis.

Masashi Akiyama:KOL impact

Concepts related to the work of other authors for whichfor which Masashi Akiyama has influence:Atopic dermatitis,  Circadian clock,  Suprachiasmatic nucleus,  Gene expression,  Bullous pemphigoid,  Epidermolysis bullosa,  Stem cells.



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Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan | Department of Dermatology, Nagoya University School of Medicine, Nagoya, Japan | Department of Dermatology, Nagoya Universi

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