Philip H Fleckman: Influence Statistics

Philip H Fleckman

Philip H Fleckman

Department of Medicine, Division of Dermatology, University of Washington, Seattle | Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, ...


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Philip H Fleckman: Expert Impact

Concepts for which Philip H Fleckman has direct influence: Harlequin ichthyosis , Granular layer , Cultured keratinocytes , Ichthyosis vulgaris , Chronic wounds , Streptococcus pyogenes , Wound healing .

Philip H Fleckman: KOL impact

Concepts related to the work of other authors for which for which Philip H Fleckman has influence: Atopic dermatitis , Wound healing , Skin barrier , Stratum corneum , Food allergy , Harlequin ichthyosis , Staphylococcus aureus .

KOL Resume for Philip H Fleckman

Year
2022

Department of Medicine, Division of Dermatology, University of Washington, Seattle

2020

Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, USA

2019

Department of Medicine, University of Washington, Seattle WA, United States of America

2018

University of Washington School of Medicine, Seattle, WA, United States

2016

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington.

2015

Division of Dermatology, University of Washington School of Medicine, 1959 Northeast Pacific Street, BB-1353, Box 356524, Seattle, WA 98195-6524, USA

2014

Department of Orthopaedics and Sports Medicine, University of Washington Medical Center, Seattle, WA

Division of Dermatology, University of Washington, Seattle, Washington, United States of America

2013

MD - Division of Dermatology, University of Washington – Washington, DC USA

University of Washington Dermatology Seattle Washington

2012

National Registry for Ichthyosis and Related Disorders

Department of Medicine (Dermatology), University of Washington, Seattle, Washington

2011

Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA

Department of Dermatology, University of Washington, Seattle (Dr Fleckman)

2010

Department of Medicine, Division of Dermatology, University of Washington, Seattle, Washington,

2009

Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA 98195, USA

2008

From the Departments of *Pathology; and †Medicine, Division of Dermatology, University of Washington School of Medicine, Seattle, WA.

Department of Medicine, Division of Dermatology, and Departments of, Pharmacy, Medicine and, Pathology, University of Washington Medical Center, Seattle, Wash., USA

2007

Department of Medicine/Dermatology, University of Washington, Seattle, Washington

2006

Department of Medicine (Dermatology),

Division of Dermatology,

2005

Division of Dermatology, University of Washington

Professor of Dermatology, Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA

2004

Department of Medicine (Dermatology), University of Washington, Seattle, WA

2003

Department of Medicine (Dermatology), University of Washington, Seattle, WA, USA.

2002

Address correspondence and reprint requests to: Philip Fleckman, MD, Division of Dermatology, University of Washington, Box 356524, HSB BB1353, Seattle, WA 98195-6524, or

Department of Medicine (Dermatology), University of Washington, Seattle, WA, USA

2001

Department of Medicine (Dermatology), University of Washington, Seattle, USA.

2000

Toronto, Ontario, Canada, Seattle, Washington, and Cannes, France

From the Department of Dermatology, University Center for Medical Mycologya; Division of Bacterial and Mycotic Infections, Centers for Disease Control and Prevention, Atlantab; Columbia Presbyterian Medical Center, New Yorkc; the Department of Dermatology, New England Medical Center, Bostond; Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center and the University of Torontoe; Ontario Ministry of Health Mycology Laboratory and the Department of Laboratory Medicine and Pathobiology, University of Torontof; Department of Medicine, University Medical Center, Jacksong; One South Prospect, Burlingtonh; Department of Medicine, Division of Dermatology, University of Washington, Seattlei; Department of Dermatology, Oregon Health Sciences University, Portlandj; University of California, San Francisco Hospitals and Clinicsk; Division of Dermatology, Eastern Virginia Medical School, Norfolkl; Greater Miami Skin and Laser Center, Mt Sinai Hospital, Miami Beachm; Section of Dermatology, Department of Medicine, Medical College of Georgia, Augustan; and Hudson, Ohio.o

Department of Medicine/Dermatology, University of Washington, Seattle, Washington, U.S.A

1999

Dermatology/Medicine and

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Wash., USA

Department of Medicine (Dermatology), University of Washington, Seattle, Washington, U.S.A.

1998

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington, U.S.A.

1997

Department of Medicine/Dermatology, University of Washington, Seattle, Washington, U.S.A.

1995

Division of Dermatology, Department of Medicine, University of Washington, Seattle, Washington 98195

Department of Medicine (Dermatology) University of Washington, Seattle, Washington, U.S.A.

1993

Institut National de la Sante et de la Recherche Medicale, Université de Nice, Parc Valrose, France

Department of Dermatology, New York University, New York, New York

1992

Department of Pediatric Dentistry, Dental Branch, University of Texas Health Science Center at Houston, Houston, Texas, U.S.A.

1990

Department of Medicine, University of Washington School of Medicine, Seattle, Washington, U.S.A.

1988

Departments of Periodontics, Oral Biology, Medicine/Dermatology and Biological Structure, University of Washington, 98195, Seattle, WA, USA

Department of Medicine (Dermatology), University of Washington School of Medicine, Seattle, Washington, U.S.A.

1987

Department of Medicine (Dermatology), University of Washington School of Medicine and Children's Hospital and Medical Center, Seattle, Washington, U.S.A.

1985

Assistant Professor of Medicine (Dermatology), Department of Medicine, University of Washington, Seattle, Washington

1984

University of Washington, School of Medicine, Department of Medicine, Division of Dermatology, Seattle, Washington 98195

1973

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis Mussouri 63110

Prominent publications by Philip H Fleckman

KOL-Index: 18936 . BACKGROUND: Onychomycosis is a relatively common condition affecting toenails more than fingernails. It is caused predominantly by dermatophytes. Onychomycosis can cause pain and discomfort and has the potential to be a source of morbidity. OBJECTIVE: We evaluated the efficacy and safety of ciclopirox nail lacquer solution 8% used to treat onychomycosis of the toe in the United States and ...
Known for Ciclopirox Nail Lacquer | Treatment Onychomycosis | United States | 48 Weeks
KOL-Index: 13123 . BACKGROUND: Many chronic diseases, such as non-healing wounds are characterized by prolonged inflammation and respond poorly to conventional treatment. Bacterial biofilms are a major impediment to wound healing. Persistent infection of the skin allows the formation of complex bacterial communities termed biofilm. Bacteria living in biofilms are phenotypically distinct from their planktonic ...
Known for Aureus Biofilm | Gene Expression | Cytokine Production | Chronic Wounds
KOL-Index: 10774 . Flaky tail (gene symbol ft) is an autosomal recessive mutation in mice that results in a dry, flaky skin, and annular tail and paw constrictions in the neonatal period. Previous studies demonstrated that the ft mutation maps to the central region of mouse chromosome 3, in the vicinity of the epidermal differentiation complex, a gene locus that includes many nonkeratin genes expressed in ...
Known for Flaky Tail | Animal Model | Ichthyosis Vulgaris | Profilaggrin Filaggrin
KOL-Index: 10645 . Filaggrin is an intermediate filament-associated protein which functions to aggregate keratin intermediate filaments in the stratum corneum of mammalian epidermis. It is synthesized as a large precursor protein, profilaggrin, that consists of multiple filaggrin units and is localized in keratohyalin granules. In this report, we describe the characterization of cosmid genomic clones ...
Known for Calcium Binding | Amino Terminus | Profilaggrin Filaggrin | Cultured Cloning
KOL-Index: 10630 . BACKGROUND: Autosomal recessive congenital ichthyosis (ARCI) is a rare hereditary disorder of cornification. Mutations in the transglutaminase-1 (TGM1) gene, which encodes for the epidermal enzyme transglutaminase-1 (TGase-1), are one of the causes of ARCI. METHODS: The TGM1 mutation spectrum was characterised and genotype-phenotype correlations investigated in 104 patients with ARCI ...
Known for Patients Arci | Recessive Congenital | Tgm1 Mutations | Collodion Membrane
KOL-Index: 9938 . Filaggrin is an intermediate filament (IF)-associated protein that aggregates keratin IFs in vitro and is thought to perform a similar function during the terminal differentiation of epidermal keratinocytes. To further explore the role of filaggrin in the cytoskeletal rearrangement that accompanies epidermal differentiation, we generated keratinocyte cell lines that express human filaggrin ...
Known for Cell Adhesion | Human Filaggrin | Epidermal Keratinocytes | Intermediate Filament
KOL-Index: 9852 . BACKGROUND: Inherited ichthyoses belong to a large, clinically and etiologically heterogeneous group of mendelian disorders of cornification, typically involving the entire integument. Over the recent years, much progress has been made defining their molecular causes. However, there is no internationally accepted classification and terminology. OBJECTIVE: We sought to establish a consensus ...
Known for Inherited Ichthyoses | Ichthyosis Consensus | Umbrella Term | Mendelian Disorders
KOL-Index: 9546 . Skin biopsies and scale samples from nine infants and one fetus affected with harlequin ichthyosis (HI) were obtained from eight families. Epidermal differentiation was examined by morphologic and biochemical criteria and cell culture studies. Two striking abnormalities were identified; first, keratin and filaggrin expression were abnormal and varied between cases, and, second, in all ...
Known for Lamellar Granules | Harlequin Ichthyosis | Inborn Error | Protein Expression
KOL-Index: 9451 . Two monoclonal antibodies (AKH1 and AKH2) were elicited with partially purified human filaggrin and characterized by immunohistochemistry on normal and abnormal skin biopsies, immunoblotting techniques, and antigen purification. Both antibodies react strongly with the granular cell layer consistent with the distribution of keratohyalin and show a more diffuse reaction with the stratum ...
Known for Monoclonal Antibodies | Filaggrin Proteins | Ichthyosis Vulgaris | Stratum Corneum
KOL-Index: 9153 . Chronic wounds are a major clinical problem that lead to considerable morbidity and mortality. We hypothesized that an important factor in the failure of chronic wounds to heal was the presence of microbial biofilm resistant to antibiotics and protected from host defenses. A major difficulty in studying chronic wounds is the absence of suitable animal models. The goal of this study was to ...
Known for Chronic Wounds | Delayed Wound Healing | Pseudomonas Aeruginosa | Biofilm Challenge
KOL-Index: 8831 . BACKGROUND: Onychomycosis is a widespread refractory disease deleteriously affecting quality of life via social stigma and disrupting daily activities. Many physicians perceive onychomycosis as a cosmetic rather than a medical problem. OBJECTIVE: Our purpose was to develop a questionnaire-based instrument to quantify the impact of onychomycosis on patients' quality of life. METHODS: The ...
Known for Quality Life | Impact Onychomycosis | Daily Activities | Social Stigma
KOL-Index: 8582 . Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades1 and now affects ∼20% of the population in the developed world. Twin and family studies have shown that predisposition to atopic disease is highly heritable2. Although most genetic studies have focused on immunological mechanisms, a primary epithelial barrier defect has ...
Known for Atopic Dermatitis | Function Variants | Major Predisposing Factor | Protein Filaggrin
KOL-Index: 8571 . Bacterial biofilm has been shown to play a role in delaying wound healing of chronic wounds, a major medical problem that results in significant health care burden. A reproducible animal model could be very valuable for studying the mechanism and management of chronic wounds. Our previous work showed that Pseudomonas aeruginosa (PAO1) biofilm challenge on wounds in diabetic (db/db) mice ...
Known for Wound Healing | Pseudomonas Aeruginosa | Mouse Model | Bacterial Biofilm
KOL-Index: 8524 . BACKGROUND: Onychomycosis, a fungal infection of the nail bed, is responsible for up to 50% of nail disorders. Although several surveys have been conducted in different parts of the world, there have been no multicenter epidemiologic surveys of onychomycosis in North America. OBJECTIVE: A 12-center study was undertaken to (1) determine the frequency of onychomycosis, (2) identify organisms ...
Known for Antifungal Susceptibility | Fungal Isolates | North America | Onychomycosis Study
KOL-Index: 8356 . Bacteria colonizing chronic wounds are believed to exist as polymicrobial, biofilm communities; however, there are few studies demonstrating the role of biofilms in chronic wound pathogenesis. This study establishes a novel method for studying the effect of biofilms on the cell types involved in wound healing. Cocultures of Staphylococcus aureus biofilms and human keratinocytes (HK) were ...
Known for Aureus Biofilms | Human Keratinocytes | Bcm Pcm | Cell Viability

Key People For Harlequin Ichthyosis

Top KOLs in the world
#1
Philip H Fleckman
harlequin ichthyosis chronic wounds granular layer
#2
Masashi Akiyama
harlequin ichthyosis ichthyosiform erythroderma atopic dermatitis
#3
Beverly A Dale
harlequin ichthyosis stratum corneum epithelial cells
#4
Hiroshi Shimizu
bullous pemphigoid epidermolysis bullosa prenatal diagnosis
#5
Virginia P Sybert
turner syndrome prenatal diagnosis epidermolysis bullosa
#6
Edel A O’Toole
type vii collagen pachyonychia congenita harlequin ichthyosis

Department of Medicine, Division of Dermatology, University of Washington, Seattle | Department of Medicine, Division of Dermatology, University of Washington, Seattle, WA, USA | Department of Medicine, University of Washington, Seattle WA, United St