Prominent publications by Scott M Grundy

KOL Index score: 18509

Plasma lipoprotein concentration, composition, and size were evaluated in two common familial forms of hypertriglyceridemia and compared with those in normal subjects. The very low density lipoproteins (VLDL) were triglyceride-enriched in familial hypertriglyceridemia (triglyceride/apoprotein B ratio: 25.7 +/- 8.9) as compared to normal (9.6 +/- 12.2, P < 0.001) or familial combined hyperlipidemia (9.7 +/- 3.3, P < 0.001). The diameter of VLDL was larger in familial hypertriglyceridemia ...

Known for Familial Combined Hyperlipidemia |  Plasma Lipoproteins |  Hdl Cholesterol |  Vldl Ldl |  Normal Subjects
KOL Index score: 17277

The effects of obesity and caloric intake on biliary lipid metabolism were investigated in a series of related studies. The degree of saturation of gallbladder bile with cholesterol was found to be significantly higher in a group of 23 obese healthy subjects than in a group of 23 nonobese controls matched for age, sex, and race. Bile was also significantly more saturated in 11 obese subjects before than after weight reduction. To determine whether supersaturated bile in obesity is due to ...

Known for Caloric Intake |  Bile Cholesterol |  Biliary Lipid Metabolism |  Weight Reduction |  Obese Subjects
KOL Index score: 17090

CONTEXT: The risk of type 2 diabetes mellitus is heterogeneous among obese individuals. Factors that discriminate prediabetes or diabetes risk within this population have not been well characterized. A dysfunctional adiposity phenotype, characterized by excess visceral fat and insulin resistance, may contribute to diabetes development in those with obesity.

OBJECTIVE: To investigate associations between adiposity phenotypes and risk for incident prediabetes and diabetes in a multiethnic, ...

Known for Obese Adults |  Prediabetes Diabetes |  Type 2 |  Weight Gain |  Insulin Resistance
KOL Index score: 17090

The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management in 2001. Since the publication of ATP III, 5 major clinical trials of statin therapy with clinical end points have been published. These trials addressed issues that were not examined in previous clinical trials of cholesterol-lowering therapy. The present document reviews the results of these recent trials and assesses their ...

Known for Cholesterol Education |  Iii Guidelines |  Risk Ldl |  Therapeutic Option |  Adult Treatment
KOL Index score: 16881

Dietary Guidelines have emerged over the past 30 years recommending that Americans limit their consumption of total fat and saturated fat as one way to reduce the risk of a range of chronic diseases. However, a low-fat diet is not a no-fat diet. Dietary fat clearly serves a number of essential functions. For example, maternal energy deficiency, possible exacerbated by very low-fat intakes (< 15% of energy), is one key determinant in the etiology of low birth weight. The debate continues ...

Known for Dietary Fat |  United States |  Total Energy |  30 Years
KOL Index score: 16226

The Adult Treatment Panel III (ATP III) of the National Cholesterol Education Program issued an evidence-based set of guidelines on cholesterol management in 2001. Since the publication of ATP III, 5 major clinical trials of statin therapy with clinical end points have been published. These trials addressed issues that were not examined in previous clinical trials of cholesterol-lowering therapy. The present document reviews the results of these recent trials and assesses their ...

Known for Cholesterol Education |  Iii Guidelines |  Risk Ldl |  Reductase Inhibitors |  Adult Treatment
KOL Index score: 15780

Foods with plant stanol or sterol esters lower serum cholesterol levels. We summarize the deliberations of 32 experts on the efficacy and safety of sterols and stanols. A meta-analysis of 41 trials showed that intake of 2 g/d of stanols or sterols reduced low-density lipoprotein (LDL) by 10%; higher intakes added little. Efficacy is similar for sterols and stanols, but the food form may substantially affect LDL reduction. Effects are additive with diet or drug interventions: eating foods ...

Known for Sterols Stanols |  Cholesterol Levels |  Plant Stanol |  Efficacy Safety |  Saturated Fat
KOL Index score: 15519

Hyperhomocysteinemia has been reported in Asian Indians (people from Indian subcontinent) to be related to relatively low plasma levels of folate and vitamin B-12. However, a true ethnic-related characteristic has not been excluded. This study was done to determine whether Asian Indians have high plasma homocysteine compared with Caucasians in the United States in the era of folate fortification, and whether low vitamin B-12 or insulin resistance may account for possible interethnic ...

Known for Asian Indians |  United States |  Plasma Homocysteine |  Vitamin B12 |  Insulin Resistance
KOL Index score: 15259

BACKGROUND: High triglyceride (TG) and low high-density lipoprotein cholesterol (HDL-C) impart risk for heart disease. This study examines the relationships of TG/HDL-C ratio to mortality from all causes, coronary heart disease (CHD), or cardiovascular disease (CVD).

SUBJECTS AND METHODS: Survival analysis was done in 39,447 men grouped by TG/HDL-C ratio cut point of 3.5 and for metabolic syndrome. National Death Index International Classification of Diseases (ICD-9 and ICD-10) codes ...

Known for 2 Diabetes |  Heart Disease |  Cholesterol Ratio |  Metabolic Syndrome |  Cvd Chd
KOL Index score: 15134

CONTEXT: The Framingham Heart Study produced sex-specific coronary heart disease (CHD) prediction functions for assessing risk of developing incident CHD in a white middle-class population. Concern exists regarding whether these functions can be generalized to other populations.

OBJECTIVE: To test the validity and transportability of the Framingham CHD prediction functions per a National Heart, Lung, and Blood Institute workshop organized for this purpose.


Known for Ethnic Groups |  Framingham Coronary |  Disease Prediction |  Risk Functions |  Chd Events
KOL Index score: 15034

Twenty patients consumed a liquid diet in which the predominant fatty acids were either saturated (Sat), monounsaturated (Mono), or polyunsaturated (Poly). The fats in these three diets comprised 40% of total calories and consisted of palm oil, high-oleic safflower oil, and high-linoleic safflower oil, respectively. During the third and fourth week of each dietary period, multiple samples of blood were taken and were analyzed for plasma total cholesterol (TC), triglycerides (TG), and ...

Known for Unsaturated Fat |  Plasma Lipids |  Poly Diet |  Hdl Cholesterol |  Ldl Levels
KOL Index score: 14820

BACKGROUND: Previous trials have demonstrated that lowering low-density lipoprotein (LDL) cholesterol levels below currently recommended levels is beneficial in patients with acute coronary syndromes. We prospectively assessed the efficacy and safety of lowering LDL cholesterol levels below 100 mg per deciliter (2.6 mmol per liter) in patients with stable coronary heart disease (CHD).

METHODS: A total of 10,001 patients with clinically evident CHD and LDL cholesterol levels of less than ...

Known for Atorvastatin Patients |  Stable Coronary |  Intensive Lipid |  26 Mmol |  Treatment 80
KOL Index score: 14702

OBJECTIVE: Visceral (VAT) and abdominal subcutaneous (SAT) adipose tissues contribute to obesity but may have different metabolic and atherosclerosis risk profiles. We sought to determine the associations of abdominal VAT and SAT mass with markers of cardiac and metabolic risk in a large, multiethnic, population-based cohort of obese adults.

DESIGN AND METHODS: Among obese participants in the Dallas Heart Study, we examined the cross-sectional associations of abdominal VAT and SAT mass, ...

Known for Obese Adults |  Vat Sat |  Abdominal Subcutaneous |  Metabolic Risk |  Hdl Cholesterol
KOL Index score: 14698

IMPORTANCE: The comparative clinical benefit of nonstatin therapies that reduce low-density lipoprotein cholesterol (LDL-C) remains uncertain.

OBJECTIVE: To evaluate the association between lowering LDL-C and relative cardiovascular risk reduction across different statin and nonstatin therapies.

DATA SOURCES AND STUDY SELECTION: The MEDLINE and EMBASE databases were searched (1966-July 2016). The key inclusion criteria were that the study was a randomized clinical trial and the reported ...

Known for Cardiovascular Risk |  Reduction Ldl |  Major Vascular Events |  094 95 |  Myocardial Infarction
KOL Index score: 14649

Atherosclerosis develops rapidly in patients with diabetes or renal insufficiency. Plasma lipoprotein profiles are frequently abnormal in these conditions and reflect an elevation in the level of the apoprotein B (ApoB)-containing components very low density lipoprotein (VLDL) and low density lipoprotein (LDL). High levels of circulating advanced glycation end products (AGEs) also occur in diabetes and end-stage renal disease (ESRD). These products arise from glucose-derived Amadori ...

Known for Renal Insufficiency |  Low Density Lipoprotein |  Advanced Glycation |  Age Ldl |  Diabetes Esrd


Scott M Grundy: Influence Statistics

Sample of concepts for which Scott M Grundy is among the top experts in the world.
Concept World rank
27 role #1
hr1 plasma concentrations #1
moderatefiber diet calcium #1
ascvd total #1
primary prevention societies #1
vldl tgs patients #1
metabolic syndrome 80 #1
clearance insulin therapy #1
goal shape recommendations #1
vldl tgs type #1
lovastatin kinetics #1
drugs lovastatin #1
hepatic steatosis ethnicity #1
normalhdl #1
bmi white women #1
age ptdm #1
hypoalphalipoproteinemia low levels #1
catabolism vldltg #1
f2α content #1
vldl vldl triglyceride #1
acidic steroids output #1
leptin percent fat #1
factors ldl #1
insulin resistance htgc #1
total cholesterol adults #1
4week placebo #1
vat lbf #1
plant sterol loss #1
ehc degree #1
hypertension metabolic ascvd #1
mice stearic diet #1
total plasma average #1
measure apolipoprotein #1
hydroxymethylglutarylcoa hyperlipidemias niacin #1
hypertriglyceridemia humans #1
betasitosterol daily absorption #1
pravastatin therapy pravastatin #1
increase vldltg #1
cholesterol facts #1
fcrs autologous ldl #1
spe feeding reduction #1
ldl receptors removal #1
cdca lipid composition #1
apoldl chd #1
weeks hypercholesterolemic patients #1
gemfibrozil production #1
doses mevinolin #1
hispanics ethnic differences #1
ethnic differences frequency #1
cholesterol issues #1

Key People For Metabolic Syndrome

Top KOLs in the world
Scott M Grundy
metabolic syndrome hdl cholesterol coronary heart disease
Paul Z Zimmet
type 2 diabetes metabolic syndrome glucose tolerance
Sidney C Smith
cardiovascular disease myocardial infarction heart association
Robert H Eckel
lipoprotein lipase insulin resistance type 1 diabetes
James I Cleeman
blood cholesterol metabolic syndrome adult treatment panel
K George M M Alberti
blood glucose diabetes mellitus insulin sensitivity

Scott M Grundy:Expert Impact

Concepts for whichScott M Grundyhas direct influence:Metabolic syndrome,  Hdl cholesterol,  Coronary heart disease,  Insulin resistance,  Fatty acids,  Bile acids,  United states,  Density lipoprotein.

Scott M Grundy:KOL impact

Concepts related to the work of other authors for whichfor which Scott M Grundy has influence:Metabolic syndrome,  Insulin resistance,  Cardiovascular disease,  Type 2 diabetes,  Blood pressure,  Hdl cholesterol,  Fatty liver.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

University of Texas Southwestern Medical Center, Dallas, Texas, USA. | Center for Human Nutrition; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas; The Veterans Administration North Texas Health Care System at

FREE Custom List