• Disease
  • Head
  • Head Neck
  • Randal Scott Weber

    Prominent publications by Randal Scott Weber

    KOL Index score: 18817

    PURPOSE: Surgery is the primary treatment for adenoid cystic carcinomas arising from major and minor salivary glands of the head and neck. However, local recurrence is frequent because of the infiltrative growth pattern and perineural spread associated with these tumors. At UTMDACC, we have had a longstanding policy of using postoperative radiotherapy to reduce the risk of local recurrence and to avoid the need for radical surgery; this 30-year retrospective study analyzes the results of ...

    Also Ranks for: Positive Margins |  nerve invasion |  adenoid cystic |  postoperative radiotherapy |  neck surgery
    KOL Index score: 17021

    BACKGROUND: Induction chemotherapy with cisplatin plus fluorouracil followed by radiotherapy is the standard alternative to total laryngectomy for patients with locally advanced laryngeal cancer. The value of adding chemotherapy to radiotherapy and the optimal timing of chemotherapy are unknown.

    METHODS: We randomly assigned patients with locally advanced cancer of the larynx to one of three treatments: induction cisplatin plus fluorouracil followed by radiotherapy, radiotherapy with ...

    Also Ranks for: Concurrent Chemotherapy |  cisplatin radiotherapy |  laryngeal cancer |  organ preservation |  locoregional control
    KOL Index score: 15478

    PURPOSE: Promoter hypermethylation is one of the major mechanisms in the transcriptional inactivation of certain carcinoma-associated genes. Concurrent methylation analysis of multiple, functionally distinct genes may provide important information on their differential alterations and potential association in head and neck squamous carcinogenesis.

    EXPERIMENTAL DESIGN: Methylation-specific PCR analysis of the CpG islands of 8 cancer-related genes was performed on 19 cell lines and 32 ...

    Also Ranks for: Methylation Status |  cell lines |  squamous carcinoma |  head neck |  p16 mgmt genes
    KOL Index score: 15417

    PURPOSE: The objectives of this study were to determine the incidence of the MYB-NFIB fusion in salivary adenoid cystic carcinoma (ACC), to establish the clinicopathologic significance of the fusion, and to analyze the expression of MYB in ACCs in the context of the MYB-NFIB fusion.

    EXPERIMENTAL DESIGN: We did an extensive analysis involving 123 cancers of the salivary gland, including primary and metastatic ACCs, and non-ACC salivary carcinomas. MYB-NFIB fusions were identified by ...

    Also Ranks for: Salivary Adenoid |  mybnfib fusion |  situ hybridization |  expression myb |  oncogene proteins
    KOL Index score: 15343

    PURPOSE: Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and MYB-NFIB gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/MYB-NFIB fusion-negative ACC remain unknown. To uncover the genetic alterations in ACC lacking the canonical translocation and fusion transcript and identify new abnormalities in translocation positive tumors.


    Also Ranks for: Mybl1 Gene |  nfib fusions |  cystic carcinoma |  salivary adenoid |  proteins fusion
    KOL Index score: 14910

    IMPORTANCE: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) serves the need for continual quality assessment in general surgery. Previously, no parallel mechanism specific to head and neck oncologic surgery existed.

    OBJECTIVE: To address the need for continual quality assessment in subspecialty surgery by adapting the ACS NSQIP platform for complex head and neck oncologic surgical procedures.


    Also Ranks for: Surgical Quality |  head neck |  reconstructive surgery |  acs nsqip |  improvement program
    KOL Index score: 14720

    PURPOSE: Combining cisplatin or cetuximab with radiation improves overall survival (OS) of patients with stage III or IV head and neck carcinoma (HNC). Cetuximab plus platinum regimens also increase OS in metastatic HNC. The Radiation Therapy Oncology Group launched a phase III trial to test the hypothesis that adding cetuximab to the radiation-cisplatin platform improves progression-free survival (PFS).

    PATIENTS AND METHODS: Eligible patients with stage III or IV HNC were randomly ...

    Also Ranks for: Neck Carcinoma |  stage iii |  cisplatin cetuximab |  pfs patients |  female head
    KOL Index score: 14475

    BACKGROUND: Supraomohyoid neck dissection is an adequate operation for the elective treatment of the neck for patients with oral cavity cancer. Squamous cell carcinoma of the oral tongue, however, metastasize to clinically negative nodes in 20% to 30% of patients. These nodes usually are located in levels I-III.

    METHODS: The medical records of 277 previously untreated patients with squamous cell carcinoma of the oral tongue were reviewed between the years 1970 and 1990. All patients had ...

    Also Ranks for: Oral Tongue |  squamous carcinoma |  neck patients |  therapeutic implications |  nodes level
    KOL Index score: 14466

    OBJECTIVE/HYPOTHESIS: Cutaneous squamous cell carcinoma (CSCC) has been reported to metastasize to parotid and cervical lymph nodes. Few prospective investigations of associated clinical and histopathologic findings and their effect on patient outcomes exist. We seek to identify risk factors for nodal metastases in CSCC and determine the impact of lymphatic spread on survival and recurrence.

    STUDY DESIGN: Subset analysis of a prospective, longitudinal database of patients with CSCC at a ...

    Also Ranks for: Lymph Node Metastases |  patients cscc |  squamous cell |  perineural invasion |  neck neoplasms humans
    KOL Index score: 14335

    PURPOSE: We tested the efficacy and toxicity of cisplatin plus accelerated fractionation with a concomitant boost (AFX-C) versus standard fractionation (SFX) in locally advanced head and neck carcinoma (LA-HNC).

    PATIENTS AND METHODS: Patients had stage III to IV carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx. Radiation therapy schedules were 70 Gy in 35 fractions over 7 weeks (SFX) or 72 Gy in 42 fractions over 6 weeks (AFX-C). Cisplatin doses were 100 mg/m(2) once ...

    Also Ranks for: Neck Carcinoma |  concurrent cisplatin |  standard fractionation |  radiation therapy |  female head
    KOL Index score: 13702

    BACKGROUND: Oropharyngeal squamous-cell carcinomas caused by human papillomavirus (HPV) are associated with favorable survival, but the independent prognostic significance of tumor HPV status remains unknown.

    METHODS: We performed a retrospective analysis of the association between tumor HPV status and survival among patients with stage III or IV oropharyngeal squamous-cell carcinoma who were enrolled in a randomized trial comparing accelerated-fractionation radiotherapy (with ...

    Also Ranks for: Oropharyngeal Cancer |  human papillomavirus |  death patients |  tobacco smoking |  tumor hpv status
    KOL Index score: 13690

    PURPOSE: To investigate the feasibility of combining concomitant boost accelerated radiation regimen (AFX-C) with cisplatin and to assess its toxicity and the relapse pattern and survival in patients with advanced head and neck carcinoma (HNC).

    PATIENTS AND METHODS: Between April and November of 2000, 84 patients with stage III to IV HNC who met the eligibility criteria were enrolled; 76 of these patients were analyzable. Radiation consisted of 72 Gy in 42 fractions over 6 weeks (daily ...

    Also Ranks for: Advanced Head |  neck carcinomas |  concomitant boost |  radiation therapy |  concurrent cisplatin
    KOL Index score: 13601

    Paratracheal lymph node (PTLN) metastasis has been implicated as an etiologic factor in peristomal recurrence after laryngectomy. To determine the relationship between the primary site, the risk of peristomal recurrence, and the prognostic significance of PTLN metastasis, the medical records of 645 patients who underwent total laryngectomy between 1978 and 1990 for squamous cell carcinoma of the larynx, hypopharynx, and cervical esophagus were reviewed. Criteria for inclusion were the ...

    Also Ranks for: Cervical Esophagus |  lymph node |  ptln metastasis |  peristomal recurrence |  carcinoma larynx


    Randal Scott Weber: Influence Statistics

    Sample of concepts for which Randal Scott Weber is among the top experts in the world.
    Concept World rank
    secondary tep complications #1
    nonwound infection #1
    primary tumors radiotherapy #1
    nac hnc #1
    312 patients head #1
    median 432 months #1
    5year disease control #1
    ctcae dysphagia #1
    thyroid teratoma #1
    study visit cevimeline #1
    planned restaging #1
    median doi range #1
    tts cutoff #1
    tts ≥ 34 #1
    tts ≥ #1
    peristomal recurrence laryngectomy #1
    opscc function #1
    transfusion prediction model #1
    pgts control #1
    metastasis neck sublevel #1
    overlapping genes histogenesis #1
    ebrt disease control #1
    practice local control #1
    carcinoma spiradenoma #1
    patients nonresected acc #1
    procedures postfeedback cohort #1
    deglutition speech intelligibility #1
    histogenesis gene profiles #1
    advanced recurrent tumors #1
    regimen postoperative reirradiation #1
    neck carcinomas #1
    tumors pni #1
    ctcae mbs #1
    length aged comorbidity #1
    pgt treatment interruption #1
    validation pfs models #1
    jhu022scc cells alpha2 #1
    graft thickness neovascularization #1
    tep timing #1
    hnc nac #1
    mhm v69 mhm #1
    guidelinecompliance #1
    aged head dnm #1
    haps comorbid conditions #1
    tpt ece #1
    ece p01 #1
    tube presence conversion #1
    neck dissection depth #1
    8 mm dss #1
    chronic rad function #1

    Key People For Head Neck

    Top KOLs in the world
    K Kian Ang
    radiation therapy spinal cord head neck
    Arlene A Forastiere
    neck cancer squamous cell radiation therapy
    Randal Scott Weber
    head neck salivary gland squamous cell
    Maura L Gillison
    human papillomavirus united states squamous cell
    William H Westra
    human papillomavirus squamous cell head neck
    Jatin P Shah
    neck dissection squamous cell thyroid cancer

    Randal Scott Weber:Expert Impact

    Concepts for whichRandal Scott Weberhas direct influence:Head neck,  Neck cancer,  Salivary gland,  Squamous cell,  Radiation therapy,  Cell carcinoma,  Neck neoplasms humans,  Neck dissection.

    Randal Scott Weber:KOL impact

    Concepts related to the work of other authors for whichfor which Randal Scott Weber has influence:Squamous cell,  Neck cancer,  Human papillomavirus,  Radiation therapy,  Oral cavity,  Adenoid cystic carcinoma,  Salivary gland.



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    Division of Surgery, Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA | Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. | Departme