• Heart Failure
    • Gordon Henry Guyatt
    • Gordon Henry Guyatt: Influence Statistics

      Gordon Henry Guyatt

      Gordon Henry Guyatt

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      Department of Health Research Methods, McMaster University, Hamilton, Ontario, Canada | Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ...

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      Gordon Henry Guyatt:Expert Impact

      Concepts for whichGordon Henry Guyatthas direct influence:Heart failure,Noncardiac surgery,Randomized controlled trials,Quality life,Medical literature,Observational studies,Randomized controlled.

      Gordon Henry Guyatt:KOL impact

      Concepts related to the work of other authors for whichfor which Gordon Henry Guyatt has influence:Quality life,Heart failure,Randomized controlled trials,Physical activity,Venous thromboembolism,Mechanical ventilation,Knee osteoarthritis.

      KOL Resume for Gordon Henry Guyatt


      Department of Health Research Methods, McMaster University, Hamilton, Ontario, Canada


      Department of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada

      Université de Sherbrooke (Lamontagne); Centre de recherche du CHU de Sherbrooke (Lamontagne), Sherbrooke, Qc; Intensive Care National Audit and Research Centre (Rowan, Guyatt), Londres, Royaume-Uni; Département des méthodes, des données et de l’incidence de la recherche en santé (Guyatt), Université McMaster, Hamilton, Ont.

      Not guideline development panel member; resource for methodology, systematic review, and content support

      MAGIC Evidence Ecosystem Foundation, Oslo, Norway

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      Sample of concepts for which Gordon Henry Guyatt is among the top experts in the world.
      Concept World rank
      active psa treatment #1
      qalys survivors #1
      evidence kappa #1
      acute fev1 #1
      antithrombotic thrombolytic #1
      crq sgrq #1
      ppis low certainty #1
      etd framework health #1
      treatmentsubgroup #1
      patients values preferences #1
      mood disorders program #1
      ≤3days #1
      rrs midodrine #1
      individual trial #1
      hrql disease severity #1
      alternative classifications #1
      guidelines biological agents #1
      incretin based treatment #1
      external fixators studies #1
      170 255 patients #1
      incidence difficile infection #1
      harms certainty #1
      patients ibdq #1
      ivermectin laboratory #1
      fibromyalgia majority #1
      gender sexual harassment #1
      autres infections #1
      surgery recommendation #1
      data eligible #1
      tka agents arthritis #1
      absolute risk reduction #1
      participants excluded #1
      judges scientific quality #1
      histamine2receptor antagonists 95 #1
      evidence quality interventions #1
      10year increase #1
      gas usage #1
      target event treatment #1
      mid ezetimibe #1
      topic outcome assessment #1
      gc treatment recommendations #1
      metaanalysis unpublished data #1
      evaluating adults #1
      stroke ezetimibe #1
      correlations sg #1
      association progressionfree survival #1
      bias trials lipus #1
      ambulatory gas usage #1
      official ats statement #1
      life questionnaire menopause #1
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      Prominent publications by Gordon Henry Guyatt

      KOL-Index: 32475

      BACKGROUND: Antibiotics alter the microbial balance within the gastrointestinal tract. Probiotics may prevent antibiotic-associated diarrhea (AAD) via restoration of the gut microflora. Antibiotics are prescribed frequently in children and AAD is common in this population.

      OBJECTIVES: The primary objectives were to assess the efficacy and safety of probiotics (any specified strain or dose) used for the prevention of AAD in children.


      Known for Incidence Aad | Control Diarrhea | Risk Bias | Dose Probiotics | Children Probiotic
      KOL-Index: 24755

      BACKGROUND: Antibiotics are widely prescribed; however they can cause disturbances in gastrointestinal flora which may lead to reduced resistance to pathogens such as Clostridium difficile (C. difficile). Probiotics are live organisms thought to balance the gastrointestinal flora.

      OBJECTIVES: The primary objectives were to assess the efficacy and safety of probiotics for preventing Clostridium difficile-associated diarrhea (CDAD) or C. difficile infection in adults and children.

      SEARCH ...

      Known for Incidence Cdad | Clostridium Difficile | Probiotics Risk | Adults Children | 95 Adverse Events
      KOL-Index: 20694

      OBJECTIVE: This collaboration between the American College of Rheumatology and the American Association of Hip and Knee Surgeons developed an evidence-based guideline for the perioperative management of antirheumatic drug therapy for adults with rheumatoid arthritis (RA), spondyloarthritis (SpA) including ankylosing spondylitis and psoriatic arthritis, juvenile idiopathic arthritis (JIA), or systemic lupus erythematosus (SLE) undergoing elective total hip (THA) or total knee arthroplasty ...

      Known for Perioperative Management | Knee Arthroplasty | Rheumatic Diseases | Elective Total Hip | Psoriatic Arthritis
      KOL-Index: 20273

      OBJECTIVE: To update the American College of Rheumatology (ACR) 2000 recommendations for hip and knee osteoarthritis (OA) and develop new recommendations for hand OA.

      METHODS: A list of pharmacologic and nonpharmacologic modalities commonly used to manage knee, hip, and hand OA as well as clinical scenarios representing patients with symptomatic hand, hip, and knee OA were generated. Systematic evidence-based literature reviews were conducted by a working group at the Institute of ...

      Known for Knee Hip | Management Patients | Recommendations Evidence | Pharmacologic Modalities | Osteoarthritis Hand
      KOL-Index: 19380

      OBJECTIVE: To compare the effects of treatments for coronavirus disease 2019 (covid-19).

      DESIGN: Living systematic review and network meta-analysis.

      DATA SOURCES: WHO covid-19 database, a comprehensive multilingual source of global covid-19 literature, up to 1 March 2021 and six additional Chinese databases up to 20 February 2021. Studies identified as of 12 February 2021 were included in the analysis.

      STUDY SELECTION: Randomised clinical trials in which people with suspected, probable, ...

      Known for Living Systematic Review | Network Meta | Mechanical Ventilation | Low Certainty | Fewer 1000
      KOL-Index: 18135

      CLINICAL QUESTION: Recent 15-year updates of sigmoidoscopy screening trials provide new evidence on the effectiveness of colorectal cancer screening. Prompted by the new evidence, we asked: "Does colorectal cancer screening make an important difference to health outcomes in individuals initiating screening at age 50 to 79? And which screening option is best?"

      CURRENT PRACTICE: Numerous guidelines recommend screening, but vary on recommended test, age and screening frequency. This ...

      Known for Cancer Screening | Harms Burdens | 15 Years | Faecal Immunochemical Testing | Fit Single Sigmoidoscopy
      KOL-Index: 18045

      BACKGROUND: Myocardial injury after non-cardiac surgery (MINS) increases the risk of cardiovascular events and deaths, which anticoagulation therapy could prevent. Dabigatran prevents perioperative venous thromboembolism, but whether this drug can prevent a broader range of vascular complications in patients with MINS is unknown. The MANAGE trial assessed the potential of dabigatran to prevent major vascular complications among such patients.

      METHODS: In this international, randomised, ...

      Known for Dabigatran Patients | Myocardial Injury | Cardiac Surgery | Mins Risk | Controlled Trial
      KOL-Index: 17635

      BACKGROUND: The aim of the CRASH-2 trial was to assess the effects of early administration of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage. Tranexamic acid significantly reduced all-cause mortality. Because tranexamic acid is thought to exert its effect through inhibition of fibrinolysis, we undertook exploratory analyses of its effect on death due to bleeding.

      METHODS: The CRASH-2 trial was undertaken in 274 ...

      Known for Tranexamic Acid | Early Treatment | Bleeding Trauma | Risk Death | Controlled Trial
      KOL-Index: 17119

      CONTEXT: Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality.

      OBJECTIVE: To compare an established low-tidal-volume ventilation strategy with an experimental strategy based on the original "open-lung approach," combining low tidal volume, lung recruitment maneuvers, and high positive-end-expiratory ...

      Known for Ventilation Strategy | Tidal Volumes | Acute Lung Injury | Randomized Controlled Trial | Recruitment Maneuvers
      KOL-Index: 16989

      BACKGROUND: This guideline focuses on antithrombotic drug therapies for primary and secondary prevention of cardiovascular disease as well as for the relief of lower-extremity symptoms and critical ischemia in persons with peripheral arterial disease (PAD).

      METHODS: The methods of this guideline follow those described in Methodology for the Development of Antithrombotic Therapy and Prevention of Thrombosis Guidelines: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American ...

      Known for Antithrombotic Therapy | Aspirin Patients | Artery Disease | Symptomatic Pad | Cardiovascular Events
      KOL-Index: 16903

      BACKGROUND: The optimal choice for the stabilization of displaced femoral neck fractures remains controversial, with alternatives including arthroplasty and internal fixation. Our objective was to determine the effect of arthroplasty (hemiarthroplasty, bipolar arthroplasty, and total hip arthroplasty), compared with that of internal fixation, on rates of mortality, revision, pain, function, operating time, and wound infection in patients with a displaced femoral neck fracture.

      METHODS: ...

      Known for Internal Fixation | Displaced Fractures | Femoral Neck | Revision Surgery | Function Patients
      KOL-Index: 16660

      Importance: Harms and benefits of opioids for chronic noncancer pain remain unclear.

      Objective: To systematically review randomized clinical trials (RCTs) of opioids for chronic noncancer pain.

      Data Sources and Study Selection: The databases of CENTRAL, CINAHL, EMBASE, MEDLINE, AMED, and PsycINFO were searched from inception to April 2018 for RCTs of opioids for chronic noncancer pain vs any nonopioid control.

      Data Extraction and Synthesis: Paired reviewers independently extracted data. ...

      Known for Chronic Noncancer Pain | Physical Functioning | Wmd 95 | Trials Rcts | Quality Studies
      KOL-Index: 16512

      This chapter about antithrombotic therapy for coronary artery disease (CAD) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that individual patients' values may lead to different choices (for a full understanding of the grading see Guyatt et al, CHEST 2004; 126:179S-187S). Among the key ...

      Known for Antithrombotic Therapy | Coronary Artery Disease | Seventh Accp Conference | Grade 1a | Patients Clopidogrel
      KOL-Index: 16443

      OBJECTIVES: To provide a comprehensive comparison of patent foramen ovale (PFO) closure versus medical therapy in patients with cryptogenic stroke or transient ischaemic attack (TIA) and demonstrated PFO.

      DESIGN: Systematic review with complete case meta-analysis and sensitivity analyses. Data sources included MEDLINE and EMBASE from 1980 up to May 2013. All randomised controlled trials (RCTs) comparing treatment with percutaneous catheter-based closure of PFO to anticoagulant or ...

      Known for Medical Therapy | Cryptogenic Stroke | Patients Pfo | Patent Foramen | Percutaneous Closure
      KOL-Index: 16316

      OBJECTIVE: To evaluate sodium-glucose cotransporter-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists in patients with type 2 diabetes at varying cardiovascular and renal risk.

      DESIGN: Network meta-analysis.

      DATA SOURCES: Medline, Embase, and Cochrane CENTRAL up to 11 August 2020.

      ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials comparing SGLT-2 inhibitors or GLP-1 receptor agonists with placebo, standard care, or other glucose lowering ...

      Known for Receptor Agonists | 2 Diabetes | Randomised Controlled Trials | Network Meta | Cardiovascular Risk

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      Department of Health Research Methods, McMaster University, Hamilton, Ontario, Canada | Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada | From the Departments of Medicine (F. Lamontagne, M.-C.B., H.Q.M

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