• Disease
  • Heart
  • Heart Failure
  • Lynne Warner Stevenson

    Prominent publications by Lynne Warner Stevenson

    KOL Index score: 19033

    IMPORTANCE: Small studies suggest that low-dose dopamine or low-dose nesiritide may enhance decongestion and preserve renal function in patients with acute heart failure and renal dysfunction; however, neither strategy has been rigorously tested.

    OBJECTIVE: To test the 2 independent hypotheses that, compared with placebo, addition of low-dose dopamine (2 μg/kg/min) or low-dose nesiritide (0.005 μg/kg/min without bolus) to diuretic therapy will enhance decongestion and preserve renal ...

    Also Ranks for: Dose Dopamine |  acute heart failure |  renal dysfunction |  difference 95 |  natriuretic peptide
    KOL Index score: 16522

    IMPORTANCE: Studies in experimental and human heart failure suggest that phosphodiesterase-5 inhibitors may enhance cardiovascular function and thus exercise capacity in heart failure with preserved ejection fraction (HFPEF).

    OBJECTIVE: To determine the effect of the phosphodiesterase-5 inhibitor sildenafil compared with placebo on exercise capacity and clinical status in HFPEF.

    DESIGN: Multicenter, double-blind, placebo-controlled, parallel-group, randomized clinical trial of 216 stable ...

    Also Ranks for: Exercise Capacity |  heart failure |  24 weeks |  clinical status |  ejection fraction
    KOL Index score: 16340

    OBJECTIVES: This study sought to assess the effect of angiotensin-converting enzyme (ACE) inhibitors and beta-blockers on all-cause mortality in patients with left ventricular (LV) systolic dysfunction according to gender, race, and the presence of diabetes.

    BACKGROUND: Major randomized clinical trials have established that ACE inhibitors and beta-blockers have life-saving benefits in patients with LV systolic dysfunction. Most patients enrolled in these trials were Caucasian men. ...

    Also Ranks for: Enzyme Inhibitors |  systolic dysfunction |  betablockers patients |  diabetic status |  diabetes women
    KOL Index score: 15755

    Approximately 50% of patients hospitalized for heart failure have preserved systolic function. These patients are more likely to be older, women, and hypertensive. Their duration of hospitalization is similar to that of heart failure patients with systolic dysfunction, but their in-hospital mortality risk is lower. This mortality risk is increased in the setting of renal insufficiency, and the two most important risk predictors are elevated blood urea nitrogen and systolic blood pressure ...

    Also Ranks for: Heart Failure |  patients psf |  acute decompensated |  systolic dysfunction |  clinical presentation
    KOL Index score: 15250

    BACKGROUND: It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation and heart failure. This approach is based in part on data indicating that atrial fibrillation is a predictor of death in patients with heart failure and suggesting that the suppression of atrial fibrillation may favorably affect the outcome. However, the benefits and risks of this approach have not been adequately studied.

    METHODS: We conducted a multicenter, randomized trial ...

    Also Ranks for: Rhythm Control |  atrial fibrillation |  heart failure |  death patients |  ventricular rate
    KOL Index score: 15013

    BACKGROUND: The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory ...

    Also Ranks for: Patients Lvads |  lvad support |  1 year |  destination therapy |  thoracic surgeons
    KOL Index score: 14817

    CONTEXT: Hospice care is traditionally used for patients with advanced cancer, but it is increasingly considered for patients with end-stage heart failure.

    OBJECTIVES: We compared enrollment patterns and clinical events of hospice patients with end-stage heart failure with those of patients with advanced cancer.

    METHODS: Using Medicare data linked with pharmacy and cancer registry data, we identified patients who were diagnosed with either heart failure or advanced cancer between 1997 ...

    Also Ranks for: Heart Failure |  hospice patients |  advanced cancer |  referral consultation |  palliative patient
    KOL Index score: 14715

    BACKGROUND: In the CHAMPION trial, significant reductions in admissions to hospital for heart failure were seen after 6 months of pulmonary artery pressure guided management compared with usual care. We examine the extended efficacy of this strategy over 18 months of randomised follow-up and the clinical effect of open access to pressure information for an additional 13 months in patients formerly in the control group.

    METHODS: The CHAMPION trial was a prospective, parallel, ...

    Also Ranks for: Heart Failure |  pulmonary artery pressure |  treatment control |  6 months |  champion trial
    KOL Index score: 14607

    BACKGROUND: Pump thrombosis remains an uncommon but potentially catastrophic complication of durable continuous-flow left ventricular assist devices (LVAD). A perceived increase in the incidence of pump thrombosis in the HeartMate II (HMII) LVAD (Thoratec, Pleasanton, CA) by clinicians prompted this analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) database.

    METHODS: Between 2006 and June 2013, 8,988 United States patients aged older than 18 ...

    Also Ranks for: Pump Thrombosis |  interagency registry |  ventricular assist device |  1 year |  circulatory support
    KOL Index score: 14410

    BACKGROUND: Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial.

    METHODS AND RESULTS: We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery disease in 177 patients (45%) and nonischemic cardiomyopathy or valvular heart disease in 213 patients (55%). Mean left ventricular ejection fraction was 0.19 +/- 0.07. ...

    Also Ranks for: Atrial Fibrillation |  prognostic significance |  heart failure |  sudden death |  patients sinus rhythm
    KOL Index score: 13918

    OBJECTIVES: The purpose of this investigation was to determine how often left ventricular function improves in recent onset dilated cardiomyopathy of sufficient severity to cause referral for heart transplantation and how to predict this improvement at the time of evaluation for transplantation.

    BACKGROUND: Improvement has been reported to occur frequently in patients with acute dilated cardiomyopathy but has not been described specifically in these patients referred for transplantation. ...

    Also Ranks for: Heart Transplantation |  patients improvement |  ventricular function |  cardiomyopathy dilated |  ejection fraction
    KOL Index score: 13713

    BACKGROUND: The independent prognostic value of elevated jugular venous pressure or a third heart sound in patients with heart failure is not well established.

    METHODS: We performed a retrospective analysis of the Studies of Left Ventricular Dysfunction treatment trial, in which 2569 patients with symptomatic heart failure or a history of it were randomly assigned to receive enalapril or placebo. The mean (+/-SD) follow-up was 32+/-15 months. The presence of elevated jugular venous ...

    Also Ranks for: Heart Failure |  venous pressure |  elevated jugular |  death hospitalization |  physical examination patients
    KOL Index score: 13645

    CONTEXT: Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients.

    OBJECTIVE: To determine whether PAC use is safe and improves clinical outcomes in patients hospitalized with severe symptomatic and recurrent heart failure.

    DESIGN, SETTING, AND PARTICIPANTS: The Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization ...

    Also Ranks for: Congestive Heart Failure |  escape trial |  patients pac |  evaluation study |  mortality hospitalization
    KOL Index score: 13612

    OBJECTIVES: The purpose of this study was to assess the importance of syncope as a warning sign for sudden death in advanced heart failure and to determine the relative importance of cardiac syncope and syncope from other causes.

    BACKGROUND: Despite remarkable advances in the pharmacologic approach to advanced heart failure, 20% to 40% of patients with advanced heart failure will die each year. In such patients, the relation between sudden death and the etiology of syncope has not been ...

    Also Ranks for: Sudden Death |  advanced heart failure |  patients syncope |  1 year |  proportional hazards
    KOL Index score: 13606

    BACKGROUND: The Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), a joint effort among the National Heart, Lung, and Blood Institute, the Food and Drug Administration, the Centers for Medicare and Medicaid Services, and others, was established in 2005 at the University of Alabama at Birmingham. The registry examined clinical outcomes and quality-of-life metrics of patients who received an Food and Drug Administration-approved durable mechanical circulatory ...

    Also Ranks for: Patients Lvads |  lvad support |  1 year |  thoracic surgeons intermacs |  destination therapy


    Lynne Warner Stevenson: Influence Statistics

    Sample of concepts for which Lynne Warner Stevenson is among the top experts in the world.
    Concept World rank
    benzothiadiazines biomarkers #1
    prevhfhosp adjusted #1
    88 outpatients transplantation #1
    intermacs profiles lvad #1
    refractory questions #1
    profiles 4 lvad #1
    control randomised access #1
    transplantation medical therapy #1
    effective diuretic infusion #1
    patients filling pressures #1
    outcomes intermacs profile #1
    resting symptoms #1
    seattle hf #1
    hfh united states #1
    access 13 months #1
    origin syncope #1
    03 ml1g1 hyperemia #1
    20 stroke volume #1
    cardiac transplantation outpatients #1
    isolated rvad lvads #1
    patients orthodema #1
    pa pressures area #1
    advanced heart failure #1
    guideline nonadherence #1
    40 recovered patients #1
    intermacs profiling #1
    ihmguided treatment #1
    permanent pulmonary artery #1
    1whether #1
    mechanical circulatory support⁎⁎editorials #1
    intensification hf #1
    hydralazine captopril #1
    diuretic adjustments intensity #1
    bmi 35 95 #1
    adverse renal response #1
    filtering 25 hz #1
    period hf #1
    milrinone eno #1
    groups 111 ± #1
    uploaded pressures investigators #1
    initial assessment congestion #1
    prognostic therapy #1
    dynamic mitral regurgitation #1
    common reason discharge #1
    patients prevhfhosp #1
    develop heart #1
    year sensor implantation #1
    product epad pressure #1
    worst symptom patients #1

    Key People For Heart Failure

    Top KOLs in the world
    John J J V McMurray
    heart failure myocardial infarction atrial fibrillation
    John George Franklin Cleland
    heart failure patients hf atrial fibrillation
    Stephan D Anker
    heart failure iron deficiency cardiac cachexia
    Greegg C Fonarow
    heart failure atrial fibrillation united states
    Karl B Swedberg
    heart failure reduced ejection fraction myocardial infarction
    Piotr P Ponikowski
    heart failure iron deficiency reduced ejection fraction

    Lynne Warner Stevenson:Expert Impact

    Concepts for whichLynne Warner Stevensonhas direct influence:Heart failure,  Advanced heart failure,  Heart transplantation,  Atrial fibrillation,  Patients heart failure,  Sudden death,  Cardiac transplantation,  United states.

    Lynne Warner Stevenson:KOL impact

    Concepts related to the work of other authors for whichfor which Lynne Warner Stevenson has influence:Heart failure,  Atrial fibrillation,  Preserved ejection fraction,  Patients hf,  Ventricular assist,  Renal function,  Cardiovascular disease.



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    Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee | Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, Vanderbilt University Medical Center, Nashville, T