• KOL
    • Heart Failure
    • Prednisone Adding To Usual...
    • Prednisone Adding to Usual Care Treatment for Refractory Decompensated Congestive Heart Failure: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Heart failure,Congestive heart,Potent diuresis,Renal function,Clinical status,Daily urine volume,Aged prednisone,Glucocorticoids heart.

      Key People For Heart Failure

      Top KOLs in the world
      #1
      John J J V McMurray
      heart failure myocardial infarction atrial fibrillation
      #2
      John George Franklin Cleland
      heart failure patients hf atrial fibrillation
      #3
      Stephan D Anker
      heart failure iron deficiency cardiac cachexia
      #4
      Greegg C Fonarow
      heart failure atrial fibrillation united states
      #5
      Karl B Swedberg
      heart failure reduced ejection fraction myocardial infarction
      #6
      Piotr P Ponikowski
      heart failure iron deficiency reduced ejection fraction

      Prednisone Adding to Usual Care Treatment for Refractory Decompensated Congestive Heart Failure

      Abstract

      The aim of the present study was to determine if prednisone, a glucocorticoid, added to conventional treatment for patients with decompensated congestive heart failure (DCHF) refractory to the conventional care, results in significant relief of congestive symptoms and improvement of clinical status. Diuretic-based strategies, as the mainstay in DCHF management, are not always effective in eliciting diuresis. However, the addition of prednisone to standard care may induce potent diuresis in this clinical setting. Thirty-five patients with DCHF were enrolled in the study, and prednisone (1 mg/kg/day with maximum dosage of 60 mg/day) was added to the standard treatment. Primary endpoints were the effects on daily urine volume, patient and physician assessed dyspnea and global clinical status, and changes in renal function. The addition of prednisone induced potent diuresis with time. As a result of the diuresis, congestive symptoms improved markedly in 80% and global clinical status improved markedly in 68.6% of the DCHF patients at the end of the study (P < 0.001). The change in serum creatinine from baseline was -12.21 micromol/L (P < 0.05). Adding prednisone to conventional care in the patients with refractory DCHF induced potent diuresis accompanied by a dramatic relief of congestive symptoms and improvements in clinical status and renal function.

      Sign-in to see all concepts, it's free!

       

    Download on the App StoreGet it on Google Play

    Copyright © 2023 KOL - Key Opinion Leaders, LLC.

    KOL does not provide medical advice, diagnosis or treatment.