• Disease
  • Sleep
  • Sleep Apnea
  • Virend Kristen Somers

    Prominent publications by Virend Kristen Somers

    KOL Index score: 17083

    BACKGROUND: The risk of sudden death from cardiac causes in the general population peaks from 6 a.m. to noon and has a nadir from midnight to 6 a.m. Obstructive sleep apnea is highly prevalent and associated with neurohormonal and electrophysiological abnormalities that may increase the risk of sudden death from cardiac causes, especially during sleep.

    METHODS: We reviewed polysomnograms and the death certificates of 112 Minnesota residents who had undergone polysomnography and had died ...

    Also Ranks for: Sudden Death |  obstructive sleep apnea |  risk sleep |  midnight 6 |  aged polysomnography
    KOL Index score: 16344

    BACKGROUND: Spectral analysis of RR interval and systolic arterial pressure variabilities may provide indirect markers of the balance between sympathetic and vagal cardiovascular control.

    METHODS AND RESULTS: We examined the relationship between power spectral measurements of variabilities in RR interval, systolic arterial pressure, and muscle sympathetic nerve activity (MSNA) obtained by microneurography over a range of blood pressures. In eight healthy human volunteers, MSNA, RR ...

    Also Ranks for: Spectral Components |  interval msna |  cardiovascular variabilities |  nerve activity |  direct measures
    KOL Index score: 15350

    BACKGROUND: Emerging evidence suggests that a mildly elevated body mass index (BMI), is related to improved survival and fewer cardiovascular events in patients with coronary artery disease (CAD). We hypothesize that these results are related to the poor diagnostic performance of BMI to detect adiposity, especially in the intermediate BMI ranges.

    METHODS AND RESULTS: A cross-sectional study of 95 patients with CAD referred to phase II cardiac rehabilitation. Body fat (BF)% was estimated ...

    Also Ranks for: Coronary Artery Disease |  diagnostic performance |  patients cad |  bmi bf |  body mass obesity
    KOL Index score: 15176

    Questions remain as to whether pediatric sleep disordered breathing increases the risk for elevated blood pressure and blood pressure-dependent cardiac remodeling. We tested the hypothesis that activity-adjusted morning blood pressure surge, blood pressure load, and diurnal and nocturnal blood pressure are significantly higher in children with sleep disordered breathing than in healthy controls and that these blood pressure parameters relate to left ventricular remodeling. 24-hour ...

    Also Ranks for: Blood Pressure |  disordered breathing |  hour ambulatory |  children sleep |  apnea hypopnea
    KOL Index score: 14889

    Patients with obstructive sleep apnea experience repetitive apneic events during sleep, with consequent hypoxia and hypercapnia. Hypoxia and hypercapnia, acting via the chemoreflexes, elicit increases in sympathetic nerve activity. The sympathetic responses to hypoxia and hypercapnia are potentiated during apnea, when the sympathetic inhibitory influence of the thoracic afferent nerves is eliminated. As a consequence of the sympathetic vasoconstrictor response to apneic events, patients ...

    Also Ranks for: Sleep Apnea |  sympathetic nervous |  blood pressure patients |  hypoxia hypercapnia |  apneic events
    KOL Index score: 14687

    BACKGROUND: In normal humans, variability of blood pressure, RR interval, and sympathetic activity occurs predominantly at a low frequency (LF; 0.04 to 0.14 Hz) and a high frequency (HF; +/-0.25 Hz). In conditions that increase sympathetic activation in normal humans, the LF component is increased relative to the HF component. Patients with heart failure have high levels of sympathetic activity. We tested the hypothesis that the LF component of sympathetic nerve activity variability is ...

    Also Ranks for: Heart Failure |  sympathetic nerve activity |  interval msna |  normal humans |  hf component
    KOL Index score: 14602

    BACKGROUND: A large randomised treatment trial (SERVE-HF) showed that treatment of central sleep apnoea with adaptive servoventilation in patients with heart failure and reduced ejection fraction (HFREF) increased mortality, although the analysis of the composite primary endpoint (time to first event of death from any cause, life-saving cardiovascular intervention, or unplanned hospital admission for worsening heart failure) was neutral. This secondary multistate modelling analysis of ...

    Also Ranks for: Adaptive Servoventilation |  heart failure |  reduced ejection fraction |  cardiovascular death |  ventricular function
    KOL Index score: 14455

    Importance: Obstructive sleep apnea (OSA) is the most common clinically significant breathing abnormality during sleep. It is highly prevalent among patients with atrial fibrillation (AF), and it promotes arrhythmogenesis and impairs treatment efficacy.

    Observations: The prevalence of OSA ranges from 3% to 49% in population-based studies and from 21% to 74% in patients with AF. Diagnosis and treatment of OSA in patients with AF requires a close interdisciplinary collaboration between ...

    Also Ranks for: Osa Patients |  atrial fibrillation |  pressure treatment |  obstructive sleep apnea |  positive airway
    KOL Index score: 14173

    OBJECTIVES: This study sought to assess the mortality risk of patients with coronary artery disease (CAD) based ona combination of body mass index (BMI) with measures of central obesity.

    BACKGROUND: In CAD patients, mortality has been reported to vary inversely with BMI (“obesity paradox”). In contrast,central obesity is directly associated with mortality. Because of this bidirectionality, we hypothesized that CAD patients with normal BMI but central obesity would have worse survival ...

    Also Ranks for: Central Obesity |  normal weight |  bmi wc |  coronary disease |  patients cad
    KOL Index score: 13956

    Background:Body mass index (BMI) is the most widely used measure to diagnose obesity. However, the accuracy of BMI in detecting excess body adiposity in the adult general population is largely unknown.Methods:A cross-sectional design of 13 601 subjects (age 20–79.9 years; 49% men) from the Third National Health and Nutrition Examination Survey. Bioelectrical impedance analysis was used to estimate body fat percent (BF%). We assessed the diagnostic performance of BMI using the World ...

    Also Ranks for: Bmi Bf |  body mass obesity |  lean mass |  diagnostic performance |  sensitivity specificity
    KOL Index score: 13880

    BACKGROUND: Recently, the apoB/apoAI ratio has been associated with the metabolic syndrome; however, is unclear if its association with insulin resistance is mediated through traditional risk factors or if it adds an independent risk by itself. The aim of this study was to assess the independent association between apoB/apoAI ratio and insulin resistance in the US non-diabetic population.

    METHODS: We examined the association between high apoB/apoAI ratio and insulin resistance among 2955 ...

    Also Ranks for: Insulin Resistance |  apob apoai ratio |  metabolic syndrome |  diabetic subjects |  adjustment age
    KOL Index score: 13665

    BACKGROUND: Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea.

    METHODS: We ...

    Also Ranks for: Heart Failure |  adaptive servo |  central sleep apnea |  death patients |  cardiovascular mortality
    KOL Index score: 13549

    Using the Mueller maneuver (MM) to simulate obstructive sleep apnea (OSA), our aim was to investigate acute changes in left-sided cardiac morphologic characteristics and function which might develop with apneas occurring during sleep. Strong evidence supports a relation between OSA and both atrial fibrillation and heart failure. However, acute effects of airway obstruction on cardiac structure and function have not been well defined. In addition, it is unclear how OSA might contribute to ...

    Also Ranks for: Heart Failure |  mueller maneuver |  atrial fibrillation |  obstructive sleep |  cardiac structure
    KOL Index score: 13507

    Obstructive sleep apnea (OSA) is a common medical condition that occurs in approximately 5% to 15% of the population. The pathophysiology of OSA is characterized by repetitive occlusions of the posterior pharynx during sleep that obstruct the airway, followed by oxyhemoglobin desaturation, persistent inspiratory efforts against the occluded airway, and termination by arousal from sleep. Obstructive sleep apnea is associated with daytime sleepiness and fatigue, likely due to fragmented ...

    Also Ranks for: Cardiovascular Disease |  obstructive sleep apnea |  osa patients |  pulmonary hypertension |  daytime sleepiness
    KOL Index score: 13445

    Current body mass index (BMI) strata likely misrepresent the accuracy of true adiposity in older adults. Subjects with normal BMI with elevated body fat may metabolically have higher cardiovascular and overall mortality than previously suspected. We identified 4,489 subjects aged ≥60 years (BMI = 18.5 to 25 kg/m(2)) with anthropometric and bioelectrical impedance measurements from the National Health and Nutrition Examination Surveys III (1988 to 1994) and mortality data linked to the ...

    Also Ranks for: United States |  normal weight |  body fat |  bmi nwo |  national health


    Virend Kristen Somers: Influence Statistics

    Sample of concepts for which Virend Kristen Somers is among the top experts in the world.
    Concept World rank
    nocturnal scd #1
    role sleep apnea #1
    bru rem #1
    5 weight #1
    osa expression #1
    repetitive handgrip training #1
    27 sdb #1
    lesion entropy #1
    leptin modulate ventilation #1
    rar age #1
    fmd early morning #1
    n9 controls #1
    1 case mets #1
    msna higher #1
    neural circulatory responses #1
    plms increased prevalence #1
    bq estimated prevalence #1
    osa patients aldosterone #1
    qt drift #1
    orthostatic stress impairment #1
    bfdefined #1
    shortening osa #1
    lqts osa #1
    msna respiration #1
    msna hf msna #1
    regression analysis mass #1
    followup nonoperative patients #1
    aldosterone levels sleep #1
    nocturnal onset osa #1
    ratio metabolic #1
    parameters cardiac structure #1
    leptin vco2 slope #1
    synchronisation ordination #1
    catheter‐based study #1
    ahi increased prevalence #1
    whr oxi #1
    sympatheticnerve activity sleep #1
    cac osa #1
    morning surge hypertension #1
    young subjects smoking #1
    premature cad mortality #1
    healthy patients osa #1
    peripheral chemoreceptors hypoxia #1
    eds cardiovascular risk #1
    stsegment occurrence #1
    hcaec osa #1
    aortic stiffness bmi #1
    csa epo concentration #1
    hypoxia minute ventilation #1
    cultured hcaecs leptin #1

    Key People For Sleep Apnea

    Top KOLs in the world
    Terry B Young
    sleep apnea disordered breathing blood pressure
    Susan S Redline
    sleep apnea african americans cardiovascular disease
    Mari Palta
    type 1 diabetes sleep apnea united states
    Guilleminault Guilleminault
    sleep apnea disordered breathing blood pressure
    James B Skatrud
    nrem sleep mechanical ventilation periodic breathing
    Paul E Peppard
    sleep apnea disordered breathing health wisconsin

    Virend Kristen Somers:Expert Impact

    Concepts for whichVirend Kristen Somershas direct influence:Sleep apnea,  Obstructive sleep apnea,  Blood pressure,  Heart failure,  Obstructive sleep,  Cardiovascular disease,  Heart rate,  Atrial fibrillation.

    Virend Kristen Somers:KOL impact

    Concepts related to the work of other authors for whichfor which Virend Kristen Somers has influence:Sleep apnea,  Metabolic syndrome,  Blood pressure,  Heart failure,  Atrial fibrillation,  Cardiovascular disease,  Bariatric surgery.



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    Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota | Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA | Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA | Department of Cardiovascular Disease