 | WILLIAM T ABRAHAM |
Prominent publications by WILLIAM T ABRAHAM
Systolic Blood Pressure at Admission, Clinical Characteristics, and Outcomes in Patients Hospitalized With Acute Heart Failure
[ PUBLICATION ]
CONTEXT: The association between systolic blood pressure (SBP) at admission, clinical characteristics, and outcomes in patients hospitalized for heart failure who have reduced or relatively preserved systolic function has not been well studied.
OBJECTIVE: To evaluate the relationship between SBP at admission, clinical profile, and outcomes in patients hospitalized for acute heart failure.
DESIGN, SETTING, AND PATIENTS: Cohort study using data from the Organized Program to Initiate ...
| Also Ranks for: Heart Failure | clinical characteristics | admission patients | systolic blood pressure | mm hg |
Organized program to initiate lifesaving treatment in hospitalized patients with heart failure (OPTIMIZE-HF): rationale and design
[ PUBLICATION ]
Heart failure (HF) affects >5 million patients in the United States, and its prevalence is increasing every year. Despite the compelling scientific evidence that angiotensin-converting enzyme inhibitors and beta-blockers reduce hospitalizations and mortality rates in patients with HF, these lifesaving therapies continue to be underused. Several studies in a variety of clinical settings have documented that a significant proportion of eligible patients with HF are not receiving treatment ...
| Also Ranks for: Organized Program | heart failure | hospitalized patients | lifesaving treatment | hospital discharge |
AIMS: Predictors of Response to Cardiac Resynchronization Therapy (CRT) (PROSPECT) was the first large-scale, multicentre clinical trial that evaluated the ability of several echocardiographic measures of mechanical dyssynchrony to predict response to CRT. Since response to CRT may be defined as a spectrum and likely influenced by many factors, this sub-analysis aimed to investigate the relationship between baseline characteristics and measures of response to CRT.
METHODS AND RESULTS: A ...
| Also Ranks for: Crt Responders | reduction lvesv | heart failure patients | clinical improvement | predictors response |
BACKGROUND: Cardiac resynchronization therapy (CRT) improves symptoms, reduces heart failure (HF)-related hospitalizations, and reverses left ventricular remodeling in some patients with moderate to severe HF and ventricular dyssynchrony defined by a prolonged QRS duration. The effects of CRT on HF outcomes in patients with asymptomatic left ventricular dysfunction (ALVD) or mild HF remain to be determined.
METHODS: The REsynchronization reVErses Remodeling in Systolic left vEntricular ...
| Also Ranks for: Ventricular Dysfunction | crt patients | cardiac resynchronization | randomized controlled | mild heart failure |
BACKGROUND: The basic pharmacology of the third-generation beta-blocking agent carvedilol differs considerably from second-generation compounds such as metoprolol. Moreover, carvedilol may produce different, ie, more favorable, clinical effects in chronic heart failure. For these reasons, we compared the effects of carvedilol and metoprolol on adrenergic activity, receptor expression, degree of clinical beta-blockade, hemodynamics, and left ventricular function in patients with mild or ...
| Also Ranks for: Ventricular Function | metoprolol carvedilol | chronic treatment | adrenergic beta | hemodynamic effects |
BACKGROUND: Patients with heart failure (HF) are at high risk for mortality and rehospitalization in the early period after hospital discharge. We developed clinical models predictive of short-term clinical outcomes in a broad patient population discharged after hospitalization for HF.
METHODS: The Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) registry is a comprehensive hospital-based registry and performance-improvement ...
| Also Ranks for: Heart Failure | hospitalized patients | organized program | risk mortality | blood pressure |
BACKGROUND: The IMPACT-HF trial demonstrated that carvedilol use at the time of heart failure (HF) hospital discharge significantly increased 90-day postdischarge treatment rates. Whether there is an early survival benefit associated with this therapeutic approach in patients hospitalized for HF is unknown. We examined the early effects on mortality and rehospitalization of carvedilol use at discharge in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) ...
| Also Ranks for: Heart Failure | hospitalized patients | organized program | initiate lifesaving treatment | beta blocker |
BACKGROUND: The role of coronary-artery bypass grafting (CABG) in the treatment of patients with coronary artery disease and heart failure has not been clearly established.
METHODS: Between July 2002 and May 2007, a total of 1212 patients with an ejection fraction of 35% or less and coronary artery disease amenable to CABG were randomly assigned to medical therapy alone (602 patients) or medical therapy plus CABG (610 patients). The primary outcome was the rate of death from any cause. ...
| Also Ranks for: Cabg Medical Therapy | cardiovascular death | ventricular dysfunction | hazard ratio | artery bypass |
BACKGROUND: B-type natriuretic peptide (BNP) is secreted from the cardiac ventricles in response to increased wall tension.
METHODS: The Breathing Not Properly Multinational Study was a 7-center, prospective study of 1586 patients who presented to the Emergency Department with acute dyspnea and had BNP measured with a point-of-care assay upon arrival. The gold standard for congestive heart failure (CHF) was adjudicated by two independent cardiologists, blinded to BNP results, who ...
| Also Ranks for: Heart Failure | emergency diagnosis | chf bnp | natriuretic peptide | brain predictive |
OBJECTIVES: We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF).
BACKGROUND: Heart failure with preserved systolic function (PSF) is common but not well understood.
METHODS: This analysis of the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure) registry compared 20,118 patients with left ventricular systolic dysfunction (LVSD) and 21,149 ...
| Also Ranks for: Heart Failure | patients psf | preserved systolic | hf registry | organized program |
Plasma B-type natriuretic peptide (BNP) can reliably identify acute congestive heart failure (CHF) in patients presenting to the emergency department (ED) with acute dyspnea. Heart failure, asthma, and chronic obstructive pulmonary disease (COPD) are syndromes where dyspnea and wheezing are overlapping signs, and hence, these syndromes are often difficult to differentiate.
OBJECTIVE: To determine whether BNP can distinguish new-onset heart failure in patients with COPD or asthma ...
| Also Ranks for: Heart Failure | chf bnp | patients copd | pulmonary disease | natriuretic peptide |
BACKGROUND: Despite evidence-based national guidelines for optimal treatment of heart failure (HF), the quality of care remains inadequate. We sought to evaluate the effect of a national hospital-based initiative on quality of care in patients hospitalized with HF.
METHODS: Two hundred fifty-nine US hospitals participating in the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF) submitted data on 48 612 patients with HF from ...
| Also Ranks for: Organized Program | hospitalized patients | heart failure | initiate lifesaving treatment | hf quality |
Effect of QRS Duration and Morphology on Cardiac Resynchronization Therapy Outcomes in Mild Heart Failure
[ PUBLICATION ]
BACKGROUND: Cardiac resynchronization therapy (CRT) decreases mortality, improves functional status, and induces reverse left ventricular remodeling in selected populations with heart failure. We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure.
METHODS AND RESULTS: Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) was a multicenter randomized trial of ...
| Also Ranks for: Qrs Duration | mild heart failure | resynchronization therapy | ventricular remodeling | crt lbbb |
CONTEXT: Cardiac resynchronization therapy (CRT) through biventricular pacing is an effective treatment for heart failure (HF) with a wide QRS; however, the outcomes of patients requiring CRT and implantable cardioverter defibrillator (ICD) therapy are unknown.
OBJECTIVE: To examine the efficacy and safety of combined CRT and ICD therapy in patients with New York Heart Association (NYHA) class III or IV congestive HF despite appropriate medical management.
DESIGN, SETTING, AND ...
| Also Ranks for: Heart Failure | quality life | cardiac resynchronization | crt icd | functional class |
BACKGROUND: Cardiac resynchronization therapy (CRT) improves LV structure, function, and clinical outcomes in New York Heart Association class III/IV heart failure with prolonged QRS. It is not known whether patients with New York Heart Association class I/II systolic heart failure exhibit left ventricular (LV) reverse remodeling with CRT or whether reverse remodeling is modified by the cause of heart failure.
METHODS AND RESULTS: Six hundred ten patients with New York Heart Association ...
| Also Ranks for: Patients Crt | new york | heart association | 12 months | cardiac resynchronization |
WILLIAM T ABRAHAM: Influence Statistics
| Concept | World rank |
|---|---|
| crtoff ihd patients | #1 |
| rhc hf sensor | #1 |
| ongoing knowledge | #1 |
| shfm peak vco2 | #1 |
| ongoing gdmt | #1 |
| age hgb | #1 |
| ntprobnp bat | #1 |
| identified patients hf | #1 |
| european cohort reverse | #1 |
| simultaneous crt patients | #1 |
| csa nmsdb | #1 |
| mannitol 138 ± | #1 |
| ≥15 baseline | #1 |
| mild hf crt | #1 |
| “responder analysis | #1 |
| cardiovascular reasons hf | #1 |
| carvedilol hf | #1 |
| nyha functional | #1 |
| groups heart failure | #1 |
| device observations patients | #1 |
| hf impedance measurements | #1 |
| echocrt | #1 |
| hyponatremia cardiac surgery | #1 |
| 24 months crt | #1 |
| nmsdb | #1 |
| md2k | #1 |
| lower rates hfh | #1 |
| p04719 | #1 |
| hbnp infusion hbnp | #1 |
| crtoff nonihd patients | #1 |
| metoprolol succinate prevention | #1 |
| insync randomized | #1 |
| individuals biventricular pacing | #1 |
| central sleep apnoea | #1 |
| parachute device | #1 |
| 30day readmission hf | #1 |
| physicians hemodynamic | #1 |
| conventional management advent | #1 |
| 10 kaliuresis | #1 |
| nonischemic patients etiology | #1 |
| 4hour study periods | #1 |
| chronic hf crt | #1 |
| clinical composite response | #1 |
| compared crt | #1 |
| hf continuous monitoring | #1 |
| tailor‐made therapy | #1 |
| simultaneous crt | #1 |
| hbnp patients | #1 |
| life carotid sinus | #1 |
| chapter 29 devices | #1 |
Key People For Heart Failure
WILLIAM T ABRAHAM:Expert Impact
Concepts for whichWILLIAM T ABRAHAMhas direct influence:Heart failure, Patients heart failure, Cardiac resynchronization, Patients hf, Heart failure hf, Coapt trial, Heart failure patients, Resynchronization therapy.
WILLIAM T ABRAHAM:KOL impact
Concepts related to the work of other authors for whichfor which WILLIAM T ABRAHAM has influence:Heart failure, Natriuretic peptide, Cardiac resynchronization, Atrial fibrillation, Renal denervation, Ejection fraction, Patients hf.
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