Prominent publications by Ernst Johan Kuipers

KOL Index score: 32769

This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE). It addresses the diagnosis and management of nonvariceal upper gastrointestinal hemorrhage (NVUGIH). Main Recommendations MR1. ESGE recommends immediate assessment of hemodynamic status in patients who present with acute upper gastrointestinal hemorrhage (UGIH), with prompt intravascular volume replacement initially using crystalloid fluids if hemodynamic instability exists (strong ...

Also Ranks for: Gastrointestinal Endoscopy |  strong recommendation |  endoscopic hemostasis patients |  european society |  moderate quality evidence
KOL Index score: 30888

BACKGROUND: The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent data sources to enable comparisons of health loss over time and across causes, age-sex groups, and countries. The GBD can be used to generate summary measures such as disability-adjusted life-years (DALYs) and healthy life expectancy (HALE) that make possible comparative ...

Also Ranks for: Epidemiological Transition |  life expectancy |  dalys hale |  188 countries |  ylls ylds
KOL Index score: 28681

BACKGROUND: Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between ...

Also Ranks for: Life Expectancy |  specific mortality |  global burden |  sdi countries |  systematic analysis
KOL Index score: 28408

BACKGROUND: Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures.


Also Ranks for: Life Expectancy |  specific mortality |  global burden |  population growth |  total deaths
KOL Index score: 26791

BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with ...

Also Ranks for: Hale Dalys |  global burden |  healthy life expectancy |  adjusted life |  systematic analysis
KOL Index score: 24966

BACKGROUND: Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and ...

Also Ranks for: Prevalence Incidence |  disability ylds |  global burden |  systematic analysis |  years lived
KOL Index score: 24802

BACKGROUND: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context.

METHODS: We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to ...

Also Ranks for: Global Burden |  metabolic risks |  study 2015 |  attributable dalys |  risk exposure
KOL Index score: 23257

BACKGROUND: The Global Burden of Disease, Injuries, and Risk Factor study 2013 (GBD 2013) is the first of a series of annual updates of the GBD. Risk factor quantification, particularly of modifiable risk factors, can help to identify emerging threats to population health and opportunities for prevention. The GBD 2013 provides a timely opportunity to update the comparative risk assessment with new data for exposure, relative risks, and evidence on the appropriate counterfactual risk ...

Also Ranks for: Metabolic Risks |  188 countries |  global burden |  systematic analysis |  middle east
KOL Index score: 21676

OBJECTIVE: Fecal immunochemical testing (FIT) is increasingly used for colorectal cancer (CRC) screening. We aimed to estimate its diagnostic accuracy in invitational population screening measured against colonoscopy.

METHODS: Participants (50-75 years) in an invitational primary colonoscopy screening program were asked to complete one sample FIT before colonoscopy. We estimated FIT sensitivity, specificity, and predictive values in detecting CRC and advanced neoplasia (carcinomas and ...

Also Ranks for: Advanced Neoplasia |  sensitivity specificity |  95 crc |  occult blood |  immunochemical fecal
KOL Index score: 21538

BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.

METHODS: Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 ...

Also Ranks for: 188 Countries |  global burden |  systematic analysis |  national incidence |  chronic diseases
KOL Index score: 19609

BACKGROUND: National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). Previous analyses of mortality amenable to health care only focused on high-income countries and faced several methodological challenges. In the present analysis, we use the highly standardised cause of death and risk factor estimates generated through the Global ...

Also Ranks for: 195 Countries |  healthcare access |  personal health |  global burden |  study 2015
KOL Index score: 18431

BACKGROUND: Screening for colorectal cancer is widely recommended, but the preferred strategy remains unidentified. We aimed to compare participation and diagnostic yield between screening with colonoscopy and with non-cathartic CT colonography.

METHODS: Members of the general population, aged 50-75 years, and living in the regions of Amsterdam or Rotterdam, identified via the registries of the regional municipal administration, were randomly allocated (2:1) to be invited for primary ...

Also Ranks for: Colorectal Cancer |  colonoscopy colonography |  advanced neoplasia |  diagnostic yield |  based screening
KOL Index score: 18201

BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths ...

Also Ranks for: Life Expectancy |  global burden |  study 2017 |  specific mortality |  child child
KOL Index score: 17977

BACKGROUND: Mouse models have shown that interleukin (IL)6 stimulates survival, proliferation and progression to cancer of intestinal epithelial cells via activation of signal transducers and activators of transcription 3 (STAT3).

OBJECTIVE: To investigate the expression of IL6/phosphorylated STAT3 (p-STAT3)/suppressor of cytokine signalling 3 (SOCS3) in biopsy specimens from patients with ulcerative colitis (UC) and UC-related colorectal cancer (CRC) progression.

METHODS: Biopsy ...

Also Ranks for: Ulcerative Colitis |  il6 stat3 |  cytokine 3 socs3 |  biopsy specimens patients |  inactive uc

Key People For Helicobacter Pylori

Top KOLs in the world
David ***** ******
helicobacter pylori gastric cancer duodenal ulcer
Martin * ******
helicobacter pylori campylobacter fetus gastric cancer
Francis ********
helicobacter pylori gastric cancer european registry
Guillermo * ***** ************
helicobacter pylori gastric cancer bacterial antigens
Peter *************
helicobacter pylori gastric cancer chronic pancreatitis
Ernst ***** *******
helicobacter pylori colorectal cancer atrophic gastritis

Ernst Johan Kuipers:Expert Impact

Concepts for whichErnst Johan Kuipershas direct influence:Helicobacter pylori,  Colorectal cancer,  Gastric cancer,  Atrophic gastritis,  Stent placement,  Intestinal metaplasia,  Cancer screening,  Advanced neoplasia.

Ernst Johan Kuipers:KOL impact

Concepts related to the work of other authors for whichfor which Ernst Johan Kuipers has influence:Helicobacter pylori,  Colorectal cancer,  Global burden,  Inflammatory bowel disease,  Physical activity,  Peptic ulcer,  Lynch syndrome.



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Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands | Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, Netherlands. | Department of Gastroenter