• Helicobacter Pylori
    • Pelayo Correa
    • Pelayo Correa: Influence Statistics

      Pelayo Correa

      Pelayo Correa

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      Vanderbilt University, Nashville, Tennessee, USA. | Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, ...

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      Pelayo Correa:Expert Impact

      Concepts for whichPelayo Correahas direct influence:Helicobacter pylori,Gastric cancer,Lung cancer,Pylori infection,Helicobacter pylori infection,Intestinal metaplasia,United states,Latin america.

      Pelayo Correa:KOL impact

      Concepts related to the work of other authors for whichfor which Pelayo Correa has influence:Gastric cancer,Helicobacter pylori,Intestinal metaplasia,Atrophic gastritis,Ulcerative colitis.

      KOL Resume for Pelayo Correa


      Vanderbilt University, Nashville, Tennessee, USA.


      Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.


      Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA


      Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, 37232, Nashville, TN, USA


      Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA


      Vanderbilt University, Nashville, Tennessee, Estados Unidos de América,

      Gastroenterology and


      Division of Gastroenterology; Department of Medicine; Vanderbilt University Medical Center; Nashville, TN USA.

      Vanderbilt University Medical Center Nashville TN USA


      Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center and Vanderbilt-Ingram Cancer Center, Nashville, TN 37232

      Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37240, USA


      Division of Gastroenterology, Vanderbilt University Medical Center, 1030C MRB IV. 2215B Garland Ave, 37232, Nashville, TN, USA

      Anne Potter Wilson Professor of Medicine, Vanderbilt University School of Medicine, Nashville.

      Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN 37232; and


      Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

      School of Public Health Louisiana State University, New Orleans, LA 70112, USA.


      Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA


      Department of Medicine, School of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University, Nashville, Tennessee

      Vanderbilt University Medical Center, Nashville, TN, USA


      Department of Pathology, Louisiana State University Health Sciences, New Orleans, Louisiana, USA


      Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine and Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, U.S.A.

      Department of Pathology, Stanley S. Scott Cancer Center, New Orleans


      Department of Pathology, Universidad del Valle, Cali, Colombia

      Louisiana State University Medical Center, New Orleans, Louisiana

      LSU Health Science Center, 1901 Perdido Street, Box P5-1, New Orleans, LA 70112, USA

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      Sample of concepts for which Pelayo Correa is among the top experts in the world.
      Concept World rank
      cancer maté #1
      juice gastritis #1
      prevalence intestinal polyps #1
      apis males #1
      japanese migrants hawaii #1
      methylation levels amph #1
      chemoprevention gastric cancer #1
      gastric tumors adenocarcinomas #1
      dysplasia precancerous #1
      evaluation gastric biopsies #1
      mustelae antibody #1
      colonization time postinfection #1
      rectum adenomatous polyps #1
      sulfomucins helicobacter pylori #1
      cervix stomach #1
      aataagata motif persons #1
      strongyllata #1
      methylation 5 genes #1
      analysis gastric #1
      epidemiology colon cancer #1
      tumaco correlation #1
      diameter epithelial atypia #1
      fur deltafur #1
      age japanese migrants #1
      lymphocytes lowerrisk population #1
      survival virulent genotypes #1
      pylori isolates coculture #1
      tumors races #1
      ferrous sulfate increase #1
      groups japanese observers #1
      strains phylogeographic origin #1
      carcinogenesis infection #1
      ubt serological tests #1
      gastric cancers hispanics #1
      children promotes #1
      βcatenin stages #1
      paraffin biopsies #1
      histological classif #1
      chronic gastritis role #1
      aataagata #1
      square pylori #1
      tobacco tars #1
      rspo2 sorcs3 #1
      tumaco gastric cancer #1
      children pylori eradication #1
      colombians japanese migrants #1
      sensitivity japanese observers #1
      severity gastritis #1
      tff1 β #1
      conditions risk #1
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      Prominent publications by Pelayo Correa

      KOL-Index: 21773

      BACKGROUND: Evidence from Europe, Asia, and North America suggests that standard three-drug regimens of a proton-pump inhibitor plus amoxicillin and clarithromycin are significantly less effective for eradication of Helicobacter pylori infection than are 5-day concomitant and 10-day sequential four-drug regimens that include a nitroimidazole. These four-drug regimens also entail fewer antibiotic doses than do three-drug regimens and thus could be suitable for eradication programmes in ...

      Known for Latin America | Day Sequential | Amoxicillin Clarithromycin | Helicobacter Pylori Infection | 5 Lansoprazole
      KOL-Index: 19861

      ObjectiveWe examined subsite- and histology-specific esophageal and gastric cancer incidence patterns among Hispanics/Latinos and compared them with non-Hispanic whites and non-Hispanic blacks.MethodsData on newly diagnosed esophageal and gastric cancers for 1998–2002 were obtained from 37 population-based central cancer registries, representing 66% of the Hispanic population in the United States. Age-adjusted incidence rates (2000 US) were computed by race/ethnicity, sex, anatomic ...

      Known for United States | Incidence Rates | Nonhispanic Whites | Gastric Cancer | Hispanic Women
      KOL-Index: 16518

      BACKGROUND & AIMS: Helicobacter pylori-induced gastric carcinogenesis has been linked to the microbial oncoprotein cytotoxin-associated gene A (CagA). Spermine oxidase (SMO) metabolizes the polyamine spermine into spermidine and generates H(2)O(2), which causes apoptosis and DNA damage. We determined if pathogenic effects of CagA are attributable to SMO.

      METHODS: Levels of SMO, apoptosis, and DNA damage (8-oxoguanosine) were measured in gastric epithelial cell lines infected with cagA(+) ...

      Known for Pylori Caga | Dna Damage | Spermine Oxidase | Smo Apoptosis | Gastric Cancer Risk
      KOL-Index: 15146

      Abstract.Background:The age-standardized and cumulative incidence rates of gastric cancer (GCA) are twice as high in males as in females.Methods:Based on age-group-specific (5-year age groups) annual incidence data of GCA among males and females published by 18 cancer registries worldwide, and on a consecutive series of 938 GCAs from Finland, we explored how the male predominance of GCA has changed over the decades and how this male predominance may possibly vary worldwide between ...

      Known for Females Males | Gastric Cancer | Male Predominance | Intestinal Subtype | Onset Aged Aged
      KOL-Index: 14834

      Several polymorphisms of the IL1B and IL10 gene promoters have been reported to be associated with gastric cancer risk in Caucasians. However, studies in other populations have shown differing results. We aimed to test for associations between polymorphisms in IL1B (-31 and +3954), IL10-592 and IL1RN variable number of tandem repeats (VNTR) and risk of gastric cancer in a Mexican population. DNA was extracted from sera of 183 gastric adenocarcinoma patients and 377 controls. The IL1B-31, ...

      Known for Gastric Cancer | Helicobacter Pylori | Mexican Population | Polymorphisms Risk | Intestinal Type
      KOL-Index: 14736

      BACKGROUND & AIMS: The gastric cancer-causing pathogen Helicobacter pylori up-regulates spermine oxidase (SMOX) in gastric epithelial cells, causing oxidative stress-induced apoptosis and DNA damage. A subpopulation of SMOX(high) cells are resistant to apoptosis, despite their high levels of DNA damage. Because epidermal growth factor receptor (EGFR) activation can regulate apoptosis, we determined its role in SMOX-mediated effects.

      METHODS: SMOX, apoptosis, and DNA damage were measured ...

      Known for Dna Damage | Gastric Epithelial Cells | Helicobacter Pylori | Signal Transduction | Intestinal Metaplasia
      KOL-Index: 14465

      BACKGROUND: Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity.

      METHODS: Serum levels of antibodies to each of 15 H. pylori proteins were assessed using multiplex serology for a sample of 689 African American and white participants from the Southern Community Cohort Study. African and European admixture was estimated using a panel of 276 ancestry genetic markers, ...

      Known for African Ancestry | United States | Helicobacter Pylori | Increased Odds | Multiplex Serology
      KOL-Index: 13640

      BACKGROUND & AIMS: Infection with the gastric mucosal pathogen Helicobacter pylori is the strongest identified risk factor for distal gastric cancer. These bacteria colonize a significant part of the world's population. We investigated the molecular mechanisms of p53 regulation in H pylori-infected cells.

      METHODS: Mongolian gerbils were challenged with H pylori and their gastric tissues were analyzed by immunohistochemistry and immunoblotting with p53 antibodies. Gastric epithelial cells ...

      Known for P53 Tumor Suppressor | Epithelial Cells | Helicobacter Pylori | Proteasomal Degradation | Activation Hdm2
      KOL-Index: 13352

      BACKGROUND: Helicobacter pylori infection is a risk factor for the development of gastric cancer, and the bacterial oncoprotein CagA contributes to gastric carcinogenesis.

      METHODS: We analyzed H. pylori isolates from persons in Colombia and observed that there was marked variation among strains in levels of CagA expression. To elucidate the basis for this variation, we analyzed sequences upstream from the CagA translational initiation site in each strain.

      RESULTS: A DNA motif (AATAAGATA) ...

      Known for Gastric Cancer | Pylori Strains | Caga Expression | Dna Motif | Infections Helicobacter
      KOL-Index: 13151

      OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin production by inhibiting cyclooxygenase (COX); they are believed to cause gastroduodenal damage by inhibiting the COX-1 isoform and to have analgesic and anti-inflammatory effects by inhibiting the COX-2 isoform. As compared to conventional NSAIDs, celecoxib, a COX-2 specific inhibitor, has been shown in previous single posttreatment endoscopy studies to be associated with lower gastroduodenal ulcer rates. In ...

      Known for Gastroduodenal Ulcers | Celecoxib Naproxen | Reduced Incidence | Antiinflammatory Agents | Ulcer Rates
      KOL-Index: 12990

      BACKGROUND & AIMS: Although the p53 tumor suppressor has been extensively studied, many critical questions remain unanswered about the biological functions of p53 homologs, p73 and p63. Accumulating evidence suggests that both p73 and p63 play important roles in regulation of apoptosis, cell differentiation, and therapeutic drug sensitivity.

      METHODS: Gastric epithelial cells were cocultured with Helicobacter pylori, and the roles of p63 and p73 proteins were assessed by luciferase ...

      Known for Helicobacter Pylori | Gastric Epithelial Cells | P53 Protein | P73 P63 | Tumor Suppressor
      KOL-Index: 12892

      T cells infiltrating tumors have a decreased expression of signal transduction proteins, a diminished ability to proliferate, and a decreased production of cytokines. The mechanisms causing these changes have remained unclear. We demonstrated recently that peritoneal macrophages stimulated with interleukin 4 + interleukin 13 produce arginase I, which decreases the expression of the T-cell receptor CD3zeta chain and impairs T-cell responses. Using a 3LL murine lung carcinoma model we ...

      Known for Tumor Microenvironment | Myeloid Cells | Levels Arginase | Cell Responses | Lung Carcinoma
      KOL-Index: 12690

      OBJECTIVE: To evaluate the long-term effect of cumulative time exposed to Helicobacter pylori infection on the progression of gastric lesions.

      DESIGN: 795 adults with precancerous gastric lesions were randomised to receive anti-H. pylori treatment at baseline. Gastric biopsies were obtained at baseline and at 3, 6, 12 and 16 years. A total of 456 individuals attended the 16-year visit. Cumulative time of H. pylori exposure was calculated as the number of years infected during follow-up. ...

      Known for Pylori Infection | Precancerous Lesions | Cumulative Time | Male Metaplasia | Year Follow

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      Vanderbilt University, Nashville, Tennessee, USA. | Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. | Division of Gastroenterology, Department of Medicine, V

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