• Disease
  • Hemorrhagic
  • Hemorrhagic Shock
  • Ernest E Jr Md Moore

    Prominent publications by Ernest E Jr MD Moore

    KOL Index score: 21850

    BACKGROUND: The Injury Severity Score (ISS) has been observed consistently to be a robust predictor of postinjury multiple organ failure (MOF). However, the ISS fails to account for multiple injuries to the same body region. Recently, the "new" ISS (NISS) has been proposed to address this shortcoming. Preliminary studies suggest the NISS is superior to the ISS in predicting trauma mortality. Our purpose was to determine whether the NISS is a better predictor of postinjury MOF than the ...

    Also Ranks for: Iss Niss |  multiple organ |  postinjury mof |  trauma mortality |  48 hours
    KOL Index score: 16690

    BACKGROUND: A variety of policy groups have recommended that screening and brief interventions (BIs) for alcohol disorders be widely implemented in health care settings. This study was conducted to determine the current status of screening and intervention programs in trauma centers and to evaluate specific barriers to implementation of screening and BIs. The hypotheses tested were that surgeons who support screening and brief interventions would be less likely to endorse the purported ...

    Also Ranks for: Alcohol Screening |  trauma surgeons |  national survey |  intervention programs |  barriers implementation
    KOL Index score: 16620

    OBJECTIVE: The expression of proinflammatory cytokines is rapidly increased in experimental models of the acute respiratory distress syndrome (ARDS), in patients at risk for ARDS, and in patients with established ARDS. Because multiple cytokines are present in bronchoalveolar lavage fluid, a common, proximal activation mechanism may operate in these settings. The proinflammatory cytokines whose expression is increased in the lungs of patients with ARDS have binding sequences in their ...

    Also Ranks for: Alveolar Macrophages |  patients ards |  acute respiratory |  nuclear factor |  distress syndrome
    KOL Index score: 16287

    BACKGROUND: There is no consensus on diagnosis and management of ASBO. Initial conservative management is usually safe, however proper timing for discontinuing non operative treatment is still controversial. Open surgery or laparoscopy are used without standardized indications.

    METHODS: A panel of 13 international experts with interest and background in ASBO and peritoneal diseases, participated in a consensus conference during the 1st International Congress of the World Society of ...

    Also Ranks for: Emergency Surgery |  bologna guidelines |  management asbo |  small bowel |  signs strangulation
    KOL Index score: 15983

    Importance: Both military and civilian clinical practice guidelines include early plasma transfusion to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known how early plasma should be given for optimal benefit. Two recent randomized clinical trials were published, with apparently contradictory results. The Prehospital Air Medical Plasma (PAMPer) clinical trial showed a nearly 30% reduction in mortality with plasma transfusion in the prehospital ...

    Also Ranks for: Prehospital Plasma |  hemorrhagic shock |  trauma patients |  transport time |  28day mortality
    KOL Index score: 15629

    BACKGROUND: In 2013 Guidelines on diagnosis and management of ASBO have been revised and updated by the WSES Working Group on ASBO to develop current evidence-based algorithms and focus indications and safety of conservative treatment, timing of surgery and indications for laparoscopy.

    RECOMMENDATIONS: In absence of signs of strangulation and history of persistent vomiting or combined CT-scan signs (free fluid, mesenteric edema, small-bowel feces sign, devascularization) patients with ...

    Also Ranks for: Surgery Asbo |  diagnosis management |  small bowel |  based guidelines |  signs strangulation
    KOL Index score: 15486

    BACKGROUND: In light of their potential for devastating consequences, a liberalized screening approach for blunt cerebrovascular injuries (BCVI) is becoming increasingly accepted. The "gold standard" for diagnosis of BCVI is arteriography; however, noninvasive diagnostic alternatives offer clear advantages. Recent series have demonstrated the ability of computed tomographic angiography (CTA) and magnetic resonance angiography (MRA) to identify BCVI, but have not compared their accuracy ...

    Also Ranks for: Blunt Cerebrovascular Injuries |  cta mra |  bcvi patients |  specificity tomography |  injury severity
    KOL Index score: 14853

    BACKGROUND: The management of colon injuries that require resection is an unresolved issue because the existing practices are derived mainly from class III evidence. Because of the inability of any single trauma center to accumulate enough cases for meaningful statistical analysis, a multicenter prospective study was performed to compare primary anastomosis with diversion and identify the risk factors for colon-related abdominal complications.

    METHODS: This was a prospective study from ...

    Also Ranks for: Primary Anastomosis |  penetrating colon |  abdominal complications |  resection diversion |  24 hours
    KOL Index score: 14498

    Thromboelastography (TEG) is emerging as the standard in the management of acute coagulopathies in injured patients. Although TEG is sensitive in detecting abnormalities in clot strength, one shortcoming is differentiating between fibrinogen and platelet contributions to clot integrity. Current American algorithms suggest platelet transfusion, whereas European guidelines suggest fibrinogen concentrates for correcting low clot strength. Therefore, we hypothesized that a TEG-based ...

    Also Ranks for: Clot Strength |  functional fibrinogen |  trauma patients |  vitro studies |  platelet contribution
    KOL Index score: 14153

    BACKGROUND: Blood transfusion has repeatedly been demonstrated to be an independent risk factor for postinjury multiple organ failure (MOF). Previously believed to represent a surrogate for shock, packed red blood cell (PRBC) transfusion has recently been shown to result in neutrophil priming and pulmonary endothelial cell activation. We have previously observed that the generation of inflammatory mediators is related to the length of PRBC unit storage. The purpose of this study was to ...

    Also Ranks for: Transfused Blood |  independent risk factor |  organ failure |  postinjury multiple |  6 hours
    KOL Index score: 13941

    HYPOTHESIS: The incidence and severity of postinjury multiple organ failure (MOF) has decreased over the last decade.

    DESIGN: A prospective 12-year inception cohort study ending December 31, 2003.

    SETTING: Regional academic level I trauma center.

    PATIENTS: One thousand three hundred forty-four trauma patients at risk for postinjury MOF. Inclusion criteria were aged older than 15 years, admission to the trauma intensive care unit, an Injury Severity Score higher than 15, and survival for ...

    Also Ranks for: Multiple Organ |  blood transfusion |  postinjury mof |  injury severity score |  incidence severity
    KOL Index score: 13768

    BACKGROUND: Despite routine prophylaxis, thromboembolic events (TEs) in surgical patients remain a substantial problem. Furthermore, the timing and incidence of hypercoagulability, which predisposes to these events is unknown, with institutional screening programs serving primarily to establish a diagnosis after an event has occurred. Emerging evidence suggests that point of care (POC) rapid thrombelastography (r-TEG) provides a real-time analysis of comprehensive thrombostatic function, ...

    Also Ranks for: Thromboembolic Events |  surgical patients |  rapid thrombelastography |  teg hypercoagulability |  analysis performed
    KOL Index score: 13522

    BACKGROUND: Aggressive screening for blunt cerebrovascular injury (BCVI) has uncovered an astonishing incidence of vertebral artery injuries (VAIs) and associated stroke rate. Stroke incidence is reduced with early recognition and prompt anticoagulation. Because of the proximity of the cervical spine and vertebral arteries, we queried whether all patients with cervical spine fractures required arteriography to rule out VAI.

    METHODS: Four-vessel cerebrovascular angiography remains the ...

    Also Ranks for: Cervical Spine Fracture |  artery injury |  blunt vertebral |  bcvi patients |  foramen transversarium
    KOL Index score: 13422

    BACKGROUND: Controversy surrounds the optimal ratios of blood (packed red blood cell [PRBC]), plasma (fresh frozen plasma [FFP]) and platelet (PLT) use for patients requiring massive transfusion (MT) owing to possible survival bias in previous studies. We sought to characterize mortality during the first 24 hours while controlling for time varying effects of transfusion to minimize survival bias.

    METHODS: Data were obtained from a multicenter prospective cohort study of adults with blunt ...

    Also Ranks for: Survival Bias |  24 hours |  plt prbc |  transfusion ratios |  hour mortality
    KOL Index score: 13386

    BACKGROUND: Nonoperative management of blunt hepatic injuries is highly successful. Complications associated with high-grade injuries, however, have not been well characterized. The purpose of the present study was therefore to define hepatic-related complications and associated treatment modalities in patients undergoing nonoperative management of high-grade blunt hepatic injuries.

    METHODS: Three hundred thirty-seven patients from two regional Level I trauma centers with grade 3 to 5 ...

    Also Ranks for: Nonoperative Management |  hepatic injuries |  complications patients |  grade blunt |  24 hours


    Ernest E Jr MD Moore: Influence Statistics

    Sample of concepts for which Ernest E Jr MD Moore is among the top experts in the world.
    Concept World rank
    ssi implant removal #1
    metabolites pmns #1
    postinjury hyperfibrinogenemia #1
    tnfagrinduced #1
    civilian rectal trauma #1
    hemorrhagic tomography #1
    ptt conventional #1
    risks exceed benefits #1
    pmn superoxide #1
    bsoi patients #1
    pis mortality #1
    body adipose content #1
    cd11b expression injury #1
    patients polyheme #1
    response ischaemic hypoxia #1
    tpa drip phase #1
    hematocrit age #1
    cl30 baseline #1
    abnormal clot strength #1
    osmolar stress #1
    transcription layers #1
    cell prbc #1
    event ards #1
    maintaining referrals #1
    grade bcvis #1
    symptom injury #1
    normotonicity tyrosine phosphorylation #1
    sham icp #1
    95 aortic imaging #1
    prbc transfusion #1
    lwe dpl patients #1
    iqr vfd #1
    saline attenuation #1
    paf superoxide generation #1
    psml lung injury #1
    teg hypercoagulability #1
    auroc peak thrombin #1
    intestinal injuries patients #1
    psml #1
    viscoelastic conventional #1
    multiple organ failure #1
    reperfusion tly30 #1
    ssi intraabdominal infections #1
    adp inhibition ali #1
    fibrinolysis dilution #1
    paf mechanism #1
    tpa ttas #1
    lps 125ialbumin leak #1
    human polymerized hemoglobin #1
    paf il6 #1

    Key People For Hemorrhagic Shock

    Top KOLs in the world
    Ernest E Jr MD Moore
    hemorrhagic shock trauma patients multiple organ failure
    Irshad H PhD Chaudry
    hemorrhagic shock trauma hemorrhage kupffer cells
    Frederick Alan Moore
    chronic critical illness surgical sepsis trauma patients
    Edwin A MD Deitch
    bacterial translocation hemorrhagic shock mesenteric lymph
    Timothy Robert Billiar
    nitric oxide hemorrhagic shock kupffer cells
    Charles E Wade
    trauma patients massive transfusion hemorrhagic shock

    Ernest E Jr MD Moore:Expert Impact

    Concepts for whichErnest E Jr MD Moorehas direct influence:Hemorrhagic shock,  Trauma patients,  Multiple organ failure,  Organ failure,  Gunshot wounds,  Emergency surgery,  Mesenteric lymph,  Abdominal trauma.

    Ernest E Jr MD Moore:KOL impact

    Concepts related to the work of other authors for whichfor which Ernest E Jr MD Moore has influence:Trauma patients,  Hemorrhagic shock,  Lung injury,  Enteral nutrition,  Blood transfusion,  Nonoperative management,  Tranexamic acid.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Departments of Surgery, School of Medicine University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. | Ernest E Moore Shock Trauma Center at Denver Health, Denver, Colorado, USA | Department of Surgery, University of Colorado Denver, A