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    • Hepatic Encephalopathy
    • Kevin Daniel Mullen
    • Kevin Daniel Mullen: Influence Statistics

      Kevin Daniel Mullen

      Kevin Daniel Mullen

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      Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USA | West Virginia University, Morgantown, WV, USA | Division of ...

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      Kevin Daniel Mullen:Expert Impact

      Concepts for whichKevin Daniel Mullenhas direct influence:Hepatic encephalopathy,Chronic hepatitis,Portacaval shunt,Portal pressure,Portacaval anastomosis,Cirrhotic patients,Liver disease,Extracellular water.

      Kevin Daniel Mullen:KOL impact

      Concepts related to the work of other authors for whichfor which Kevin Daniel Mullen has influence:Hepatic encephalopathy,Chronic hepatitis,Liver disease,Cirrhotic patients,Metabolic syndrome,Portal hypertension,Hepatocellular carcinoma.

      KOL Resume for Kevin Daniel Mullen

      Year
      2019

      Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USA

      2018

      West Virginia University, Morgantown, WV, USA

      2017

      Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Cleveland, OH, USA

      Dr Pantham is a clinical instructor of medicine at Case Western University in Cleveland, Ohio, and a hospitalist in the Department of Medicine at the University Hospitals Cleveland Medical Center in Cleveland, Ohio. Dr Mullen is the section chief of digestive diseases and a professor of medicine at the West Virginia University School of Medicine in Morgantown, West Virginia.

      2016

      Division of Gastroenterology, Metrohealth Medical Center, Case Western Reserve University, Cleveland, OH, USA

      2015

      MetroHealth Medical Center, Liver Research Section Case Western Reserve University Cleveland OH.

      Case Western Reserve University School of Medicine, Cleveland, US

      2014

      Case Western Reserve University Division of Gastroenterology, MetroHealth Medical Center Cleveland OH

      2013

      Case Western Reserve University School of Medicine, Cleveland, Ohio

      Gastroenterology Department Metrohealth Medical Center Cleveland OH USA

      2012

      Division of Gastroenterology and Hepatology, Case Western Reserve University, Cleveland, Ohio

      2011

      Division of Gastroenterology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

      Metro Health Medical Center, Cleveland, OH

      2010

      Division of Gastroenterology, MetroHealth Medical Center, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109, USA;

      Professor of Medicine Case Western Reserve University Director, Gastroenterology Fellowship Program Department of Gastroenterology MetroHealth Medical Center Cleveland, Ohio.

      Metrohealth Medical Center, Case Western Reserve University, Cleveland (K.D.M.), and University of Cincinnati Medical Center, Cincinnati (G.N.) — both in Ohio

      2009

      MetroHealth Medical Center, Division of Gastroenterology

      2008

      Division of Gastroenterology, MetroHealth Medical Center, Case Western University, Cleveland, Ohio

      2007

      Department of Gastroenterology/Hepatology, MetroHealth Medical Center, Cleveland, OH, USA

      2006

      Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH

      Division of Gastroenterology, MetroHealth Medical Center, Cleveland, Ohio

      2005

      Case Western Reserve School of Medicine, Cleveland, Ohio

      2004

      From the *Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, Virginia and the †Cleveland HCV Consortium, Cleveland, Ohio.

      Case Western Reserve University, Cleveland, OH

      2003

      Case Western Reserve University, MetroHealth Medical Center, Cleveland, Ohio 44109, USA.

      Division of Gastroenterology (KDM), MetroHealth Medical Center, Cleveland, Ohio, USA

      2002

      FRCPI, GI Division, 6th Floor, Bell Greve Building, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109‐1998. Telephone: 216‐778‐2235; FAX: 216‐778‐4873

      Liver Transplant Center, Cleveland Clinic Foundation, Cleveland, OH

      Departments of Gastroenterology, The Cleveland Clinic Foundation, Cleveland, Ohio

      2001

      Gastrointestinal Division, Department of Medicine, MetroHealth Medical Center, 2500 MetroHealth Drive, Bell Greve Building, 44109-1998, Cleveland, OH, USA

      2000

      Division of Gastroenterology, Metro Health Medical Center, Case Western Reserve University, Cleveland, Ohio

      1999

      Case Western Reserve University, Cleveland, Ohio

      1998

      MetroHealth Medical Center, Case Western Reserve University (KDM), Cleveland, Ohio

      Departments of Medicine and Pediatrics, Case Western Reserve University, Cleveland, OH

      1997

      Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA

      From Case Western Reserve University, Metrohealth Medical Center, Cleveland, Ohio, U.S.A.

      1996

      Gastroenterology Division, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

      Department of Gastrointestinal and Liver Diseases, Academic Medical Centre, Amsterdam

      1995

      Staff Gastroenterologist Associate Professor of Medicine Case Western Reserve University Cleveland, OH

      1994

      MetroHealth Medical Center, 2500 MetroHealth Drive, Room W603, Cleveland, Ohio 44109–1998, USA

      Brain Research Laboratory, Case Western Reserve University, Cleveland, OH.

      1993

      Division of Gastroenterology Department of Medicine MetroHealth Medical Center Case Western Reserve University Cleveland, Ohio, USA

      1992

      Departments of Medicine and Pediatrics, Case Western Reserve University, Cleveland, Ohio, USA

      1991

      Liver Disease Section, NIDDK, National Institutes of Health, Bethesda, Maryland.

      Gastroenterology Division, MetroHealth Medical Center, Cleveland, Ohio, USA

      Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44109

      1990

      Department of Neurological Surgery, State University of New York, Stony Brook, New York, USA

      Liver Diseases Section, Digestive Diseases Branch, NIDDK, National Institutes of Health, 20892, Bethesda, Maryland

      Division of Gastroenterology, Cleveland Metropolitan General Hospital, Cleveland, OH, U.S.A.

      1989

      Division of Gastroenterology Cleveland Metropolitan General Hospital Case Western Reserve University Cleveland, Ohio 44109

      Liver Diseases Section, Digestive Diseases Branch, NIDDK National Institutes of Health, 20892, Bethesda, Maryland

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      Sample of concepts for which Kevin Daniel Mullen is among the top experts in the world.
      Concept World rank
      life rifamycins #1
      persistent cognitive defects #1
      cirrhosis broad range #1
      neuropsychiatric disorder patients #1
      brain receptors benzodiazepines #1
      “therapeutic studies #1
      justification placebocontrolled trials #1
      disorder encephalopathy humans #1
      pcm encephalopathy humans #1
      correlation ammonia levels #1
      resolution severe forms #1
      cirrhosis nitrogen #1
      cirrhosis patient quality #1
      flumazenil animal models #1
      dehydration constipation #1
      hospitalization retrospective #1
      latest data easl #1
      brain uptake 3h #1
      decades major problem #1
      mhe cardiovascular hepatic #1
      shunting addition #1
      hepatic encephalopathy decades #1
      sections outcome parameters #1
      concomitant lactulose #1
      apparent increase density #1
      70 kda composition #1
      precipitants hospitalization #1
      superimposed viral hepatitis #1
      cpss presence #1
      amantadine 200 #1
      minimal hepatic bottle #1
      symptoms mhe #1
      ammonia crucial role #1
      encephalopathy transfer #1
      alcoholic cirrhosis abstinence #1
      enteric bacteria neomycin #1
      referred hcv #1
      hepatic encephalopathy terminology #1
      efficacy bz antagonists #1
      pharmaceutical bzs #1
      clinical scales tests #1
      gabaergic tone mechanisms #1
      neurologic conditions epilepsy #1
      hepatic encephalopathy enemy #1
      rifaximin reduced #1
      therapy ammonia generation #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Kevin Daniel Mullen

      KOL-Index: 14965

      BACKGROUND: Hepatic encephalopathy is a chronically debilitating complication of hepatic cirrhosis. The efficacy of rifaximin, a minimally absorbed antibiotic, is well documented in the treatment of acute hepatic encephalopathy, but its efficacy for prevention of the disease has not been established.

      METHODS: In this randomized, double-blind, placebo-controlled trial, we randomly assigned 299 patients who were in remission from recurrent hepatic encephalopathy resulting from chronic ...

      Known for Hepatic Encephalopathy | Rifaximin Treatment | Patients Placebo | Hazard Ratio | Risk Hospitalization
      KOL-Index: 14917

      BACKGROUND: There are several known predictors of an incomplete colonoscopy or difficult colonoscopy. In addition, inadequate bowel preparation has been reported in procedures scheduled later in the day. Operator fatigue, which tends to be higher as the day passes on, may also impact colonoscopy completion rate.

      AIMS: To determine the influence of performing outpatient colonoscopies in the afternoon versus morning on the completion rates of colonoscopy and adequacy of bowel ...

      Known for Afternoon Colonoscopies | Patients Morning | Incomplete Colonoscopy | Inadequate Bowel Preparation | Higher Failure Rates
      KOL-Index: 14728

      Using H2[18O] tracer isotope dilution and corrected bromide space as standard reference techniques, we determined total body water and extracellular water in cirrhotic patients with (four men and four women) and without (seven men and six women) ascites and compared them with a normal control group (eight men and six women). These results were then compared with calculations of total body and extracellular water determined by the bioelectrical impedance analysis technique. According to ...

      Known for Cirrhotic Patients | Extracellular Water | Total Body | Bioelectrical Impedance | Ascites Controls
      KOL-Index: 12407

      PURPOSE: Because the correlation between ammonia levels and the severity of hepatic encephalopathy remains controversial, we prospectively evaluated the correlation in 121 consecutive patients with cirrhosis.

      METHODS: The diagnosis of hepatic encephalopathy was based on clinical criteria, and the severity of hepatic encephalopathy was based on the West Haven Criteria for grading of mental status. Arterial and venous blood samples were obtained from each patient. Four types of ammonia ...

      Known for Hepatic Encephalopathy | Ammonia Levels | Partial Pressure | Illness Statistics | Venous Blood
      KOL-Index: 12176

      In an attempt to improve the efficacy of antiviral therapy for chronic hepatitis C, a three-drug combination of pegylated interferon α-2b, ribavirin, and amantadine has been suggested. Despite the initial enthusiasm, the role of amantadine in the treatment of chronic hepatitis C remains controversial. In a multi-center, open-label clinical trial, the potential efficacy and safety of this triple combination regimen were assessed. In this open-label pilot study, two separate patient ...

      Known for Chronic Hepatitis | Ribavirin Amantadine | Patients Genotypes | 24 Weeks | Response Svr
      KOL-Index: 11629

      Three separate, but allosterically interacting, sites on the gamma-aminobutyric acid (GABA) supramolecular complex in the brain were pharmacologically blocked in rabbits with hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure to determine whether decreased GABAergic neurotransmission can ameliorate the syndrome of hepatic encephalopathy. Bicuculline (a GABAA receptor blocker), Ro 15-1788 (a benzodiazepine receptor antagonist), or isopropylbicyclophosphate (a ...

      Known for Hepatic Encephalopathy | Benzodiazepine Receptor | Rabbit Model | Visual Evoked | Increased Resistance
      KOL-Index: 11187

      Retreatment of interferon-resistant chronic hepatitis C represents a significant clinical challenge. In an open-label, pilot study, the safety and efficacy of interferon alpha-2b, ribavirin, and amantadine were assessed. Twenty patients with chronic hepatitis C who had previously failed to respond to a course of interferon monotherapy followed by a course of combination therapy (10 patients received interferon alpha-2b [3 million units three times a week] plus ribavirin [800 mg/d] and 10 ...

      Known for Chronic Hepatitis | Ribavirin Amantadine | 24 Weeks | Combination Therapy | Interferon Alpha
      KOL-Index: 10677

      The role of the GABA-benzodiazepine receptor complex in the pathogenesis of hepatic encephalopathy was investigated by recording the electrophysiological responses of single cerebellar Purkinje neurons from rabbits with hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure. Both the GABAmimetic muscimol and the benzodiazepine receptor agonist flunitrazepam were 3-4 times more potent in depressing the spontaneous activity of Purkinje neurons from rabbits with ...

      Known for Hepatic Encephalopathy | Animal Model | Benzodiazepine Receptor | Neurons Gaba | Control Rabbits
      KOL-Index: 10171

      BACKGROUND: Superimposed non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) may affect HCV-related fibrosis. We performed a study to determine the relationship between NAFLD and chronic hepatitis C.

      METHODS: One hundred and twenty patients with chronic hepatitis C and available liver biopsies were included. Baseline liver biopsies were read by 1 hepatopathologist using Metavir, as well as a fatty liver pathology protocol. Patients' baseline clinical, ...

      Known for Fatty Liver | Chronic Hepatitis | Steatosis Patients | Obesity Bmi | Hcv Genotype
      KOL-Index: 9867

      BACKGROUND/AIMS: Interferon-based regimens (alone or with ribavairin) are standard therapies for chronic hepatitis C. The aim of this study was to compare a 24-week regimen of interferon alpha-2b + ribavirin (IFN + RIBA) to interferon alpha-2b + amantadine (IFN + AMANT) in non-responders to previous interferon monotherapy.

      METHODS: In a multi-center, double-blind clinical trial, 118 patients (non-responders to previous interferon monotherapy) were equally randomized into the two arms: ...

      Known for Interferon Monotherapy | Amantadine Treatment | Chronic Hepatitis | Alpha2b Ribavirin | Controlled Trial
      KOL-Index: 9638

      Portacaval anastomosis causes delayed growth, decreased testes and liver weights, and elevated estradiol serum levels in male rats compared with sham-operated controls. Female rats treated with portacaval anastomosis grow at a normal rate despite changes in liver weight and estradiol levels similar to those observed in the male rats. This study examined the pituitary gonadal axis in both genders in this animal model. The rats receiving portacaval anastomosis were compared with both ...

      Known for Portacaval Anastomosis | Male Rats | Food Intake | Growth Hormone | Rat Model
      KOL-Index: 9499

      Forty-five patients with chronic hepatitis B were entered into a randomized controlled trial of recombinant human alpha-interferon therapy. All patients had hepatitis B surface antigen in serum for at least 1 yr and had stable serum levels of both hepatitis B virus deoxyribonucleic acid and hepatitis B e antigen. During the 4-mo period of therapy, 10 of 31 (32%) treated patients and only 1 of 14 (7%) control patients became negative for serum hepatitis B virus deoxyribonucleic acid and ...

      Known for Chronic Hepatitis | Interferon Patients | Recombinant Human Α | Controlled Trial | Topic Dna
      KOL-Index: 9188

      BACKGROUND: Hepatic encephalopathy (HE) is a brain disorder that often results from cirrhosis due to viral hepatitis, metabolic and alcohol-related liver disease, and is characterised by cognitive, psychiatric and motor impairments. Recurrent bouts of overt HE negatively impact daily functioning and quality of life.

      AIM: To evaluate the effect of rifaximin on health-related quality of life (HRQL) in cirrhotic patients with HE.

      METHODS: Patients with cirrhosis in remission from HE (Conn ...

      Known for Hepatic Encephalopathy | Cirrhotic Patients | Health‐related Quality | Life Hrql | Illness Surveys
      KOL-Index: 8898

      OBJECTIVE: Thrombocytopenia or leukopenia in patients with chronic liver disease is often attributed to functional overactivity of the spleen (hypersplenism). Despite being a fairly common phenomenon, there is a paucity of reports on the prevalence of this syndrome in stable chronic liver disease patients with or without severe fibrosis/cirrhosis. The aim of this study was to establish the prevalence of peripheral blood cytopenia in patients with nonalcoholic cirrhosis/severe fibrosis ...

      Known for Patients Cirrhosis | Chronic Liver | Platelet Count | Peripheral Blood Cytopenia | Mild Fibrosis
      KOL-Index: 8586

      In previous studies employing interferons (IFNs) in the treatment of chronic hepatitis C, there have been few reliable predictors of sustained responses. We retrospectively evaluated the predictive value of hepatitis C virus (HCV)-RNA measurements in the first few months during consensus interferon (CIFN) treatment using a sensitive reverse-transcriptase polymerase chain reaction assay to determine sustained responses. Data from two large treatment trials, one of IFN-naive patients and ...

      Known for Chronic Hepatitis | Interferon Treatment | Hcv Rna | Sustained Responses | 6 Months

      Key People For Hepatic Encephalopathy

      Top KOLs in the world
      #1
      Peter Ferenci
      chronic hepatitis hepatic encephalopathy wilson disease
      #2
      Kevin Daniel Mullen
      hepatic encephalopathy chronic hepatitis portacaval shunt
      #3
      Juan Córdoba
      hepatic encephalopathy liver transplantation brain edema
      #4
      Roger F Butterworth∗
      hepatic encephalopathy acute liver failure thiamine deficiency
      #5
      Karin Weissenborn
      hepatic encephalopathy liver transplantation ischemic stroke
      #6
      Andrés T Blei
      brain edema hepatic encephalopathy acute liver failure

      Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USA | West Virginia University, Morgantown, WV, USA | Division of Gastroenterology and Hepatology, MetroHealth Medical Center, Cleveland, OH, USA | Dr Panth

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