• KOL
    • Hepatic Encephalopathy
    • Roger F Butterworth∗
    • Roger F Butterworth∗: Influence Statistics

      Roger F Butterworth∗

      Roger F Butterworth∗

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      Department of Medicine, University of Montreal, 45143 Cabot Trail, Englishtown, NS B0C 1H0 Canada | Department of Medicine, University of Montreal, Montreal, Canada | ...

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      Roger F Butterworth∗:Expert Impact

      Concepts for whichRoger F Butterworth∗has direct influence:Hepatic encephalopathy,Acute liver failure,Liver failure,Thiamine deficiency,Cirrhotic patients,Brain edema,Portacaval anastomosis,Mild hypothermia.

      Roger F Butterworth∗:KOL impact

      Concepts related to the work of other authors for whichfor which Roger F Butterworth∗ has influence:Hepatic encephalopathy,Acute liver failure,Thiamine deficiency,Liver cirrhosis,Oxidative stress,Brain edema,Cirrhotic patients.

      KOL Resume for Roger F Butterworth∗

      Year
      2021

      Department of Medicine, University of Montreal, 45143 Cabot Trail, Englishtown, NS B0C 1H0 Canada

      2020

      Department of Medicine, University of Montreal, Montreal, Canada

      2019

      Department of Medicine, University of Montreal, 45143 Cabot Trail, B0C 1H0, Englishtown, NS, Canada

      University of Montreal (St-Luc Hospital), Montreal, QC

      2018

      CHUM St-Luc Hospital and Department of Medicine, University of Montreal, Canada.

      University of Montreal (St-Luc Hospital), Montreal, Québec, Canada

      2015

      Department of Medicine, University of Montreal, Montreal, Quebec, Canada

      2014

      Neuroscience Research Unit, Hopital St-Luc (CHUM) and Department of Medicine, University of Montreal, Montreal, QC H2W 3J4, Canada

      2013

      Neuroscience Research Unit, Hôpital St-Luc (CHUM), 1058 Rue St-Denis, H2X 3J4, Montreal, QC, Canada

      2012

      Neuroscience Research Unit, Saint-Luc Hospital (CHUM), University of Montreal, Montreal, Quebec, Canada

      2011

      Department of Medicine, University of Montreal, Neuroscience Research Unit, Montreal, Quebec, Canada

      2010

      Neuroscience Research Unit, Hôpital Saint-Luc (CHUM), University of Montreal, 1058 St. Denis Street, Montreal, Quebec, Canada

      2009

      Neuroscience Research Unit, Hôpital Saint‐Luc, CHUM, Montreal, QC, Canada

      2008

      Neuroscience Research Unit, Université de Montréal, Montreal, QC, Canada

      2007

      Neuroscience Research Unit, CHUM (Campus Saint-Luc), University of Montreal, 1058, Saint-Denis Street, H2X 3J4, Montreal, Quebec, Canada

      2006

      Neuroscience Research Unit, University of Montreal (CHUM), Hôpital Saint-Luc, 1058 St-Denis Street, Montreal, Que., Canada H2X 3J4

      2005

      Neuroscience Research Unit, Hôpital Saint-Luc (CHUM), Montréal, Quebec, Canada

      2004

      Neuroscience Research Unit, Montreal, Quebec, Canada

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      Sample of concepts for which Roger F Butterworth∗ is among the top experts in the world.
      Concept World rank
      pca rats pca #1
      portacavalshunted pcs rats #1
      glutamine synthetase capacity #1
      age time interval #1
      heneuropathology #1
      encephalopathy hypothermia #1
      selective reversible decreases #1
      thiamine deficiency activities #1
      pfco #1
      overt encephalopathy alterations #1
      cerebellar amino acids #1
      ouabain pyrimethamine #1
      pse portalsystemic shunting #1
      failure amino #1
      iii flumazenil #1
      parkinsonism cirrhosis #1
      alf rats #1
      cox2 tle #1
      hyperammonemia accounts #1
      increased activity katpase #1
      atp free coenzyme #1
      specific energy metabolism #1
      proinflammatory mechanisms pathogenesis #1
      seesection #1
      pca portacaval anastomosis #1
      astrocytic integrity #1
      ligand3hpk11195 #1
      stress encephalopathy #1
      hypothesis hepatic encephalopathy #1
      lola nash #1
      astrocytic glycine transporter #1
      normalisation enzyme activities #1
      major role mechanisms #1
      tissue distribution neuropathology #1
      portacaval‐shunted rat #1
      treatment mild encephalopathy #1
      encephalopathy binding #1
      edema formation mnsod #1
      deficiency transketolase #1
      inherited ataxias characteristics #1
      varying degrees pss #1
      ammonia removal brain #1
      brain glutamine severity #1
      methylspiperone pet #1
      encephalopathy prevention #1
      3hpk11195 rats #1
      vulnerable medial thalamus #1
      ammonia increased production #1
      nac neurological complications #1
      liver spleen ratios #1
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      Prominent publications by Roger F Butterworth∗

      KOL-Index: 15110

      Modulation of soluble guanylate cyclase (sGC) by nitric oxide (NO) is altered in brain from experimental animals with hyperammonemia with or without liver failure. The aim of this work was to assess the content and modulation of sGC in brain in chronic liver failure in humans. Expression of the alpha-1, alpha-2, and beta-1 subunits of sGC was measured by immunoblotting in autopsied frontal cortex and cerebellum from cirrhotic patients and controls. The contents of alpha-1 and alpha-2 ...

      Known for Guanylate Cyclase | Cirrhotic Patients | Modulation Sgc | Nitric Oxide Brain | Cerebellum Activation
      KOL-Index: 14499

      Encephalopathy and brain edema are serious complications of acute liver failure (ALF). The precise pathophysiologic mechanisms responsible have not been fully elucidated but it has been suggested that oxidative/nitrosative stress is involved. In the present study we evaluated the role of oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy and brain edema in rats with ALF resulting from hepatic devascularization. We also studied the effect of hypothermia, a ...

      Known for Brain Edema | Alf Rats | Nitrosative Stress | Liver Failure | Coma Stages
      KOL-Index: 13463

      Acute liver failure (ALF) results in alterations of energy metabolites and of glucose-derived amino acid neurotransmitters in brain. However, the dynamics of changes in glucose metabolism remain unclear. The present study was undertaken using (1)H and (13)C nuclear magnetic resonance (NMR) spectroscopy to determine the rates of incorporation of glucose into amino acids and lactate via cell-specific pathways in relation to the severity of encephalopathy and brain edema in rats with ALF ...

      Known for Brain Lactate | Acute Liver | Magnetic Resonance | Coma Stages | Amino Acids
      KOL-Index: 13045

      BACKGROUND & AIMS: Mild hypothermia has a protective effect on brain edema and encephalopathy in both experimental and human acute liver failure. The goals of the present study were to examine the effects of mild hypothermia (35 degrees C) on brain metabolic pathways using combined (1)H and (13)C-Nuclear Magnetic Resonance (NMR) spectroscopy, a technique which allows the study not only of metabolite concentrations but also their de novo synthesis via cell-specific pathways in the ...

      Known for Acute Liver | Mild Hypothermia | Brain Glucose Metabolism | Magnetic Resonance | Frontal Cortex
      KOL-Index: 12967

      It has been proposed that alterations of excitatory and inhibitory amino acids play a role in the pathogenesis of hepatic encephalopathy in acute liver failure. To evaluate this possibility, in vivo cerebral microdialysis was used to sample extracellular concentrations of amino acids in the frontal cortex of unanesthetized rats at various times during the progression of encephalopathy resulting from acute liver failure. Liver failure was induced by portacaval anastomosis followed 24 ...

      Known for Amino Acids | Frontal Cortex | Acute Liver Failure | Extracellular Concentrations | Hepatic Encephalopathy
      KOL-Index: 12801

      Mild hypothermia is effective in the prevention of brain edema associated with cerebral ischemia and traumatic brain injury. Brain edema is also a serious complication of acute liver failure (ALF). To assess the effectiveness of hypothermia in ALF, groups of rats were subjected to hepatic devascularization (portacaval anastomosis, followed 48 hours later by hepatic artery ligation), and body temperatures were maintained at either 35 degrees C (hypothermic) or 37 degrees C (normothermic). ...

      Known for Mild Hypothermia | Brain Edema | Acute Liver | Rats Alf | Hepatic Encephalopathy
      KOL-Index: 12255

      Brain edema, leading to intracranial hypertension and brain herniation, is a major cause of death in fulminant liver failure. Astrocyte swelling is a prominent neuropathological feature in experimental fulminant liver failure. It has been postulated that the osmotic effects of glutamine, generated in astrocytes from ammonia and glutamate in a reaction catalyzed by glutamine synthetase, could mediate brain swelling. Normal rats and rats that received a portacaval anastomosis were infused ...

      Known for Intracranial Hypertension | Brain Edema | Portacaval Anastomosis | Ammonium Acetate | Osmotic Effects
      KOL-Index: 12110

      The effects of chronic liver insufficiency resulting from end-to-side portacaval anastomosis (PCA) on glutamine synthetase (GS) activities, protein and gene expression were studied in brain, liver and skeletal muscle of male adult rats. Four weeks following PCA, activities of GS in cerebral cortex and cerebellum were reduced by 32% and 37% (p<0.05) respectively whereas GS activities in muscle were increased by 52% (p<0.05). GS activities in liver were decreased by up to 90% (p<0.01), a ...

      Known for Skeletal Muscle | Portacaval Anastomosis | Gene Expression | Surgical Rna | Pca Rats
      KOL-Index: 12083

      Encephalopathy and brain edema are serious complications of acute liver failure (ALF). The precise pathophysiologic mechanisms responsible have not been fully elucidated but it has been recently proposed that microglia-derived proinflammatory cytokines are involved. In the present study we evaluated the role of microglial activation and the protective effect of the anti-inflammatory drug minocycline in the pathogenesis of hepatic encephalopathy and brain edema in rats with ALF resulting ...

      Known for Brain Edema | Liver Failure | Rats Alf | Microglial Activation | Pathogenesis Hepatic Encephalopathy
      KOL-Index: 11822

      There is evidence to suggest that, in acute liver failure (ALF), brain ammonia and proinflammatory cytokines may act synergistically to cause brain edema and its complications (intracranial hypertension, brain herniation). However, the molecular mechanisms involved remain to be established. In order to address this issue, semi-quantitative RT-PCR was used to measure the expression of genes coding for astrocytic proteins with an established role in cell volume regulation in cerebral ...

      Known for Brain Edema | Liver Failure | Proinflammatory Cytokines | Astrocytic Proteins | Cultured Astrocytes
      KOL-Index: 11726

      Although earlier studies on thiamine deficiency have reported increases in extracellular glutamate concentration in the thalamus, a vulnerable region of the brain in this disorder, the mechanism by which this occurs has remained unresolved. Treatment with pyrithiamine, a central thiamine antagonist, resulted in a 71 and 55% decrease in protein levels of the astrocyte glutamate transporters GLT-1 and GLAST, respectively, by immunoblotting in the medial thalamus of day 14 symptomatic rats ...

      Known for Medial Thalamus | Glutamate Transporter | Glt1 Glast | Spraguedawley Statistics | Protein Levels
      KOL-Index: 11620

      N-acetylcysteine (NAC) is an effective antidote to treat acetaminophen (APAP)-induced acute liver failure (ALF). NAC is hepatoprotective and prevents the neurological complications of ALF, namely hepatic encephalopathy and brain edema. The protective effect of NAC and its mechanisms of action in ALF due to other toxins, however, are still controversial. In the present study, we investigated the effects of NAC in relation to liver pathology, hepatic and cerebral glutathione, plasma ...

      Known for Liver Failure | Nac Alf | Induced Acute | Aom Mice | Brain Edema
      KOL-Index: 11027

      The pathogenesis of brain edema in acute liver failure is poorly understood. We have previously shown that rats with ischemic acute liver failure (portacaval anastomosis followed by hepatic artery ligation) exhibit brain edema and intracranial hypertension, with swelling of cortical astrocytes as the most prominent neuropathological abnormality. Because ammonia has been shown to induce swelling of astrocytes in vivo and in vitro, we examined the relationship between brain ammonia, amino ...

      Known for Amino Acids | Brain Edema | Portacaval Anastomosis | Liver Failure | Glutamine Alanine
      KOL-Index: 11019

      Astrocytes play a key role in the pathogenesis of ammonia-induced neurotoxicity and hepatic encephalopathy. As shown here, ammonia induces protein tyrosine nitration in cultured rat astrocytes, which is sensitive to the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801. A similar pattern of nitrated proteins is produced by NMDA. Ammonia-induced tyrosine nitration depends on a rise in [Ca2+]i, IkB degradation, and NO synthase (iNOS) induction, which are prevented by MK-801 and the ...

      Known for Rat Astrocytes | Glutamine Synthetase | Protein Tyrosine | Ammonia Induces | Oxide Nitric
      KOL-Index: 10991

      Acute liver failure (ALF) is characterized neuropathologically by cytotoxic brain edema and biochemically by increased brain ammonia and its detoxification product, glutamine. The osmotic actions of increased glutamine synthesis in astrocytes are considered to be causally related to brain edema and its complications (intracranial hypertension, brain herniation) in ALF. However studies using multinuclear (1)H- and (13)C-NMR spectroscopy demonstrate that neither brain glutamine ...

      Known for Brain Edema | Acute Liver Failure | Hepatic Encephalopathy | Intracranial Hypertension | Glutamine Synthesis

      Key People For Hepatic Encephalopathy

      Top KOLs in the world
      #1
      Peter Ferenci
      chronic hepatitis hepatic encephalopathy wilson disease
      #2
      Kevin Daniel Mullen
      hepatic encephalopathy chronic hepatitis portacaval shunt
      #3
      Juan Córdoba
      hepatic encephalopathy liver transplantation brain edema
      #4
      Roger F Butterworth∗
      hepatic encephalopathy acute liver failure thiamine deficiency
      #5
      Karin Weissenborn
      hepatic encephalopathy liver transplantation ischemic stroke
      #6
      Andrés T Blei
      brain edema hepatic encephalopathy acute liver failure

      Department of Medicine, University of Montreal, 45143 Cabot Trail, Englishtown, NS B0C 1H0 Canada | Department of Medicine, University of Montreal, Montreal, Canada | Department of Medicine, University of Montreal, 45143 Cabot Trail, B0C 1H0, English

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