Robert H Purcell: Influence Statistics

Robert H Purcell

Robert H Purcell

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD | Hepatic Pathogenesis Section, ...

Robert H Purcell: Expert Impact

Concepts for which Robert H Purcell has direct influence: Hepatitis virus , Viral hepatitis , Monoclonal antibodies , United states , Acute hepatitis , Hepatitis virus hev , Cell culture .

Robert H Purcell: KOL impact

Concepts related to the work of other authors for which for which Robert H Purcell has influence: Hepatitis virus , Hcv infection , Hepatocellular carcinoma , Liver disease , Blood donors , Immune response , Monoclonal antibodies .

KOL Resume for Robert H Purcell

Year
2020

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD

2018

National Institutes of Health

2017

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

2016

National Institute of Allergy and Infectious Diseases Bethesda MD

2015

Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland; The JiVitA Maternal and Child Health Research Project, Gaibandha, Bangladesh; Hepatitis Viruses Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Rockville, Maryland.

Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA

National Institute of Allergy and Infectious Diseases, National Institutes of Health Laboratory of Infectious Diseases Bethesda MD

2014

National Institute of Allergy and Infectious Diseases National Institutes of Health Laboratory of Infectious Diseases Bethesda Maryland

2013

National Institutes of Health, Bethesda, Maryland, USA (R.H. Purcell)

University of the Witwatersrand, Johannesburg, South Africa (C. Dickens, M.C. Kew, A. Kramvis);

Groote Schuur Hospital, Cape Town, South Africa (M.C. Kew);

2012

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892

National Institutes of Health, Bethesda, Maryland, United States of America

2011

Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892-8009, USA

From the Critical Care Medicine Department (LA, XC, YL, JS, YF, PQE), Clinical Center, and Laboratories of Infectious Diseases (ZC, RP) and Bacterial Diseases (MM, SHL), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and Macrogenics Inc. (SJ), Rockville, MD.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892

2010

Sections of Hepatitis Viruses and Molecular Hepatitis, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesda, Maryland

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and

2009

Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

Laboratory of Infectious Diseases and

2008

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8009, Bethesda, MD 20892-8009, USA

2007

Hepatitis Viruses Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892

Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, USA

2006

Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and †Department of Infectious Diseases, Hvidovre University Hospital, 2650 Hvidovre, Denmark

Coley Pharmaceutical Canada, Ottawa, Canada;, Bioqual Inc., Rockville, Md., and, National Institute of Allergy and Infectious Disease, Bethesda, Md., USA

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892‐8009

2005

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;

Hepatitis Viruses

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8009

2004

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8009, Bethesda, MD 20892-8009

Hepatitis Virus

2003

Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health

2002

Hepatitis Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland

2001

Molecular Hepatitis and Hepatitis Viruses Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Bioqual, Incorporated, 2501 Research Boulevard, Rockville, MD 20850; Liver Research and Education Foundation, Incorporated, Rancho Los Amigos Hospital, Downey, CA 90242; Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852; Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0342; and Center for Cancer Research, National Cancer Institute–Frederick, Frederick, MD 21702-1201

From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the Clinical Center Blood Bank, National Institute of Health (address reprint requests to Dr Purcell at the Laboratory of Infectious Disease. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 7, Bethesda. MD 200(4), USA.

Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0740, USA

Prominent publications by Robert H Purcell

KOL-Index: 17360 . Specific-pathogen-free pigs were inoculated with one of two hepatitis E viruses (HEV) (one recovered from a pig and the other from a human) to study the relative pathogenesis of the two viruses in swine. Fifty-four pigs were randomly assigned to three groups. Seventeen pigs in group 1 served as uninoculated controls, 18 pigs in group 2 were intravenously inoculated with the swine HEV ...
Known for Hev Pigs | United States | Hepatitis Lesions | Pig Human
KOL-Index: 14635 . Avian hepatitis E virus (avian HEV), recently identified from a chicken with hepatitis-splenomegaly syndrome in the United States, is genetically and antigenically related to human and swine HEVs. In this study, sequencing of the genome was completed and an attempt was made to infect rhesus monkeys with avian HEV. The full-length genome of avian HEV, excluding the poly(A) tail, is 6654 bp ...
Known for Avian Hev | Complete Genomic Sequence | Human Swine | Polya Tail
KOL-Index: 14448 . BackgroundIn spite of the large number of studies that have evaluated DNA-based immunization, few have directly compared the immune responses generated by different routes of immunization, particularly in non-human primates. Here we examine the ability of a hepatitis B surface antigen (HBsAg)-encoding plasmid to induce immune responses in mice and non-human primates (rhesus monkeys: Macaca ...
Known for Immune Responses | Human Primates | Intramuscular Injections | Intranasal Administration
KOL-Index: 14297 . Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and ...
Known for Vaccinia Virus | Monoclonal Antibodies | A33 Mabs | Protective Efficacy
KOL-Index: 13978 . Hepatitis E virus (HEV) is endemic in many developing and some industrialized countries. It has been hypothesized that animals may be the source of infection. The recent identification of swine HEV in U.S. pigs and the demonstration of its ability to infect across species have lent credence to this hypothesis. To assess the potential risk of zoonotic HEV infection, we tested a total of 468 ...
Known for United States | Blood Donors | Swine Hev | Sar55 Antigen
KOL-Index: 13746 . Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. Development of vaccines to prevent HCV infection, or at least prevent progression to chronicity, is a major goal. In mice and rhesus macaques, a DNA vaccine encoding cell-surface HCV-envelope 2 (E2) glycoprotein stimulated stronger immune responses than a vaccine encoding intracellular E2. Therefore, we used ...
Known for Challenge Chimpanzees | Hepatitis Virus | Dna Vaccine | Chimpanzee Immunization
KOL-Index: 13371 . Two monoclonal antibodies (MAbs) against the ORF2 protein of the SAR-55 strain of hepatitis E virus (HEV) were isolated by phage display from a cDNA library of chimpanzee (Pan troglodytes) gamma1/kappa antibody genes. Both MAbs, HEV#4 and HEV#31, bound to reduced, denatured open reading frame 2 (ORF2) protein in a Western blot, suggesting that they recognize linear epitopes. The affinities ...
Known for Monoclonal Antibodies | Phage Display | Capsid Protein | Hepatitis Virus Hev
KOL-Index: 13339 . Hepatitis D virus is a defective human pathogen that requires hepatitis B virus for its replication. A hybridization-based assay for the 1.75 kb RNA genome of hepatitis D virus was developed using as probe a radiolabeled transcript of a cloned cDNA fragment (pKD3 hepatitis D virus DNA). Sera from 120 chronic carriers of HBsAg with confirmed hepatitis D virus infection were analyzed for the ...
Known for Hepatitis Virus | Rna Serum | Clinical Significance | Patients Chronic
KOL-Index: 12988 . A novel virus of pigs, swine hepatitis E virus (swine HEV), was recently identified and shown to be antigenically and genetically related to human HEV. In the present study, we attempted to infect specific-pathogen-free (SPF) pigs experimentally with swine HEV or with human strains of HEV. Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs ...
Known for Swine Hev | Human Strains | Experimental Infection | Virus Pigs
KOL-Index: 12777 . Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro, ...
Known for Vaccinia Virus | Human Mabs | Causative Agent | Binding Affinities
KOL-Index: 12756 . Hepatitis E virus (HEV) is a very important public health concern in many developing countries where epidemics of hepatitis E are common. Sporadic cases of clinical hepatitis E not only occur in these countries but also occur uncommonly in patients with no known epidemiological exposure to HEV in industrialized countries. The source of infection in industrialized countries is unknown but ...
Known for Pigs Hev | Countries Hepatitis | Human Population | Sporadic Cases
KOL-Index: 12699 . Prior to the recent discovery of the swine hepatitis E virus (swine HEV) in pigs from the midwestern United States, HEV was not considered endemic to this country. Since swine HEV is antigenically and genetically related to human strains of HEV, it was important to characterize this new virus further. The infectivity titer of a pool of swine HEV in pigs was determined in order to prepare a ...
Known for Swine Hev | United States | Species Infection | Human Strains
KOL-Index: 12353 . Recently, a novel DNA virus, TT virus (TTV), was identified in patients with post-transfusion non-A-G hepatitis. We analyzed the prevalence and clinical implications of TTV infection in a cohort of 96 Spanish patients on long-term hemodialysis. TTV DNA was detected by nested PCR in 51 (53%) of 96 patients, a prevalence significantly higher than that found in healthy blood donors. ...
Known for Liver Disease | Mixed Infections | Ttv Patients | Dna Virus

Key People For Hepatitis Virus

Top KOLs in the world
#1
Robert H Purcell
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#2
Anna Shuk‐Fong Lok
chronic hepatitis hepatocellular carcinoma united states
#3
Michael Peter Manns
chronic hepatitis liver transplantation hepatocellular carcinoma
#4
Harvey J Alter
hepatitis virus blood donors hcv infection
#5
Stefan S Zeuzem
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#6
Michael A Houghton
hepatitis virus hepatocellular carcinoma hcv infection

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD | Hepatic Pathogenesis Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Dise