KOL | Robert H PurcellLaboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD | Hepatic Pathogenesis Section, ... |
KOL Resume for Robert H Purcell
| Year | |
|---|---|
| 2020 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD |
| 2018 | National Institutes of Health |
| 2017 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland |
| 2016 | National Institute of Allergy and Infectious Diseases Bethesda MD |
| 2015 | Department of International Health, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, Maryland; The JiVitA Maternal and Child Health Research Project, Gaibandha, Bangladesh; Hepatitis Viruses Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Rockville, Maryland. Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA National Institute of Allergy and Infectious Diseases, National Institutes of Health Laboratory of Infectious Diseases Bethesda MD |
| 2014 | National Institute of Allergy and Infectious Diseases National Institutes of Health Laboratory of Infectious Diseases Bethesda Maryland |
| 2013 | National Institutes of Health, Bethesda, Maryland, USA (R.H. Purcell) University of the Witwatersrand, Johannesburg, South Africa (C. Dickens, M.C. Kew, A. Kramvis); Groote Schuur Hospital, Cape Town, South Africa (M.C. Kew); |
| 2012 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 National Institutes of Health, Bethesda, Maryland, United States of America |
| 2011 | Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20892-8009, USA From the Critical Care Medicine Department (LA, XC, YL, JS, YF, PQE), Clinical Center, and Laboratories of Infectious Diseases (ZC, RP) and Bacterial Diseases (MM, SHL), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and Macrogenics Inc. (SJ), Rockville, MD. National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892 |
| 2010 | Sections of Hepatitis Viruses and Molecular Hepatitis, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of HealthBethesda, Maryland Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and |
| 2009 | Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Laboratory of Infectious Diseases and |
| 2008 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8009, Bethesda, MD 20892-8009, USA |
| 2007 | Hepatitis Viruses Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, USA |
| 2006 | Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and †Department of Infectious Diseases, Hvidovre University Hospital, 2650 Hvidovre, Denmark Coley Pharmaceutical Canada, Ottawa, Canada;, Bioqual Inc., Rockville, Md., and, National Institute of Allergy and Infectious Disease, Bethesda, Md., USA National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892‐8009 |
| 2005 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Hepatitis Viruses National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8009 |
| 2004 | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8009, Bethesda, MD 20892-8009 Hepatitis Virus |
| 2003 | Hepatitis Viruses and Molecular Hepatitis Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health |
| 2002 | Hepatitis Viruses Section, Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland |
| 2001 | Molecular Hepatitis and Hepatitis Viruses Sections, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; Bioqual, Incorporated, 2501 Research Boulevard, Rockville, MD 20850; Liver Research and Education Foundation, Incorporated, Rancho Los Amigos Hospital, Downey, CA 90242; Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852; Department of Biomedical Sciences and Pathobiology, Center for Molecular Medicine and Infectious Diseases, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0342; and Center for Cancer Research, National Cancer Institute–Frederick, Frederick, MD 21702-1201 From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, and the Clinical Center Blood Bank, National Institute of Health (address reprint requests to Dr Purcell at the Laboratory of Infectious Disease. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 7, Bethesda. MD 200(4), USA. Hepatitis Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0740, USA |
Robert H Purcell: Influence Statistics
| Concept | World rank |
|---|---|
| anthrax spores mice | #1 |
| envelope protein hcv | #1 |
| strain s52 4a | #1 |
| ns3 region patients | #1 |
| hev severe avh | #1 |
| hev sar55 strain | #1 |
| antitmv rabbit serum | #1 |
| genotypes hev genotypes | #1 |
| agm27 sequences | #1 |
| angeles germany | #1 |
| treatment emergency protection | #1 |
| anti apoc1 | #1 |
| plasma samples pa | #1 |
| enhances acute | #1 |
| chimeras hm175 | #1 |
| delayed treatment w1mab | #1 |
| denv4 library | #1 |
| laaqfmk | #1 |
| autoimmune hepatitis 12 | #1 |
| agents human hepatitis | #1 |
| aa262 | #1 |
| hepatic encephalopathy rna | #1 |
| chimpanzees† | #1 |
| hav hm175 | #1 |
| macaques pe2surf | #1 |
| phav 7 | #1 |
| biopsy carrier | #1 |
| antibodies antibody response | #1 |
| denmark hepatitis humans | #1 |
| macaques plasmids | #1 |
| viral biotin blotting | #1 |
| viral aotidae | #1 |
| chimpanzee patient | #1 |
| chimpanzee fab antibody | #1 |
| antibody iaha | #1 |
| chimpanzees primers | #1 |
| mutant lacking amino | #1 |
| frames pan rna | #1 |
| detection serological markers | #1 |
| hbv infection sera | #1 |
| agm27 strain hav | #1 |
| carriers infectivity | #1 |
| tamarins hepatitis virus | #1 |
| viral hepatitis hepatitis | #1 |
| epidemiologic features disease | #1 |
| estimated binding affinities | #1 |
| transcripts infectious | #1 |
| patients free clinic | #1 |
| dhbv region | #1 |
Open the FULL List in Excel | |
Prominent publications by Robert H Purcell
Comparative Pathogenesis of Infection of Pigs with Hepatitis E Viruses Recovered from a Pig and a Human
[ PUBLICATION ]
Specific-pathogen-free pigs were inoculated with one of two hepatitis E viruses (HEV) (one recovered from a pig and the other from a human) to study the relative pathogenesis of the two viruses in swine. Fifty-four pigs were randomly assigned to three groups. Seventeen pigs in group 1 served as uninoculated controls, 18 pigs in group 2 were intravenously inoculated with the swine HEV recovered from a pig in the United States, and 19 pigs in group 3 were intravenously inoculated with the ...
| Known for Hev Pigs | United States | Hepatitis Lesions | Pig Human | Inoculated Swine |
Avian hepatitis E virus (avian HEV), recently identified from a chicken with hepatitis-splenomegaly syndrome in the United States, is genetically and antigenically related to human and swine HEVs. In this study, sequencing of the genome was completed and an attempt was made to infect rhesus monkeys with avian HEV. The full-length genome of avian HEV, excluding the poly(A) tail, is 6654 bp in length, which is about 600 bp shorter than that of human and swine HEVs. Similar to human and ...
| Known for Avian Hev | Complete Genomic Sequence | Human Swine | Polya Tail | Hepatitis Virus |
Route and Method of Delivery of DNA Vaccine Influence Immune Responses in Mice and Non-Human Primates
[ PUBLICATION ]
BackgroundIn spite of the large number of studies that have evaluated DNA-based immunization, few have directly compared the immune responses generated by different routes of immunization, particularly in non-human primates. Here we examine the ability of a hepatitis B surface antigen (HBsAg)-encoding plasmid to induce immune responses in mice and non-human primates (rhesus monkeys: Macaca mulatta) after delivery by a number of routes.Materials and MethodsEight different injected ...
| Known for Immune Responses | Human Primates | Intramuscular Injections | Intranasal Administration | Highest Levels |
Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and located within amino acid residues 99 to 185 at the C terminus of A33. One or more of the MAbs were ...
| Known for Vaccinia Virus | Monoclonal Antibodies | A33 Mabs | Protective Efficacy | Human Anti |
Hepatitis E virus (HEV) is endemic in many developing and some industrialized countries. It has been hypothesized that animals may be the source of infection. The recent identification of swine HEV in U.S. pigs and the demonstration of its ability to infect across species have lent credence to this hypothesis. To assess the potential risk of zoonotic HEV infection, we tested a total of 468 veterinarians working with swine (including 389 U.S. swine veterinarians) and 400 normal U.S. blood ...
| Known for United States | Blood Donors | Swine Hev | Sar55 Antigen | Hepatitis Virus |
Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. Development of vaccines to prevent HCV infection, or at least prevent progression to chronicity, is a major goal. In mice and rhesus macaques, a DNA vaccine encoding cell-surface HCV-envelope 2 (E2) glycoprotein stimulated stronger immune responses than a vaccine encoding intracellular E2. Therefore, we used DNA encoding surface-expressed E2 to immunize chimpanzees 2768 and 3001. Chimpanzee 3001 developed ...
| Known for Challenge Chimpanzees | Hepatitis Virus | Dna Vaccine | Chimpanzee Immunization | Control Animal |
Two monoclonal antibodies (MAbs) against the ORF2 protein of the SAR-55 strain of hepatitis E virus (HEV) were isolated by phage display from a cDNA library of chimpanzee (Pan troglodytes) gamma1/kappa antibody genes. Both MAbs, HEV#4 and HEV#31, bound to reduced, denatured open reading frame 2 (ORF2) protein in a Western blot, suggesting that they recognize linear epitopes. The affinities (equilibrium dissociation constants, K(d)) for the SAR-55 ORF2 protein were 1.7 nM for HEV#4 and ...
| Known for Monoclonal Antibodies | Phage Display | Capsid Protein | Hepatitis Virus Hev | Sar55 Strain |
Type D hepatitis: The clinical significance of hepatitis D virus RNA in serum as detected by a hybridization‐based assay
[ PUBLICATION ]
Hepatitis D virus is a defective human pathogen that requires hepatitis B virus for its replication. A hybridization-based assay for the 1.75 kb RNA genome of hepatitis D virus was developed using as probe a radiolabeled transcript of a cloned cDNA fragment (pKD3 hepatitis D virus DNA). Sera from 120 chronic carriers of HBsAg with confirmed hepatitis D virus infection were analyzed for the presence of hepatitis D virus RNA. Serum hepatitis D virus RNA was detected in 43 of 74 (58%) ...
| Known for Hepatitis Virus | Rna Serum | Clinical Significance | Patients Chronic | Acute Phase |
Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV
[ PUBLICATION ]
A novel virus of pigs, swine hepatitis E virus (swine HEV), was recently identified and shown to be antigenically and genetically related to human HEV. In the present study, we attempted to infect specific-pathogen-free (SPF) pigs experimentally with swine HEV or with human strains of HEV. Serum samples collected from naturally infected pigs were used as the source of swine HEV. Pigs inoculated intravenously with serum samples containing swine HEV seroconverted to anti-HEV 4 to 8 weeks ...
| Known for Swine Hev | Human Strains | Experimental Infection | Virus Pigs | Hepatitis Viral |
Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus
[ PUBLICATION ]
Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro, protected mice from subsequent intranasal challenge with virulent vaccinia virus, protected mice when ...
| Known for Vaccinia Virus | Human Mabs | Causative Agent | Binding Affinities | Chimpanzee Fabs |
Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population
[ PUBLICATION ]
Hepatitis E virus (HEV) is a very important public health concern in many developing countries where epidemics of hepatitis E are common. Sporadic cases of clinical hepatitis E not only occur in these countries but also occur uncommonly in patients with no known epidemiological exposure to HEV in industrialized countries. The source of infection in industrialized countries is unknown but it has been suggested that animals might serve as a reservoir for HEV in both settings. We recently ...
| Known for Pigs Hev | Countries Hepatitis | Human Population | Sporadic Cases | Swine Herds |
Genetic and experimental evidence for cross-species infection by swine hepatitis E virus.
[ PUBLICATION ]
Prior to the recent discovery of the swine hepatitis E virus (swine HEV) in pigs from the midwestern United States, HEV was not considered endemic to this country. Since swine HEV is antigenically and genetically related to human strains of HEV, it was important to characterize this new virus further. The infectivity titer of a pool of swine HEV in pigs was determined in order to prepare a standardized reagent and to evaluate the dose response in pigs. Although the sequence of swine HEV ...
| Known for Swine Hev | United States | Species Infection | Human Strains | Virus Hepatitis |
Recently, a novel DNA virus, TT virus (TTV), was identified in patients with post-transfusion non-A-G hepatitis. We analyzed the prevalence and clinical implications of TTV infection in a cohort of 96 Spanish patients on long-term hemodialysis. TTV DNA was detected by nested PCR in 51 (53%) of 96 patients, a prevalence significantly higher than that found in healthy blood donors. Persistent liver test abnormalities were found in only 2 (7.7%) of 26 patients infected with TTV alone, ...
| Known for Liver Disease | Mixed Infections | Ttv Patients | Dna Virus | Viral Human Humans |
Key People For Hepatitis Virus
Robert H Purcell:Expert Impact
Concepts for whichRobert H Purcellhas direct influence:Hepatitis virus, Viral hepatitis, Monoclonal antibodies, United states, Acute hepatitis, Hepatitis virus hev, Cell culture, Hepatitis virus hcv.
Robert H Purcell:KOL impact
Concepts related to the work of other authors for whichfor which Robert H Purcell has influence:Hepatitis virus, Hcv infection, Hepatocellular carcinoma, Liver disease, Blood donors, Immune response, Monoclonal antibodies.
Tools
Is this your profile? Claim your profile Copy URL Embed Link to your profile |