• Hidradenitis Suppurativa
    • Errol Prospero Prens
    • Errol Prospero Prens: Influence Statistics

      Errol Prospero Prens

      Errol Prospero Prens

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      Department of Dermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Laboratory for Experimental Immunodermatology, Erasmus University Medical ...

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      Errol Prospero Prens:Expert Impact

      Concepts for whichErrol Prospero Prenshas direct influence:Hidradenitis suppurativa,Topical corticosteroids,Dendritic cells,Atopic dermatitis,Combination therapy,Psoriasis severity,Cd40 ligation,Laser therapy.

      Errol Prospero Prens:KOL impact

      Concepts related to the work of other authors for whichfor which Errol Prospero Prens has influence:Hidradenitis suppurativa,Atopic dermatitis,Dendritic cells,Skin inflammation,Patients psoriasis,Psoriatic arthritis,Metabolic syndrome.

      KOL Resume for Errol Prospero Prens


      Department of Dermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Laboratory for Experimental Immunodermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

      European Hidradenitis Suppurativa Foundation e.V., Dessau, Germany


      Laboratory for Experimental Immunodermatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands


      CHU de Reims, Hôpital Robert Debré, Service de Dermatologie, Reims Cedex, France

      Department of Dermatology Erasmus Medical Centre, Rotterdam, the Netherlands.

      Erasmus University Medical Center, Rotterdam, Netherlands


      Department of Dermatology, Erasmus MC, Rotterdam, the Netherlands


      Department of Dermatology, Erasmus University Medical Centre Rotterdam, Rotterdam, Netherlands.


      Department of Dermatology Erasmus University Medical Centre Rotterdam the Netherlands

      Dermatology, and


      Dermatology, Erasmus MC, Rotterdam the Netherlands, Rotterdam, Netherlands

      Department of Dermatology Erasmus MC, University Medical Center Rotterdam.

      European Hidradenitis Suppurativa Foundation e.V, Dessau, Germany


      Departments of Dermatology and Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands

      European Hidradenitis Suppurativa Foundation e.V.; Dessau Germany


      Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands



      Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, Burg. s’ Jacobplein 51, 3015 CA, Rotterdam, The Netherlands


      Immunology, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands


      Department of Dermatology Erasmus MC, University Medical Center Rotterdam, The Netherlands


      Department of Dermatology, Erasmus University Medical Center, 3015 GE Rotterdam, the Netherlands


      Departments of Dermatology and Immunology, Erasmus University Medical Center, Rotterdam, and, Department of Dermatology, Deventer Hospital, Deventer, The Netherlands;, Department of Dermatology, Roskilde Hospital, Health Sciences Faculty, University of Copenhagen, Copenhagen, Denmark

      Department of Dermatology and Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, .


      Department of Dermatology and Venereology (Paediatric Dermatology), Erasmus MC, 3015 CE Rotterdam, the Netherlands

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      Sample of concepts for which Errol Prospero Prens is among the top experts in the world.
      Concept World rank
      recurrent inflammatory nodules #1
      omiganan daily #1
      helper17 interleukin23 #1
      severity male sex #1
      earlyonset clinical characteristics #1
      il1βmediated responses #1
      epidermal gata3 #1
      wwt transgenic models #1
      preclinical imid models #1
      hsaffected body sites #1
      search pathogenic mechanisms #1
      hyposensitization uvb control #1
      genetic background aberrant #1
      rationale tnf‐α #1
      nicastrin ncstn mutation #1
      patients lentigo maligna #1
      omiganan 25 #1
      il10 bcc #1
      label dosing interval #1
      cohort higher density #1
      ifn responses patients #1
      reduced mast cells #1
      pilot study capability #1
      fdr s100a12 #1
      effects cyclosporine treatment #1
      local il6 production #1
      backgroundperianal fistula #1
      whr hidradenitis suppurativa #1
      bcc complete lack #1
      inverse body areas #1
      clinical improvement apremilast #1
      lower abscess #1
      transwell skin #1
      psoriasis mouse models #1
      nickel anti #1
      protein expression hbd2 #1
      psoriasis concomitant methotrexate #1
      marked reductions t6 #1
      nonlesional skin microbiota #1
      skin tests langerhans #1
      prolongation successful #1
      azathioprine lacks #1
      meaningful local #1
      skin elevated levels #1
      distinct cytokine bead #1
      perianal fistula 66 #1
      cd20 adalimumab #1
      poly responses #1
      cytokine skin statistics #1
      atypical melanocytes psu #1
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      Prominent publications by Errol Prospero Prens

      KOL-Index: 27228

      BACKGROUND: Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis ...

      Known for Topical Corticosteroids | Atopic Dermatitis | Patients Dupilumab | 3 Trial | Monoclonal Antibodies
      KOL-Index: 21784

      BACKGROUND: Dupilumab blocks the shared receptor component for interleukin (IL)-4 and IL-13. It is approved in the U.S.A. for patients aged ≥ 12 years with moderate-to-severe atopic dermatitis (AD) uncontrolled by topical prescription medicines or who cannot use topical medicines, for patients in Japan whose AD is uncontrolled with existing therapies, for patients with moderate-to-severe AD in Europe who are candidates for systemic therapy and for patients aged ≥ 12 years for maintenance ...

      Known for Conjunctivitis Dupilumab | Patients Atopic Dermatitis | Nasal Polyps | Chronic Rhinosinusitis | Increased Incidence
      KOL-Index: 12271

      BACKGROUND: Hidradenitis suppurativa is a painful, chronic inflammatory skin disease with few options for effective treatment. In a phase 2 trial, adalimumab, an antibody against tumor necrosis factor α, showed efficacy against hidradenitis suppurativa.

      METHODS: PIONEER I and II were similarly designed, phase 3 multicenter trials of adalimumab for hidradenitis suppurativa, with two double-blind, placebo-controlled periods. In period 1, patients were randomly assigned in a 1:1 ratio to 40 ...

      Known for Hidradenitis Suppurativa | Patients Adalimumab | Pioneer Period | 12 Weeks | Phase 3
      KOL-Index: 11093

      We report on the levels of expression of IL-1 and IL-6 in skin from psoriasis patients. Different approaches were pursued. Initially, the levels of IL-1 beta and IL-6 were measured in suction blister fluid from lesional and uninvolved skin from psoriasis patients, using a sensitive enzyme-linked immunoabsorbent assay (ELISA) and bio-assay. Skin sections were also examined for the presence of IL-1 and IL-6 using IL-1 beta- and IL-6-specific antibodies. Finally, the expression of IL-1 and ...

      Known for Psoriasis Lesions | Il1 Beta | Blister Fluid | Healthy Individuals | Levels Il6
      KOL-Index: 10955

      Topical application of imiquimod (IMQ), a TLR7/8 ligand and potent immune activator, can induce and exacerbate psoriasis, a chronic inflammatory skin disorder. Recently, a crucial role was proposed for the IL-23/IL-17 axis in psoriasis. We hypothesized that IMQ-induced dermatitis in mice can serve as a model for the analysis of pathogenic mechanisms in psoriasis-like dermatitis and assessed its IL-23/IL-17 axis dependency. Daily application of IMQ on mouse back skin induced inflamed ...

      Known for Inbred Balb Mice | Knockout Psoriasis Receptors | Induced Psoriasis | Il23 Il17 Axis | Animal Humans
      KOL-Index: 10888

      Psoriasis is a chronic inflammatory skin disease that is associated with an increased cardiovascular risk profile. The systemic inflammation present in psoriasis, various systemic treatments for psoriasis and an increased prevalence of unhealthy life style factors may all contribute to this unfavorable risk profile. The purpose of this article is to provide an overview of what is known about these risk factors in psoriasis, the way they influence the cardiovascular risk of psoriasis ...

      Known for Cardiovascular Risk | Psoriasis Patients Psoriasis | Increased Prevalence | Systemic Inflammation | Homocysteine Levels
      KOL-Index: 10607

      The peritumoural inflammatory infiltrate in basal cell carcinoma (BCC) of the skin consists mainly of T lymphocytes which hardly invade the tumour nests. The absence of intercellular adhesion molecule-1 (ICAM-1) on BCC cells may explain the lack of tumour-infiltrating cells and the lack of an active cell-mediated immune response in this tumour. In this study, the induction of ICAM-1 was investigated in BCC biopsies using recombinant human interferon-gamma (rHuIFN-gamma). The expression ...

      Known for Intercellular Adhesion | Basal Cell Carcinoma | Immune Surveillance | Tumour Cells | Interferon Gamma
      KOL-Index: 10435

      Narrow-band ultraviolet-B (NB-UVB) phototherapy is an effective treatment for psoriasis. The molecular mechanisms underlying its efficacy are incompletely understood. To identify NB-UVB-induced molecular pathways that may account for its anti-inflammatory efficacy, gene expression profiling was performed using epidermal RNA from lesional and nonlesional skin from patients with psoriasis undergoing NB-UVB therapy. Downregulation of Th17 signaling pathway was observed during NB-UVB therapy ...

      Known for Th17 Pathway | Monoclonal Antibodies | Nbuvb Therapy | Band Uvb | Type Ifn
      KOL-Index: 10341

      BACKGROUND: The role of antigen presenting cells (APC) in allergic rhinitis is underexposed. Allergen presentation to T lymphocytes is probably an important aspect of the pathophysiological mechanism of allergic rhinitis.

      OBJECTIVES: The aim of the study was to investigate the presence and dynamics of APC with special emphasis on Langerhans cells (LC) in the nasal mucosa of patients with an isolated grass pollen allergy during an out-of-season 2-week allergen exposure, mimicking the ...

      Known for Nasal Mucosa | Allergen Provocation | Presenting Cells | Allergic Rhinitis | Lamina Propria
      KOL-Index: 9960

      BACKGROUND AND OBJECTIVE: Pulsed Dye Laser (PDL) is currently the gold standard treatment for port wine stains (PWS), although the degree of lesion blanching is variable and often unpredictable. This appears to be due to reformation and reperfusion of blood vessels. Rapamycin has shown potential as an antiangiogenic agent and may prevent the revascularization after PDL treatment. The objective of this study was to evaluate the efficacy of adjuvant use of (commercially available) topical ...

      Known for Dye Laser | Port Wine Stains | Pdl Treatment | Topical Rapamycin | Randomized Controlled
      KOL-Index: 9861

      Keratinocytes play a key role in innate immune responses of the skin to bacterial and viral pathogens. Viral double-stranded RNA and its synthetic analogue polyriboinosinic-polyribocytidylic acid (poly-IC) are recognized via multiple pathways involving the receptors Toll-like receptor 3 (TLR3), protein kinase R (PKR), and the recently described cytosolic RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We show that preincubation ...

      Known for Human Keratinocytes | Rna Receptors | Protein Kinase | Interferon Alpha | Dead Box
      KOL-Index: 9853

      BACKGROUND: Dendritic cells (DC) are the most potent antigen-presenting cells (APC) and stimulators of T cells. Dendritic cells are also likely to be essential for the initiation of allergic immune responses in the lung. However, there are not many data on the presence of dendritic cells in the airways of patients with atopic asthma and on the effects of corticosteroid-treatment on such dendritic cells.

      OBJECTIVE: We investigated the distribution of dendritic cells in the bronchial ...

      Known for Dendritic Cells | Bronchial Mucosa | Asthmatic Patients | Increased Numbers | Inhaled Corticosteroids
      KOL-Index: 9719

      Interleukin(IL-)6 is overproduced in psoriatic lesions. We investigated the contribution of dermal fibroblasts to the local IL-6 production. Fibroblasts (passageno. 2 to 6) derived from lesional psoriatic (PP) and normal human (NN) skin were used to analyse the secretion of IL-6, and the related cytokines IL-1, IL-8 and TNF-alpha, and the expression of their corresponding mRNA by bioassay, ELISA and Northern hybridization, respectively. PP fibroblasts cultured under serum-free conditions ...

      Known for Psoriatic Fibroblasts | Il6 Production | Mrna Expression | Culture Media | Interleukin1 Interleukin6
      KOL-Index: 9637

      BACKGROUND: The pathogenesis of hidradenitis suppurativa (HS) is largely unknown and the disease is difficult to treat. Patients are in high need of an effective treatment. Although it is not known whether the levels of tumour necrosis factor (TNF)-α are aberrant in HS skin, anti-TNF-α biologics are used, with variable clinical efficacy.

      OBJECTIVES: To determine the cytokine profile in lesional and perilesional HS skin.

      METHODS: We cultured 20 lesional and 10 normal-appearing ...

      Known for Elevated Levels | Tumour Necrosis Factor | Hidradenitis Suppurativa | Skin Il1β | Tnf Α

      Key People For Hidradenitis Suppurativa

      Top KOLs in the world
      Gregor Borut Ernst Jemec
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      hidradenitis suppurativa human sebocytes sebaceous glands
      Jean E Revuz
      toxic epidermal necrolysis hidradenitis suppurativa plasma exchange
      Lennart Emtestam
      hidradenitis suppurativa electrical impedance atopic dermatitis
      Hessel Hindrik van der Zee
      hidradenitis suppurativa perianal fistula sexual health

      Department of Dermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands; Laboratory for Experimental Immunodermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands. | European Hidradenitis Suppur

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