Charles L Loprinzi

BACKGROUND: Mucositis is a significant toxicity of cancer therapy with numerous systemic sequelae. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for the management of mucositis.

METHODS: The literature was reviewed systematically to identify interventions for mucositis. Studies were rated according to the presence of major and minor flaws ...

This chapter will address a number of issues regarding cancer anorexia/ cachexia. These include (1) the significance of this clinical problem; (2) potential mechanisms that cause cancer anorexia/cachexia; (3) mechanisms for studying antidotes for cancer anorexia/cachexia; (4) clinical trials of potential drugs; and (5) current recommendations for the therapy of cancer anorexia/cachexia.

BASOPHILIA and eosinophilia are common findings during an "accelerated phase" of chronic myeloproliferative disorders, particularly chronic myelogenous leukemia.1,2 When these diseases involve the meninges, it is invariably as "leukemic meningitis," usually during the blastic transformation to acute leukemia, and blasts are the primary cell found in the CSF.3 A case of an undifferentiated myeloproliferative disorder (Philadelphia chromosome negative) occurred, in which the terminal event ...

The article by Virgo et al1 in this issue of JAMA examines the question, "What is appropriate follow-up for colorectal cancer patients treated with an intent to cure?" The authors approach this topic by summarizing 11 different strategies and then dealing with financial aspects of proposed follow-up testing recommendations. While such financial considerations are important, there are other important factors to be considered in determining appropriate follow-up practices, these primarily ...