Prominent publications by Joel Michael Palefsky†

KOL Index score: 24778

BACKGROUND: The rate of anal cancer is increasing among both women and men, particularly men who have sex with men. Caused by infection with human papillomavirus (HPV), primarily HPV type 16 or 18, anal cancer is preceded by high-grade anal intraepithelial neoplasia (grade 2 or 3). We studied the safety and efficacy of quadrivalent HPV vaccine (qHPV) against anal intraepithelial neoplasia associated with HPV-6, 11, 16, or 18 infection in men who have sex with men.

METHODS: In a substudy ...

Known for Anal Intraepithelial Neoplasia |  Hpv Vaccine |  18 Human Papillomavirus |  16 Human
KOL Index score: 18509

Human papillomavirus 16 (HPV 16) and HPV 18 antibody responses in a 2- versus 3-dose HPV vaccine (Gardasil) trial were measured by a pseudovirus neutralizing antibody (PsV NAb) assay and by the Merck competitive Luminex immunoassay (cLIA). Eight hundred twenty-four female subjects assigned to three dosing regimens (group 1, 9 to 13 years old; 2 doses, months 0 and 6 [n = 259]; group 2, 9 to 13 years old; 3 doses, months 0, 2, and 6 [n = 260]; group 3, 16 to 26 years old; 3 doses, months ...

Known for Human Papillomavirus |  Hpv 16 |  Antibody Responses |  Neutralizing Antibodies |  Psv Nab
KOL Index score: 18269

OBJECTIVES: To study anal intraepithelial neoplasia and its associations with anal and cervical human papillomavirus (HPV), cervical neoplasia, host immune status, and demographic and behavioral risk factors in women with and at risk for HIV infection.

DESIGN: Point-prevalence analysis nested within a prospective study of women seen at three clinical centers of the Women's Interagency HIV Study.

METHODS: In 2001-2003 participants were interviewed, received a gynecological examination, ...

Known for Anal Intraepithelial |  Infected Women |  Risk Hiv |  Cervical Neoplasia |  Multisite Study
KOL Index score: 17929

BACKGROUND: Infection with human papillomavirus (HPV) and diseases caused by HPV are common in boys and men. We report on the safety of a quadrivalent vaccine (active against HPV types 6, 11, 16, and 18) and on its efficacy in preventing the development of external genital lesions and anogenital HPV infection in boys and men.

METHODS: We enrolled 4065 healthy boys and men 16 to 26 years of age, from 18 countries in a randomized, placebo-controlled, double-blind trial. The primary ...

Known for Quadrivalent Hpv Vaccine |  Hpv Infection |  16 18 |  External Genital Lesions |  95 Protocol
KOL Index score: 17518

CONTEXT: US cervical cancer screening guidelines for human immunodeficiency virus (HIV)-uninfected women 30 years or older have recently been revised, increasing the suggested interval between Papanicolaou (Pap) tests from 3 years to 5 years among those with normal cervical cytology (Pap test) results who test negative for oncogenic human papillomavirus (HPV). Whether a 3-year or 5-year screening interval could be used in HIV-infected women who are cytologically normal and oncogenic ...

Known for Infected Women |  Cervical Precancer |  Cd4 Cell Count |  Early Detection |  500 Cells
KOL Index score: 17089

CONTEXT: Homosexual and bisexual men infected with human immunodeficiency virus (HIV) are at increased risk for human papillomavirus-related anal neoplasia and anal squamous cell carcinoma (SCC).

OBJECTIVE: To estimate the clinical benefits and cost-effectiveness of screening HIV-positive homosexual and bisexual men foranal squamous intraepithelial lesions (ASIL) and anal SCC.

DESIGN: Cost-effectiveness analysis performed from a societal perspective that used reference case ...

Known for Anal Scc |  Clinical Effectiveness |  Life Expectancy |  Hiv Disease |  Quality Adjusted
KOL Index score: 16095

CONTEXT: Recent cervical cancer screening guidelines state that the interval between screenings can be safely extended to 3 years in healthy women 30 years or older who have normal cytology results and have negative test results for oncogenic human papillomavirus (HPV) DNA.

OBJECTIVE: To determine the incidence of squamous intraepithelial lesions (SILs) in HIV-seropositive women with normal cytology results, by baseline HPV DNA results.

DESIGN, SETTING, AND PATIENTS: Participants were ...

Known for Cell Counts |  Intraepithelial Lesions |  Incidence Sil |  Women Cd4 |  Hpv Dna
KOL Index score: 16007

CONTEXT: Low-grade squamous intraepithelial lesions (LSILs) have been described as a benign cytological consequence of active human papillomavirus (HPV) replication. Several studies have reported that certain behavioral and biological risks exist for LSIL, suggesting that HPV alone is not sufficient for the development of LSIL. However, because most of these studies have been cross-sectional, it is not known whether behavioral and biological risks are simply risks for HPV infection ...

Known for Papillomavirus Infection |  Young Females |  Lsil Hpv |  Sexual Behavior |  Grade Squamous
KOL Index score: 15992

OBJECTIVE: The purpose of this study was to determine the incidence and predictors of genital warts and vulvar intraepithelial neoplasia among women with the human immunodeficiency virus.

STUDY DESIGN: This was a multicenter prospective cohort study comprised of women without warts or vulvar intraepithelial neoplasia at baseline who underwent CD4 count, human immunodeficiency virus RNA measurement, examination, Papanicolaou test, and biopsy, as indicated, every 6 months. Human ...

Known for Human Immunodeficiency Virus |  Antiretroviral Therapy |  Genital Warts |  Vulvar Intraepithelial Neoplasia |  Cd4 Count
KOL Index score: 15451

PURPOSE: High-resolution anoscopy is colposcopy of the anus after applying 3 percent acetic acid. High-resolution anoscopy with biopsy was used as the standard for detecting high-grade anal neoplasia and was compared to detection of high-grade anal neoplasia by anal cytology, human papillomavirus testing, or the combination.

METHODS: A total of 125 men who have sex with men (MSM) were enrolled from a group of MSM identified by random digit dialing: HIV-negative = 85, HIV-positive = 35, ...

Known for Grade Anal |  Resolution Anoscopy |  Human Papillomavirus Testing |  Performance Characteristics |  Sensitivity Specificity
KOL Index score: 15278

BACKGROUND: India has a large population of HIV-positive individuals, including men who have sex with men (MSM), and the incidence of human papillomavirus (HPV)-related cancers is high. In developed countries, HIV-positive MSM exhibit the highest prevalence of anal HPV infection and incidence of anal cancer. Little is known about anal HPV infection in HIV-positive Indian MSM.

METHODS: We evaluated 300 HIV-positive MSM from 2 cities in India. Men were tested for anal HPV infection using ...

Known for Anal Hpv |  Infection Hiv |  Positive Msm |  Human Papillomavirus |  29 Types
KOL Index score: 15208

BACKGROUND: Although cervical cancer is the leading cancer in Cambodia, most women receive no routine screening for cervical cancer and few treatment options exist. Moreover, nothing is known regarding the prevalence of cervical HPV or the genotypes present among women in the country. Young sexually active women, especially those with multiple sex partners are at highest risk of HPV infection. We examine the prevalence and genotypes of cervical HPV, as well as the associated risk factors ...

Known for Hiv Infection |  Phnom Penh |  Young Women |  Cervical Hpv |  Sexual Partners
KOL Index score: 14902

BACKGROUND: Anal cancers are thought to arise from squamous intraepithelial lesions in the anal canal, and women infected with human immunodeficiency virus-1 (HIV) may be at higher risk of anal cancer. Our aim was to determine the prevalence of human papillomavirus (HPV)-related abnormalities of the anal canal in women and to characterize risk factors for these lesions.

METHODS: We evaluated HPV-related abnormalities in 251 HIV-positive and in 68 HIV-negative women. We completed physical ...

Known for Anal Squamous |  Intraepithelial Lesions |  Women Hiv |  Risk Abnormal |  Human Immunodeficiency


Joel Michael Palefsky†: Influence Statistics

Sample of concepts for which Joel Michael Palefsky† is among the top experts in the world.
Concept World rank
urine testing gc #1
pain vin #1
hpvrelated cancers people #1
hpvrelated cancers #1
hpvassociated disease #1
mononuclear leukoplakia #1
amino acid bmrf2 #1
lesions hsils #1
cervix surveys #1
hpv 47 #1
msm neoplasia #1
treatment hsil #1
selfcollected samples concordance #1
akc2 invasion #1
incidence anal cancer #1
anal cancers hsil #1
anal screening programs #1
factors anal #1
bmrf2 protein role #1
cervical carcinoma distribution #1
incidence persistent infection #1
hpv types participants #1
hiv1 clinical manifestations #1
increased production mmp1 #1
prevent anal #1
willingness gay bisexual #1
zimbabwe hpv #1
highrisk hpv persistence #1
hsil higher levels #1
progression anal #1
quality assurance metrics #1
hsil cancer #1
infection hpv6 #1
role bmrf2 #1
effective art art #1
bmrf2 extracellular domain #1
ckiimediated e7 phosphorylation #1
anal lsil #1
hpv awareness willingness #1
hiv hsil development #1
anus incidence #1
concomitant anal #1
ebv bmrf2 protein #1
lsil studies #1
hpv 70 hpv #1
incident detection hpv #1
cysteine s100a8 #1
quadrivalent hpv vaccine #1
hivpositive #1
adult anus #1

Key People For Human Papillomavirus

Top KOLs in the world
Chris J L M Meijer
cervical cancer human papillomavirus hpv dna
Keerti V Shah
human papillomavirus cervical cancer simian virus
Nubia Muñoz
cervical cancer human papillomavirus hpv dna
Mark H Schiffman
human papillomavirus costa rica cervical cancer
Peter J F Snijders
human papillomavirus cervical cancer hpv dna
Francesc Xavier Bosch
cervical cancer human papillomavirus hpv types

Joel Michael Palefsky†:Expert Impact

Concepts for whichJoel Michael Palefsky†has direct influence:Human papillomavirus,  Anal cancer,  Hpv infection,  Puerto rico,  Human immunodeficiency virus,  Anal cytology,  Anal intraepithelial neoplasia,  Hiv infection.

Joel Michael Palefsky†:KOL impact

Concepts related to the work of other authors for whichfor which Joel Michael Palefsky† has influence:Human papillomavirus,  Cervical cancer,  Hpv infection,  Genital warts,  United states,  Intraepithelial neoplasia,  Squamous cell.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Department of Medicine, University of California, San Francisco, California, USA | University of California, San Francisco, 513 Parnassus Ave, Room S420, Box 0654, San Francisco, CA 94143, USA | Department of Medicine, University of California, San F

FREE Custom List