Prominent publications by Jane Carolyn Sterling

KOL Index score: 11959

BACKGROUND: Neural stem cells are a potential source of cells for drug screening or cell-based treatments for neurodegenerative diseases. However, ethical and practical considerations limit the availability of neural stem cells derived from human embryonic tissue. An alternative source of human neural stem cells is needed; a source that is readily accessible, easily expanded, and reliably induced to a neural fate.

METHODS: Dermis isolated from biopsy samples of adult human skin was ...

Known for Neural Precursors |  Stem Cells |  Adult Human Skin |  Efficient Generation |  Growth Factor
KOL Index score: 11136

BACKGROUND: Human papillomaviruses (HPV) are the aetiological agents of certain benign and malignant tumours of skin and mucosae; the most important of which is cervical cancer. Also, the incidence of ano-genital warts, HPV-anal cancer and oropharyngeal cancers are rising. To help ascertain a useful PCR detection protocol for oropharyngeal cancers, we directly compared three commonly used primer sets in detection of HPV from different clinical samples.

METHODS: We compared PGMY09/11, ...

Known for Hpv Detection |  My09 11 |  Oropharyngeal Cancer |  Gp5 6 |  Cervical Samples
KOL Index score: 10500

BACKGROUND: The low-risk human papillomavirus types 6 and 11 are responsible for approximately 90% of anogenital wart cases, with approximately 190,000 new and recurrent cases reported in the UK in 2010. The UK has recently selected the quadrivalent HPV vaccine, which conveys protection against both HPV6 and HPV 11, as part of its immunisation programme for 2012 and it is expected that this will reduce disease burden in the UK. The aims of the study were to evaluate current strategies ...

Known for Condylomata Acuminata |  Hpv Types |  Dna Viral |  Genital Warts |  Papillomavirus Infections
KOL Index score: 9848

BACKGROUND: Human papillomaviruses (HPV) are causally associated with ano-genital and a subset of head and neck cancers. Rising incidence of HPV+ anal cancers and head and neck cancers have now been demonstrated in the developed world over the last decade. The majority of published data on HPV prevalence at the anal and oro-pharyngeal sites are from studies of higher-risk populations. There is a paucity of data on the prevalence of HPV at non-cervical sites in lower risk, non-HIV+ women ...

Known for Prevalence Hpv |  Anal Cancers |  Cervix Anus |  Sites Women |  Human Papillomaviruses
KOL Index score: 9515

Skin-derived precursor cells (SKPs) are multipotent neural crest-related stem cells that grow as self-renewing spheres and are capable of generating neurons and myelinating glial cells. SKPs are of clinical interest because they are accessible and potentially autologous. However, although spheres can be readily isolated from embryonic and neonatal skin, SKP frequency falls away sharply in adulthood, and primary sphere generation from adult human skin is more problematic. In addition, the ...

Known for Adult Skin |  Dermal Papilla |  Hair Follicle |  Precursor Cells |  Neural Crest
KOL Index score: 9141

The objective of this study was to determine the clinical effectiveness of a prime-boost human papillomavirus (HPV) vaccine regimen. A nonrandomized phase II prime-boost vaccine trial was conducted. Women with biopsy-proven anogenital intraepithelial neoplasia (AGIN) 3 were vaccinated with three doses of a recombinant fusion protein comprising HPV 16, E6/E7/L2 (TA-CIN) followed by one dose of a recombinant vaccinia virus encoding HPV 16 and 18 E6/E7 (TA-HPV). Clinical responses were ...

Known for Intraepithelial Neoplasia |  Clinical Responses |  Female Human |  Hpv E6 E7 |  Papillomavirus Vaccines
KOL Index score: 9114

BACKGROUND: Cutaneous warts are common and caused by a number of different types of human papillomaviruses (HPVs).

OBJECTIVE: The aim of this study was to investigate the HPV types causing common warts and to determine any association between the HPV type and the duration of warts and response to cryotherapy.

METHODS: Eighty wart samples from 76 immunocompetent patients were taken from warts by paring prior to cryotherapy and analysed by in situ hybridization (ISH) with HPV probes ...

Known for Hpv Type |  Duration Warts |  Response Treatment |  Human Papillomavirus |  Wart Samples
KOL Index score: 8551

BACKGROUND: Human papillomavirus (HPV) is well known as the major etiological agent for ano-genital cancer. In contrast to cervical cancer, anal cancer is uncommon, but is increasing steadily in the community over the last few decades. However, it has undergone an exponential rise in the men who have sex with men (MSM) and HIV + groups. HIV + MSM in particular, have anal cancer incidences about three times that of the highest worldwide reported cervical cancer incidences.


Known for Anal Cancer |  Hpv Infection |  Msm Hiv |  Human Papillomavirus |  Anus Neoplasms Carcinoma
KOL Index score: 8048

This study investigates the clinical course of low grade squamous intraepithelial lesions (LSIL), HPV status and HPV16-specific immune response in a large prospective study of 125 women with LSIL followed cytologically, virologically and histologically. Women with low-grade abnormal smears were recruited and followed-up for one year. Colposcopy, cervical biopsy for histology and brushings for HPV typing was performed at recruitment, 6 months (no biopsy) and upon completion of the study ...

Known for Cell Responses |  Intraepithelial Lesions |  Hpv16 E6 |  Female Human |  Grade Squamous
KOL Index score: 7862

Human papillomavirus (HPV) infections of cutaneous and genital mucosae are very common but the majority of individuals clear the infection without overt clinical disease. Those who develop lesions, also in most cases, mount an effective cell-mediated immune response and the lesions regress. The increased prevalence of HPV infections in individuals with a range of immunodeficiencies, including immunosuppression as a consequence of HIV infection, demonstrates the central importance of the ...

Known for Human Papillomavirus |  Hpv Infections |  Immune Response |  Viral Persistence |  Innate Immunity
KOL Index score: 7780

INTRODUCTION: Immunological response to human papillomavirus (HPV) in the development and progression of HPV16+ oropharyngeal squamous cell carcinoma (OPSCC) (accounting for the majority of viral associated cases) is largely unknown and may provide important insights for new therapeutic strategies.

METHODS: In this prospective clinical trial (UKCRN11945), we examined cell-mediated immune responses to HPV16 E2, E6 and E7 in peripheral blood using IFN-γ enzyme-linked immunosorbent spot ...

Known for Human Papillomavirus |  Oropharyngeal Cancer |  Cell Response |  E7 Proteins |  Carcinoma Opscc
KOL Index score: 7728

Epidermodysplasia verruciformis (EV)-type human papillomavirus (HPV) DNA have been detected by PCR in squamous cell carcinomas (SCC) from both organ transplant recipients (OTR) and immunocompetent individuals. Their role in skin cancer remains unclear, and previous studies have not addressed whether the viruses are transcriptionally active. We have used in situ hybridization to investigate the transcriptional activity and DNA localization of HPV. EV-HPV gene transcripts were demonstrated ...

Known for Human Papillomavirus |  Immunocompetent Individuals |  Squamous Cell |  Gene Expression |  Hpv Dna
KOL Index score: 7412

Iatrogenic complications associated with current treatment protocols for oropharyngeal squamous cell carcinoma are noted to cause high rates of acute and chronic morbidity. The aims of this study are to provide an overview of the current de-escalation trials for human papillomavirus positive (HPV+) oropharyngeal carcinoma and to evaluate the evidence supporting improved response to treatment of patients within this viral cohort. This study reviewed all completed or in progress randomised ...

Known for Oropharyngeal Squamous |  Human Papillomavirus |  Cell Carcinoma |  Treatment Protocols |  Current Clinical Trials
KOL Index score: 6352

Condylomata acuminata (genital warts) are the most common sexually transmitted viral diseases. These lesions are caused by infection with mucosal human papillomaviruses (HPVs). However, there is limited information on HPV strain distribution involved in the molecular pathogenesis of these lesions. To address this, the strain prevalence and the frequency of multiple HPV infections were determined in wart tissue obtained from 31 patients attending a wart clinic. These lesions were bisected ...

Known for Anogenital Warts |  Viral Load |  Human Papillomavirus Genotypes |  Multiple Infections |  Condylomata Acuminata


Jane Carolyn Sterling: Influence Statistics

Sample of concepts for which Jane Carolyn Sterling is among the top experts in the world.
Concept World rank
types wart #1
evidence hpvs #1
wart surface #1
warts molluscum #1
hpvs skin carcinogenesis #1
wart cases #1
review warts #1
irritants infections #1
wart lesion #1
management cutaneous warts #1
warts salicylic acid #1
determined wart #1
warts molluscum contagiosum #1
neoplasia british #1
contagiosum salicylic #1
immunosuppressed people proportion #1
people highquality trials #1
individuals immune defect #1
warts cryotherapy #1
trials warts #1
verruciformis hair #1
immune defect evidence #1
response wart #2
clearance recalcitrant warts #2
response cryotherapy #2
cryotherapy situ hybridization #2
multiple hpv typing #2
warts response #2
preservcyt solution utility #2
hpv preservcyt #2
diagnostic specimen hpv #2
immunotherapy lasers #2
preservcyt reagent kits #2
papillomaviridae diagnostic specimen #2
hpv type warts #2
anal cancer incidences #2
dominant genotypes populations #2
viral persistence implementation #2
infection profiles interplay #2
wart samples #2
cutaneous genital mucosae #2
cryotherapy cutaneous warts #2

Key People For Human Papillomavirus

Top KOLs in the world
Chris J L M Meijer
cervical cancer human papillomavirus hpv dna
Keerti V Shah
human papillomavirus cervical cancer simian virus
Nubia Muñoz
cervical cancer human papillomavirus hpv dna
Mark H Schiffman
human papillomavirus costa rica cervical cancer
Peter J F Snijders
human papillomavirus cervical cancer hpv dna
Francesc Xavier Bosch
cervical cancer human papillomavirus hpv types

Jane Carolyn Sterling:Expert Impact

Concepts for whichJane Carolyn Sterlinghas direct influence:Human papillomavirus,  Anal cancer,  Intraepithelial neoplasia,  Oropharyngeal cancers,  Adult skin,  Verrucous carcinoma,  Neural precursors,  Highly enriched niche.

Jane Carolyn Sterling:KOL impact

Concepts related to the work of other authors for whichfor which Jane Carolyn Sterling has influence:Human papillomavirus,  Stem cells,  Cervical cancer,  Hpv infection,  Genital warts,  Squamous cell,  Neural crest.



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Department of Dermatology Cambridge University Hospitals NHS Foundation Trust Cambridge UK | Department of Medicine University of Cambridge Cambridge UK | Department of Dermatology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundatio

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