KOL | William H WestraDepartments of Pathology, Molecular and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, 10029, USA. Electronic address: ... |
KOL Resume for William H Westra
| Year | |
|---|---|
| 2021 | Departments of Pathology, Molecular and Cell-Based Medicine, The Icahn School of Medicine at Mount Sinai Hospital, New York, NY, 10029, USA. Electronic address: Department of Pathology, Icahn School of Medicine at the Mount Sinai Hospital, New York, New York, USA |
| 2020 | Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY |
| 2019 | Departments of Pathology at the Icahn School of Medicine at Mount Sinai Hospital, 10029 New York, NY. Electronic address: Department of Pathology, The Icahn School of Medicine at Mount Sinai Hospital, Annenberg Bldg. 15-54, 1468 Madison Ave, 10029, New York, NY, USA Icahn School of Medicine at Mount Sinai, New York, NY |
| 2018 | Department of Otolaryngology – Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States Otolaryngology-Head and Neck Surgery, The Johns Hopkins University, Baltimore, MD. Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA Oncology. |
| 2017 | Departments of Pathology, Otolaryngology and Oncology Johns Hopkins Medical Institutions Baltimore MD USA Department of Pathology Johns Hopkins Hospital Baltimore Maryland Otolaryngology/Head and Neck Surgery, Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD |
| 2016 | Department of Pathology-Surgical Pathology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA Shanthi Marur and William H. Westra, Johns Hopkins University, Baltimore, MD; Shuli Li, Dana Farber Cancer Institute, Boston, MA; Anthony J. Cmelak, Jill Gilbert, and Barbara A. Murphy, Vanderbilt University, Nashville, TN; Maura L. Gillison and Weiqiang J. Zhao, Ohio State University, Columbus, OH; Robert L. Ferris and Julie E. Bauman, University of Pittsburgh, Pittsburgh, PA; Lynne I. Wagner, Wake Forest School of Medicine, Winston-Salem, NC; David R. Trevarthen, Colorado Cancer Research Program, Denver, CO; Jahagirdar Balkrishna, University of Minnesota, St Paul, MN; Nishant Agrawal, University of Chicago Medicine, Chicago, IL; A. Dimitrios Colevas, Stanford University, Stanford, CA; Christine H. Chung, Moffitt Cancer Center, Tampa, FL; and Barbara Burtness, Yale University, New Haven, CT. |
| 2015 | Oncology Department, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA Departments of Pathology and Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland. Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231 The Johns Hopkins University School of Medicine, Baltimore, MD |
| 2014 | Johns Hopkins Medical Institutions Department of Pathology Baltimore Maryland |
William H Westra: Influence Statistics
| Concept | World rank |
|---|---|
| rna ish presence | #1 |
| suspected hnsccs | #1 |
| opsqccs | #1 |
| presence metastatic carcinoma | #1 |
| mec 2 variants | #1 |
| opsccs nonop hnsccs | #1 |
| squamous papillomas sps | #1 |
| hpv sinonasal carcinomas | #1 |
| overt level | #1 |
| carcinomas papillomavirus infections | #1 |
| regulation 16 genes | #1 |
| opscc tumors hpv16 | #1 |
| convalescent salivary rinses | #1 |
| spts contralateral tonsil | #1 |
| neck 16 humans | #1 |
| phase trial ccr | #1 |
| neck hpv | #1 |
| 95 10year increase | #1 |
| patients contralateral tonsil | #1 |
| nevi female head | #1 |
| hpvopcs | #1 |
| nonop hnsccs p16 | #1 |
| postradiation stromal atypia | #1 |
| tonsillar carcinomas spts | #1 |
| neck anaplastic | #1 |
| nsclc 10 genes | #1 |
| hnsqcc hpv | #1 |
| bcl2 hpv | #1 |
| origin hpv16 | #1 |
| hpv pretreatment bcl2 | #1 |
| ciliated mec | #1 |
| lesions microarray analysis | #1 |
| hpv hpv positivity | #1 |
| carcinomas harbor | #1 |
| 82 nonoperative treatment | #1 |
| neck squamous papillomas | #1 |
| sps head | #1 |
| fish bsns diagnosis | #1 |
| older cases controls | #1 |
| nevi congenital | #1 |
| squamoid variant head | #1 |
| sqccs head | #1 |
| frozen malignancy | #1 |
| primary tumor p16 | #1 |
| immune checkpoints insight | #1 |
| predilection sinonasal tract | #1 |
| mmp1 aggressive tumors | #1 |
| positive oropharyngeal cancers | #1 |
| neck pax8 | #1 |
| locoregional failures lrfs | #1 |
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Prominent publications by William H Westra
Evidence for transcriptional activation of the viral oncoproteins E6 and E7 is regarded as the gold standard for the presence of clinically relevant human papillomavirus (HPV), but detection of E6/E7 mRNA requires RNA extraction and polymerase chain reaction amplification-a challenging technique that is restricted to the research laboratory. The development of RNA in situ hybridization (ISH) probes complementary to E6/E7 mRNA permits direct visualization of viral transcripts in routinely ...
| Known for E7 Mrna | Viral Head | Neck Squamous | Risk Hpv | P16 Expression |
Association Between BRAF V600E Mutation and Mortality in Patients With Papillary Thyroid Cancer
[ PUBLICATION ]
IMPORTANCE: BRAF V600E is a prominent oncogene in papillary thyroid cancer (PTC), but its role in PTC-related patient mortality has not been established.
OBJECTIVE: To investigate the relationship between BRAF V600E mutation and PTC-related mortality.
DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of 1849 patients (1411 women and 438 men) with a median age of 46 years (interquartile range, 34-58 years) and an overall median follow-up time of 33 months (interquartile range, 13-67 ...
| Known for Braf V600e | Patients Ptc | Papillary Thyroid Cancer | 1000 Personyears | Interquartile Range |
Quantitative Detection of Promoter Hypermethylation of Multiple Genes in the Tumor, Urine, and Serum DNA of Patients with Renal Cancer
[ PUBLICATION ]
Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of human cancers and is a promising marker for cancer detection. We investigated the feasibility of detecting aberrant DNA methylation in the urine and serum samples of renal cancer patients. We examined the tumor and the matched urine and serum DNA for aberrant methylation of nine gene promoters (CDH1, APC, MGMT, RASSF1A, GSTP1, p16, RAR-beta2, and ARF) from ...
| Known for Serum Dna | Promoter Hypermethylation | Renal Cancer | Quantitative Detection | Multiple Genes |
Improved Survival of Patients With Human Papillomavirus–Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial
[ PUBLICATION ]
BACKGROUND: The improved prognosis for patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) relative to HPV-negative HNSCC observed in retrospective analyses remains to be confirmed in a prospective clinical trial.
METHODS: We prospectively evaluated the association of tumor HPV status with therapeutic response and survival among 96 patients with stage III or IV HNSCC of the oropharynx or larynx who participated in an Eastern Cooperative ...
| Known for Human Papillomavirus | Patients Hnscc | Positive Head | Cell Carcinoma | Prospective Clinical Trial |
Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
[ PUBLICATION ]
The role of aberrant tumor suppressor gene methylation in the aggressiveness of papillary thyroid cancer (PTC) has not been documented. By showing promoter methylation-induced gene silencing in PTC-derived cell lines, we first demonstrated the functional consequence of methylation of several recently identified tumor suppressor genes, including those for tissue inhibitor of metalloproteinase-3 (TIMP3), SLC5A8, death-associated protein kinase (DAPK) and retinoic acid receptor beta2 ...
| Known for Aberrant Methylation | Braf Mutation | Tumor Suppressor | Papillary Thyroid Cancer | Ptc Timp3 |
The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer
[ PUBLICATION ]
BACKGROUND: Human papillomavirus (HPV) is a well-established prognostic marker for oropharyngeal squamous cell cancer (OPSCC). Because of the limited numbers of women and nonwhites in studies to date, sex and racial/ethnic differences in prognosis have not been well explored. In this study, survival differences were explored by the tumor HPV status among 1) patients with OPSCCs by sex and race and 2) patients with nonoropharyngeal (non-OP) head and neck squamous cell cancers ...
| Known for Squamous Cell | Human Papillomavirus | Nonoropharyngeal Head | Prognostic Role | Sex Race |
OBJECTIVES: Evaluation of human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma (OPSCC) has become increasingly important for prognostication and clinical trial enrollment. This assessment is confounded in OPSCCs that are p16 positive by immunohistochemistry (IHC) but HPV negative by DNA in situ hybridization (DISH). This study evaluates whether E6/E7 mRNA in situ hybridization (RISH) can detect transcriptionally active HPV in these problematic cases.
MATERIALS AND ...
| Known for Hpv Status | Situ Hybridization | Squamous Cell | P16 Positive | Messenger Rna |
IMPORTANCE: Human papillomavirus type 16 (HPV-16) is a major causative factor in oropharyngeal squamous cell carcinoma (OPSCC). The detection of primary OPSCC is often delayed owing to the challenging anatomy of the oropharynx.
OBJECTIVE: To investigate the feasibility of HPV-16 DNA detection in pretreatment and posttreatment plasma and saliva and its potential role as a marker of prognosis.
DESIGN, SETTING, AND PARTICIPANTS: This is a retrospective analysis of a prospectively collected ...
| Known for Saliva Plasma | Neck Cancer | Human Papillomavirus | Polymerase Chain | Recurrence Patients |
OBJECTIVES: The importance of detecting human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has resulted in a growing expectation for HPV testing of clinical samples. Although testing protocols vary, most pertain to primary tumor biopsies/resections. Testing of fine-needle aspirates and core biopsies (FNACBs) is advantageous, but it is unclear whether technical and biological factors adversely affect the fidelity of HPV detection in these samples.
METHODS: Data ...
| Known for Hpv Testing | P16 Staining | Human Papillomavirus | Surrogate Marker | Tumor Biopsy |
Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma (HMSC), originally known as HPV-related carcinoma with adenoid cystic carcinoma-like features, is a peculiar neoplasm that is restricted to the sinonasal tract, exhibits features of both a surface-derived and salivary gland carcinoma (particularly adenoid cystic carcinoma), and is associated with high-risk HPV. Given the limited number of published cases, the full clinicopathologic spectrum of this neoplasm is ...
| Known for Sinonasal Carcinoma | Situ Hybridization | Cases Hmsc | Hpv Type | Female Head |
High-risk human papillomavirus (HPV) is an established cause of head and neck carcinomas arising in the oropharynx. The presence of HPV has also been reported in some carcinomas arising in the sinonasal tract, but little is known about their overall incidence or their clinicopathologic profile. The surgical pathology archives of The Johns Hopkins Hospital were searched for all carcinomas arising in the sinonasal tract from 1995 to 2011, and tissue microarrays were constructed. p16 ...
| Known for Sinonasal Tract | Hpv Carcinomas | Adenoid Cystic Carcinoma | P16 Expression | Situ Hybridization |
HPV Analysis in Distinguishing Second Primary Tumors From Lung Metastases in Patients With Head and Neck Squamous Cell Carcinoma
[ PUBLICATION ]
For patients with head and neck squamous cell carcinoma (HNSqCC), the development of squamous cell carcinoma (SqCC) in the lung may signal a new primary or the onset of metastatic dissemination. Although the distinction influences prognosis and therapy, it may not be straightforward on histologic or clinical grounds. The human papillomavirus (HPV) is an etiologic agent for SqCCs arising from the oropharynx but not for SqCCs arising from other head and neck sites. For patients with HNSqCC ...
| Known for Squamous Cell Carcinoma | Lung Metastases | Primary Tumor | Hpv Analysis | Head Neck |
Quantitation of Promoter Methylation of Multiple Genes in Urine DNA and Bladder Cancer Detection
[ PUBLICATION ]
BACKGROUND: The noninvasive identification of bladder tumors may improve disease control and prevent disease progression. Aberrant promoter methylation (i.e., hypermethylation) is a major mechanism for silencing tumor suppressor genes and other cancer-associated genes in many human cancers, including bladder cancer.
METHODS: A quantitative fluorogenic real-time polymerase chain reaction (PCR) assay was used to examine primary tumor DNA and urine sediment DNA from 15 patients with bladder ...
| Known for Promoter Methylation | Bladder Cancer | Urine Dna | Multiple Genes | 100 Specificity |
Key People For Human Papillomavirus
William H Westra:Expert Impact
Concepts for whichWilliam H Westrahas direct influence:Human papillomavirus, Squamous cell, Cell carcinoma, Head neck, Squamous cell carcinoma, Situ hybridization, Lung cancer, Neck squamous.
William H Westra:KOL impact
Concepts related to the work of other authors for whichfor which William H Westra has influence:Squamous cell, Human papillomavirus, Lung cancer, Head neck, Gene expression, Dna methylation, Papillary thyroid.
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