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      Robert Stern

      Robert Stern

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      Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA. | Division of Basic Biomedical Sciences, Touro College of Osteopathic ...

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      Robert Stern:Expert Impact

      Concepts for whichRobert Sternhas direct influence:Hyaluronic acid,Wound healing,Fetal wound healing,Hyaluronidase activity,Trabecular meshwork,Cardiac myxoma,Extracellular matrix,Tumor cells.

      Robert Stern:KOL impact

      Concepts related to the work of other authors for whichfor which Robert Stern has influence:Hyaluronic acid,Extracellular matrix,Wound healing,Molecular weight,Tissue engineering,Growth factor,Cancer cells.

      KOL Resume for Robert Stern

      Year
      2018

      Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA.

      Division of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, 230 West‐125th Street, New York, New York, 10027

      2017

      Department of Basic Biomedical Sciences, Touro-Harlem College of Osteopathic Medicine, 230 West-125th Street, New York, NY 10027, USA,

      2015

      Division of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY†

      2014

      Touro College of Osteopathic Medicine Department of Basic Biomedical Sciences New York New York

      2013

      Department of Basic Biomedical Sciences, Touro/Harlem College of Osteopathic Medicine, New York, NY, USA

      2012

      Department of Basic Biomedical Sciences, Touro/Harlem College of Osteopathic Medicine, 230 West-125th St, 10027, New York, NY, USA

      2011

      Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, 230 West-125th Street, New York, NY 10027, USA

      2010

      Department of Pathology, Touro College of Osteopathic Medicine, New York, New York 10027

      2009

      Department of Pathology, Al Quds University, Abu-Dies, East Jerusalem 20002, Palestinian Territory

      2008

      University of California.

      2007

      Department of Pathology, School of Medicine and UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143-0511, USA

      2006

      Department of Pathology and UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, 513 Parnassus Avenue, S-564, San Francisco, CA 94143-0511, USA

      2005

      University of California, San Francisco, CA‐94143‐0511, USA

      2004

      Department of Pathology and UCSF Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA

      2003

      Department of Pathology, School of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S-564, San Francisco, CA 94143-0511, USA

      2002

      Department of Pathology, School of Medicine, UC San Francisco, San Francisco, CA 94143‐0511

      2001

      University of California at San Francisco Medical Center, San Francisco, CA, USA

      2000

      Department of Pathology, School of Medicine, University of California, San Francisco, CA 94143-0506;

      1999

      Department of Pathology, University of California, San Francisco, California, USA, US

      1998

      Department of Pathology, School of Medicine, University of California, San Francisco, California, 94143

      1997

      Department of Pathology, School of Medicine, University of California, San Francisco, San Francisco, California, 94143-0506

      Graduate Program in Oral Biology, School of Dentistry, University of California, San Francisco 94143, USA.

      1996

      Department of Pathology, School of Medicine, University of California, San Francisco, CA 94143-0506, U.S.A.

      1995

      Fetal Treatment Center, University of California, San Francisco School of Medicine, San Francisco, CA, USA.

      1994

      Department of Pathology, University of California, San Francisco 94143-0506.

      1993

      Department of Oral and Maxillofacial Surgery, School of Dentistry, and the Department of Pathology, San Francisco, California †Department of Oral and Maxillofacial Surgery, School of Medicine, University of California, San Francisco, San Francisco, California

      Univ Calif San Francisco, Sch Med, Dept Pathol, San Francisco, CA 94143, USA and Univ Calif San Francisco, Sch Dent, Dept Oral & Maxillofacial Surg, San Francisco, CA 94143, USA

      1992

      University of California, San Francisco, USA

      1991

      From the Fetal Treatment Program and the Departments of Surgery and Pathology University of California, San Francisco, California

      1990

      From the University of California, San Francisco, California and Marion Laboratories, Inc., Kansas City, Missouri, Professor, Department of Pathology, From the University of California, San Francisco, California and Marion Laboratories, Inc., Kansas City, Missouri

      Fetal Treatment Program and The Departments of Surgery and Pathology, University of California, San Francisco, CA, USA

      Manchester, England

      1989

      From the Fetal Treatment Program and the Departments of Surgery and Pathology, † University of California, San Francisco, San Francisco, California

      Logan, Utah, USA

      1988

      Department of Oral Biology, Division of Oral Pathology, School of Dentistry, University of Washington, Seattle, Washington 98195 USA

      1984

      Department of Pathology, University of California-San Francisco, San Francisco, CA, 94143

      1983

      Department of Pathology, San Francisco Medical Center, University of California at San Francisco, San Francisco, California 94143

      1982

      Department of Pathology University of California San Francisco San Francisco, California 94143, USA

      1980

      Department of Pathology, University of California, San Francisco, San Francisco, California 94143 USA

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      Sample of concepts for which Robert Stern is among the top experts in the world.
      Concept World rank
      fresh nonembalmed cadavers #1
      large hyaluronan polymers #1
      hyaluronic acid determination #1
      acas cd44s #1
      hyaluronan levels day #1
      overlapping reactions prevalence #1
      local islet cells #1
      acidactive enzyme #1
      rapid tissue growth #1
      fibroblast hyaluronidase #1
      hyaluronidases hyaluronan substrate #1
      anticd44 mab administration #1
      tsg6 protein product #1
      intermediatesize fragments #1
      hyaluronan hyaluronan polymer #1
      digestion cell lines #1
      blotting hyaluronidase #1
      matrix tumor cells #1
      hyaluronan wound #1
      enzyme entirety #1
      sinusoidal liver endothelium #1
      lesions extensive thickening #1
      hyaluronan process #1
      cd44 lactate #1
      chondroitin chitin #1
      differing polymer size #1
      fasciacytes new cell #1
      hyaluronoglucosaminidase hyaluronan #1
      targeted hyal1 allele #1
      inherently unstable isoforms #1
      chondroitin evolution #1
      substrate microtiter plate #1
      hyaluronidases products #1
      skin enlightenment #1
      hyaluronidase abnormalities #1
      aging process hyaluronan #1
      “fasciacytes #1
      painful connections #1
      keloids observed #1
      5 new assay #1
      gel alcian blue #1
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      Prominent publications by Robert Stern

      KOL-Index: 15198

      The interaction between epithelial tumor cells and their surrounding stroma is important in tumor progression and metastasis. This is accomplished through a number of transmembrane receptors that interact with stromal extracellular matrix molecules. One of these receptors, CD44, binds to extracellular matrix component hyaluronic acid (HA). The purpose of this study was to evaluate the significance of HA, CD44s, and CD44v6 in benign, hyperplastic, atypical, and malignant endometrial ...

      Known for Hyaluronic Acid | Cd44s Cd44v6 | Complex Hyperplasia | Tumor Progression | Stromal Cells
      KOL-Index: 11949

      OBJECTIVES: Hyaluronan (HA) and CD44 are most likely associated with tumor invasion and metastasis. Malignancies with different degrees of aggressiveness may express different levels and patterns of HA and CD44. The aim of this project was to examine the distribution of HA and CD44 in minor salivary gland tumors to determine if staining could be correlated with biologic behavior or tumor type.

      MATERIALS AND METHODS: Biotinylated hyaluronan binding protein as a probe for HA and monoclonal ...

      Known for Salivary Gland | Cd44 Expression | Tumor Carcinoma | Adenoid Cystic | Low Grade
      KOL-Index: 11902

      Cultured bovine corneal endothelial cells can be grown in three ways: on plastic, on plastic with fibroblast growth factor present in the media, and on their own preformed extracellular matrix. On plastic alone, cells grow in a disorderly fashion and secrete matrix on all cell surfaces. Cells grown on plastic with growth factor or on a matrix, at confluence, have matrix deposition only on the basal surface of the cells and an orderly contact-inhibited pattern of growth. This correlates ...

      Known for Growth Factor | Collagen Synthesis | Extracellular Matrix | Plastic Cells | Basal Surface
      KOL-Index: 10158

      The hyaluronidase first isolated from human plasma, Hyal-1, is expressed in many somatic tissues. The Hyal-1 gene, HYAL1, also known as LUCA-1, maps to chromosome 3p21.3 within a candidate tumor suppressor gene locus defined by homozygous deletions and by functional tumor suppressor activity. Hemizygosity in this region occurs in many malignancies, including squamous cell carcinomas of the head and neck. We have investigated whether cell lines derived from such malignancies expressed ...

      Known for Tumor Suppressor | Squamous Cell | Hyal1 Mrna | Head Neck | Expression Regulation
      KOL-Index: 9956

      Fetal wound healing occurs rapidly and without inflammation, fibrosis, or scar formation. It is a process fundamentally different from adult wound healing. The mechanisms that underlie such unique healing properties are unknown. However, hyaluronic acid, a glycosaminoglycan component of the extracellular matrix, is prominent throughout the course of fetal wound healing, and is thought to play a major role in the healing process. Amniotic fluid contains high levels of hyaluronic acid. ...

      Known for Hyaluronic Acid | Amniotic Fluid | Fetal Wound Healing | Extracellular Matrix | Scar Formation
      KOL-Index: 9685

      BACKGROUND: Dimethylnitrosamine (DMN), a potent hepatotoxin, administered to rats, provides a convenient model for toxic liver injury. Indicators of early liver injury are important clinically, for surveillance, for screening new drugs that are potentially hepatotoxic and for identifying drugs that protect against liver injury. Both cirrhosis and wound healing culminate in deposition of fibrous connective tissue and scarring. Increased hyaluronan (HA) occurs in the earliest stage of ...

      Known for Liver Injury | Drug Rats | Levels Hyaluronan | Intraperitoneal Injections | Hyaluronic Acid
      KOL-Index: 9664

      We recently cloned and expressed the major hyaluronidase activity from human plasma, HYAL1, and found that the protein is 40% identical to the testicular hyaluronidase, PH-20. The HYAL1 mRNA sequence was used in a homology search of the mouse database of expressed sequence tags (dbEST). Two ESTs were obtained and, in combination with 5'RACE-PCR, were used to clone the mouse HYAL1 ortholog (Hyal1). Hyal1 codes for a protein of 462 amino acids that is 73% identical to the human sequence. ...

      Known for Tumor Suppressor | Hyaluronidase Gene | Human Pair | Situ Hybridization | Mouse Hyal1
      KOL-Index: 9649

      Extracellular matrix hyaluronan is prominent during wound healing, appearing at elevated levels early in the repair process. It is prevalent throughout the course of fetal wound healing, which is scar-free, but decreases late in adult wound repair, that is often marked by scarring. To determine whether aberrant hyaluronan metabolism is associated with the excessive scarring that characterizes keloids, cultured fibroblasts derived from keloids and from the dermis of normal human skin and ...

      Known for Keloid Fibroblasts | Reduced Hyaluronan | Normal Skin | Wound Healing | Cell Types
      KOL-Index: 9514

      Hyaluronan is a major component of the extracellular matrix of skin. The large volume of water of hydration associated with hyaluronan may be a mechanism for maintaining the normal hydration of skin. As such, decreasing levels of hyaluronan deposition might underlie the changes associated with the aging process. To test this hypothesis, hyaluronan levels were determined in extracts of skin obtained at autopsy from individuals of different ages. However, no significant differences in ...

      Known for Human Skin | Function Age | Hyaluronan Levels | Extracellular Matrix | Major Component
      KOL-Index: 9245

      Fetal wound healing without scar formations, fibrosis, or contracture might be accompanied by major differences in the wound extracellular matrix. The matrix of fetal wounds is rich in hyaluronic acid, a glycosaminoglycan found in high concentrations whenever there is tissue proliferation, regeneration, and repair. Although hyaluronic acid is a critical molecule for both embryonic development and wound healing, no factor has yet been identified that modulates hyaluronic acid in a ...

      Known for Hyaluronic Acid | Wound Healing | Fetal Serum | Amniotic Fluid | Extracellular Matrix
      KOL-Index: 9175

      Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that interacts with cell-surface receptors, including CD44. Although HA usually exists as a high molecular mass polymer, HA of a much lower molecular mass that shows a variety of biological activities can be detected under certain pathological conditions, particularly in tumors. We previously reported that low molecular weight HAs (LMW-HAs) of a certain size range induce the proteolytic cleavage of CD44 from the surface of ...

      Known for Tumor Cells | Cd44 Cleavage | Hyaluronan Receptors | Pathological Conditions | Biological Activities
      KOL-Index: 9044

      Collagen-like proteins have been found in the egg shell membranes of the hen. Materials similar to types I and V collagens were detected in each of the two layers of this membrane, the thick outer membrane and the thin inner membrane. Collagen was extracted by acid-pepsin digestion and isolated by differential salt precipitation. Identification of type-specific collagen-like material was established by coelectrophoresis on SDS-polyacrylamide gels using known collagen standards. These ...

      Known for Shell Membranes | Collagen Membrane | Microscopy Electron | Acidpepsin Digestion | Chick Embryo
      KOL-Index: 9019

      Recent clinical and experimental evidence suggests that the fetus responds to injury in a fashion fundamentally different from that of the adult. Our initial experience with human open fetal surgery reinforces experimental observations that the fetal wounds heal without the scarring, inflammation, and contraction that often accompany adult wounds. In this study we examine fetal wound fluid in an attempt to elucidate the control mechanisms that endow the fetus with unique healing ...

      Known for Hyaluronic Acid | Fetal Wound | Stimulating Activity | Extracellular Matrix | Unique Properties
      KOL-Index: 8959

      Hyaluronan is a straight chain, glycosaminoglycan polymer of the extracellular matrix composed of repeating units of the disaccharide [-D-glucuronic acid-beta1,3-N-acetyl-D-glucosamine-beta1,4-]n. Hyaluronan is synthesized in mammals by at least three synthases with products of varying chain lengths. It has an extraordinary high rate of turnover with polymers being funneled through three catabolic pathways. At the cellular level, it is degraded progressively by a series of enzymatic ...

      Known for Hyaluronan Fragments | Wound Repair | Biological Functions | Glycosaminoglycan Polymer | Cellular Level

      Key People For Hyaluronic Acid

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      Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA. | Division of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA | Division of Basic Biomedical Sciences, Touro Colleg

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