Prominent publications by Shoshichi Takeuchi

KOL Index score: 12673

Irinotecan (CPT-11) and cisplatin are singly active against cervical cancer. We evaluated the efficacy and toxicity of CPT-11 plus cisplatin as first-line chemotherapy in patients with advanced or recurrent cervical cancer. Twenty-nine chemotherapy-naive patients with advanced or recurrent cervical cancer were treated with CPT-11 (60 mg/m(2)) on days 1, 8, and 15 by intravenous infusion over 90 min, followed by cisplatin (60 mg/m(2) i.v.) on day 1 over 90 min. The patients' median age ...

Known for Cervical Cancer |  Irinotecan Cisplatin |  3 Patients |  Recurrent Disease |  Cpt11 60
KOL Index score: 9391

To elucidate an immunological mechanism in terms of the effectiveness of vaccination of the unexplained habitual aborters with their husband's lymphocytes, 20 patients were selected as the experimental group, and 10 fertile couples were selected as the control group. Subjects were studied by mixed lymphocyte reaction-blocking assay so as to determine whether they had blocking antibodies (BAbs) in their sera. In the experimental group, BAb levels were found to be significantly lower as ...

Known for Successful Pregnancy |  Unexplained Recurrent Aborters |  Husbands Lymphocytes |  Blocking Antibodies |  Immunological Mechanism
KOL Index score: 8808

Tumor-specific antibodies reacted with an isografted ascitic form of mouse mammary tumor, MM2, with a higher sensitivity in an immune adherence test than in an immune cytotoxicity test. Immune adherence and immune adherence inhibition tests were applied for the detection of surface antigens of MM2 tumor reacting with tumor-specific antibodies. After treatment with ether, ethanol, methanol, ethanol-ether mixture, acetone, chloroform-methanol mixture, deoxycholate, triton × 100, snake ...

Known for Immune Adherence |  Surface Antigens |  Immunological Studies |  Mammary Tumor |  Mm2 Cells
KOL Index score: 8130

Immunohistochemical localization of HLA antigens and placental proteins (alpha hCG, beta hCG CTP, hPL and SP1) in villous and extravillous trophoblast at various stages of normal human gestation were studied, using hysterectomy specimens. In the chorionic villi, the capacity for synthesizing placental proteins seemed to develop in parallel with the morphological change from mononuclear cells to multinucleated syncytiotrophoblast and no villous trophoblast expressed HLA antigens. In ...

Known for Extravillous Trophoblast |  Beta Subunit |  Normal Human |  Chorionic Villi |  Pregnancy Proteins
KOL Index score: 7458

OBJECTIVE: To evaluate the efficacy and toxicity of a combination of irinotecan (CPT-11) and cisplatin as first-line chemotherapy in advanced ovarian cancer.

METHODS: Twenty-six patients with previously untreated advanced epithelial ovarian cancer were enrolled in this study. CPT-11 60 mg/m(2) was administered intravenously on days 1, 8, and 15 in combination with cisplatin 60 mg/m(2) on day 1. Cycles were repeated every 28 days for at least two cycles. The median patient age was 55 ...

Known for Ovarian Cancer |  Combination Cisplatin |  Firstline Chemotherapy |  1 8 |  Humans Irinotecan
KOL Index score: 7436

After injection of isografted mammary tumor MM2 sensitized with rabbit antiserum, resistance was induced in C3H/He mice after repeated challenges with MM2. The serum taken from these mice was found to be cytotoxic against MM2 cells. The serum also inhibited the outgrowth of transplant of primary tissue culture cells of spontaneous mammary tumor of C3H/He mice. A series of transplanted mammary tumors recently converted into ascitic form in our laboratory (MM3, MM4-1, MM4-2, MM4-3, MM6, ...

Known for Mammary Tumors |  Immunological Studies |  C3h Mice |  Mm2 Cells |  Tumor‐specific Antibodies
KOL Index score: 7364

Thirty-nine unexplained recurrent aborters underwent vaccination using husband's lymphocytes according to the previously reported protocol. No mixed lymphocyte culture reaction-blocking antibodies (MLR-BAbs) were observed in these patients prior to vaccination. Of 35 newly pregnant patients after vaccination(s), pregnancy successfully continued in 28 (80.0%) and have already been terminated with a liveborn offspring. Pregnancy outcome was also analyzed in unexplained recurrent aborters ...

Known for Unexplained Recurrent |  Immunotherapy Patients |  Blocking Antibodies |  Habitual Adult |  Husbands Lymphocytes
KOL Index score: 7118

To evaluate the clinical effects of the anti-tumor polysaccharide Schizophyllan (SPG), a randomized study was done on 220 patients with Stage II or Stage III cervical cancer who had been given irradiation, concomitantly. The tumor-reducing effect of SPG was significant in patients in either stage. The time to recurrence was longer in SPG-dosed patients with Stage II cancer, compared with findings in the control group. There was no significant difference in the time to recurrence in ...

Known for Cervical Cancer |  Clinical Evaluation |  Spg Patients |  Difference Time |  Randomized Controlled Study
KOL Index score: 6872

BACKGROUND: The failure rate with radiation therapy alone for Stage III cervical cancer is quite high, and therefore other modalities are being pursued as adjuvants to radiation therapy in hopes of improving the results.

METHODS: A randomized, controlled, comparative study on the efficacy and safety of radiation therapy combined with LC9018 (a biologic response modifier prepared from heat-killed Lactobacillus casei YIT9018) was conducted using 228 patients with Stage IIIB cervical ...

Known for Radiation Therapy |  Prolonged Survival |  Lactobacillus Casei |  Uterine Cervical |  Randomized Controlled
KOL Index score: 6577

An isografted tumor MM2, originating from a spontaneous mammary tumor in a C3H/He/mouse, killed 4- to 5-week-old mice within 30 days through intraperitoneal injection of 2 × 104 cells per mouse. It was shown that resistance to the isograft was induced by injection of 1.5 × 105 or 2.0 × 105 tumor cells sensitized with serum (5 μg antibody N) of rabbits immunized with the tumor. Four weeks after injection of the sensitized MM2 cells, 173 C3H/He mice were challenged intraperitoneally with ...

Known for Immunological Studies |  Mammary Tumor |  C3h Mice |  Intraperitoneal Injection |  Mm2 Cells
KOL Index score: 5419

Abstract Lipopolysaccharide (LPS) has been recognized as a potent antitumor agent in animal tumor models; however, its use in human cancer therapy has been limited to only one trial, in which LPS from Salmonella was given intravenously. It was not very successful because of poor tumor response and was also toxic. We originally developed LPS prepared from Pantoea agglomerans (LPSp), and this was a well-purified, small-molecular-mass (5 kDa) agent. We chose intradermal rather than ...

Known for Intradermal Administration |  Lpsp Treatment |  Pantoea Agglomerans |  Tumor Regression |  Lipopolysaccharide Lps
KOL Index score: 5257

A high incidence of autoimmune oophoritis can be induced in (C57BL/6Cr x A/J)F1 mice that were thymectomized at 3 days of age. The vaginal opening day was significantly delayed (thymectomized mice [n = 35], 38.1 +/- 5.8 days [mean +/- SD] versus sham thymectomized mice [n = 26], 34.0 +/- 5.2 days; p less than 0.02). Most of the thymectomized mice showed irregular estrous cycles during the first several weeks and then fell into continuous diestrus. Local infiltration of mononuclear and ...

Known for Autoimmune Oophoritis |  Premature Ovarian Failure |  3 Age |  Zona Pellucida |  Mice Thymectomized
KOL Index score: 4917

Antigens present in mouse mammary tumor MM2 reacting with tumor-specific antibodies were extracted with 0.2% deoxycholate. After the removal of deoxycholate by dialysis, most antigens were precipitated by centrifugation at 105,000 × g for 60 min. Hyperimmunization of C3H/He mice with these antigens induced heightened resistance against MM2. Antibodies appeared in the serum after a booster injection of deoxycholate extract of tumor cells was given. Antigens were solubilized from ...

Known for Mammary Tumor |  Immunological Studies |  C3h Mice |  Heightened Resistance |  Antigen Antibody
KOL Index score: 4617

The authors studied data of combination assays of tumor markers, because simultaneous elevation of different types of tumor markers in the serum was puzzling. They interpreted such phenomena regarding cancer antigen 125, carcinoembryonic antigen, and carbohydrate determinant 19-9 in ovarian tumors. The tissue expression of the antigens was compared with preoperative serum levels. Several different factors were found to cause the simultaneous elevation of two or three of these markers in ...

Known for Ovarian Tumors |  Carcinoembryonic Antigen |  Tumor Markers |  Tissue Expression |  Preoperative Serum Levels


Shoshichi Takeuchi: Influence Statistics

Sample of concepts for which Shoshichi Takeuchi is among the top experts in the world.
Concept World rank
trophoblastic embolism #2

Key People For Hydatidiform Mole

Top KOLs in the world
Ross Stuart Berkowitz
ovarian cancer molar pregnancy gestational trophoblastic
Donald Peter Goldstein
molar pregnancy gestational trophoblastic hydatidiform mole
Rosemary Ann Fisher
hydatidiform mole molar pregnancies gestational trophoblastic
Michael J Seckl
gestational trophoblastic hydatidiform mole molar pregnancy
Kenneth D Bagshawe
germ cell hydatidiform mole human chorionic gonadotrophin
Neil James Sebire
hydatidiform mole wilms tumor twin pregnancies

Shoshichi Takeuchi:Expert Impact

Concepts for whichShoshichi Takeuchihas direct influence:Hydatidiform mole,  Radiation therapy,  Cervical cancer,  Uterine cervical cancer,  Nude mice,  Placental proteins,  Trophoblastic disease,  Invasive mole.

Shoshichi Takeuchi:KOL impact

Concepts related to the work of other authors for whichfor which Shoshichi Takeuchi has influence:Cervical cancer,  Uterine cervix,  Hydatidiform mole,  Neoadjuvant chemotherapy,  Irinotecan hydrochloride,  Spontaneous abortion,  Radiation therapy.



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National Defense Medcl Coll, Tokorozawa, Saitama, Japan; Tohoku Univ, Sch of Medicine, Sendai, Japan; Aichi Cancer Ctr Hosp, Nagoya, Japan; Osaka City Gen Hosp, Osaka, Japan; Jichi Medcl Coll, Tochigi, Japan; Tottori Univ, Sch of Medicine, Yonago, Ja

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