Prominent publications by Dagny Holle

KOL Index score: 10161

BACKGROUND: Transcatheter aortic valve implantation (TAVI) is associated with a higher risk of neurological events for both the transfemoral and transapical approach than surgical valve replacement. Cerebral magnetic resonance imaging has revealed more new, albeit clinically silent lesions from procedural embolization, yet the main source and predominant procedural step of emboli remain unclear.

METHODS AND RESULTS: Eighty-three patients underwent transfemoral (Medtronic CoreValve ...

Bekannt für Valve Implantation |  cerebral embolization |  procedural hits |  transfemoral tavi |  transcatheter aortic
KOL Index score: 9689

BackgroundCalcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory.MethodsClinical routine data of highly ...

Bekannt für Migraine Patients |  3 months |  gene peptide |  monoclonal antibodies |  cgrp receptor
KOL Index score: 9316

BACKGROUND: Transcranial direct current stimulation (tDCS) of the primary motor cortex has been shown to modulate pain and trigeminal nociceptive processing.

METHODS: Ten patients with classical trigeminal neuralgia (TN) were stimulated daily for 20 minutes over two weeks using anodal (1 mA) or sham tDCS over the primary motor cortex (M1) in a randomized double-blind cross-over design. Primary outcome variable was pain intensity on a verbal rating scale (VRS 0-10). VRS and attack ...

Bekannt für Trigeminal Neuralgia |  current stimulation |  transcranial direct |  primary motor cortex |  pain intensity
KOL Index score: 8870

Trigeminal neuralgia (TN) is supposedly caused by an ectatic blood vessel affecting the trigeminal nerve at the root entry zone of the brain stem. Recent evidence suggests an additional central component within trigeminal pain-processing in the pathophysiology of TN. Therefore, we aimed to identify specific brain regions possibly associated with the development or maintenance of TN using magnetic resonance imaging (MRI) voxel-based morphometry (VBM). Sixty patients with classical TN were ...

Bekannt für Chronic Pain |  trigeminal neuralgia |  gray matter |  volume reduction |  patients healthy controls
KOL Index score: 8509

BACKGROUND: Right-to-left cardiac shunt (RLS) is considered a risk factor for stroke, especially in patients aged <55 years. We aimed to investigate the current management and prognosis in consecutive patients with RLS and otherwise cryptogenic cerebrovascular events.

METHODS: In total, 1,126 patients with cryptogenic stroke or TIA were included from 17 German neurology departments. During a mean follow-up of 28.4 months, we assessed current antithrombotic medication, percutaneous device ...

Bekannt für Recurrent Stroke |  cardiac catheterization |  cerebrovascular events |  secondary prevention |  patients cryptogenic
KOL Index score: 8248

INTRODUCTION: Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.

METHODS: History and clinical features of 209 consecutive cluster headache patients (144 eCH, 65 cCH; male:female ratio 3.4 : 1) were obtained in a tertiary headache centre by face-to-face interviews. Relationship between occurrence of accompanying symptoms, pain intensity, comorbid migraine, and circannual and circadian rhythmicity was ...

Bekannt für Cluster Headache |  comorbid migraine |  clinical characteristics |  pain intensity |  attacks patients
KOL Index score: 7973

BACKGROUND: Episodic cluster headache (ECH) is a primary headache disorder that severely impairs patient's quality of life. First-line therapy in the initiation of a prophylactic treatment is verapamil. Due to its delayed onset of efficacy and the necessary slow titration of dosage for tolerability reasons prednisone is frequently added by clinicians to the initial prophylactic treatment of a cluster episode. This treatment strategy is thought to effectively reduce the number and ...

Bekannt für Cluster Headache |  oral prednisone |  prophylactic treatment |  efficacy safety |  controlled trial
KOL Index score: 7968

Migraine is a common neurological disorder, characterised by severe headaches. Epidemiological studies in the USA and Europe have identified a subgroup of migraine patients with chronic migraine. Chronic migraine is defined as ≥15 headache days per month for ≥3 months, in which ≥8 days of the month meet criteria for migraine with or without aura, or respond to treatment specifically for migraine. Chronic migraine is associated with a higher burden of disease, more severe psychiatric ...

Bekannt für Chronic Migraine |  primary physicians |  15 headache |  global health |  cost illness
KOL Index score: 7806

BACKGROUND: Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood.

METHODS: Thirty-two patients with posttraumatic headache following whiplash injury were investigated within 14 days after the accident and again after 3 months using magnetic resonance-based voxel-based morphometry. Twelve patients developed chronic headache lasting longer than 3 months and were studied a third time ...

Bekannt für Gray Matter |  posttraumatic headache |  3 months |  whiplash injury |  patients chronic
KOL Index score: 7530

We aimed to investigate the prevalence of cardiac right left shunts (RLS) in population-based samples of subjects with migraine with aura (n = 42), migraine without aura (n = 44) and controls without headache (n = 41). Cardiac RLS was assessed with transcranial Doppler sonography with intravenous injection of saline. Prevalence of RLS was highest in migraineurs with aura (45.2%) compared to migraineurs without aura (34.1%) and controls (41.5%). Permanent as opposed to latent RLS was more ...

Bekannt für Migraine Aura |  prevalence rls |  patent humans |  case control |  foramen ovale
KOL Index score: 7372

Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide. Bi-center prospective study was done enrolling four diagnostic groups: episodic migraine with and without aura, episodic cluster headache, frequent episodic tension-type headache, and healthy individuals. In migraineurs, venous ...

Bekannt für Primary Headaches |  neurotrophic factor |  migraine attacks |  cluster headache |  brain derived
KOL Index score: 6241

BACKGROUND: Prednisone is commonly used for initial short-term therapy of episodic cluster headaches before preventive medication such as verapamil becomes effective, but this strategy has not been tested in large randomised trials. We aimed to access the safety and efficacy of this treatment approach.

METHODS: This study was a multicentre, randomised, double-blind, placebo-controlled trial done in ten specialised headache centres in Germany. Patients with episodic cluster headaches who ...

Bekannt für Cluster Headache |  drug therapy |  patients episodic |  calcium channel
KOL Index score: 5969

OBJECTIVE: The study was conducted to investigate the after-effect of transcranial direct current stimulation (tDCS) applied over the human primary motor cortex (M1) on trigeminal and extracranial nociceptive processing.

BASIC PROCEDURES: Nineteen healthy volunteers were stimulated using cathodal, anodal (both 1 mA) or sham tDCS for 20 minutes. Pain processing was assessed by recording trigeminal and extracranial pain-related evoked potentials (PREPs) following electrical stimulation of ...

Bekannt für Motor Cortex |  current stimulation |  transcranial direct |  cathodal anodal |  nociceptive processing

Vestibular migraine

KOL Index score: 5944

BACKGROUND: The combination of vertigo, dizziness and balance disturbance with migraine is called vestibular migraine. Although it is estimated that up to 1% of the population suffers from this disease, it is still widely unknown and often underdiagnosed. Recently, the International Headache Society and the Báràny Society published the first joint document with mutually accepted diagnostic criteria for vestibular migraine.

METHOD: This review summarizes current knowledge on vestibular ...

Bekannt für Vestibular Migraine |  differential diagnosis |  clinical presentation |  vertigo dizziness |  therapeutic recommendations
KOL Index score: 5922

BACKGROUND: The connection of cluster headache (CH) attacks with rapid eye movement (REM) sleep has been suggested by various studies, while other authors challenge this assumption. We performed serial polysomnography to determine the association of nocturnal CH attacks and sleep.

METHODS: Five patients diagnosed with CH (two with the episodic and three with the chronic subtype) were included and studied over four consecutive nights to evaluate connections between attacks onset and sleep ...

Bekannt für Cluster Headache |  attacks sleep |  rapid eye movement |  aged polysomnography |  disordered breathing

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Dagny Holle:Expertenwirkung

Konzepte für welcheDagny Hollehat direkten Einfluss:Cluster headache,  Hypnic headache,  Chronic migraine,  Vestibular migraine,  Trigeminal neuralgia,  Episodic cluster headache,  Headache disorders,  Recurrent stroke.

Dagny Holle:KOL -Auswirkungen

Konzepte im Zusammenhang mit der Arbeit anderer Autoren, für diefor which Dagny Holle hat Einfluss:Cluster headache,  Chronic migraine,  Aortic valve,  Trigeminal neuralgia,  Neuropathic pain,  Medication overuse,  Patent foramen.



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Department of Neurology, West German Headache Center, University hospital Essen, Essen, Germany | Department of Neurology and Centre for Translational Neuro‐ and Behavioural Sciences (C‐TNBS), West German Headache Center, University Hospital Essen, U