• Disease
  • Mechanical
  • Mechanical Ventilation
  • David J Pierson

    Prominent publications by David J Pierson

    KOL Index score: 9364

    We studied eleven patients during 14 attempts at weaning from mechanical ventilation to determine whether central ventilatory drive, measured as airway occlusion pressure 0.1 s after onset of inspiration (P 0.1), during spontaneous breathing before and during a brief hypercapnic challenge, could accurately predict the success or failure of the attempt. All patients were recovering from acute respiratory failure and could breathe spontaneously for 20 minutes on a T-piece but were judged ...

    Also Ranks for: Hypercapnic Challenge |  occlusion pressure |  success failure |  mechanical ventilation |  spontaneous breathing
    KOL Index score: 9308

    BACKGROUND: There is little data about the combined effects of COPD and obesity. We compared dyspnea, health-related quality of life (HRQoL), exacerbations, and inhaled medication use among patients who are overweight and obese to those of normal weight with COPD.

    METHODS: We performed secondary data analysis on 364 Veterans with COPD. We categorized subjects by body mass index (BMI). We assessed dyspnea using the Medical Research Council (MRC) dyspnea scale and HRQoL using the St. ...

    Also Ranks for: Obese Patients |  obesity copd |  normal weight |  inhaled medications |  healthrelated quality
    KOL Index score: 8770

    To clarify the clinical value of the International Labor Office (ILO) roentgenographic classification of pneumoconiosis in assessing asbestos-exposed persons, we determined the relationships among spirometric values, radiographic evidence of parenchymal pulmonary fibrosis and/or pleural thickening, and cigarette smoking history in 684 consecutively enrolled male plumbers and pipefitters participating in a larger cross-sectional prevalence study. The subjects were mainly marine ...

    Also Ranks for: Smoking Status |  pulmonary function |  pleural abnormalities |  fvc fev1 |  restrictive impairment
    KOL Index score: 8610

    Hypoxic (HVR) and hypercapnic (HCVR) ventilatory responses are influenced by both metabolic activity and hormonal factors. By studying 67 subjects of both sexes, including those at the extremes of stature, we examined the influence of gender, CO2 production (VCO2), O2 consumption (VO2), body surface area (BSA), and vital capacity (VC) on resting ventilation (VE), HVR, and HCVR. We measured resting VE, VO2, and VCO2 and then performed isocapnic progressive hypoxic and hypercapnic ...

    Also Ranks for: Body Size |  hvr hcvr |  vo2 vco2 |  control ventilation |  co2 production
    KOL Index score: 7463

    Most patients with extreme obesity do not exhibit alveolar hypoventilation, but an intriguing minority do. The mechanism(s) of this phenomenon remain unknown. A disorder in ventilatory control has been suggested as a major factor in the pathogenesis of the obesity-hypoventilation syndrome. Accordingly, hypoxic and hypercapnic ventilatory drives were measured in 10 patients with the typical symptoms of the syndrome: obesity, hypersomnolence, hypercapnia, hypoxemia, polycythemia and cor ...

    Also Ranks for: Ventilatory Drive |  hypoventilation syndrome |  patients hypercapnia |  vital capacity |  decreased hypoxic
    KOL Index score: 7296

    The obstructive sleep apnoea syndrome occurs predominantly in men. To determine the effect of testosterone on ventilatory function and whether testosterone may play a role in the development of obstructive apnoea, we performed waking ventilatory drive studies and sleep studies in five hypogonadal men. These androgen-deficient subjects were studied both while receiving no treatment and after six weeks of testosterone replacement therapy (testosterone oenanthate 200 mg i.m. every 2 weeks). ...

    Also Ranks for: Testosterone Replacement |  obstructive sleep |  2 weeks |  oxygen saturation |  humans hypogonadism
    KOL Index score: 7065

    Alveolar hypoventilation is known to occur in myxedema. To clarify the role of hypoxic ventilatory drive and hypercapnic ventilatory drive in thyroid hormone insufficiency states, 10 patients with myxedema and seven with hypothyroidism (thyroid ablation) were studied before and after thyroid replacement. An index developed for hypoxic ventilatory drive was markedly reduced in myxedema: 17 plus or minus 4.7 (S.E.M.) (normal, 126 plus or minus 8.7) (P smaller than 0.01) and increased to 78 ...

    Also Ranks for: Ventilatory Control |  thyroid replacement |  alveolar hypoventilation |  aged myxedema |  thyroxine triiodothyronine
    KOL Index score: 6954

    Acetazolamide (A) is a potent inhibitor of carbonic anhydrase. It has been shown to be efficacious in preventing acute mountain sickness as well as decreasing the O2 desaturation that occurs during sleep in individuals with chronic mountain sickness who live at altitude. Very little data, however, are available about its effect on exercise. We studied six healthy males in a double-blind cross-over design using acetazolamide and placebo (P) during normoxic and hypoxic (fractional inspired ...

    Also Ranks for: Hypoxic Exercise |  normoxia hypoxia |  carbonic anhydrase |  metabolic acidosis |  bicycle ergometer
    KOL Index score: 6890

    To establish guidelines for the interpretation of changes in arterial blood gas (ABG) values, we studied 29 clinically stable ICU patients for spontaneous variability in PaO2, PaCO2 and pH. ABGs were sampled six times over a 50-minute period, during which all patients received a fixed FIO2 of 0.5 via endotracheal tube and underwent no therapeutic interventions. Each sample was analyzed in duplicate with careful attention to method of collection and measurement. The range separating the ...

    Also Ranks for: Stable Patients |  blood gas |  pao2 paco2 |  spontaneous variability |  mm hg
    KOL Index score: 6682

    Three hundred fourteen consecutive patients were studied prospectively during 354 episodes of assisted ventilation in a 5 month period. These patients ranged in age from 15 to 95 years, and ventilatory support was required for from 1 hour to 54 days. Over-all survival was 64 per cent. Eighteen complications were studied prospectively, of which three (intubation of the right mainstem bronchus, endotracheal tube malfunction and alveolar hypoventilation) were associated with decreased ...

    Also Ranks for: Assisted Ventilation |  mainstem bronchus |  endotracheal intubation |  ventilatory support |  aged airway
    KOL Index score: 6680

    Sputum induction (SI) is a sensitive and specific method for diagnosing Pneumocystis carinii pneumonia (PCP) in patients with AIDS. Although less expensive than bronchoscopy with bronchoalveolar lavage (BAL), SI followed by BAL does not necessarily reduce costs compared with BAL alone. Cost analysis demonstrates that the cost of diagnosing PCP is dependent on the prevalence of PCP (PCPprevalence) in the studied population, the sensitivity of SI (SIsensitivity) for diagnosing PCP, and the ...

    Also Ranks for: Bronchoalveolar Lavage |  sputum induction |  pneumocystis carinii pneumonia |  cost analysis |  sensitivity specificity
    KOL Index score: 5716

    The total lung capacity (TLC) is frequently used as a measure of respiratory impairment in patients with asbestosis. Because asbestosis and chronic obstructive pulmonary disease (COPD) exert opposite effects on the TLC, it may be an insensitive measure of impairment in patients with both abnormalities. To assess this, we compared asbestos-exposed patients with functional evidence of COPD and radiographic evidence of interstitial fibrosis (group 1) to those with interstitial fibrosis ...

    Also Ranks for: Lung Capacity |  chronic obstructive |  pulmonary fibrosis |  opposite effects |  volume measurements
    KOL Index score: 5485

    Because the therapeutic and toxic effects of oral therapy with bronchodilator drugs are poorly documented in patients with chronic obstructive pulmonary disease (COPD), we investigated the effects of administration of terbutaline (5 mg) and of a combination drug (Marax) containing ephedrine (25 mg), theophylline (130 mg), and hydroxyzine (10 mg) on pulmonary function, seven-hour taped electrocardiograms, blood pressure, and symptoms in a controlled double-blind study in 16 such patients. ...

    Also Ranks for: Therapy Terbutaline |  obstructive pulmonary |  forced expiratory |  16 patients |  heart rate


    David J Pierson: Influence Statistics

    Sample of concepts for which David J Pierson is among the top experts in the world.
    Concept World rank
    cycle safety alarms #1
    bpf mechanical #1
    inspection chest roentgenogram #1
    bpf bronchopleural #1
    maximum air leak #1
    oxygen respiratory #1
    tracheostomy mediastinal drains #1
    mediastinal emphysema pathophysiology #1
    respiratory drives #1
    air leaks admission #1
    normalizing arterial oxygenation #1
    mortality 39 patients #1
    avoidable misadventures #1
    traditional larger values #1
    continuum fascial planes #1
    pneumothorax barotrauma #1
    underlying traumarelated #1
    mediastinal drains recommendedarch #1
    pneumothorax barotrauma article #1
    bpf mechanical ventilation #1
    barotrauma viewpoints #1
    respiratory bronchial #1
    trauma softtissue infections #1
    smaller maximum leaks #1
    equipmentrelated complications #1
    early 1970s pao2 #1
    barotrauma adults #1
    intern subcutaneous emphysema #1
    pattern ventilator settings #1
    hospital lower values #1
    discussion pneumothorax #1
    betacoefficient 12 #1
    unintended respiratory alkalosis #1
    prompt recognition underlying #1
    bronchopleural air #1
    1 day years #1
    variety avoidable misadventures #1
    article barotrauma #1
    aberrant air areas #1
    publication barotrauma humans #1
    bronchopleural air leak #1
    tall short #2

    Key People For Mechanical Ventilation

    Top KOLs in the world
    Laurent Jean Brochard
    mechanical ventilation respiratory distress lung injury
    Arthur S MD Slutsky
    mechanical ventilation lung injury respiratory distress
    Michael Anthony Matthay
    acute lung injury pulmonary edema respiratory distress
    Andrés Esteban
    mechanical ventilation septic shock respiratory distress
    Boyd Taylor Thompson
    acute lung injury septic shock distress syndrome
    Deborah J MD Cook
    critically patients intensive unit critical illness

    David J Pierson:Expert Impact

    Concepts for whichDavid J Piersonhas direct influence:Mechanical ventilation,  Fiberoptic bronchoscopy,  Hypercapnic challenge,  Chronic bronchitis,  Assisted ventilation,  Pulmonary function,  Journal club,  Bronchoalveolar lavage.

    David J Pierson:KOL impact

    Concepts related to the work of other authors for whichfor which David J Pierson has influence:Mechanical ventilation,  Sleep apnea,  Subcutaneous emphysema,  Respiratory failure,  Pulmonary function,  Ventilatory response,  Carbon dioxide.



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    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington | From the Division of Pulmonary & Critical Care Medicine (RPD, DLH, WJEL, DJP, RWG, LR), School of Medicine, University of Wa