Direct Impact

Concepts for which Scott H Korn has direct influence:

ibuprofen lysine
hepatic insufficiency
acute pain
nocturnal acid
cyclobenzaprine hydrochloride
meq anc combination
muscle spasm

External impact

Concepts related to the work of other authors for which Scott H Korn has influence:

elderly volunteers
cognitive effects
pharmacokinetic considerations
oral diphenhydramine
regular intervals
commonly held belief
three-period crossover

Prominent publications by Scott H. Korn

KOL-Index: 7 BACKGROUND: Cyclobenzaprine hydrochloride is a muscle relaxant that is effective in improving muscle spasm, reducing local pain and tenderness, and increasing range of motion in acute, painful musculoskeletal conditions. Sedation is the most common adverse event associated with its use at the usual dosage of 10 mg TID. Studies in healthy adults suggest that a lower dose may produce less ...
Known for
Cyclobenzaprine Primary | Compared Acute
KOL-Index: 6 This single-dose, double-blind, parallel-group, single-site study compared ibuprofen lysine 400 mg with acetaminophen 1000 mg and placebo in 240 patients with moderate-to-severe postoperative dental pain. The relative onset of analgesic response, overall analgesic efficacy, duration of effect, and safety were assessed over a 6-hour postdose period. Analgesic efficacy was assessed by patient ...
Known for
Meaningful Pain Relief | Self-Rating | Additional Analgesic Medication | 6-Hour Postdose Period
KOL-Index: 6
Known for
Meq Anc Combination | Omeprazole
KOL-Index: 5 The pharmacokinetics and bioavailability of cyclobenzaprine, a widely used muscle relaxant, were investigated in four clinical studies, and the effects of age, gender, and hepatic insufficiency were characterized. Cyclobenzaprine plasma clearance was 689 ml/min, and the bioavailability of a 5 mg oral dose was 0.55. Following oral doses of 2.5 to 10 mg tid in healthy young subjects, ...
Known for
Plasma Dosing | Elderly Young | Concentrations Cyclobenzaprine | Doses Tid
KOL-Index: 5 BACKGROUND: Opiates, acetaminophen, nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase-2-selective inhibitors such as rofecoxib are used in the treatment of acute pain because of their anti-inflammatory and/or analgesic properties. Rofecoxib has demonstrated an improved gastrointestinal safety profile compared with nonselective NSAIDs. OBJECTIVE: The aim of this ...
Known for
Pain Moderate | Analgesic Time | Improved Gastrointestinal Safety Profile | Active Comparator-Controlled

Merck Research Laboratories, West Point, Pennsylvania, USA

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