Nancy J. Newman

Nancy J. Newman

Department Of Ophthalmology, Emory University School Of Medicine, 1365-B Clifton Road Ne, Suite B4500, Atlanta, Ga 30322, United States; Department Of Neurology, Emory ...

Direct Impact

Concepts for which Nancy J Newman has direct influence:

idiopathic intracranial hypertension
optic nerve
visual loss
diagnostic error
homonymous hemianopia
fundus photography

External impact

Concepts related to the work of other authors for which Nancy J Newman has influence:

idiopathic intracranial hypertension
visual acuity
leber hereditary optic neuropathy
6 months
central retinal artery occlusion
vision loss
optic nerve

Prominent publications by Nancy J. Newman

KOL-Index: 95 BACKGROUND: Diagnostic error is prevalent and costly, occurring in up to 15% of US medical encounters and affecting up to 5% of the US population. One-third of malpractice payments are related to diagnostic error. A complex and specialized diagnostic process makes neuro-ophthalmologic conditions particularly vulnerable to diagnostic error. EVIDENCE ACQUISITION: English-language literature on ...
Known for
Diagnostic Process | 60-70 | Electronic Search | Neuro Ophthalmology
KOL-Index: 94 Idiopathic intracranial hypertension (IIH) is a disorder of unknown etiology that results in isolated raised intracranial pressure. Classic symptoms and signs of IIH include headache, papilledema, diplopia from sixth nerve palsy and divergence insufficiency, and pulsatile tinnitus. Atypical presentations include: (1) highly asymmetric or even unilateral papilledema, and IIH without ...
Known for
Iih Papilledema | Cerebrospinal Fluid Leak | Nerve Palsy | Diplopia
KOL-Index: 84 Background/objectivesREALITY is an international observational retrospective registry of LHON patients evaluating the visual course and outcome in Leber hereditary optic neuropathy (LHON).Subjects/methodsDemographics and visual function data were collected from medical charts of LHON patients with visual loss. The study was conducted in 11 study centres in the United States of America and ...
Known for
Bcva Logmar | Severe Permanent Deterioration | 9 20 | Carried Nd4
KOL-Index: 59 PURPOSE OF REVIEW: To summarize recent developments in the classification, investigation and management of pediatric optic neuritis (PON). RECENT FINDINGS: A recent surge in interest surrounding antibodies to myelin oligodendrocyte glycoprotein antibody (MOG-Ab) has instigated a paradigm shift in our assessment of children with PON. This serological marker is associated with a broad spectrum ...
Known for
Children Pon | Phenotype Mog | Neuritis Presenting
KOL-Index: 50 Objective: This work aimed to compare the evolution of visual outcomes in Leber hereditary optic neuropathy (LHON) patients treated with intravitreal gene therapy to the spontaneous evolution in prior natural history (NH) studies. Design: A combined analysis of two phase three randomized, double-masked, sham-controlled studies (REVERSE and RESCUE) and their joint long-term extension trial ...
Known for
Loess | Nd4 Mutation | Clin06 | Loss Reverse
KOL-Index: 45 REVERSE is a randomized, double-masked, sham-controlled, multicenter, phase 3 clinical trial that evaluated the efficacy of a single intravitreal injection of rAAV2/2-ND4 in subjects with visual loss from Leber hereditary optic neuropathy (LHON). A total of 37 subjects carrying the m.11778G>A (MT-ND4) mutation and with duration of vision loss between 6 to 12 months were treated. Each ...
Known for
Left Eye | Plausible Mechanistic Explanation | Sustained Visual Improvement | 11 Ratio
KOL-Index: 43 Mitochondrial diseases frequently manifest neuro-ophthalmologic symptoms and signs. Because of the predilection of mitochondrial disorders to involve the optic nerves, extraocular muscles, retina, and even the retrochiasmal visual pathways, the ophthalmologist is often the first physician to be consulted. Disorders caused by mitochondrial dysfunction can result from abnormalities in either ...
KOL-Index: 41 PURPOSE: To determine whether MRI signs suggesting elevated intracranial pressure (ICP) are preferentially found in patients with idiopathic intracranial hypertension (IIH) than in those with cerebral venous thrombosis (CVT). METHODS: Among 240 patients who underwent standardized contrast-enhanced brain MRI/MRV at our institution between 9/2009 and 9/2011, 60 with abnormal imaging findings ...
Known for
Globes | Bilateral Tss | Sella Turcica | Cortical Veins
KOL-Index: 40 BACKGROUND: Mechanisms of peri-operative ischaemic optic neuropathy remain poorly understood. Both specific pre-operative and intra-operative factors have been examined by retrospective studies, but no animal model currently exists. OBJECTIVES: To develop a rodent model of peri-operative ischaemic optic neuropathy. In rats, we performed head-down tilt and/or haemodilution, theorising that ...
Known for
Pre-Operative Intra-Operative | Activation Optic | Tilted Haemodiluted | Str Retinal
KOL-Index: 39 BACKGROUND: A relationship between idiopathic intracranial hypertension and spontaneous skull base cerebrospinal fluid (CSF) leaks has been proposed, by which CSF leak decreases intracranial pressure (ICP) and masks the symptoms and signs of elevated ICP. These patients are at risk of developing papilledema, symptoms of elevated ICP, or a recurrent CSF leak after CSF leak repair. The ...

Department of Ophthalmology, Emory University School of Medicine, 1365-B Clifton Road NE, Suite B4500, Atlanta, GA 30322, United States; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, United States; Department of Neu

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