Prominent publications by Pavel Mares̆

KOL Index score: 11573

An antagonist of type I metabotropic glutamate receptors MPEP was found to exhibit anticonvulsant action in adult rodents. Present experiments were focused on action of this drug against pentetrazol-induced motor seizures in immature rats 12-, 18- and 25-days old. Dose of pentetrazol (100 mg/kg s.c.) was chosen to elicit minimal clonic seizures and (after a longer latency) generalized tonic-clonic seizures. Pretreatment with MPEP (doses from 10 to 80 mg/kg i.p.) resulted in a ...

Known for Immature Rats |  Anticonvulsant Action |  Glutamate Receptors |  Drug Epilepsy |  Mpep Antagonist
KOL Index score: 11553

Previous studies demonstrated that selected agonists for metabotropic glutamate group II and group III receptors can provide protection against seizures in adult animals. The present study has examined the potential effect of some of these compounds on seizures induced in immature rats by intracerebroventricular infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side). Rat pups were sacrificed during generalised clonic-tonic seizures, 50--60 min after infusion. Comparable time intervals ...

Known for Metabotropic Glutamate |  Immature Rats |  Homocysteic Acid |  Wistar Receptors |  Seizures Induced
KOL Index score: 11289

The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side). For biochemical analyses, rat pups were sacrificed during generalized clonic-tonic seizures, approximately 45-50 min after infusion. ...

Known for Immature Rats |  Homocysteic Acid |  Metabotropic Glutamate |  2r4r Apdc |  Seizures Induced
KOL Index score: 11158

The present study has examined the effect of free radical spin trap N-tert-butyl-alpha-phenylnitrone (PBN) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (dl-HCA, 600 nmol/side). PBN was given i.p. in two doses (100 mg/kg each), 30 min prior and 30 min after dl-HCA infusion. PBN did not significantly influence the severity of seizures, evident both from the behavioral symptoms and EEG recordings. PBN ...

Known for Immature Rats |  Homocysteic Acid |  Seizures Induced |  Free Radical |  Cerebral Cortex
KOL Index score: 10028

PURPOSE: Antagonists of group I metabotropic glutamate receptors (mGluRs) are known to exhibit anticonvulsant action without serious side effects. Recently we found anticonvulsant effects of specific antagonists of mGluR subtypes 1 and 5 (AIDA and MTEP) against pentetrazol-induced convulsions in developing rats. In order to determine if the effects of these two antagonists are not exclusively restricted to pentetrazol-induced seizures, we studied their action in a novel seizure model ...

Known for Glutamate Receptors |  Immature Rats |  Wistar Receptor |  Aida Doses |  Anticonvulsant Action
KOL Index score: 9935

Antagonists of type I of metabotropic glutamate receptors exhibit anticonvulsant action in adult as well as immature rodents. To know the anticonvulsant profile of a specific mGluR5 antagonist MPEP in developing rats, two models of epileptic seizures were used. MPEP (10, 20 or 40 mg/kg i.p.) suppressed in a dose-dependent manner epileptic afterdischarges induced by electrical stimulation of sensorimotor cortical area in three age groups (12, 18 and 25 days old). The anticonvulsant action ...

Known for Anticonvulsant Action |  Metabotropic Glutamate |  Immature Rats |  Animal Doseresponse Relationship |  Electrical Stimulation
KOL Index score: 9814

The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study. Rat pups were sacrificed during generalized clonic-tonic seizures, approximately 45 to 50 min after infusion. Comparable time intervals were used for sacrificing the ...

Known for Immature Rats |  Homocysteic Acid |  Metabotropic Glutamate |  Wistar Receptors |  Seizures Induced
KOL Index score: 9761

Glutamate is the main excitatory neurotransmitter in the brain and ionotropic glutamate receptors mediate the majority of excitatory neurotransmission (Dingeldine et al. 1999). The high level of glutamatergic excitation allows the neonatal brain (the 2(nd) postnatal week in rat) to develop quickly but it also makes it highly prone to age-specific seizures that can cause lifelong neurological and cognitive disability (Haut et al. 2004). There are three types of ionotropic glutamate ...

Known for Ampa Receptors |  Status Epilepticus |  Subunit Composition |  Immature Rats |  Neonatal Brain
KOL Index score: 9685

Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival. Electrographic recordings from sensorimotor cortex, hippocampus, and striatum demonstrated isolated spikes in the hippocampus and/or striatum as the first sign of dl-HCA action. Generalization of epileptic activity occurred during generalized ...

Known for Immature Rats |  Homocysteic Acid |  Wistar Receptors |  Seizures Induced |  Nmda Receptor
KOL Index score: 9290

PURPOSE: To study the possible relation between spontaneous recurrent seizures (SRS) and the derangement of cognitive memory.

METHODS: Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i.p.) and interrupted after 2 h by clonazepam (CZPs mg/kg, i.p.). In addition to the animals that were given pilocarpine and CZP (group P), two groups received ketamine (100 mg/kg, i.p.): the first group 15 minutes after SE onset (group K15), and the second immediately ...

Known for Status Epilepticus |  Cognitive Functions |  Spontaneous Recurrent Seizures |  Animals Pilocarpine |  Long Evans
KOL Index score: 8615

GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzo-diaz epi ne), a non-competitive non-NMDA receptor antagonist, was tested against epileptic afterdischarges elicited by cortical stimulation in 12-, 18- and 25-day-old rats with implanted electrodes. Shortening of afterdischarges and a decrease in intensity of clonic movements accompanying both stimulation and afterdischarges were induced by the 20 mg/kg dose of GYKI 52466 in 18- and 25-day-old animals, whereas ...

Known for Gyki 52466 |  Cortical Afterdischarges |  Immature Rats |  Wistar Receptors |  Receptor Antagonist
KOL Index score: 8188

GABA(B) receptors mediate inhibition at early stages of development but mixed anti-and proconvulsant action of their agonists affecting all receptors was found in immature rats. Positive allosteric modulators of GABA(B) receptors potentiate only already active GABA(B) receptors and therefore more specific action is expected. Possible anticonvulsant action of CGP7930 was studied in a model of pentetrazol-induced seizures previously used for studies with agonists baclofen and SKF97541. ...

Known for Anticonvulsant Action |  Gabab Receptor |  Immature Rats |  Tonic Phase |  Positive Allosteric Modulators
KOL Index score: 8177

The direct injection of endothelin-1 (ET-1) into brain parenchyma was recently suggested as a suitable model of stroke. The present study was designed to assess whether intrahippocampal injection of ET-1 in immature rats causes neurodegeneration and immediate seizures, and results in impairment of motor development, cognitive decline, epilepsy and chronic hippocampal lesion. ET-1 was injected unilaterally into the dorsal hippocampus in doses of 20 or 40 pmol at the age of 12 (P12) or 25 ...

Known for Immature Rats |  Intrahippocampal Injection |  P12 P25 |  Development Epilepsy |  Dose Et1
KOL Index score: 8145

Electrical stimulation of sensorimotor cortex was used to study early and late effects of administration of kainic acid in a dose (6 mg/kg i.p.) eliciting only nonconvulsive seizures in rats. Thresholds for elicitation of four phenomena--movements directly related to stimulation; epileptic afterdischarges (ADs) of the spike-and-wave type; clonic seizures accompanying these ADs; and mixed type of ADs where spike-and-wave activity transgresses into limbic type of epileptic phenomena--were ...

Known for Kainic Acid |  Sensorimotor Cortex |  Electrical Stimulation |  Thresholds Phenomena |  Clonic Seizures


Pavel Mares̆: Influence Statistics

Sample of concepts for which Pavel Mares̆ is among the top experts in the world.
Concept World rank
seizures antagonists #1
ads characterized #1
8 hz frequency #1
zonisamide selective suppression #1
anticonvulsant action tbps #1
immature brain brain #1
ontogeny ethosuximide action #1
action gabab #1
ifenprodil wistar receptors #1
receptors amn082 #1
clonazepam 19 #1
rma esm #1
hippocampal lesion dose #1
nmda immature rats #1
decreased sensitivity drugs #1
transition limbic ads #1
period precede #1
status se12 #1
zonisamide pediatric neurology #1
2alpha3alphaepoxy ring 3alphahydroxyl #1
immature 12day rats #1
midazolam metrazol #1
testing modulate #1
rma model #1
generation arrest #1
lesion et1 #1
bar holding tests #1
pilocarpine animals #1
vigabatrin control animals #1
tight developmental link #1
action clonazepam #1
antagonists anticonvulsant effects #1
incidences jerks #1
automatisms clonic #1
immature animals mpep #1
administration partial #1
absences induced #1
recurrent ads #1
drug epilepsy rats #1
aci wistar #1
528 rats #1
ontogenesis ghb #1
field tests memantine #1
rat pups felbamate #1
hippocampus α4 subunit #1
18 25dayold animals #1
anxiolytic learning #1
electrocorticographic epileptic #1
aida mtep #1
pentylenetetrazol agegroups #1

Key People For Immature Rats

Top KOLs in the world
Pavel Mares̆
immature rats anticonvulsant action status epilepticus
Hana Kubová
immature rats status epilepticus anticonvulsant action
Solomon L Moshe´
status epilepticus substantia nigra infantile spasms
Yehezkel Ben‐Ari
kainic acid wistar receptors mossy fibers
Gregory L Holmes
status epilepticus neonatal seizures kainic acid
quantitative histochemistry glucuronidase hydrolysis brain iii

Pavel Mares̆:Expert Impact

Concepts for whichPavel Mares̆has direct influence:Immature rats,  Anticonvulsant action,  Status epilepticus,  Epileptic afterdischarges,  Clonic seizures,  Developing rats,  Wistar receptors,  Motor performance.

Pavel Mares̆:KOL impact

Concepts related to the work of other authors for whichfor which Pavel Mares̆ has influence:Status epilepticus,  Immature rats,  Kainic acid,  Infantile spasms,  Antiepileptic drugs,  Absence epilepsy,  Glutamate receptors.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic;,, (P.M.);,, (L.K.);,, (A.M.) | Department of Develop

FREE Custom List