• Disease
  • Lyme
  • Lyme Disease
  • Raphael B Stricker

    Prominent publications by Raphael B Stricker

    KOL Index score: 14843

    Background: Recent reports indicate that more than 300,000 cases of Lyme disease are diagnosed yearly in the USA. Preliminary clinical, epidemiological and immunological studies suggest that infection with the Lyme disease spirochete Borrelia burgdorferi (Bb) could be transferred from person to person via intimate human contact without a tick vector. Failure to detect viable Borrelia spirochetes in vaginal and seminal secretions would argue against this hypothesis. Methods: Patients with ...

    Also Ranks for: Borrelia Spirochetes |  lyme disease |  genital secretions |  culture concentrates |  identical strains
    KOL Index score: 11765

    Problem: Intravenous Immunoglobulins (IVIG) are widely used off label in the treatment of early reproductive failure. As IVIG is expensive, and may have side-effects, evidence of efficacy is needed. Previous results have suggested that the pre-conception treatment of primary recurrent abortion patients might be effective, but the data set has been too small for adequate statistical power. More recently it has been suggested that IVIG may improve the success rate of in vitro fertilization ...

    Also Ranks for: Intravenous Immunoglobulins |  embryo transfer |  pregnancy failure |  ivf patients |  vitro fertilization
    KOL Index score: 10429

    BACKGROUND: Controversy exists regarding the diagnosis and treatment of Lyme disease. Patients with persistent symptoms after standard (2-4-week) antibiotic therapy for this tickborne illness have been denied further antibiotic treatment as a result of the perception that long-term infection with the Lyme spirochete, Borrelia burgdorferi, and associated tickborne pathogens is rare or nonexistent.

    METHODS: I review the pathophysiology of B. burgdorferi infection and the peer-reviewed ...

    Also Ranks for: Lyme Disease |  persistent symptoms |  antibiotic therapy |  burgdorferi infection |  animal dogs
    KOL Index score: 9867

    BACKGROUND: Morgellons disease (MD) is a complex skin disorder characterized by ulcerating lesions that have protruding or embedded filaments. Many clinicians refer to this condition as delusional parasitosis or delusional infestation and consider the filaments to be introduced textile fibers. In contrast, recent studies indicate that MD is a true somatic illness associated with tickborne infection, that the filaments are keratin and collagen in composition and that they result from ...

    Also Ranks for: Morgellons Disease |  borrelia burgdorferi |  dermatological specimens |  md patients |  delusional infestation
    KOL Index score: 8357

    A patient with a lymphoproliferative disorder developed bleeding associated with a prolonged bleeding time and a selective defect of platelet aggregation in response to ristocetin. The patient's purified IgG was shown to inhibit aggregation of washed normal platelets by ristocetin and von Willebrand factor (F VIII:vWF). By Western blotting, it was shown that antibody bound specifically to an antigen of Mr 210,000 present on normal platelets but missing on platelets from patients with ...

    Also Ranks for: Willebrand Factor |  soulier syndrome |  molecular weight |  platelet aggregation |  membrane glycoproteins
    KOL Index score: 8178

    BACKGROUND: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due to formation of different morphological forms of B. burgdorferi, namely round bodies (cysts) and biofilm-like colonies. Better understanding of the effect of antibiotics on ...

    Also Ranks for: Morphological Forms |  lyme disease |  antibiotic therapy |  borrelia burgdorferi |  round bodies
    KOL Index score: 7834

    Complement split products C3a and C4a are reportedly elevated in patients with acute Lyme disease. We have now examined these immunologic markers in patients with chronic Lyme disease compared to appropriate disease controls. The study population consisted of 29 healthy controls, 445 patients with chronic Lyme disease, 11 patients with systemic lupus erythematosus (SLE) and six patients with AIDS. The Lyme disease patients were divided according to predominant musculoskeletal symptoms ...

    Also Ranks for: Lyme Disease |  c3a c4a |  antibiotic therapy
    KOL Index score: 7830

    OBJECTIVE: To evaluate the efficacy of low-dose intravenous immunoglobulin (IVIG) treatment in older women with immunologic abnormalities and recurrent spontaneous abortion (RSA), a condition referred to as immunologic abortion.

    DESIGN: Prospective clinical trial.

    SETTING: Outpatient referral practice.

    PATIENT(S): Forty-seven women were enrolled in the study. The mean age of the women was 37 years (range, 28-45 years), and the mean number of prior miscarriages was 3.7. Immunologic ...

    Also Ranks for: Immunologic Abortion |  ivig treatment |  habitual adult antibodies |  pregnancy women |  intravenous immunoglobulin
    KOL Index score: 7618

    Background: Borrelia spirochetes are tick-borne Gram-negative bacteria that cause disease in humans and animals. Although many studies have focused on Borrelia burgdorferi (Bb), the agent of Lyme disease, recent studies have examined the role of Relapsing Fever Borrelia (RFB) in human disease. In this pilot study, we have evaluated serological reactivity against Bb and RFB in patients residing in California.

    Methods: Serological testing for reactivity to Bb and RFB antigens was performed ...

    Also Ranks for: Bb Rfb |  relapsing fever |  tick borne |  patients tested |  residing california
    KOL Index score: 6984

    Patients with the acquired immune deficiency syndrome (AIDS) and AIDS-related conditons are known to have abnormalities of T cell subpopulations, including a decreased helper/inducer (bearing the CD4 antigen) to suppressor/cytotoxic (bearing the CDS antigen) T cell ratio and decreased absolute numbers of T cells with the CD4+ phenotype1,2. Infection of T cells with a retrovirus, termed human immunodeficiency virus (HIV), is thought to be important in these abnormalities3–5. HIV infection ...

    Also Ranks for: Cd4 Cells |  antigen cell |  absolute numbers |  human immunodeficiency virus |  immunodeficiency syndrome
    KOL Index score: 6842

    INTRODUCTION: Lyme disease is a tickborne illness that generates controversy among medical providers and researchers. One of the key topics of debate is the existence of persistent infection with the Lyme spirochete, Borreliaburgdorferi, in patients who have been treated with recommended doses of antibiotics yet remain symptomatic. Persistent spirochetal infection despite antibiotic therapy has recently been demonstrated in non-human primates. We present evidence of persistent Borrelia ...

    Also Ranks for: Lyme Disease |  borrelia infection |  ongoing symptoms |  antibiotic therapy |  patients persistent
    KOL Index score: 6627

    BACKGROUND: Chronic Lyme disease (LD) is a debilitating illness caused by tickborne infection with the spirochete Borrelia burgdorferi. Although immunologic abnormalities appear to play a role in this disease, specific immunologic markers of chronic LD have not been identified.

    METHODS: We evaluated 73 patients with chronic LD for lymphocyte subset abnormalities using flow cytometry. Of these, 53 patients had predominant musculoskeletal symptoms, while 20 patients had predominant ...

    Also Ranks for: Chronic Lyme |  antibiotic treatment |  disease ld |  cd57 lymphocyte subset |  patients symptoms


    Raphael B Stricker: Influence Statistics

    Sample of concepts for which Raphael B Stricker is among the top experts in the world.
    Concept World rank
    cd57 levels #1
    cultures genital #1
    ease crossspecies transfer #1
    evidencebased refutation #1
    ongoing lyme #1
    cld lyme disease #1
    latestage filamentous fibers #1
    positive serological testing #1
    dermal filaments #1
    viable borrelia spirochetes #1
    13 lyme #1
    case musical hallucinations #1
    rfb detected #1
    dinitrochlorobenzene hiv #1
    clinicians textile fibers #1
    culture concentrates #1
    mysterious skin disorder #1
    gershon letter #1
    counties seropositivity #1
    guidelines reform #1
    microscopy spirochete #1
    spirochetal forms burgdorferi #1
    chandra publication antibodies #1
    subcutaneous fibers #1
    fiberlike strands #1
    laboratory confirmation ld #1
    antitrust laws conflict #1
    improved cognition fatigue #1
    biofilmlike colonies doxycycline #1
    covid19 35 people #1
    patients acute ld #1
    visible spirochetes #1
    antibiotic therapy case #1
    repeated dncb #1
    hiv1 precursor virus #1
    laboratories blinded #1
    positive staining keratinocytes #1
    hiv denialists #1
    hp amyloid markers #1
    chronic ld #1
    lyme big data #1
    rfb seropositivity counties #1
    md borrelia #1

    Key People For Lyme Disease

    Top KOLs in the world
    Allen C Steere
    lyme disease borrelia burgdorferi united states
    Gary P Wormser
    lyme disease erythema migrans united states
    Alan G Barbour
    lyme disease borrelia burgdorferi relapsing fever
    Durland Fish
    lyme disease united states borrelia burgdorferi
    Stephen E Malawista
    lyme disease borrelia burgdorferi polymorphonuclear leukocytes
    Raymond J Dattwyler
    lyme disease borrelia burgdorferi bacterial antigens

    Raphael B Stricker:Expert Impact

    Concepts for whichRaphael B Strickerhas direct influence:Lyme disease,  Morgellons disease,  Chronic lyme disease,  Immunologic abortion,  Hiv disease,  Antibiotic therapy,  Persistent symptoms,  Chronic lyme.

    Raphael B Stricker:KOL impact

    Concepts related to the work of other authors for whichfor which Raphael B Stricker has influence:Lyme disease,  Hiv infection,  Human immunodeficiency virus,  Borrelia burgdorferi,  Myasthenia gravis,  Plasma exchange,  Intravenous immunoglobulin.



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    Alan E. Beer Medical Center for Reproductive Immunology, Los Gatos, CA, USA | Union Square Medical Associates, San Francisco, CA, USA | Union Square Medical Associates, San Francisco, CA, USA. Electronic address: rstricker@usmamed.com. | Union Square