• Disease
  • Disseminated
  • Disseminated Histoplasmosis
  • Lawrence Joseph Wheat

    Prominent publications by Lawrence Joseph Wheat

    KOL Index score: 16038

    The effects of prolonged itraconazole exposure on the susceptibility of Candida albicans isolates to itraconazole and fluconazole have not been well characterized. A recent placebo-controlled study of long-term itraconazole antifungal prophylaxis in persons with advanced human immunodeficiency virus infection afforded the opportunity to address this question. Mucosal Candida sp. isolates were obtained from subjects who developed oropharyngeal or esophageal candidiasis, and in vitro ...

    Also Ranks for: Candida Albicans |  itraconazole fluconazole |  vitro azole resistance |  immunodeficiency virus |  mucosal candidiasis
    KOL Index score: 12790

    We review the experience at our institution with galactomannan (GM) testing of bronchoalveolar lavage (BAL) fluid in the diagnosis of invasive pulmonary aspergillosis (IPA) among solid-organ transplant recipients. Among 81 patients for whom BAL GM testing was ordered (heart, 24; kidney, 22; liver, 19; lung, 16), there were five cases of proven or probable IPA. All five patients had BAL GM of > or = 2.1 and survived following antifungal therapy. The sensitivity, specificity, and positive ...

    Also Ranks for: Bronchoalveolar Lavage |  transplant recipients |  bal gm |  specificity positive predictive |  invasive pulmonary
    KOL Index score: 12666

    CONTEXT: Management of antiretroviral treatment failure in patients receiving protease inhibitor (PI)-containing regimens is a therapeutic challenge.

    OBJECTIVE: To assess whether adding a second PI improves antiviral efficacy of a 4-drug combination in patients with virologic failure while taking a PI-containing regimen.

    DESIGN: Multicenter, randomized, 4-arm trial, double-blind and placebo-controlled for second PI, conducted between October 1998 and April 2000, for which there was a ...

    Also Ranks for: Viral Load |  protease inhibitor |  24 weeks |  saquinavir indinavir |  prior exposure
    KOL Index score: 12483

    Pulmonary aspergillosis in nonimmunocompromised hosts, although rare, is being increasingly recognized. The diagnosis of pulmonary aspergillosis is difficult, since the recovery of Aspergillus from respiratory samples cannot differentiate colonization from invasion. We assessed the role of bronchoalveolar lavage (BAL) in detecting galactomannan (GM) for diagnosing pulmonary aspergillosis in 73 nonimmunocompromised patients with pulmonary infiltrates for whom the test was ordered. Six ...

    Also Ranks for: Pulmonary Aspergillosis |  bronchoalveolar lavage |  sensitivity specificity |  galactomannan diagnosis |  bal gm
    KOL Index score: 12354

    A randomized, open-label, comparative study was conducted in 30 male patients with moderately advanced human immunodeficiency virus (HIV) infection to examine the pharmacokinetics of an investigational intravenous preparation of itraconazole compared with pharmacokinetics after administration of itraconazole capsules. The study also assessed whether adequate plasma concentrations of itraconazole could be rapidly achieved with the intravenous formulation and then maintained after ...

    Also Ranks for: Intravenous Itraconazole |  plasma concentrations |  oral administration |  virus infection |  capsules patients
    KOL Index score: 11720

    BACKGROUND: Detection of antigen in BAL is useful for diagnosis of histoplasmosis. The MVista Histoplasma antigen enzyme immunoassay has been modified to permit quantification. The purpose of this study is to compare the sensitivity of the quantitative antigen detection assay with cytopathology and culture of BAL specimens.

    METHODS: BAL from patients with histoplasmosis who were evaluated at the Indiana University Medical Center and controls without histoplasmosis were studied. BAL fluid ...

    Also Ranks for: Antigen Detection |  patients histoplasmosis |  bal fluid |  serum urine |  diagnosis sensitivity
    KOL Index score: 11559

    PURPOSE: Oropharyngeal candidasis (thrush) is the most common opportunistic infection in individuals who are positive for the human immunodeficiency virus (HIV) and those who have progressed to AIDS. Itraconazole has a broad in vitro spectrum of activity, including a wide variety of Candida species. Our study determined the relative efficacy of a new oral solution formulation of itraconazole and fluconazole tablets in the treatment of oropharyngeal candidiasis.


    Also Ranks for: Itraconazole Oral Solution |  oropharyngeal candidiasis |  aids patients |  fluconazole treatment |  7 14
    KOL Index score: 11384

    The diagnosis of Histoplasma capsulatum infection by serologic testing for the presence of antibodies is limited by a high rate of false positive and false negative results and by the requirement that the patient have a normal immune response. We have developed a radioimmunoassay for the detection of H. capsulatum antigen in urine and serum specimens. Antigenuria was noted in 20 of 22 episodes of disseminated histoplasmosis that occurred in 16 patients, in 6 of 32 patients with ...

    Also Ranks for: Capsulatum Antigen |  disseminated histoplasmosis |  urine specimens |  16 patients |  serologic testing
    KOL Index score: 10708

    Background: Central nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of Histoplasma capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the ...

    Also Ranks for: Histoplasma Meningitis |  cerebrospinal fluid |  cns histoplasmosis |  antibody csf |  central nervous
    KOL Index score: 10429

    PURPOSE: Disseminated histoplasmosis is a serious and often rapidly progressive, opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), supporting the importance of rapid diagnostic tests. We investigated Histoplasma capsulatum polysaccharide antigen (HPA) detection, a promising new method for rapid diagnosis of histoplasmosis.

    PATIENTS AND METHODS: Sixty-one cases of disseminated histoplasmosis in patients with AIDS form the basis of this report. Control ...

    Also Ranks for: Disseminated Histoplasmosis |  patients aids |  immunodeficiency syndrome |  hpa urine |  antigen detection
    KOL Index score: 10221

    PURPOSE: The purpose of this study was to establish the effect of induction and maintenance treatment with amphotericin B on levels of Histoplasma capsulatum var. capsulatum polysaccharide antigen (HPA) in the urine and blood of patients with acquired immunodeficiency syndrome (AIDS) and disseminated histoplasmosis.

    PATIENTS AND METHODS: This was a retrospective study of the effect of amphotericin B treatment on levels of HPA in the urine or serum from 70 patients with AIDS and ...

    Also Ranks for: Histoplasma Capsulatum |  urine serum |  successful treatment |  patients amphotericin |  disseminated histoplasmosis
    KOL Index score: 10175

    BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell ...

    Also Ranks for: Consensus Definitions |  european organization |  mycoses study |  invasive fungal |  patients cancer
    KOL Index score: 9565

    We have evaluated the Platelia Aspergillus enzyme immunoassay for detection of galactomannan in bronchoalveolar lavage (BAL) specimens in solid organ transplant patients with aspergillosis. The precision and reproducibility in serum or BAL to which galactomannan was added were similar. Sensitivity was 81.8% in patients with aspergillosis, and specificity was 95.8% in lung transplant patients who underwent BAL for surveillance for infection or rejection. Among transplant controls, ...

    Also Ranks for: Bronchoalveolar Lavage |  aspergillus galactomannan |  performance characteristics |  sensitivity specificity |  patients aspergillosis


    Lawrence Joseph Wheat: Influence Statistics

    Sample of concepts for which Lawrence Joseph Wheat is among the top experts in the world.
    Concept World rank
    invasive aspergillosis physicians #1
    staphylococcus epidermidis antigens #1
    higg elisa #1
    histoplasmosis marked #1
    itraconazole capsules 28 #1
    histoplasmosis1–4 #1
    xray computed indium111 #1
    imaging procedures osteomyelitis #1
    patients disseminated histoplasmosis #1
    study histoplasma #1
    antifungal treatment time #1
    acute pulmonary histoplasmosis #1
    histoplasmosis panama #1
    200 intravenous itraconazole #1
    flu 75 day #1
    excellent laboratory methods #1
    agents histoplasmosis #1
    panama histoplasmosis humans #1
    concern murine model #1
    50saturated ammonium sulfate #1
    ambflu #1
    4 survivors mice #1
    histoplasmosis exposure #1
    histoplasmosis hpa #1
    histoplasmosis cases institution #1
    hpa detected #1
    falsely negative specimens #1
    indiana central indiana #1
    25 normal 95 #1
    intracellular proliferation capsulatum #1
    anti histoplasma #1
    histoplasmosis false #1
    antibodies blastomyces dermatitidis #1
    dogs antibody eia #1
    sensitivity mvista #1
    histoplasma capsulation #1
    gastrointestinal histoplasmosis gih #1
    hpa syndrome antigens #1
    chronic meningitis patient #1
    basis positive culture #1
    syndrome amphotericin #1
    antih capsulatum #1
    histoplasmosis mvista #1
    20 22 episodes #1
    cases lfa #1
    serogroup 1 infections #1
    dermatitidis antigen patients #1
    coccidioides cross #1
    positive edta treatment #1
    twins agents antigens #1

    Key People For Disseminated Histoplasmosis

    Top KOLs in the world
    Lawrence Joseph Wheat
    disseminated histoplasmosis histoplasma capsulatum antigen detection
    Carol A Kauffman
    fungal infections zoster vaccine endemic mycoses
    David S McKinsey
    fluconazole therapy hiv treatment histoplasmosis patients
    George A Sarosi
    disseminated histoplasmosis fungal infections pulmonary blastomycosis
    James E Loyd
    pulmonary hypertension bmpr2 mutation mediastinal fibrosis
    Roger M Des Prez
    bacterial endotoxin mediastinal fibrosis apical localization

    Lawrence Joseph Wheat:Expert Impact

    Concepts for whichLawrence Joseph Wheathas direct influence:Disseminated histoplasmosis,  Histoplasma antigen,  Capsulatum antigen,  Histoplasma capsulatum,  Fungal antigens,  Antigen detection,  Rapid diagnosis,  Enzyme immunoassay.

    Lawrence Joseph Wheat:KOL impact

    Concepts related to the work of other authors for whichfor which Lawrence Joseph Wheat has influence:Fungal infections,  Disseminated histoplasmosis,  Histoplasma capsulatum,  Invasive aspergillosis,  Central nervous,  Immunocompromised patients,  Diabetic foot.



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