• Disease
  • Inducible
  • Inducible Factor
  • Gregg L Semenza

    Prominent publications by Gregg L Semenza

    KOL Index score: 21325

    Stimulation of human colon cancer cells with insulin-like growth factor 1 (IGF-1) induces expression of the VEGF gene, encoding vascular endothelial growth factor. In this article we demonstrate that exposure of HCT116 human colon carcinoma cells to IGF-1 induces the expression of HIF-1 alpha, the regulated subunit of hypoxia-inducible factor 1, a known transactivator of the VEGF gene. In contrast to hypoxia, which induces HIF-1 alpha expression by inhibiting its ubiquitination and ...

    Also Ranks for: Factor Expression |  kinase signaling |  endothelial growth |  phosphatidylinositol 3 |  induces hypoxia
    KOL Index score: 19667

    Hypoxia stimulates a number of pathways critical to cancer cell survival, including the activation of vascular endothelial growth factor (VEGF) transcription. In normal fibroblasts, hypoxia-induced activation of the protein tyrosine kinase, Src, is required for VEGF expression. We show here in both pancreatic and prostate carcinoma cell lines cobalt chloride (used to mimic hypoxia) -induced VEGF expression requires Src activation and leads to increased steady-state levels of HIF-1α and ...

    Also Ranks for: Vegf Expression |  hif1α stat3 |  apyrimidinic site |  prostate carcinomas |  neoplastic humans
    KOL Index score: 18739

    Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important clinical contexts, including myocardial ischemia, retinal disease, and tumor growth. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix protein that activates transcription of the human erythropoietin gene in hypoxic cells. Here we demonstrate the involvement of HIF-1 in the activation of ...

    Also Ranks for: Factor Gene |  endothelial growth |  vegf transcription |  hypoxic cells |  hif1 activation
    KOL Index score: 18267

    Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator composed of HIF-1alpha and HIF-1beta subunits. Several dozen HIF-1 targets are known, including the gene encoding vascular endothelial growth factor (VEGF). Under hypoxic conditions, HIF-1alpha expression increases as a result of decreased ubiquitination and degradation. The tumor suppressors VHL (von Hippel-Lindau protein) and p53 target HIF-1alpha for ubiquitination such that their inactivation in tumor cells increases ...

    Also Ranks for: Factor Expression |  vascular endothelial |  messenger rna |  oncogene proteins |  tumor cells
    KOL Index score: 17218

    Hypoxia-inducible factor 1 (HIF-1) is a transcription factor involved in normal mammalian development and in the pathogenesis of several disease states. It consists of two subunits, HIF-1alpha, which is degraded during normoxia, and HIF-1beta, which is constitutively expressed. Activated HIF-1 induces the expression of genes involved in angiogenesis, erythropoiesis, and glucose metabolism. We have previously reported that insulin stimulates vascular endothelial growth factor (VEGF) ...

    Also Ranks for: Factor 1 |  signaling pathway |  vegf expression |  endothelial growth |  insulin stimulates
    KOL Index score: 16961

    The genetic hallmark of hemangioblastomas and clear cell-renal cell carcinomas (CC-RCCs) is loss-of-function of the von Hippel-Lindau (VHL) tumor suppressor protein. VHL is required for oxygen-dependent degradation of hypoxia-inducible factor-1alpha (HIF-1alpha). In hemangioblastomas and CC-RCCs, HIF-1alpha is constitutively overexpressed leading to increased transcription of HIF-1-regulated genes, including vascular endothelial growth factor (VEGF). Because loss of VHL function is ...

    Also Ranks for: Cxcr4 Expression |  stromal cell |  messenger receptors |  tumor suppressor |  hippel lindau
    KOL Index score: 16723

    Vascular endothelial growth factor (VEGF) upregulation is induced by many receptor and intracellular oncogenic proteins commonly activated in cancer, rendering molecular targeting of VEGF expression a complex challenge. While VEGF inducers abound, only two major transcription activators have been identified for its promoter: hypoxia inducible factor-1 (HIF-1) and signal transducer and activator of transcription (Stat3). Both HIF-1 expression and Stat3 activity are upregulated in diverse ...

    Also Ranks for: Vegf Expression |  stat3 hif1 |  growth factor |  neoplastic humans |  signaling pathways
    KOL Index score: 16715

    Iron chelators are pluripotent neuronal antiapoptotic agents that have been shown to enhance metabolic recovery in cerebral ischemia models. The precise mechanism(s) by which these agents exert their effects remains unclear. Recent studies have demonstrated that iron chelators activate a hypoxia signal transduction pathway in non-neuronal cells that culminates in the stabilization of the transcriptional activator hypoxia-inducible factor-1 (HIF-1) and increased expression of gene ...

    Also Ranks for: Iron Chelators |  oxidative stress |  dna binding |  inducible factor |  induced apoptosis
    KOL Index score: 16603

    Chronic intermittent hypoxia (CIH) occurs in patients with sleep apnoea and has adverse effects on multiple physiological functions. Previous studies have shown that reflexes arising from carotid bodies mediate CIH-evoked cardio-respiratory responses, and reactive oxygen species (ROS) play important roles in eliciting systemic responses to CIH. Very little is known about the molecular mechanisms underlying CIH. The transcriptional activator hypoxia-inducible factor-1 (HIF-1) mediates a ...

    Also Ranks for: Intermittent Hypoxia |  mice exposed |  ros cih |  reactive oxygen |  carotid body
    KOL Index score: 15742

    Understanding molecular mechanisms regulating angiogenesis may lead to novel therapies for ischemic disorders. Hypoxia-inducible factor 1 (HIF-1) activates vascular endothelial growth factor (VEGF) gene expression in hypoxic/ischemic tissue. In this study we demonstrate that exposure of primary cultures of cardiac and vascular cells to hypoxia or AdCA5, an adenovirus encoding a constitutively active form of HIF-1alpha, modulates the expression of genes encoding the angiogenic factors ...

    Also Ranks for: Gene Expression |  cell type |  growth factor |  cardiac neovascularization |  hypoxia adca5
    KOL Index score: 15324

    In response to hypoxia, mammalian cells express multiple gene products [including erythropoietin (EPO) and vascular endothelial growth factor (VEGF)] that serve to increase O2 delivery, as well as glucose transporters and glycolytic enzymes (such as enolase 1) that allow metabolic adaptation to decreased O2 availability. Increased transcription of the genes encoding these proteins in hypoxic cells is mediated by hypoxia-inducible factor 1 (HIF-1), a basic helix-loop-helix transcription ...

    Also Ranks for: Factor 1 |  endothelial growth |  expression hypoxia |  messenger rats receptor |  erythropoietin epo
    KOL Index score: 15236

    N(6)-methyladenosine (m(6)A) modification of mRNA plays a role in regulating embryonic stem cell pluripotency. However, the physiological signals that determine the balance between methylation and demethylation have not been described, nor have studies addressed the role of m(6)A in cancer stem cells. We report that exposure of breast cancer cells to hypoxia stimulated hypoxia-inducible factor (HIF)-1α- and HIF-2α-dependent expression of AlkB homolog 5 (ALKBH5), an m(6)A demethylase, ...

    Also Ranks for: Nanog Mrna |  stem cell |  breast cancer |  alkb homolog |  m6a demethylase


    Gregg L Semenza: Influence Statistics

    Sample of concepts for which Gregg L Semenza is among the top experts in the world.
    Concept World rank
    hypoxia druginduced senescence #1
    ser692 pka #1
    cancer knockout myocytes #1
    noc18 hif1alpha hydroxylation #1
    alpha subunit luciferases #1
    small molecular medicine #1
    hif1α himf #1
    aerobic cancer cells #1
    mobilization bmdacs #1
    expression bcsc #1
    evasion 5nucleotidase animals #1
    adrenal medulla cb #1
    hif1a 15 exons #1
    hypoxiainducible factor dinitrate #1
    hif1alpha degradation #1
    pluripotency factor #1
    nonhypoxic conditions ubiquitination #1
    itgb1 itga5 #1
    diverse cancers stat3 #1
    transcription factor hif1 #1
    epo transcriptional activation #1
    o2 regulated #1
    angiogenesis mrna expression #1
    inducible factor #1
    hifs nv #1
    tension‐dependent manner #1
    fx11 progression #1
    transactivation inducible factor #1
    hif1α taz #1
    tgepo4 #1
    calr breast cancer #1
    animal model phenomenon #1
    hif2α mice #1
    hif1dependent manner #1
    inducible myc hif1 #1
    hypoxiainducible factor genetic #1
    enrichment breast #1
    induced bcsc #1
    glycolytic switch warburg #1
    3 phds #1
    hypoxiainducible enhancer #1
    rack1 competes #1
    cbs knockdown #1
    pkm2 gene #1
    pair alpha subunit #1
    brca cells ecs #1
    murine kidney liver #1
    vegf sph #1
    kdm6a bcsc enrichment #1
    subunit ischemic #1

    Key People For Inducible Factor

    Top KOLs in the world
    Gregg L Semenza
    inducible factor breast cancer gene expression
    Peter John Ratcliffe
    inducible factor gene expression oxygen sensing
    Patrick Henry Maxwell
    inducible factor gene expression mother cells
    Christopher W Pugh
    inducible factor gene expression prolyl hydroxylation
    Randall Scott Johnson
    inducible factor skeletal muscle myeloid cells
    Bing‐Hua Jiang
    tumor growth ovarian cancer inducible factor

    Gregg L Semenza:Expert Impact

    Concepts for whichGregg L Semenzahas direct influence:Inducible factor,  Factor 1,  Hypoxiainducible factor,  Hypoxia inducible,  Breast cancer,  Gene expression,  Growth factor,  Intermittent hypoxia.

    Gregg L Semenza:KOL impact

    Concepts related to the work of other authors for whichfor which Gregg L Semenza has influence:Cancer cells,  Inducible factor,  Gene expression,  Oxidative stress,  Tumor microenvironment,  Cell proliferation,  Endothelial growth.



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    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA | Stanley Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. | Armstrong Oxygen Biology Research Center, | Departme